1VBJ,4FZI,4F40


Conserved Protein Domain Family
AKR_AKR5A1_2
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cd19156: AKR_AKR5A1_2 
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AKR5A family of aldo-keto reductase (AKR)
Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.
Links
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Statistics
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PSSM-Id: 381382
Aligned: 10 rows
Threshold Bit Score: 513.219
Created: 18-Apr-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active sitecatalytic
Conserved site includes 32 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1VBJ: Trypanosoma brucei prostaglandin F synthase in complex with cofactor NADP; contacts at 4A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                      ###                       #   ##                        # #       
1VBJ_A        12 LKLSNGVMMPVLGFGMWklqDGNEAETATMWAIKSGYRHIDTAAIYKNEESAGRAIASCGvPREELFVTTKLWNsDQGYE 91  Trypanosoma brucei
4FZI_A        16 VTLHNSVRMPQLGLGVWraqDGAETANAVRWAIEAGYRHIDTAYIYSNERGVGQGIRESGvPREEVWVTTKVWNsDQGYE 95  Trypanosoma cru...
4F40_A        13 VTLSNGVKMPQFGLGVWqspAGEVTENAVKWALCAGYRHIDTAAIYKNEESVGAGLRASGvPREDVFITTKLWNtEQGYE 92  Leishmania major
Q9GV41         7 LKLSNGVMMPVLGFGMWklqDGNEAETATMWAIKSGYRHIDTAAIYKNEESAGRAIASCGvPREELFVTTKLWNsDQGYE 86  Trypanosoma bru...
P22045         9 VTLSNGVKMPQFGLGVWqspAGEVTENAVKWALCAGYRHIDTAAIYKNEESVGAGLRASGvPREDVFITTKLWNtEQGYE 88  Leishmania major
Q4DJ07         8 VTLHNSVRMPQLGLGVWraqDGAETANAVRWAIEAGYRHIDTAYIYSNERGVGQGIRESGvPREEVWVTTKVWNsDQGYE 87  Trypanosoma cru...
CPW22259      16 KKLANGNEMPRLGLGVWrveDGSEATNSVKWALEVGYRLIDTAAVYKNEVGVGEGIRQSGiPREEIFVTTKLWNeDQGYE 95  Mycobacterium a...
NP_814868      7 KKLANGNEMPRLGLGVWrveDGSEATNSVKWALEVGYRLIDTAAVYKNEVGVGEGIRQSGiPREEIFVTTKLWNeDQGYE 86  Enterococcus fa...
XP_022833487   7 KELANGSVIPRLGLGVWqvkDGAEAVNSVKWALEAGYRLIDTAAAYKNEESVGEGLRQSGiPRDEIFVTTKLWNaDQGYD 86  Spodoptera litura
NP_464350      7 VKLANGVEMPRLGFGVWkvqDGDEAVNSVKWAIEAGYISIDTAAAYKNEEGVGQAIKESGiKREDLFVTTKLWNaEQGYE 86  Listeria monocy...

Feature 1                               ##                                   ##                  
1VBJ_A        92 STLSAFEKSIKKLGlEYVDLYLIHWPgk--------dKFIDTWKAFEKLYADKKVRAIGVSNFhEHHIEELLKHCKVaPM 163 Trypanosoma brucei
4FZI_A        96 KTLAAFERSRELLGlEYIDLYLIHWPgk--------kKFVDTWKALEKLYEEKKVRAIGVSNFePHHLTELFKSCKIrPM 167 Trypanosoma cru...
4F40_A        93 STLAAFEESRQKLGvDYIDLYLIHWPrgkdilskegkKYLDSWRAFEQLYKEKKVRAIGVSNFhIHHLEDVLAMCTVtPM 172 Leishmania major
Q9GV41        87 STLSAFEKSIKKLGlEYVDLYLIHWPgk--------dKFIDTWKAFEKLYADKKVRAIGVSNFhEHHIEELLKHCKVaPM 158 Trypanosoma bru...
P22045        89 STLAAFEESRQKLGvDYIDLYLIHWPrgkdilskegkKYLDSWRAFEQLYKEKKVRAIGVSNFhIHHLEDVLAMCTVtPM 168 Leishmania major
Q4DJ07        88 KTLAAFERSRELLGlEYIDLYLIHWPgk--------kKFVDTWKALEKLYEEKKVRAIGVSNFePHHLTELFKSCKIrPM 159 Trypanosoma cru...
CPW22259      96 NAIKAFDKSLEKLGlDYVDLYLIHWPva--------gKYKESWKALEEIYASGRAKAIGVSNFhQHHLEDLLTEANVvPM 167 Mycobacterium a...
NP_814868     87 NAIKAFDKSLEKLGlDYVDLYLIHWPva--------gKYKESWKALEEIYASGRAKAIGVSNFhQHHLEDLLTEANVvPM 158 Enterococcus fa...
XP_022833487  87 STLQAFDESLKKLElDYVDLYLIHWPve--------gKYKDSWRAMEEIYKSGRAKAIGVSNFhAHHIEDLLTTAEVtPM 158 Spodoptera litura
NP_464350     87 STLAAFDESLRKLElDYVDLYLIHWPvk--------gKFKDTWRAFEKLYKDKRVRAIGVCNFhEHHLKELMEDAEIaPM 158 Listeria monocy...

Feature 1          #                         #######     #                #              ######  
1VBJ_A       164 VNQIELHPLLnQKALCEYCKSKnIAVTAWSPLGQGh---LVEDARLKAIGGKYGKtAAQVMLRWEIQAGVITIPKSGNEA 240 Trypanosoma brucei
4FZI_A       168 VNQVELHPLFqQRTLREFCKQHnIAITAWSPLGSGeeagILKNHVLGEIAKKHNKsPAQVVIRWDIQHGIVTIPKSTNKG 247 Trypanosoma cru...
4F40_A       173 VNQVELHPLNnQADLRAFCDAKqIKVEAWSPLGQGk---LLSNPILSAIGAKYNKtAAQVILRWNIQKNLITIPKSVHRE 249 Leishmania major
Q9GV41       159 VNQIELHPLLnQKALCEYCKSKnIAVTAWSPLGQGh---LVEDARLKAIGGKYGKtAAQVMLRWEIQAGVITIPKSGNEA 235 Trypanosoma bru...
P22045       169 VNQVELHPLNnQADLRAFCDAKqIKVEAWSPLGQGk---LLSNPILSAIGAKYNKtAAQVILRWNIQKNLITIPKSVHRE 245 Leishmania major
Q4DJ07       160 VNQVELHPLFqQRTLREFCKQHnIAITAWSPLGSGeeagILKNHVLGEIAKKHNKsPAQVVIRWDIQHGIVTIPKSTNKG 239 Trypanosoma cru...
CPW22259     168 VDQIELHPTLtQEPLRKYLAENkIAVEAWSPLGQGn---LLSEPVLVKIGEKYGKsAAQVIIRWHLQNDIIVIPKSVHEK 244 Mycobacterium a...
NP_814868    159 VDQIELHPTLtQEPLRKYLAENkIAVEAWSPLGQGn---LLSEPVLVKIGEKYGKsAAQVIIRWHLQNDIIVIPKSVHEK 235 Enterococcus fa...
XP_022833487 159 VDQIELHPTLtQEPLRKFLKDHnIAVEAWSPLGQGk---ILENPTLVELGKKYHKtAAQIIIRWHLQSDSIVIPKSVHQE 235 Spodoptera litura
NP_464350    159 VNQIELHPQLtQEPLRKFCAENnIVVEAWSPLGNGk---LLSNPEIKAIADAHGKsVAQVILRWDLQIGVVTIPKSVHQE 235 Listeria monocy...

Feature 1        #  ##                               #
1VBJ_A       241 RIKENGNIFDFELTAEDIQVIDGMNAGHRYGPDPEVF 277 Trypanosoma brucei
4FZI_A       248 RIQENFNVWDFKLTEEEMRQIDELNEDKRIGADPDNF 284 Trypanosoma cruzi strain CL Brener
4F40_A       250 RIEENADIFDFELGAEDVMSIDALNTNSRYGPDPDEA 286 Leishmania major
Q9GV41       236 RIKENGNIFDFELTAEDIQVIDGMNAGHRYGPDPEVF 272 Trypanosoma brucei brucei
P22045       246 RIEENADIFDFELGAEDVMSIDALNTNSRYGPDPDEA 282 Leishmania major
Q4DJ07       240 RIQENFNVWDFKLTEEEMRQIDELNEDKRIGGDPDNF 276 Trypanosoma cruzi strain CL Brener
CPW22259     245 RIQENFAVFDFELTPEEITAINQLNKDHRFGADPDNF 281 Mycobacterium abscessus
NP_814868    236 RIQENFAVFDFELTPEEITAINQLNKDHRFGADPDNF 272 Enterococcus faecalis
XP_022833487 236 RINQNFDVFDFELTIEDMKRIDQLNTNERLGPDPDNF 272 Spodoptera litura
NP_464350    236 RIIQNADIFDFELTEEEVAKISGLNKDERTGPDPDNF 272 Listeria monocytogenes

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