2E2Q,2E2N,2E2O,2E2P


Conserved Protein Domain Family
ASKHA_NBD_StHK-like
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cd24080: ASKHA_NBD_StHK-like 
nucleotide-binding domain (NBD) of Sulfurisphaera tokodaii ATP-dependent hexokinase (StHK) and similar proteins
The family includes a group of uncharacterized proteins similar to Sulfurisphaera tokodaii ATP-dependent hexokinase (StHK). Hexokinase (EC 2.7.1.1) catalyzes the phosphorylation of glucose to glucose 6-phosphate by using ATP as a phosphoryl donor. StHK is a novel hexokinase that can phosphorylate not only glucose but also GlcNAc, glucosamine, and mannose. It differs from other known hexokinases and glucokinases in that its activity is strongly inhibited by ADP. It is distinct in its broad substrate specificity from the GlcNAc kinases, which are specific for GlcNAc.
Links
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Statistics
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PSSM-Id: 466930
Aligned: 9 rows
Threshold Bit Score: 369.445
Created: 23-Jan-2023
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 30 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:2E2Q; Sulfurisphaera tokodaii hexokinase in complex with xylose and MgADP, contacts at 4A
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             #### #                                                           # #    
2E2Q_A      2 MIIVGVDAGGTKTKAVAYDCeGNFIGEGSSGPGNyHNVGLTRAIENIKEAVKIAAkg------eaDVVGMGVAGlDSKFD 75  Sulfolobus tokodaii
2E2N_A      2 MIIVGVDAGGTKTKAVAYDCeGNFIGEGSSGPGNyHNVGLTRAIENIKEAVKIAAkg------eaDVVGMGVAGlDSKFD 75  Sulfolobus tokodaii
2E2O_A      2 MIIVGVDAGGTKTKAVAYDCeGNFIGEGSSGPGNyHNVGLTRAIENIKEAVKIAAkg------eaDVVGMGVAGlDSKFD 75  Sulfolobus tokodaii
2E2P_A      2 MIIVGVDAGGTKTKAVAYDCeGNFIGEGSSGPGNyHNVGLTRAIENIKEAVKIAAkg------eaDVVGMGVAGlDSKFD 75  Sulfolobus tokodaii
Q97U07      1 MILVGVDGGGSKTSAIAYTCsGSFLGKGLAGPANfHNVGVEEAVKNVNRAILLATkgm-----kpDVAYVGLAGvDSRYD 75  Saccharolobus solf...
KSW11641    1 MLVAGVDAGATRTRALVYDTgSGGVWAGSAGPGNpVNVGAASAGAAVREAVEAALrgtghrasrvSLVVAGFAGlDSRLL 80  Pyrodictium occultum
OYT28839    8 VIILAIDGGGSKTEAIALNDkADVLGRGLAGPSNpNVVGLKSCIEAILLAARRALkegg--lekaDILVAGIAGaGRFKT 85  Thermofilum sp. ex...
RLE79716    1 MRILGVDSGGSKTEAVVIDEkGRVLRYFLGRGCNiAVENEENIRKIFSRVFEQVGs--------vDLAVLGMAGaGRKKH 72  Thermoprotei archaeon
RLE81442    2 EVLLGVDGGGTRTEALTVDLkGRIVGYGTAGPSNiNLVGVEAAEREVVLAIKRALkpg----lriRRAVLGFAGaGRKGS 77  Thermoprotei archaeon

Feature 1                          ##                   #####           #  ###    #   #       
2E2Q_A     76 WENFTPLAsl---iaPKVIIQHDGVIALFAEtlgePGVVVIAGTGSVVEGYNg-kEFLRVGGRGWLLSDDGSAYWVGRKA 151 Sulfolobus tokodaii
2E2N_A     76 WENFTPLAsl---iaPKVIIQHDGVIALFAEtlgePGVVVIAGTGSVVEGYNg-kEFLRVGGRGWLLSDDGSAYWVGRKA 151 Sulfolobus tokodaii
2E2O_A     76 WENFTPLAsl---iaPKVIIQHDGVIALFAEtlgePGVVVIAGTGSVVEGYNg-kEFLRVGGRGWLLSDDGSAYWVGRKA 151 Sulfolobus tokodaii
2E2P_A     76 WENFTPLAsl---iaPKVIIQHDGVIALFAEtlgePGVVVIAGTGSVVEGYNg-kEFLRVGGRGWLLSDDGSAYWVGRKA 151 Sulfolobus tokodaii
Q97U07     76 YNIMAEALrs---iaKNVYVDHDGFVALYAEtrgnPGVIVIAGTGSVIVGYDg-nRRVRFGGLGWLIADEGSAYWIGREA 151 Saccharolobus solf...
KSW11641   81 AGQLAGLIasasgygGRLVVEHDAHIALVHAtgggPGALVIAGTGSIAYALTprgERIIVGDHGWLLGDEGSGFWVAREA 160 Pyrodictium occultum
OYT28839   86 KSLIKDSLskt-giaKKYLIFSDAEIYLVAStrgsSGIMVNSGTGMIVLGMDdrgRIARSGGWGYLIDDEGSGFWIGREA 164 Thermofilum sp. ex...
RLE79716   73 VKKATEILsri-isaKKLIVLSDAEVALIASthysPGVLIIAGTGSIAFSLNenrRVHRCGGLGYLLGDEGGGYWIGLRA 151 Thermoprotei archaeon
RLE81442   78 LEKYTAIVkkl--gfQNFTVTTDGFISLIAAtqfnPGVMVSAGTGTITMGIDgggRVVRASGWGYLVGDEGSGFWIGSRI 155 Thermoprotei archaeon

Feature 1                                                    ## ##  #                         
2E2Q_A    152 LRKVLKMMDGLenkTILYNKVLKTINvkDLDELVMWSYTSSCqiDLVASIAKAVDEAANEgDTVAMDILKQGAELLASQA 231 Sulfolobus tokodaii
2E2N_A    152 LRKVLKMMDGLenkTILYNKVLKTINvkDLDELVMWSYTSSCqiDLVASIAKAVDEAANEgDTVAMDILKQGAELLASQA 231 Sulfolobus tokodaii
2E2O_A    152 LRKVLKMMDGLenkTILYNKVLKTINvkDLDELVMWSYTSSCqiDLVASIAKAVDEAANEgDTVAMDILKQGAELLASQA 231 Sulfolobus tokodaii
2E2P_A    152 LRKVLKMMDGLenkTILYNKVLKTINvkDLDELVMWSYTSSCqiDLVASIAKAVDEAANEgDTVAMDILKQGAELLASQA 231 Sulfolobus tokodaii
Q97U07    152 LRAFGKMLDGRinkTIIADKIMKNLNinDVDDLIKWAYHEGHkvKDIASLAKIVDEAANEgDWIALDILKNAAFELASYA 231 Saccharolobus solf...
KSW11641  161 LRTLLRALDGRgehSCLTRVLASTLGvtSGDELAYWFYLTRGrvDKIASLAPRVAEAAEEgCMEARSILERGAVELAEAA 240 Pyrodictium occultum
OYT28839  165 LNAVFRSLDGRgppTLLSEEVLRFFNseDFDDLIIKIYSSLTp-TDISKLTHVVDKLYET-DGVSRDIVRRAAQELAKAV 242 Thermofilum sp. ex...
RLE79716  152 LRLLARILDGReekSRLAERLMEALGvsDIDELVEKTYSELSv-SEIASLAKIVVELSEV-DSYARRIVEDACTELARLA 229 Thermoprotei archaeon
RLE81442  156 LNMLSREIDGRsdvTGLADIVFKWFKveDFDSLLEKIYSSKNpvVLIASLLEAVQEVWHQ-HPVLYNIIQEAARELALGV 234 Thermoprotei archaeon

Feature 1                       ### ##                                         
2E2Q_A    232 VYLARKIg---tNKVYLKGGMFRS-NIYHKFFTLYLEKEgiisd---lgkrsPEIGAVILAYKEV 289 Sulfolobus tokodaii
2E2N_A    232 VYLARKIg---tNKVYLKGGMFRS-NIYHKFFTLYLEKEgiisd---lgkrsPEIGAVILAYKEV 289 Sulfolobus tokodaii
2E2O_A    232 VYLARKIg---tNKVYLKGGMFRS-NIYHKFFTLYLEKEgiisd---lgkrsPEIGAVILAYKEV 289 Sulfolobus tokodaii
2E2P_A    232 VYLARKIg---tNKVYLKGGMFRS-NIYHKFFTLYLEKEgiisd---lgkrsPEIGAVILAYKEV 289 Sulfolobus tokodaii
Q97U07    232 VQLAVKIg---vDKIFLKGGMFNS-SVYYNFFRNYLDNNnikgv---iaehePEQGALLLAFKYS 289 Saccharolobus solfataricus
KSW11641  241 RVAAEKAg---aEIVYTTGSMFKS-RVFAERFRRELEAHgigvs---gkrvyPVVGALMLALERL 298 Pyrodictium occultum
OYT28839  243 EAVRAKLnlrypVRVYCVGGAFEM-KSLLSEFERALGDKyfisk----vklsPVVGAAILGLKEL 302 Thermofilum sp. ex4484_79
RLE79716  230 KCAADKArl-nyPIVYYQGGLFSS-KIFRKVFYEKLLEIfknrvilkkplfkPVAGSLLIAWRYL 292 Thermoprotei archaeon
RLE81442  235 AAVVKRLdlkppVKVYYGGGVFNLgERFIELFTRELKKLigavsv-hgstfkPVFGAVLYAFKLE 298 Thermoprotei archaeon

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