1F8A,1E0L,1E0M,1EG3,1I5H,1K5R


Conserved Protein Domain Family
WW
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cd00201: WW 
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Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.
Links
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Statistics
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PSSM-Id: 238122
Aligned: 134 rows
Threshold Bit Score: 32.885
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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binding pocket
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1:binding pocket
Evidence:
  • Comment:binds X-P motifs
  • Structure:CTD repeat (Y-pS-P-T-pS-P-S)
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                     #          #     
1F8A_B      12 PPGWEKRMSRssGRVYYFNhITNASQWERPSG 43   human
1175361     92 NDSWVVVFTKk-NRYFFHNlKSHESYWEPPLE 122  fission yeast
1176535     99 LNGWFEYETDv-GRTFFFNkETGKSQWIPPRF 129  Caenorhabditis elegans
4589466    284 ATPWRELVDEasGAPFFFNvETGDTTWELPAA 315  Chlamydomonas reinhardtii
6005948    125 KGRWVEGITSe-GYHYYYDlISGASQWEKPEG 155  human
AAF48272  2015 PPAWNWQVTSd-GDIYYYNlRERISQWEPPSP 2045 fruit fly
AAF54130   114 PEIWVETKAEd-GRSYYYHaVTRETTWSRPDG 144  fruit fly
7487624    240 KEEWIETFDEasGHKYFYNtRTHVSQWEPPAS 271  thale cress
9055380    126 KGGWVEGVTAd-GHCYYYDlITGASQWEKPEG 156  house mouse
9506443    533 GTPWCVVWTGd-ERVFFYNpTTRLSMWDRPDD 563  house mouse

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