5MRG,2N4P


Conserved Protein Domain Family
TDP43_N
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pfam18694: TDP43_N 
Transactive response DNA-binding protein N-terminal domain
This domain can be found at the N-terminal region of transactive response DNA-binding protein 43 kDa (TDP-43), an RNA transporting and processing protein whose aberrant aggregates are implicated in neurodegenerative diseases. TDP-43 N-terminal domain has been shown to play an important role in the aggregation of TDP-43 monomers and its loss of function affects the RNA metabolic levels. Secondary structure of the N-terminal domain consists of six beta-strands and it resembles axin 1.
Links
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Statistics
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PSSM-Id: 465833
Aligned: 67 rows
Threshold Bit Score: 61.81
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5MRG_A        16 YIRVTEDENDEPIEIPSED-DGTVLLSTVTAQFPGACGLRYRNPVSQCMRGVRLVEGILHA--PDAGWGNLVYVVNY 89 
VDN04485       3 RVHV------QPVDIELDQ-ESSILITTLQAALPGAVGLYYYD--SDCKACVAFDGKKFLV--PNGGWKERTYYAIL 68 
EYC18868      40 YVVVADSSG-EAMELPTAP-DNSLYMTTLQSTYPGATGMKYKNPKTGALRAVAVDATGTKLlpPVDGWDDKVFTVIT 114
D0VWM8        47 FITVQDPNGDEPIELPTV--DGVVLMTTLQASFPGATGLKYKNPKTGANRAVQVDPSGLKLiaPADGWENKTFFVIV 121 Caenorhabditis ele...
VDN06287      22 FVVVSNAMGGKGIEIPVCPtHGVLHMKMLKSIFKDATGLKYRNPDSGLDRVLLMDHDETFFitPIGGWKDKTFTVVR 98 
XP_003138446  22 WVVVSNAIGSRGIEIPLCPsHGVLHVRTLRNVFKDAAGLKYRNPETGLDRVLLMDHDETCFiaPAGGWKNKTFTVVR 98 
KHN82123      23 YVVVADSEDGDRLELPTQPeDGSLGLSTLTHAYPGAQGLKFKNPQTGASRALLVDPTGTRFmpPAGGWANKVFFVIY 99 
VDD86169      24 YVLVGESEDGEKLELPTNPpDKSLGFSTLTHAFPGAQGLKFKNPVTKASRALLMDSSGTKFlpPADGWKDKTFIVIY 100
VDN52619      18 YVIVAETDDGEQIELPTLPeDGSLGFSTLTHAFPGAHGLKYKTA-NGVSRALLIDPSGTRFfpPADGWKGKTFFVIY 93 
VDN88217      33 YVVVSETEESERLELPLLPeDCSLSLNTLVHAFPGAHGLKYKNSITGASRALLMDPQGTRFlaPPDGWKNKTFIVIY 109
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