2DUT,2H4R


Conserved Protein Domain Family
serpinB_MENT-like
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cd02058: serpinB_MENT-like 
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serpin family B, Myeloid and Erythroid Nuclear Termination stage-specific protein (MENT) and similar proteins
Gallus gallus Myeloid and Erythroid Nuclear Termination stage-specific protein (MENT) is a nonhistone heterochromatin-associated serpin that is an effective inhibitor of cathepsin L as well as the papain-like cysteine proteases cathepsins K, L, and V in vitro. It's reactive center loop, which is essential for chromatin bridging, is able to mediate formation of a loop-sheet oligomer. It also contains an M-loop which contains two critical functional motifs: a classical nuclear localization signal (NLS) that is required for nuclear import and an AT-hook motif that is involved in chromatin and DNA binding. MENT belongs to the clade B of the serpin superfamily. In general, SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate blood coagulation cascades. Non-inhibitory serpins perform many diverse functions such as chaperoning proteins or transporting hormones. Serpins are of medical interest because mutants can cause blood clotting disorders, emphysema, cirrhosis, and dementia. A classification based on evolutionary relatedness has resulted in the assignment of serpins to 16 clades designated A-P along with some orphans.
Links
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Statistics
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PSSM-Id: 381014
Aligned: 5 rows
Threshold Bit Score: 608.914
Created: 14-Dec-2004
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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reactive centerputative DNA
Conserved site includes 21 residues -Click on image for an interactive view with Cn3D
Feature 1:reactive center loop (RCL)
Evidence:
  • Comment:depending on the conformational state, RCL is surface accessible in the active form or buried and inserted as the central beta strand in the inactive form
  • Comment:the RCL of MENT is essential for chromatin bridging in vivo and in vitro, and is able to mediate formation of a loop-sheet oligomer
  • Structure:2DUT_A: Gallus gallus MENT RCL, native conformation
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
2DUT_A        43 EQVSASIGNFTVDLFNKLNETnrdKNIFFSPWSISSALALTYlaaKGSTAREMAEVLHFeq------------------- 103 chicken
2H4R_A         7 EQVSASIGNFTVDLFNKLNETnrdKNIFFSPWSISSALALTYlaaKGSTAREMAEVLHFteavraesssvarpsr-grpk 85  chicken
O73790         2 EQVSASIGNFTVDLFNKLNETnrdKNIFFSPWSISSALALTYlaaKGSTAREMAEVLHFteavraesssvarpsr-grpk 80  chicken
XP_019469322   2 ESFSASTNSFSVDLYKKLDETskgQNIFFAPWSIATALAMVHlgaKGDTAMQIAKVLHFnqtareespsemtapsmgrpk 81  turkey
XP_018420167  89 EALVKSYNEVCMKLYQKLIEDn-dQNIAFSPWSIAAAVTMVYvgtKGNTEVQMSENTGTvh------------------- 148 Nanorana parkeri

Feature 1                                                                                        
2DUT_A       104 ----------aeNIHSGFKELLTAFNKPRNNYSLRSANRIYVEKTYALLPTYLQLSKKYYkaEPQKVNFKtapEQSRKEI 173 chicken
2H4R_A        86 rrrmdpeheqaeNIHSGFKELLTAFNKPRNNYSLRSANRIYVEKTYALLPTYLQLSKKYYkaEPQKVNFKtapEQSRKEI 165 chicken
O73790        81 rrrmdpeheqaeNIHSGFKELLTAFNKPRNNYSLRSANRIYVEKTYALLPTYLQLSKKYYkaEPQKVNFKtapEQSRKEI 160 chicken
XP_019469322  82 krdmgpeydeteNIHSGFKELLSAINKPRNTYLLKSANQLFEDKTYPLLPKFLELITRYYqvKPQAVNFKtdvEQARAQI 161 turkey
XP_018420167 149 ----------iqNIPRAFEELFSNVNQRRNQFILKTANRLYSEKSFHIVQQYQQLIKKHFraEIQAVDFAqkaEDVRNKI 218 Nanorana parkeri

Feature 1                                                                                        
2DUT_A       174 NTWVEKQTESKIKNLLSSddVKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKnKSKPVKMMYMRDtFPVLIMEkm 253 chicken
2H4R_A       166 NTWVEKQTESKIKNLLSSddVKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKnKSKPVKMMYMRDtFPVLIMEkm 245 chicken
O73790       161 NTWVEKQTESKIKNLLSSddVKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKnKSKPVKMMYMRDtFPVLIMEkm 240 chicken
XP_019469322 162 NSWVENETERKIQNLLPAgsLDSHTVLVLVNAIYFKGNWEKRFLKKDTSEMPFRLSKtKTKPVQMMFLTDtFLMFHEQtm 241 turkey
XP_018420167 219 NTWVEEQTESKIKDLLPQdsVDSLTKLVLVNALYFKGNWDVKFPEENTEQKPFRLSKtKTKMVPMMFQRNkYNMFYIEel 298 Nanorana parkeri

Feature 1                                                                                        
2DUT_A       254 nFKMIELPYVkRELSMFILLPDDIKDgtTGLEQLERELTYERLSEWAdsKMMTETLVDLHLPKFSLEDRIDLRDTLRNMG 333 chicken
2H4R_A       246 nFKMIELPYVkRELSMFILLPDDIKDgtTGLEQLERELTYERLSEWAdsKMMTETLVDLHLPKFSLEDRIDLRDTLRNMG 325 chicken
O73790       241 nFKMIELPYVkRELSMFILLPDDIKDgtTGLEQLERELTYERLSEWAdsKMMTETLVDLHLPKFSLEDRIDLRDTLRNMG 320 chicken
XP_019469322 242 kFKIIELPYVeNEVSMFILLPDDISDntTGLELVERELTHKKLAEWSnsASMMKVEVELYLPKLKMEENYDLTSTLSNMG 321 turkey
XP_018420167 299 eTKVLELPYVnKETSMIILLPDDIKDntTGLEKLQKELNYVNLKEWTsaDGMMLTEVELELPRIRLEENYDLKSYLSKMG 378 Nanorana parkeri

Feature 1                                                                                        
2DUT_A       334 MTTAFTtn------------------------------------------------------------------------ 341 chicken
2H4R_A       326 MTTAFTtn------------------------------------------------------------------------ 333 chicken
O73790       321 MTTAFTtn------------------------------------------------------------------------ 328 chicken
XP_019469322 322 IQNAFDpvqadftrmsakkdlfiskvihkafaeplnmdslstanstfaldllrqlreksntknlffspfsissalsmill 401 turkey
XP_018420167 379 MSDLFNpe------------------------------------------------------------------------ 386 Nanorana parkeri

Feature 1                                                                                        
2DUT_A           --------------------------------------------------------------------------------     chicken
2H4R_A           --------------------------------------------------------------------------------     chicken
O73790           --------------------------------------------------------------------------------     chicken
XP_019469322 402 gskgntesqiakvlslnkaedahngyqsllseinnpdtkyilrtanrlygektfkflssfvessqkfyhagleqadfkna 481 turkey
XP_018420167     --------------------------------------------------------------------------------     Nanorana parkeri

Feature 1                                                                                        
2DUT_A           --------------------------------------------------------------------------------     chicken
2H4R_A           --------------------------------------------------------------------------------     chicken
O73790           --------------------------------------------------------------------------------     chicken
XP_019469322 482 sedsrrqingwveektegkiqkllaegiinsmtrlvlvnaiyfkgnweqkfdkectnevpfkinknetkpvqmmfrkgky 561 turkey
XP_018420167     --------------------------------------------------------------------------------     Nanorana parkeri

Feature 1                                                                                        
2DUT_A           --------------------------------------------------------------------------------     chicken
2H4R_A           --------------------------------------------------------------------------------     chicken
O73790           --------------------------------------------------------------------------------     chicken
XP_019469322 562 nmtyigdletqvleipyvgnelsmiillpdaikdestgleklereltyeklmdwinpemmdstevrlslprfkleesydl 641 turkey
XP_018420167     --------------------------------------------------------------------------------     Nanorana parkeri

Feature 1                                                  #####################                 
2DUT_A       342 -----------------aDFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAAATAVIISFTTSVInhvlKFKVDHPFHFFI 404 chicken
2H4R_A       334 -----------------aDFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAAATAVIISFTTSVInhvlKFKVDHPFHFFI 396 chicken
O73790       329 -----------------aDFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAAATAVIISFTTSVInhvlKFKVDHPFHFFI 391 chicken
XP_019469322 642 npilsnmgmrdafdlqtaNFSGISSGNELVLSEVVHKSFVEVNEEGTEAAAATAGVMMLRCAMIv--pNFTADHPFLFFI 719 turkey
XP_018420167 387 ----------------kaDLTGISEKGNLYVSQIFHKVFVDINEEGTEAAAATGAIATVRSGPIv--vKVKADHPFLFII 448 Nanorana parkeri

Feature 1                         
2DUT_A       405 RHNKSKTILFFGRFCCP 421 chicken
2H4R_A       397 RHNKSKTILFFGRFCCP 413 chicken
O73790       392 RHNKSKTILFFGRFCCP 408 chicken
XP_019469322 720 RHNKTSSILFCGRFCSP 736 turkey
XP_018420167 449 RHNKTKAILFFGAFTSP 465 Nanorana parkeri

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