2J9P,1W8Q,2EXB,3A3D


Conserved Protein Domain Family
Peptidase_S13

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pfam02113: Peptidase_S13 
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D-Ala-D-Ala carboxypeptidase 3 (S13) family
This family of serine peptidases belong to MEROPS peptidase family S13 (D-Ala-D-Ala carboxypeptidase C, clan SE). The active site residues occur in the motif SXXK. D-Ala-D-Ala carboxypeptidase C is involved in the metabolism of cell components. There are three families of serine-type D-Ala-D-Ala peptidase (designated S11, S12 and S13), which are also known as low molecular weight penicillin-binding proteins. Family S13 comprises D-Ala-D-Ala peptidases that have sufficient sequence similarity around their active sites to assume a distant evolutionary relationship to other clan members; members of the S13 family also bind penicillin and have D-amino-peptidase activity.
Statistics
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PSSM-Id: 396611
Aligned: 9 rows
Threshold Bit Score: 372.191
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2J9P_B     7 LSGQIDKILADhPALEGAMAGITVRSAETGAVLYEHSGDTRMRPASSLKLLTAAAALSVLGENYSFTTEVRTDGTLKGKK 86  Bacillus subtilis s...
1W8Q_A     5 LREDIDAILED-PALEGAVSGVVVVDTATGEELYSRDGGEQLLPASNMKLFTAAAALEVLGADHSFGTEVAAESAPGRRG 83  Actinomadura sp. R39
Q55728    46 LQQKLESHLQQ-PELSRAQWGIAIQPLTDSQPIYQYQADRFFIPASNQKLITTAMALQELGPNFRFTTQVYQ------RD 118 Synechocystis sp. P...
2EXB_A     1 -mANVDEYITQlPA--GANLALMVQKVGASAPAIDYHSQQMALPASTQKVITALAALIQLGPDFRFTTTLETKGNVENGV 77  Escherichia coli
3A3D_A     1 -mINVSDLTQKlPE--GSNAGVIAKNINQNQIIADYNGSTFMLPASTQKVFTAVAAKLALGDQFQFETALLSNGKIQNGN 77  Haemophilus influenzae
O85665    13 LLASLAAHALDtGRIPQNEIAVYVQELDSGKVIIDHRAGIPVNPASTMKLVTAFAAFKTFGSNYRWATEFKSNGTVNDGT 92  Neisseria gonorrhoeae
Q9Z541    78 LVKNLDERLAD-ERLGTDVSGV-VLDADSDTALWDHNGSTALMPASNAKLATATTALTLLGANHEFTTKVVYG------- 148 Streptomyces coelic...
O06380    72 VTAALAVVAAD-PDL-GKLAGR-ITDALTGQELWQRLDDVPLVPASTNKILTAAAALLTLDRQARISTRVVAGG----QN 144 Mycobacterium tuber...
OAR21422  56 LAAALASALAD-PSL-GSFGGR-ITDAMTAKELWQQQDDMPLVPASANKLLTAAAALLTLDRQTRISTRVVAAG----PN 128 Mycobacterium lepra...
2J9P_B    87 LNGNLYLKGKGDPTLLPSD------------FDKMAEI----LKHSGVKVI-KGNLIGDDTWHDDMRLSPDMPWSDEYTY 149 Bacillus subtilis s...
1W8Q_A    84 EVQDLYLVGRGDPTLSAED------------LDAMAAE----VAASGVRTV-RGDLYADDTWFDSERLVDDWWPEDEPYA 146 Actinomadura sp. R39
Q55728   119 GGKKVQVISSGDPSFDVDD------------LTAIAKG----LKDRGVTAIeELELV--DTIAPQDYQRPSWEWDDLHYG 180 Synechocystis sp. P...
2EXB_A    78 LKGDLVARFGADPTLKRQD------------IRNMVAT----LKKSGVNQI-DGNVLIDTSIFASHDKAPGWPWNDMTQC 140 Escherichia coli
3A3D_A    78 LDGNLIVSFTGDPDLTRGQ------------LYSLLAE----LKKQGIKKI-NGDLVLDTSVFSSHDRGLGWIWNDLTMC 140 Haemophilus influenzae
O85665    93 LDGNLYWAGSGDPVFNQEN------------LLAVQRQ----LRDKGIRNI-TGRLMLDHSLW-GEVGSPDHFEADSGSP 154 Neisseria gonorrhoeae
Q9Z541   149 -EGTLTLVGGGDRTLTGED------------VAELARTaadgLRAAGRTDV---QVRVDDSLFADPSLAEGW-------- 204 Streptomyces coelic...
O06380   145 PQGPVVLVGAGDPTLSAAPpgqdtwyhgaarIGDLVEQ----IRRSGVTPT---AVQVDASAFSGPTMAPGWDPADIDNG 217 Mycobacterium tuber...
OAR21422 129 AQGPVVLVGAGDPTLSAASpdqstwyrgaprISDLVEQ----VRRSGVTPT---AVQVDTSLFTGPTMAQGWDPADVDNG 201 Mycobacterium lepra...
2J9P_B   150 YGAPISALTAspnedyDAGTVIVEVTPnQKEGEEPAVSVSPKTDYITIKNDAK--TTAAGSEKDLTIEREHGTNTITIEG 227 Bacillus subtilis s...
1W8Q_A   147 YSAQISALTVahgerfDTGVTEVSVTP-AAEGEPADVDLGAAEGYAELDNRAV--TGAAGSANTLVIDRPVGTNTIAVTG 223 Actinomadura sp. R39
Q55728   181 YAPPVNGAIL------TGNQVILTLTP-QNLGEPLTPTWSDPIAGAQWQIINQt-ETAVDPHQPPQVQQIFGQRQLVITG 252 Synechocystis sp. P...
2EXB_A   141 FSAPPAAAIV------DRNCFSVSLYSaPKPGDMAFIRVASYYPVTMFSQVRTlpRGSAEAQYCELDVVPGDLNRFTLTG 214 Escherichia coli
3A3D_A   141 FNSPPAAANI------DNNCFYAELDAnKNPGEIVKINVPAQFPIQVFGQVYV--ADSNEAPYCQLDVVVHDNNRYQVKG 212 Haemophilus influenzae
O85665   155 FMTPPNPTML------SAGMVMVRAER-NAAGSTDILTDPPLPHIFAQNNLKItaSQAACPSVKKLMRASFSGNTLKLRG 227 Neisseria gonorrhoeae
Q9Z541   205 ----------------NEGYYPTEVAP---------------------------------------------VRSLVVDG 223 Streptomyces coelic...
O06380   218 DIAPIEAAMI------DAGRIQPTTVN----------------------------------------------------- 238 Mycobacterium tuber...
OAR21422 202 YTAPIESAMI------DAGRIQPTTVK----------------------------------------------------- 222 Mycobacterium lepra...
2J9P_B   228 SVPVDANKTKEWISVWEPAGYALDLFKQSLKKQGITVKGDIKTGEAP---SSSDVLLSHRSMPLSKLFVPFMKLSNNGHA 304 Bacillus subtilis s...
1W8Q_A   224 SLPADAAPVTALRTVDEPAALAGHLFEEALESNGVTVKGDVGLGGVPadwQDAEVLADHTSAELSEILVPFMKFSNNGHA 303 Actinomadura sp. R39
Q55728   253 GLPPAGETRSITLAVADPQQYFLASLQQKLAEQGISVSTSIVSANTKa--IAPAPLLALTSPPLWTLIKTVNQDSNNLYA 330 Synechocystis sp. P...
2EXB_A   215 CLPQRSEPLPLAFAVQDGASYAGAILKYELKQAGITWSGTLLRQTQVn--EPGTVVASKQSAPLHDLLKIMLKKSDNMIA 292 Escherichia coli
3A3D_A   213 CLARQYKPFGLSFAVQNTDAYAAAIIQRQLRKLGIEFNGKVLLPQKP---QQGQLLAKHLSKPLPDLLKKMMKKSDNQIA 289 Haemophilus influenzae
O85665   228 NIPESCLGKPVGVRMFALDELIRQTFTNRWLLGGGRISDGIGIADTP---EGAHTLAVAHSKPMKEILTDMNKRSDNLIA 304 Neisseria gonorrhoeae
Q9Z541   224 A------------AVQDTSIDAGKVFAKKLAAQGITVTGEVGRQTAK---QSDVPVAQHKSAPLSDIVKKMLKTSDNNIA 288 Streptomyces coelic...
O06380   239 -----------SRRSRTPALDAGRELAKALGLD----PAAVTIASAP---AGARQLAVVQSAPLIQRLSQMMNASDNVMA 300 Mycobacterium tuber...
OAR21422 223 -----------SRRSRTPALDAGRELAKALGVA----PDAVTIVKAS---SGARQLAVVQSAPLVQRLSEMMDNSDNVLA 284 Mycobacterium lepra...
2J9P_B   305 EVLVKEMGKVK-KGEGSWEKGLEVLNSTL-PEFGVDSKSLVLRDGSGISHIDAVSSDQLSQLLYDIQ--DQSWFSAYLNS 380 Bacillus subtilis s...
1W8Q_A   304 EMLVKSIGQET-AGAGTWDAGLVGVEEAL-SGLGVDTAGLVLNDGSGLSRGNLVTADTVVDLLGQAG--SAPWAQTWSAS 379 Actinomadura sp. R39
Q55728   331 EALLNAIQ------PPSQATDWQSYVERL----GLATTTVRLRDGSGLSRQDLVTPQALVQLLINQT--QKSTGTIYQQS 398 Synechocystis sp. P...
2EXB_A   293 DTVFRMIGHARfNVPGTWRAGSDAVRQILrQQAGVDIGNTIIADGSGLSRHNLIAPATMMQVLQYIA--QHDNELNFISM 370 Escherichia coli
3A3D_A   290 DSLFRAVAFNYyKRPASFQLGTLAVKSIL-QKQGIRFGNSILADGSGLSRHNLVAPKTMLSVLEYIA--KNEDKLHLMET 366 Haemophilus influenzae
O85665   305 RSVFLKLGGDG-KLPAVSEQAASAVRREL-AVSGIDVADLVLENGSGLSRKERVTARMMAQILETAY--FSPFAQDFIDT 380 Neisseria gonorrhoeae
Q9Z541   289 ETLLRMTAVEL-GKPGTFEAGTALVRQVL-SSYGISLDNFEMHDGSGLSRADRIPAATLAQLLDAIT--ESPALGSILEG 364 Streptomyces coelic...
O06380   301 ECIGREVAVAI-NRPQSFSGAVDAVTSRL-NTAHIDTAGAALVDSSGLSLDNRLTARTLDATMQAAAgpDQPALRPLLDL 378 Mycobacterium tuber...
OAR21422 285 ECIGREVAAAI-NRPLSFAGAVDAVTNRL-GTAHIDTTGAALVDSSGLSVNNRLTAKTLGGAVQAAAgpDQPVLRALLDL 362 Mycobacterium lepra...
2J9P_B   381 LPVAGNPdrmvgGTLRNRMK----GTPAQGKVRAKTGSLSTVSSLSGY----------AETKSGKkLVFSILLNGl-IDE 445 Bacillus subtilis s...
1W8Q_A   380 LPVAGESdpfvgGTLANRMR----GTAAEGVVEAKTGTMSGVSALSGY----------VPGPEGE-LAFSIVNNG--HSG 442 Actinomadura sp. R39
Q55728   399 LAVAGRS-----GTLERSFA----DTPLVGKMRGKTGTLTGVVSLTGY----------VENQQWGtVAFSFMVNNsdLGA 459 Synechocystis sp. P...
2EXB_A   371 LPLAGYD-----GSLQYRAGl--hQAGVDGKVSAKTGSLQGVYNLAGF----------ITTASGQrMAFVQYLSGyaVEP 433 Escherichia coli
3A3D_A   367 FPIAGVD-----GTISGRGGl--iSPPLVKNVIAKTGSLKGVYNLAGF----------MTNARGEkVAFVQFINGysTGD 429 Haemophilus influenzae
O85665   381 LPIAGTD-----GTLRNRFK------QSGGLLRLKTGTLNNVRALAGYwlgdkpmavvVIINSGRaV--SLLPD---LDN 444 Neisseria gonorrhoeae
Q9Z541   365 LPVSGEAga-slGPEWGRFDdp-nSECAVGKVHAKTGTLTGAIALSGV----------TRTDDGDwRIFSFIEN---NST 429 Streptomyces coelic...
O06380   379 LPIAGGS-----GTLGERFLdaatDQGPAGWLRAKTGSLTAINSLVGV----------LTDRSGRvLTFAFISN------ 437 Mycobacterium tuber...
OAR21422 363 LPIAGGS-----GTLSDRFLssatHQGPAGWLRAKTGSLTAINSLVGV----------VTDRSGRvLTFAFISN------ 421 Mycobacterium lepra...
2J9P_B   446 EDGKDIEDQIAVILANQ 462 Bacillus subtilis subsp. subtilis str. 168
1W8Q_A   443 PAPLAVQDAIAVRLAEY 459 Actinomadura sp. R39
Q55728   460 SVLREAMKQMVLWTAQV 476 Synechocystis sp. PCC 6803
2EXB_A   434 ADQRNRRIPLVRFESRL 450 Escherichia coli
3A3D_A   430 LESKTKRAPLVQFERNL 446 Haemophilus influenzae
O85665   445 FVAKNIISGGDGWLDAK 461 Neisseria gonorrhoeae
Q9Z541   430 ADPSDIKDAMDGLAATV 446 Streptomyces coelicolor
O06380   438 EAGPNGRNAMDALATKL 454 Mycobacterium tuberculosis H37Rv
OAR21422 422 DAGPTGRAAMDELATRL 438 Mycobacterium leprae 3125609
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