1KU1,4D7R,1BC9,3LTL


Conserved Protein Domain Family
Sec7

?
pfam01369: Sec7 
Sec7 domain
The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.
Statistics
?
PSSM-Id: 460178
Aligned: 370 rows
Threshold Bit Score: 36.669
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
1KU1_A                     23 RKTEFIECTNAFNEk--pKKgIPMLIEKGFIa------------SDSd-------------------KD----------I 59   b...
EFC48659                  439 QKHKYMEIVALFNSs--pQEaITQLLQLHNIsipkdltqfiksdSSNeqesttvdwneaivllqraaEK----------I 506 
XP_001523780              135 KQANLETEKEHFSSqtstSEpASKADSTTQTsk----------eDVNp-------------------NLql-------aI 178 
XP_001567651              938 DKRIFQEAVQRINAgr-wREaKEFLESRGLTtalap----sageRADp-------------------TSvvtgtssyslF 993 
Q4E275                    631 NKRIAQEAMQYINRgh-wRDgMKLLEQRGYIsha--------deATRw-------------------SD----------F 672  T...
Q381I9                    621 SKRTAQLAVGLINKgq-wRQaMSFLKERDYI-------------PAEg-------------------EEgw------saF 661  T...
WGS:AAFB:cds.EHI_103820A  352 KKEKDEKIALSFNRn--iQSgLELYKKTYFPd-----------qQELt------------------pKQ----------I 390 
XP_001016011              788 SQNLLEIGISLFNSs--pLCgLSFLILFDYI-------------KPEs-------------------ED----------I 823 
A0DVC2                    116 DYNTENLAIDLFNHs--yFMgISYMISTQII-------------RPTp-------------------QS----------I 151  P...
XP_001322120              413 IKENEEEGLSIFKNn--pQQgLEYYIQNKFV-------------KDDk-------------------KE----------I 448 
1KU1_A                     60 AEFLFNNn-----------------NRMNKKTI---------------------GLLLC-----HPD------------- 83   b...
EFC48659                  507 SKFLLDYn-----------------MWLDKQKIvdyfnsfssppstvvdikvnmGSIVIpedqlNHNtylipilsktrkd 569 
XP_001523780              179 TLFQDKY------------------ATVTPAEV---------------------THFIA-----GGDn------------ 202 
XP_001567651              994 ARFLFEY------------------PGISREAL---------------------SAIFEkv--nQKDg------------ 1020
Q4E275                    673 ARFLKTY------------------PGIERSAL---------------------CSIFErv-lkDSD------------- 699  T...
Q381I9                    662 ALFLKTY------------------EGVERGAL---------------------CGIFErv-lkDKD------------- 688  T...
WGS:AAFB:cds.EHI_103820A  391 ATFFRNT------------------KGLDKQFI---------------------GDFFE-----KRKe------------ 414 
XP_001016011              824 VKFLMQNpstpvsaqqansleqtylLKKSKQAI---------------------TEILT-----DLSlq----------- 866 
A0DVC2                    152 INWLFHNi-----------------EQKNKIQI---------------------SKLLT-----NLNlq----------- 177  P...
XP_001322120              449 GNFIFNR------------------NDLDKQSV---------------------TTIL------ESDa------------ 471 
1KU1_A                     84 ------KVsLLNEYIRLFDF-SGLRVDEAI-RILLT--KFRLPG-ESQQIERIIEAFSSAYCenQdYDPSkisdn----- 147  b...
EFC48659                  570 hlrnalPLeVMRQFMDGFDF-YGMRMEECM-RYFIN--RCKISG-EGQQVERIIKLLGESYYr-D-NNTHfalerndssk 642 
XP_001523780              203 -----eAKqIRTYYMNQFKW-SQ-NLLTAT-RQLCA--KLYLKA-ESQELDRILSSFTKSYL--Q-QHPN---------- 258 
XP_001567651             1021 -----aSRmLLLEYLHCFDY-KDVPIDVALrDTTCKfmSWERPTfEAKVWETIQECFGNEYA--N-QNPH---------- 1081
Q4E275                    700 ------CDrILREYMQLFPY-KGVTIDVALrDTTCEfmSWERPTfEAQVWAVIQRRFGEAYA--A-QNPR---------- 759  T...
Q381I9                    689 ------CDrILREYLQHFSY-RNVPIDIALrDTTCEfmSWDRPTfEAQVWVVIQQRFGEVYA--A-QNPR---------- 748  T...
WGS:AAFB:cds.EHI_103820A  415 -----iQIaTLKEYLY--EFiKDKDILTGF-VAFVQ--SLKLPK-ETNSINHIFEDYAKYFA--E-VHPE---------- 470 
XP_001016011              867 -----eNCeILYYYSTFFSF-SNSSFCSAL-RYFVQ--DLQLQN-DPEQIDILLSCFAKKFF--Q-QNQQqs-------- 925 
A0DVC2                    178 -----eQSqILKLFVDRV-V-TNQNLINSL-HSLFS--KLLVQN-DPYLLDILVKEFSRRYY--E-LNFNsks------- 236  P...
XP_001322120              472 -----ySE-CLDEFLE-NNFkLE-KFSDIL-LNILK--RLIIPD-DLTHIDNILTHFTQKFY--R-SHPS---------- 526 
1KU1_A                    148 ----aeddIStvqPDADSVFILSYSIIMLNTDLHNPQV----KEHMSFEDYSGNLKGCC------N-----H-K-DFPFW 206  b...
EFC48659                  643 nrtipaipYI---DNGEQAWILAVALMLLHTDLHHQNN----RNRMNLADFMKTI-GYH------D-----ElK-GIPQE 702 
XP_001523780              259 --------NVfqtKNFEQIYIIIYSLILLNTSLHNPQLn--kRSRISQTDFIKNTFTTFslqqnnEslkdkTkKlDIRQK 328 
XP_001567651             1082 --------S----ITARDADAMAGVLLFLHSNLHNVLMk---NERMQMSQFVRDANDCL------------EfP--MMVE 1132
Q4E275                    760 --------S----ITVKDADAMAGVLLFLHTSLHNENMr---NNRMTVEEFVRNGNECV--------------DfAFLEQ 810  T...
Q381I9                    749 --------S----ISPDDANAMAGVLLFLHTSLHNANVr---SSRMTMKDFVRNGNECV--------------AvPFPED 799  T...
WGS:AAFB:cds.EHI_103820A  471 --------LY---SSDDVLFMIS-AMLLLNVELHHPVM----KNKRTKKEFVQAMKEMI------P-------K--VNED 519 
XP_001016011              926 -------sLF---ESSDSVHMLAFATFMLDIDIH---FhkehDLPKLIQEFQMNIQGIN------G-----G-K-NFSQD 979 
A0DVC2                    237 -----qsfPF---KSEDSLHMFCFALVIFDIDNTKYD------KDYAFKSFFQNIQTIN------N-----G-D-NFNSK 289  P...
XP_001322120              527 --------VY---ETAEDVYNMIFASIICYANTHYSD-----HTDFSFEEFLRIC-GKN------T-------Q-N---- 571 
1KU1_A                    207 Y-----LDRVYCSIRDKEI 220  baker's yeast
EFC48659                  703 E-----LHKVYHYLLANEF 716 
XP_001523780              329 IaieneLSSFYEDLLKEEL 347 
XP_001567651             1133 D-----LQAIFNRVLQCKW 1146
Q4E275                    811 D-----MRDMYYRVAQRKW 824  Trypanosoma cruzi
Q381I9                    800 V-----MCEMYTRVARSKW 813  Trypanosoma brucei
WGS:AAFB:cds.EHI_103820A  520 I-----FNTIYDYIDQNEF 533 
XP_001016011              980 F-----INNIIENLLDKKI 993 
A0DVC2                    290 F-----ISEIIEQLQYKPI 303  Paramecium tetraurelia
XP_001322120              572 ------LGEIFETIKNTNI 584 
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap