1SOX,1OGP,1SOX


Conserved Protein Domain Family
eukary_SO_Moco

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cd02111: eukary_SO_Moco 
Click on image for an interactive view with Cn3D
molybdopterin binding domain of sulfite oxidase (SO). SO catalyzes the terminal reaction in the oxidative degradation of the sulfur-containing amino acids cysteine and methionine. Common features of all known members of the sulfite oxidase (SO) family of molybdopterin binding domains are that they contain one single pterin cofactor and part of the coordination of the metal (Mo) is a cysteine ligand of the protein and that they catalyze the transfer of an oxygen to or from a lone pair of electrons on the substrate.
Statistics
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PSSM-Id: 239029
Aligned: 12 rows
Threshold Bit Score: 482.661
Created: 13-Jan-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Moco bindingmetaldimerization
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:Moco binding site
Evidence:
  • Structure:1SOX; chicken liver sulfite oxidase

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                  ## # #                                             
1SOX_A    106 GLRVNSQKPFNAEPPAELLAERFLTPNELFFTRNHLPVPAVEPs-----SYRLRVDGpg--------gGTLSLSlAELRs 172 chicken
XP_395316 250 VLKINGEKPFCAEPPSSLLIESFITPMELFYVRNHLPVPEIDLk-----TYTLELAIee--------vTKKILKfEDIKk 316 honey bee
XP_483475  19 ALKINSKEPFNAEPHRSALVSSYITPVDFFYKRNHGPIPIVDDl----sRYSVSITGiv--------nKNVQLSmADIRs 86  Japanese rice
1OGP_A     19 SLKVNAKEPFNAEPPRSALVSSYVTPVDLFYKRNHGPIPIVDHl----qSYSVTLTGli--------qNPRKLFiKDIRs 86  thale cress
NP_510561 178 ALLVRNSKPFNAETPPSLLTDHFYTPNELFFVRNHLPVPDIKTe-----NHRLTVETik--------gKTVDLSvEELKk 244 nematode
Q9VWP4    210 LLKPASKRPFNAEPPIGLLAEQFYTPNELFYVRNHLPVPVINPe-----DYELEIEGg---------aKDKTLTlDGIKa 275 fruit fly
P51687    128 ALKVNSQRPFNAEPPPELLTENYITPNPIFFTRNHLPVPNLDPd-----TYRLHVVGap-------ggQSLSLSlDDLHn 195 human
1SOX_B    106 GLRVNSQKPFNAEPPAELLAERFLTPNELFFTRNHLPVPAVEPs-----SYRLRVDGpg--------gGTLSLSlAELRs 172 chicken
AAH77584  199 VLKVNSMKPFNAEPPPYMLTESFITPTELFFKRNHLPVPQINPg-----DYKLVIERpngn----thnKPLNLTlSDLKt 269 African clawed frog
EAK83437    2 AQIVRQDSPLNTEPCSEELASSYITPNELVFNRNHDSAVSATEhhstevGWSIDISVeddqalssihvTQPSLPlESLKa 81  Ustilago maydis 521
EAA59680    5 HIEYTKENPLNREPPVRELVSSFITPSSTSYDRNHGPIPHLSAd-----THTIEVDGlv--------kTPLRLSvHQLAt 71  Aspergillus nidula...
XP_327217 273 RLVTHTAKPRNAETPSDLVGADFKTDENVFYVRHHMWVPVVDDap--eeKHVLSVELpd--------gETRGYTlKELKe 342 Neurospora crassa
Feature 1                 #                                                                   
1SOX_A    173 rfpKHEVTATLQCAGNRRSEMSRVRPv-KGLPWDIGAISTARWGGARLRDVLLHAGfpeel------------------- 232 chicken
XP_395316 317 y-pKYTITSAIMCAGNRRSEMTKEKQl-KGLNWGVGAVGNATWTGTRLCDILKDLKiked-------------------- 374 honey bee
XP_483475  87 l-pKYDVTATLQCAGNRRTAMSKVRKv-RGVGWDISALGNATWGGAKLSDVLELVGipklssv----------------- 147 Japanese rice
1OGP_A     87 l-pKYNVTATLQCAGNRRTAMSKVRNv-RGVGWDVSAIGNAVWGGAKLADVLELVGipkltas----------------- 147 thale cress
NP_510561 245 kykSYTIGSVIQCAGNRRADMNQYKKv-QGLMWEGTAISNAEWTGVRLRDLLADAGidvfd------------------- 304 nematode
Q9VWP4    276 l-pKHSVTAAIMCGGNRRSEMTKVKAv-KGLSWGAGAVGNAKWSGARLCDILREQGvqpd-------------------- 333 fruit fly
P51687    196 f-pRYEITVTLQCAGNRRSEMTQVKEv-KGLEWRTGAISTARWAGARLCDVLAQAGhqlc-------------------- 253 human
1SOX_B    173 rfpKHEVTATLQCAGNRRSEMSRVRPv-KGLPWDIGAISTARWGGARLRDVLLHAGfpeel------------------- 232 chicken
AAH77584  270 kfpKHEITATLQCAGNRRSEMSAVKPv-KGLEWTTGAISTAHWAGARLRDVLLEAGyteds------------------- 329 African clawed frog
EAK83437   82 nyeKVEVVATLECAGNRRAELAASHQpaEGIQWGDAVIANVIWGGASLRSVLLAAGipdpfchhsdltslkp----saea 157 Ustilago maydis 521
EAA59680   72 efpQHEVLCALECAGNRRHTMRTMLKevDGIDWGDAAIMNCKWRGPRLRDVLHRAGvdqck------------------- 132 Aspergillus nidula...
XP_327217 343 rfrRHKVTATLQCSGNRRNDMTRHAGktNGLQWGVGAISNAEWEGVLLRDVLKDAGlkvadpstatavpvqpssspssns 422 Neurospora crassa
Feature 1                                      #                              #    #       #  
1SOX_A    233 --------qgewHVCFEGLdadp------ggaPYGASIPYGRALspaaDVLLAYEMNGTELPRDHGFPVRVVVPGVVGAR 298 chicken
XP_395316 375 ---------dynHIQFEGYdldp------sgtPYGASIPISKAMdsraDIILAYEMNEQPIPRDHGFPIRVIVPGVVGAR 439 honey bee
XP_483475 148 ------tslggkHVEFVSVdrcke----ekggPYKASIPLKQATdpeaDVLLAYEMNGETLNRDHGYPLRVVVPGVIGAR 217 Japanese rice
1OGP_A    148 ------tnlgarHVEFVSVdrcke----enggPYKASITLSQATnpeaDVLLAYEMNGETLNRDHGFPLRVVVPGVIGAR 217 thale cress
NP_510561 305 --------dkikHVHFEGAdvdp------tgtPYGASIPIEKARg--dEVIVAYHMNGVDIPRDHGAPLRVIVPGNVGAR 368 nematode
Q9VWP4    334 ---------etkHVIFEGAdldp------tshPYGASIPLAKALdprgDVILAYEMNDEPLSRDHGFPIRVIVPGTVGAR 398 fruit fly
P51687    254 --------eteaHVCFEGLdsdp------tgtAYGASIPLARAMdpeaEVLLAYEMNGQPLPRDHGFPVRVVVPGVVGAR 319 human
1SOX_B    233 --------qgewHVCFEGLdadp------ggaPYGASIPYGRALspaaDVLLAYEMNGTELPRDHGFPVRVVVPGVVGAR 298 chicken
AAH77584  330 --------tqtlHVHFEGLdqdl------tgtNYGASISFQQAMakenEVLLAYEMNGQELPKDHGFPLRVIVPGVVGAR 395 African clawed frog
EAK83437  158 sladaaswahslHLHIYSAqessesddptrkeVFAASIPLVTALhpnqNCLLSYEYNRTPLTQRHGAPLRAVIPGHVGAR 237 Ustilago maydis 521
EAA59680  133 -------grpglHVAFSSFqvqc-----eedeWFGGSVELERGLdeeaDVILALEMNDAPLEPRHGFPVRVVLPGIAGAR 200 Aspergillus nidula...
XP_327217 423 dggddipsqkdlHVQFSALe------------AYGASIPLSKALdptgDVLLAFGMNGRALPRDHGFPLRAIVPGHVAAR 490 Neurospora crassa
Feature 1     # ##                                                                            
1SOX_A    299 SVKWLRRVAVSPDESPSHWQqndykg----------fspcvDWDTVDYRTAPAIQeLPVQSAVTQprpga---------- 358 chicken
XP_395316 440 NVKWLAKIIVSKKESQSQWQqndykv----------fspntDWDNVDFSKAPAIQeMPVISAICKpeqsei--------- 500 honey bee
XP_483475 218 SVKWLDSINIIEEECQGFFVqkdykm----------fppsvDWDNINWSTRRPQMdFPVQSAICTledvd---------- 277 Japanese rice
1OGP_A    218 SVKWLDSINVIAEESQGFFMqkdykm----------fppsvNWDNINWSSRRPQMdFPVQSAICSvedvq---------- 277 thale cress
NP_510561 369 QVKWLRKIIVSEKESDSHWQqkdyra---------fspavnIGDELKWNTVPSIQeYPVQCAICSpapntk--------- 430 nematode
Q9VWP4    399 NVKWLTRIVVADKESDSHWQqndykg----------fspstDWDTVDFSKSDAIQaMPVTSAICTpqpgarv-------- 460 fruit fly
P51687    320 HVKWLGRVSVQPEESYSHWQrrdykg----------fspsvDWETVDFDSAPSIQeLPVQSAITEprdge---------- 379 human
1SOX_B    299 SVKWLRRVAVSPDESPSHWQqndykg----------fspcvDWDTVDYRTAPAIQeLPVQSAVTQprpga---------- 358 chicken
AAH77584  396 NVKWLGKIVVSKEESSSHWQqndykg----------fnpcvDWDNVDFASSPAIQdLPVQSAITEphpgqe--------- 456 African clawed frog
EAK83437  238 WVKWLNGLKISARENDSPPMrqdykllvphaqseekdfadkAANGSEFRKQQLHQkKPLQQLAAScsvtlprndaq---- 313 Ustilago maydis 521
EAA59680  201 WVKWLDRITVQDQESTNFYQrrdyk------------vlpeEAVNRDAAEPFWDQ-TPAISEISInsvvavpedn----- 262 Aspergillus nidula...
XP_327217 491 SVKWLNKIVVSDEESPSQWQrrdyk-----------sfgpnEGANPDWERAKSIQeMPVTSAITGvwvgsdclkgkyqsh 559 Neurospora crassa
Feature 1                                                                                     
1SOX_A    359 -----------------------------------------avppGELTVKGYAWSGGGREVVRVDVSLDGGRTWKVARL 397 chicken
XP_395316 501 ----------------------------------------ikvinGKINVKGYAWSGGGRKIIRVDVTNDQGETWYTANL 540 honey bee
XP_483475 278 -----------------------------------------vikeGKARIAGYAVSGGGRGIERVDISVDGGKTWVEAHR 316 Japanese rice
1OGP_A    278 -----------------------------------------mvkpGKVSIKGYAVSGGGRGIERVDISLDGGKNWVEASR 316 thale cress
NP_510561 431 ----------------------------------------vdrgdETVDISGYAWSGGGRGIIRIEVSVDGGETWNSVEM 470 nematode
Q9VWP4    461 ---------------------------------------kvdddeGHITVRGYAWSGGGRKIVRVDLTNDEGVSWHVAEL 501 fruit fly
P51687    380 -----------------------------------------tvesGEVTIKGYAWSGGGRAVIRVDVSLDGGLTWQVAKL 418 human
1SOX_B    359 -----------------------------------------avppGELTVKGYAWSGGGREVVRVDVSLDGGRTWKVARL 397 chicken
AAH77584  457 ---------------------------------------vtpnidGELTVKGYAWSGGGREIVRVDVSVDGGKTWKVAEL 497 African clawed frog
EAK83437  314 -----------------------------------avqvtkertiEVKGYAVGQDGCPATKVYVALIPEAEASTEEVLVS 358 Ustilago maydis 521
EAA59680  263 ------------------------------------etvylsdvgKLEVKGYAVPQGSGGPVVKVQVSGDGGRTWIDAEI 306 Aspergillus nidula...
XP_327217 560 dnkqkettvdlagvdglkvgcsktatattttatpsgpspvetkpkIPITMQGYAYSGGGRAIARVDVSLDNGRTWDQAEL 639 Neurospora crassa
Feature 1                                                                                     
1SOX_A    398 MGdkap-----------pgraWAWALWELTVPVEag----------tELEIVCKAVDSSYNVQPDSVAPIWNLRGVLSTA 456 chicken
XP_395316 541 DAednna---------kvgryWSWTLWSIDLPVKke---------lkEMEIWTKAVDASYNVQPENIKNIWNLRGGKFIM 602 honey bee
XP_483475 317 YQksnvpyis----dgprsdkWAWVLFEATLDVPa------------NAEIVAKAVDSAANVQPEKVEDVWNLRGILNTS 380 Japanese rice
1OGP_A    317 TQepgkqyis----ehsssdkWAWVLFEATIDVSq------------TTEVIAKAVDSAANVQPENVESVWNLRGVLNTS 380 thale cress
NP_510561 471 EQeekqd----------qehmYAWTLFKAEVKIPpg---------vkEFNIIAKAVDRAYNTQPETASGIWNVRGLIHNA 531 nematode
Q9VWP4    502 EQeemp-----------dgrhYGWSLWTARLPVSeaqr------ragDVEIWAKAVDSAYNVQPEKFEHIWNLRGVLANA 564 fruit fly
P51687    419 DGeeqr-----------prkaWAWRLWQLKAPVPag---------qkELNIVCKAVDDGYNVQPDTVAPIWNLRGVLSNA 478 human
1SOX_B    398 MGdkap-----------pgraWAWALWELTVPVEag----------tELEIVCKAVDSSYNVQPDSVAPIWNLRGVLSTA 456 chicken
AAH77584  498 TGeqqk-----------dgqaWAWKLWQLNVPLPpk---------scDFTIICKAVDSSYNVQPDTVAPIWNLRGVLNNA 557 African clawed frog
EAK83437  359 LSadlvwkqaefhtqdpsnwsWAWTLWHVQLPAPr------------HADQKWILIARCAAGVEQEKISDWNLRGFCNRS 426 Ustilago maydis 521
EAA59680  307 GKsesaga-------dgrvrkWCWVLWRVEVEVEtg----------eGKEVISRAIDAQGNMQAEHSQWNLRGVGYSGYG 369 Aspergillus nidula...
XP_327217 640 ID-------------------DFKAIDEAYNTQPeshagiynvrgnlATAWHRVRICPECVVACPDGEGGGGGGGGKGVK 700 Neurospora crassa
Feature 1             
1SOX_A    457 WHRVRVSV 464 chicken
XP_395316 603 DLPIIITY 610 honey bee
XP_483475 381 WHRIKIQN 388 Japanese rice
1OGP_A    381 WHRVLLRL 388 thale cress
NP_510561 532 WHRVPIIV 539 nematode
Q9VWP4    565 YHKVKVKI 572 fruit fly
P51687    479 WHRVHVYV 486 human
1SOX_B    457 WHRVRVSV 464 chicken
AAH77584  558 WHRVHVTV 565 African clawed frog
EAK83437  427 WSVVRNLR 434 Ustilago maydis 521
EAA59680  370 RAKNLTVR 377 Aspergillus nidulans FGSC A4
XP_327217 701 WVTGKVVG 708 Neurospora crassa

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