Conserved Protein Domain Family
Miro1
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cd01893: Miro1 
Mitochondrial Rho family 1 (Miro1), N-terminal
Miro1 subfamily. Miro (mitochondrial Rho) proteins have tandem GTP-binding domains separated by a linker region containing putative calcium-binding EF hand motifs. Genes encoding Miro-like proteins were found in several eukaryotic organisms. This CD represents the N-terminal GTPase domain of Miro proteins. These atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis. Most Rho proteins contain a lipid modification site at the C-terminus; however, Miro is one of few Rho subfamilies that lack this feature.
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Statistics
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PSSM-Id: 206680
Aligned: 16 rows
Threshold Bit Score: 249.947
Created: 6-Jan-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:GTP/Mg2+ binding site [chemical binding site]
Evidence:
  • Comment:Rho molecules assume an active conformation when bound to GTP and inactive when GTP is hydrolyzed to GDP
  • Comment:Mg2+ ion plays a key role in bringing together the functional regions of the phosphate-binding, switches I and II
  • Citation:PMID 9545299
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                ######                                         ## #                  
CAD56957    3 RDVRILLLGEAQVGKTSLILSLVGEEFPEE---VPPRAEEITIPa-DVTPEKVPTHIVDYSEAEQTDEELREEiHKANVV 78  human
NP_198106  16 KSVRIVVVGDKGTGKSSLIVAAATDSFPPN---VPPVLPDYKLPi-EFFPDGIPVTIVDTSSRPEDRDIVAEElKRADAV 91  thale cress
NP_500620   8 ADVRIVLIGDEGCGKTSLVMSLLEDEWVDA---VPRRLDRVLIPa-DVTPENVTTSIVDLSIKEEDENWIVSEiRQANVI 83  Caenorhabditis ele...
NP_567139  13 TSLRVAVAGDKGTGKSSLISAVASETFPDN---VPRVLPPITLPa-DAFPDYIPITIVDTPSSIDNRIKLIEEfRKADVV 88  thale cress
NP_651205  10 KNVRILLVGDAGVGKTSLILSLVSEEYPEE---VPPRAEEITIPa-NVTPEQVPTSIVDFSAVEQSEDALAAEiNKAHVV 85  fruit fly
AAT77915   14 QGVRVVVIGDPGTGKSSLVVSVATEAFPEN---VPRVMPPTRLPa-DYFPDRVPITIVDTSSSPEHRAKLIAEcQAADAV 89  Oryza sativa (japo...
AAW44051    5 DLVRIVLVGDDGVGKSSIITSLIKEAFVTN---VPHVVPEVTIPp-EITPENFTTSIVDTSSNPRSRPHLLSSiSRAHVI 80  Cryptococcus neofo...
XP_758785   3 KDVRIVLAGDPDVGKSTLITSLVKEAYVAK---VQKVVPPITLPp-EVAPEAVVTKIVDTSSSPEHRANLEAElRRANVI 78  Ustilago maydis 521
CAA18306    2 KEVRVVICGDQGVGKSSLISALIQEDNVTS---IPKVFPIISIPsnPDSNDDVSLVLVDTQSDSNEREYLAAEiKKANVI 78  fission yeast
AAT77912   13 LDVRVAVIGDHGTGKSSLVATIATGRFPDQddgVARVLPPARLPv-DYFPARVPVTIVDTSSRYCQTADAVVL-TYACDR 90  Japanese rice

Feature 1                                                                # #                  
CAD56957   79 CVVYDVSEEATIEKirTKWIPLVNGgttq-------------------gprvPIILVGNKSDLRSGss-----mEAVLPI 134 human
NP_198106  92 VLTYACDRPETLERlsEYWLPELRRlev----------------------kiPIIVAGCKLDFRDDnnqv-sleQVMSPI 148 thale cress
NP_500620  84 CVVYSVTDESTVDGiqTKWLPLIRQsfge-------------------yhetPVILVGNKSDGTANn------tDKILPI 138 Caenorhabditis ele...
NP_567139  89 LLTYACDQPSTLDRlsSYWLPELRRlei----------------------kaPVIVVGCKLDLRDErspa-rleDIMSPI 145 thale cress
NP_651205  86 CIVYAVDDDDTLDRitSHWLPLVRAkcnpsldgegdaeaeaegdtqrepirkPIVLVGNKIDLIEYst-----mDSVLAI 160 fruit fly
AAT77915   90 VLTYACDRPATLERlsTFWLPELRRlql----------------------kaPVIVVGCKLDLRDEqqv--sleQVMAPI 145 Oryza sativa (japo...
AAW44051   81 CLVYSIADPSSFDRvaEYWLPLFRRegi----------------------nvPVILVGNKIDLRGGrvtnqgleDESAPI 138 Cryptococcus neofo...
XP_758785  79 CIVYSISAPSSFDRipTYWLPYIRSlgv----------------------nvPVILVGNKIDLRSGdvtnaaleDELAPV 136 Ustilago maydis 521
CAA18306   79 CLVYSDNYSYERVS--IFWLPYFRSlgv----------------------nvPIVLCENKSEDLDNyqglhtieHEMIPL 134 fission yeast
AAT77912   91 PNTLERITTFWLPK--IRRLLQSKV---------------------------PVILAGCKVDLSDKqqqa-gleNVLDFI 140 Japanese rice

Feature 1                   ##                   
CAD56957  135 MSQFSEIETCVECSAKNLRNISELFYYAQKAVLHP 169 human
NP_198106 149 MQQFREIETCIECSALKQLQAQEVFYYAQKTVLHP 183 thale cress
NP_500620 139 MEANTEVETCVECSARTMKNVSEIFYYAQKAVIYP 173 Caenorhabditis elegans
NP_567139 146 MKEYREIETCIECSALTLIQVPDVFYFASKAVLHP 180 thale cress
NP_651205 161 MEDYPEIESCVECSAKSLHNISEMFYYAQKAVLHP 195 fruit fly
AAT77915  146 MQTFREIETCIECSALRQIQVPEVFYYAQKAVLHP 180 Oryza sativa (japonica cultivar-group)
AAW44051  139 MREFKEVETVVECSALLPLNVSEVFYFAQKAVLHP 173 Cryptococcus neoformans var. neoformans JEC21
XP_758785 137 MAEFKEVETCVECSARIPLNVSEVFYFAQKAVLYP 171 Ustilago maydis 521
CAA18306  135 INEFKEIEACILCSALEKINVNELFYMCRACVIYP 169 fission yeast
AAT77912  141 MCTFREVEIYLECSALHRIKVDEVFYCAQMAVLRP 175 Japanese rice

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