2CPQ


Conserved Protein Domain Family
KH_I_FXR1_rpt2
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cd22507: KH_I_FXR1_rpt2 
second type I K homology (KH) RNA-binding domain found in fragile X mental retardation syndrome-related protein 1 (FXR1) and similar proteins
FXR1 is an RNA-binding protein required for embryonic and postnatal development of muscle tissue. It may regulate intracellular transport and local translation of certain mRNAs. FXR1 protein may be present in amyloid form in brain of different species of mammals. It may regulate memory and emotions. FXR1 contains three K-homology (KH) RNA-binding domains. The model corresponds to the second one.
Links
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Statistics
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PSSM-Id: 411935
Aligned: 7 rows
Threshold Bit Score: 128.587
Created: 17-Aug-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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putativeGXXG motif
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:putative nucleic acid binding site [nucleic acid binding site]
Evidence:
  • Comment:flanked by the GXXG motif and a variable ssRNA/DNA binding loop
  • Comment:Based on the structure evidence that other KH-I superfamily members bind RNA/ssDNA.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                  # ### #####  ##  ##     ####                         
2CPQ_A        14 AFHEEFVVReDLMGLAIGTHGSNIQQARKVpGVTAIELDedtGTFRIYGEsaDAVKKARGFLE 76  Homo sapiens
NP_001012619 218 AFHEEFVVReDLMGLAIGTHGSNIQQARKVpGVTAIELEedtGTFRIYGEtaDAVKKARSYLE 280 chicken
XP_014341534 156 AFHEEFTVReDLMGLAIGTHGSNIQQARKVsGVTAIELDedsGTFRIYGEsaEAVSKARSYLE 218 coelacanth
NP_958458    218 AFQEEFTVReDLMGLAIGSHGSNIQQARKVpGVTAIELEeetGTFRIYGEstEAVQKARNYLE 280 zebrafish
XP_007905956 218 AFQEEFTVReDLMGLAIGTHGSNIQQARKVsGVTAIELDevtGTFRIYGEseEAVQKARNYLE 280 elephant shark
P51114       218 AFHEEFVVReDLMGLAIGTHGSNIQQARKVpGVTAIELDedtGTFRIYGEsaDAVKKARGFLE 280 human
Q7ZTQ5       218 AFHEEFDVReDLMGLAIGTHGSNIQQARKVpGITAIELDedsGTFRIYGEseEAVKKARSYLE 280 African clawed frog

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