1UHZ


Conserved Protein Domain Family
DSRM_STAU2_rpt4
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cd19886: DSRM_STAU2_rpt4 
fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
Staufen 2 is an RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. Staufen 2 contains five double-stranded RNA binding motifs (DSRMs). This model describes the fourth motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure.
Links
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Statistics
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PSSM-Id: 380715
Aligned: 7 rows
Threshold Bit Score: 154.727
Created: 24-Oct-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
putative RNA
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:putative RNA binding site [nucleic acid binding site]
Evidence:
  • Comment:Based on structure evidence that Drosophila melanogaster Staufen (1EKZ) binds a RNA hairpin.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1               #  ## ##              ######                   #   #                     
1UHZ_A         4 GSSGPISRLAQIQQARKEKEPDYILLSERGMPRRREFVMQVKVGNEVATGTGPNKKIAKKNAAEAMLLQLGYKASTSLQD 83  house mouse
Q7ZW47       304 QGMNPISRLAQIQQAKKEKEPEYMLLSERGMPRRREFIMQVKVGTEVTTGTGPNKKVAKRNAAEAMLLQLGYKASTPLQN 383 zebrafish
Q5M7M7       322 QGMNPISRLAQIQQAKKEKEPEYVLLSERGIQRRREFVMQVKVGEETATGTGPNKKTAKRNAAEAMLLQLGYKASSPVVE 401 western clawed ...
XP_014349083 388 QGMNPISRLAQIQQAKKEKEPDYVLLSERGMPRRREFVMQVKVGSEVATGTGPNKKVAKRNAAEAMLLQLGYKASTPVQN 467 coelacanth
NP_001026112 376 QGMNPISRLAQIQQAKKEKEPEYVLLSERGMPRRREFVMQVKIGNEITTGTGPNKKIAKRNAAEAMLLQLGYKASTPLQD 455 chicken
XP_007885184 124 QGMNPISRLAQIQQAKKEKEPEYLLLSERGLPRRREFLMQVKVGMDMATGTGPNKKVAKRNAAEAMLLQLGYKASTPLQS 203 elephant shark
Q9NUL3       304 QGMNPISRLAQIQQAKKEKEPDYVLLSERGMPRRREFVMQVKVGNEVATGTGPNKKIAKKNAAEAMLLQLGYKASTNLQD 383 human

Feature 1              
1UHZ_A        84 SGPSSG 89  house mouse
Q7ZW47       384 TPEKMD 389 zebrafish
Q5M7M7       402 KTGKRG 407 western clawed frog
XP_014349083 468 QPEKSS 473 coelacanth
NP_001026112 456 QTEKVR 461 chicken
XP_007885184 204 PQEKLG 209 elephant shark
Q9NUL3       384 QLEKTG 389 human

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