1V85


Conserved Protein Domain Family
SAM_BAR
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cd09513: SAM_BAR 
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SAM domain of BAR subfamily
SAM (sterile alpha motif) domain of BAR (Bifunctional Apoptosis Regulator) subfamily is a protein-protein interaction domain. In addition to the SAM domain, this type of regulator has a RING finger domain. Proteins of this subfamily are involved in the apoptosis signal network. Their overexpression in human neuronal cells significantly protects cells from a broad range of cell death stimuli. SAM domain can interact with Caspase8, Bcl-2 and Bcl-X resulting in suppression of Bax-induced cell death.
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Statistics
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PSSM-Id: 188912
Aligned: 7 rows
Threshold Bit Score: 107.579
Created: 8-Mar-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1V85_A        17 VDKWTTEEVVLWLEQLGPWAS--LYRDRFLSERVNGRLL-LTLTEEEFSRAPYTIENSSHRRVILTELERVRSG 87  house mouse
Q9NZS9       179 VAKWTAEEVVLWLEQLGPWAS--LYRERFLSERVNGRLL-LTLTEEEFSKTPYTIENSSHRRAILMELERVKAL 249 human
NP_001088347 175 VAKWTAEEVVLWLEQLGPWAS--HYKEHFLSGNVNGRLL-LTLAEEEFSKNPYSIENSSHRKAILLELDRVKTL 245 African clawed frog
XP_414737    167 VAKWTAEEVALWLEQLGPWAS--LYKERFLMEKVNGRLL-LTLTEEDFTKEPYSIENNNHKKAITTELECVKTL 237 chicken
CAF98116     180 VSRWTPEEVLSWLDQLGTWAQ--LYREPFQQENVNGRLL-LMLGEEELLKPPFNVENQAHRRAVLAELDRIKLL 250 spotted green pufferfish
XP_001203248  21 LSRWRPADVSQWLSELGAWAAd-GYSRQFNASEINGVLLeGLQSEGELEKEPFNINNSLHRQAILIALEKVKQL 93  purple urchin
XP_002736414 194 VIKWTSSEVAEWVAEFGAWAIdnHYPEKFLTNNVDGRLL-LGITEDDLKVPPFNINIQLYRRAIMSELRFVKXX 266 Saccoglossus kowalevskii
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