Conserved Protein Domain Family
PRK09222

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PRK09222: PRK09222 
NADP-dependent isocitrate dehydrogenase
Statistics
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PSSM-Id: 236416
Aligned: 55 rows
Threshold Bit Score: 739.782
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
189184546   4 VIPVTIAYGDGIGPEIMEAVVYVLKEAAVPLRLETIEIGEKLYNKYYTYGITEDTWSQIFRTKALLKGPVTTPQGEGYKS 83 
46199474   19 RKLITVIPGDGVGPECVEATLKVLEAAKAPLAYEVREAGASVFRRGIASGVPQETIESIRKTRVVLKGPLETPVGYGEKS 98 
55981504   19 RKLITVIPGDGIGPECVEATLKVLEAAKAPLAYEVREAGASVFRRGIASGVPQETIESIRKTRVVLKGPLETPVGYGEKS 98 
285019899  14 ARTIAVAEGDGIGPEITRAVLKILTAADPGLSFTPLTVGLEAYRAGHAAGFDRSVIDAVTEHGVLLKGPITTPQGGGYKS 93 
221632664  20 KKLVTLIPGDGIGPEIVESACRLIEAVGAPIEWEVRRAGASVFREGIASGVPDDTIESIKRTRVVLKGPLETPVGYGEKS 99 
209964234   4 VTKVTIARGDGIGPEIMDATLEILEAAGAALEYEEIQIGESVYRRGILNGMEPAAWDSLRRTRVFLKAPITTPQGGGYKS 83 
225872640  21 PIPVTVAAGDGIGPEITAAVMSILSAAGAHLDAEYVEVGEQVYLRGNTSGIPQEAWDSIARTRVMLKGPITTPQGGGYKS 100
256372736   8 PTPITVAYGDGIGPEIMSAVLEVLEKAGARLAIETIEVGEALWRRGITSGIEPSAWESLRRTKVFLKAPITTPRGGGMKS 87 
297565725   3 KTPITVAYGDGIGPEIMEAVLKILDAAQARIAPEVIEIGESVYLRGHTSGIEESAWESLRRTKVFLKAPITTPRGGGYKS 82 
291295520   3 KTPITVAYGDGIGPEIMQATLQILEAGGAQLEPEVIEIGESVYRRGHTSGIEERAWESLRRTRVFLKAPITTPQGGGYKS 82 
189184546  84 LNVTLKKTLGLYANVRPSISYFPFVNTSAP--EIDVVIIRENEEDLYTGIEYHHTADTYESIKLISRSGSEKIIRFAFEY 161
46199474   99 ANVTLRKLFETYANVRPVREF-PNVPTPYAgrGIDLVVVRENVEDLYAGIEHMQTPSVAQTLKLISWKGSEKIVRFAFEL 177
55981504   99 ANVTLRKLFETYANVRPVREF-PNVPTPYAgrGIDLVVVRENVEDLYAGIEHMQTPSVAQTLKLISWKGSEKIVRFAFEL 177
285019899  94 VNVSLRKTFGLYANLRPCVAYHPFVATHHP--GMDVVIVRENEEDTYAGIEHQQTDEVVQCLKLVSRPGCERIVRYAFEY 171
221632664 100 ANVTLRKLFEAFANVRPVREL-PSVPTPYRgrNIDLVVVRENIEDLYAAIEYRETPGVTIAHKLISYKGSEKIIRFAFEL 178
209964234  84 LNVTIRGALGLYANIRPCVSYHPFVNTKHP--QMDVVIVRENEEDLYAGIEYRQTQDVTQAVKLISRPGSEKIIRYAFEY 161
225872640 101 LNVTMRKTLGLYANVRPCRTYKPIVTTRHP--DMDVVIVRENEEDLYAGIEHRQTQDVAQCLKLITRSGSERIARYAFEY 178
256372736  88 LNVTIRKALGLFANVRPCPTYAPFIQTAHP--GMDVVVIRENEEDLYGGIEHRQTEDVVQCLKLISRPGTERLVRYAFAY 165
297565725  83 LNVTVRKTLGLYANVRPVQSYEPFVTTKHK--SIDLVIVRENEEDLYAGIEHQQTDEVVQCLKLISRPGTERIVRYAYEF 160
291295520  83 LNVTVRKTLGLYANVRPVQSYEPFVTTKHK--SIDLVIVRENEEDLYAGIEHQQTDEVVQCLKLISRPGTERIVRYAYEF 160
189184546 162 ALKNNRKKISCFSKDNIMKFTDGIFHNTFNEIASQYSNIQVDHYLIDIGSARLISSPQKFDVIVTSNLYGDILSDIAAEI 241
46199474  178 ARAEGRKKVHCATKSNIMKLAEGTLKRAFEQVAQEYPDIEAVHIIVDNAAHQLVKRPEQFEVIVTTNMNGDILSDLTSGL 257
55981504  178 ARAEGRKKVHCATKSNIMKLAEGTLKRAFEQVAQEYPDIEAVHIIVDNAAHQLVKRPEQFEVIVTTNMNGDILSDLTSGL 257
285019899 172 ARAHGRGKVTCMTKDNIMKLTDGLFHRVFDEIAKEYPEIANDHMIIDIGTAKMAVDPRRFDVVVTPNLYGDILSDVAAEV 251
221632664 179 ARAEGRKKVTCATKSNILKLTEGWFQHIFEEIASEYPDIEANHLIIDNCAHQLVKAPEQFEVIVTTNLNGDIISDLASGL 258
209964234 162 ARANHRRKVTAFVKDNIMKISDGLFHRVFDEIAAEYPEIEHETMIIDIGAARLADTPEQFDVIVTLNLYGDIISDIAAQI 241
225872640 179 ARQHGRSKITCMIKDNIMKLTDGLFHRVFDEVAREYPEIQAHSQIVDFGMANFVHRPEDYDVVLLPNLYGDILSDIAAQM 258
256372736 166 AERHGRHKVTCLVKDNIMKLTDGLFRQVFEEVAREYPNLETETLIVDIGTARLAARPEDFDVVVTPNLYGDIVSDVVAEV 245
297565725 161 ARRNGCRKITCITKDNIMKLTDGLFHRVFDEVGQEYPELQKEHMIVDIGAARLAEMPERFDVILAPNLYGDILSDIAAEV 240
291295520 161 ARRNGRKKVTCITKDNIMKLTDGLFHRVFDEIGQEYPELQKEHMIVDIGAARLAEMPERFDVILAPNLYGDILSDIAAEV 240
189184546 242 SDSIGLAGSANIGKDYAMFEAVHGSAPDIAGQNIANPSGLLNAAIMMLVHLGLTEHAAKIENALKKTIEDG-IHTADIYN 320
46199474  258 IGGLGFAPSANIGNEVAIFEAVHGSAPKYAGKNVINPTAVLLSAVMMLRYLEEFATADLIENALLYTLEEGrVLTGDVVG 337
55981504  258 IGGLGFAPSANIGNEVAIFEAVHGSAPKYAGKNVINPTAVLLSAVMMLRYLEEFATADLIENALLYTLEEGrVLTGDVVG 337
285019899 252 AGSIGLAPSSNIGRHCAMFEAVHGSAPDIAGRDLANPSGLLLSAVMMLVHLQRPAAATAIHNAWLRTLEEG-LHTADIFG 330
221632664 259 VGGLGFAASGNYGHEVAIFEPVHGTAPKYAGKNVINPTAMILTAVMMLRYIDEFETAETIEQALIVTLEEGkALTRDVVG 338
209964234 242 TGSVGLAGSSNIGDQCAMFEAIHGSAPNIAGKGIANPSGLILASVMMLVHVGQAEAAERIHNAWLRMIEDG-IHTVDIFK 320
225872640 259 TGSVGLGGSVNIGSGGAIFEAIHGSAPDLA-RDVANPSGLLLAAVEMLRHLKLDSIAAKVMNAWLCTLEEG-IHTVDI-A 335
256372736 246 AGSVGLGASANVGAEVAMFEAIHGSAPEIAGRGIANPSGLLLAAVLMLVHVGQGDVAERVHNAWLATIEDG-IHTADVYH 324
297565725 241 AGSVGLAGSANVGDEVAMFEAVHGSAPDIAGKGIANPSGLLQGAILMLVHIGQSEVAARIKNAWLKTLEDG-IHTPDIYD 319
291295520 241 AGSVGLAGSANVGDDCAMFEAVHGSAPDIAGKGIANPSGLLQGAILMLVHIGQPEAAARIKNAWLKTLEDG-IHTADIYD 319
189184546 321 PSISSKKVGTKEFAQAIINNLEYKPKKLKIAEYHnld---vesNIINNSQIQTITETRQQKKLVGVDVFFDSHNIIDYh- 396
46199474  338 YDRGAK---TTEYTEAIIQNLGKTPRKTQVRGYKp--------FRLPQVDGAIAPIVPRSRRVVGVDVFVETNLLPE--- 403
55981504  338 YDRGAK---TTEYTEAIIQNLGKTPRKTQVRGYKp--------FRLPQVDGAIAPIVPRSRRVVGVDVFVETNLLPE--- 403
285019899 331 SH-SQRQVGTQEFADAVIARLGQKPQQIAAVDYPe-------qPKQSAAPVIESARAKVAKTLEGVDVFVHWDHPGRDad 402
221632664 339 DERA---VSTTAFTDAIIANLGRRSATWKTRPYQp--------IRIPAQRPELDPVRPSRRRVVGVDLIVEGTEPPQ--- 404
209964234 321 RGISKARVGTRDFAANLIDRLGERPVTLTPASYEv-------gAKATFAGIQLKTRNDAKKRLVGCDIFIDHTGGDGG-- 391
225872640 336 GAHTKERAGTRRFTEAVIERLGRRPVQLAAVDEPatqstepleTGVSANPTSVLNTPVEKKTLVGVDVFVDEAGVLPD-- 413
256372736 325 PERSRAKVSTEGFAAAVIERLGASPATLPVVHYP---------ASAEAIRVEPSPRHASVKVQVGLDVFVEWTGTVD--- 392
297565725 320 ERVSEKKVGTQEFAQAVIERLGQEPERLRPARFGk--------PSPEPMVPKLERKTPAQKELVGVDVFFNWRGQKPE-- 389
291295520 320 ERVSVKKVGTAEFAQAVIERLGQQPERLRPAKFGe-------aSKQPMVPLMVRNPKPAKKELVGIDVFFNWRGTKPE-- 390
189184546 397 RITKQLTKriaslSSLHG-MHLVTISAKGLKLWPNSTVREMFSDHWCCRFMVQssgkdktvTAKNLTMKDILSLLNDLva 475
46199474  404 ALGKALED-----LAAGTpFRLKMISNRGTQVYPPTGGLTDLVDHYRCRFLYT--------GEGEAKDPEILDLVSRVas 470
55981504  404 ALGKALED-----LAAGTpFRLKMISNRGTQVYPPTGGLTDLVDHYRCRFLYT--------GEGEAKDPEILDLVSRVas 470
285019899 403 TLGNQLQA-----LAGPD-LRLALITNRGVKVYPSGLQQTTRTDHWRCRFLAA--------DGTTLKPAHICSLLLRLse 468
221632664 405 ILGPNLER-----LIDDLpLRLHLISSRGLQVYPDVGTTIDYVDHWRCRFLS---------HDGEVSTATVTALLERLsa 470
209964234 392 AMAARVLP-----LVQDG-LKLSVISNRGQKVWPDGAPETFCIDHWRLRVMGE--------GNAEVSQNAIAALIVRMad 457
225872640 414 ALAAKLQA-----ASTGE-FTLKMITNRGVKVWPNGREETLCTDHWRCRF-----------EGANPRNADVAGLLANLah 476
256372736 393 ELAERLSA-----AAPVG-IRLDMITNRGQKVWPDGLPETFCVDHWRCRFVT---------DAGAMAPAEGVALLGALae 457
297565725 390 ELAAMLEP-----LAGQN-LELVMITNRGVKVWPGGFPETFRTDHWRGRFMG---------QGREVRHSDVVALLGRLae 454
291295520 391 ELAKLLEP-----LSTEK-FKLTLITNRGVKVWPGGFPETFRTDHWRGRFMA---------QQGTPNHHDIVELLGKIaa 455
189184546 476 tinnpihseskddnydnsikFELIKV 501
46199474  471 -------------------rFRWMHL 477
55981504  471 -------------------rFRWMHL 477
285019899 469 ------------------agFETVKT 476
221632664 471 -------------------rYRWSRV 477
209964234 458 ------------------agFDIVQT 465
225872640 477 ------------------agIDFIKT 484
256372736 458 ------------------agLAFVKV 465
297565725 455 ------------------agLDFIKT 462
291295520 456 ------------------agMDFIKT 463
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