CDD Conserved Protein Domain Family: zf_C2H2

pfam18387: zf_C2H2_ZHX

Zinc-fingers and homeoboxes C2H2 finger domain

This is a C2H2 zinc-finger domain found in ZHX proteins such as ZHX1. ZHXs are multidomain proteins comprising two C2H2 zinc finger motifs and five homeodomains. Both homeodomains and zinc fingers are short protein modules involved in protein-DNA and/or protein-protein interactions; they are frequently associated with roles in transcriptional regulation. All members of the ZHX family are reported to be able to form both homo- and heterodimers via the region containing homeodomain 1. ZHX1 is a transcriptional repressor which is ubiquitously expressed. It interacts with nuclear factor Y subunit A (NFYA) and DNA methyl transferase 3B (DNMT3B) for its repression activity. Changes in expression profiles of rat ZHX1 ortholog have been associated with glomerular disease. In addition to the five homeodomains, ZHX1, which also contains of two N terminal C2H2 zincfingers forms homodimers via homeodomain and can also form heterodimers with ZHX3.

2GHF_A 47 LNSSYVCVECNFLTKRYDALSEHNLKYHP----GEENFKLTMVKRNNQTIFEQTIND 99 XP_017213824 100 AQPNFYCLSCKVSAVKFEGLALHNAKSHPelhtAHKRVSLQVTKRDGAITVEQSLFT 156 AFH29422 98 LNSSYVCVECNFLTKRYDALSEHNLKYHP----GEENFKLTMVKRNNQTIFEQTIND 150 XP_019662338 106 LNPLYVCAECNFTTKKYDSLSDHNSKFHP----GETNFKLKLIKRNNQTVLEQSIEA 158 XP_007474394 101 KDPTFVCIECSFMAKTSEGLSLHNAKCHT----GEISFIWNVAKQDNHITVEQIISD 153 XP_006121947 101 KDPSFVCVECSFLAPNHQGLLHHNAECHT----GEASFLWNVAKQDNHTTVEQSLSD 153 KFV79374 100 KDPVFVCVACNFLAKSHEGLSHHNAESHA----SEASFIWSVAKKDNHTTVEQSLCD 152 KGL77803 100 QDPVFVCVACSFLAKSHEGLSQHNAESHA----GETSLVWSVAKQDKQTTVEQSLCE 152 XP_016851680 101 KDPSFVCVQCSFLVKTHKELSCHNAEHHA----GETSLIWNVVKQGDQTIVEQTTGV 153 XP_005986805 98 MDPIFVCLECAFLAKNYNGLALHNAERHS----GETSFLWNVVKQNSQTLVEQSFSG 150

2GHF

Conserved Protein Domain Familyzf_C2H2_ZHX

Conserved Protein Domain Family
zf_C2H2_ZHX