Conserved Protein Domain Family
MetRS_RNA
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cd00939: MetRS_RNA 
MetRS_RNA binding domain. This short RNA-binding domain is found at the C-terminus of MetRS in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is repeated in Drosophila MetRS. This domain consists of a helix-turn-helix structure, which is similar to other RNA-binding proteins. It is involved in both protein-RNA interactions by binding tRNA and protein-protein interactions, which are important for the formation of aaRSs into multienzyme complexes.
Links
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Statistics
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PSSM-Id: 238475
Aligned: 8 rows
Threshold Bit Score: 52.8598
Created: 24-Sep-2002
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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tRNA binding
Feature 1:tRNA binding site [nucleic acid binding site]
Evidence:
  • Comment:based on similarity to EPRS RNA binding domain
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                      # #  #    #    #   #       #       #  
NP_004981           845 LMDEVTKQGNIVRELKAQKadKNEVAAEVAKLLDLKKQLAVAEGK 889  human
FlyBase:CG15100-PA  828 LEKAVQAQADKVRELKASTkdKAIWQPEVTKLLDLKKQLEEAKKK 872  fruit fly
FlyBase:CG15100-PA  966 LEDKIAQQAEKVRTLKATGd-AAVWKPEVDILLSLKNELAALTGT 1009 fruit fly
AAM50099            885 LEKAIQEQGDKVRKLKGSTkdKTVWQPEVNILLDLKKQLEAVQKA 929  fruit fly
AAH57463            857 LTALVAEQGEKVRALKAQKaeKSAIGVEVAKLLDLKNQLCLAEGK 901  zebrafish
EAA12906            843 AQKAVDEQAAKVRKIKSSGadRTVWQPEVNILLELKKQLQTLSQP 887  Anopheles gambiae str. PEST
EAA12906            915 TEEEIAQQGNKVRKLKEANsdKSVWQPEVSLLLSLKQKLASLTGV 959  Anopheles gambiae str. PEST
AAH77353            848 LMQEVEKQGNHVRELKGKKaeKSTIDSEVQKLLALKKELALAEGK 892  African clawed frog

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