4IOJ


Conserved Protein Domain Family
MIS1

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COG2759: MIS1 
Formyltetrahydrofolate synthetase [Nucleotide transport and metabolism]
Statistics
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PSSM-Id: 442046
Aligned: 355 rows
Threshold Bit Score: 820.436
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4IOJ_A         4 VPSDIE--IAQAAKMKPVMELARGLGIQEDEVELYGKYKAKISLDVYRRLKDKPDGKLILVTAITPTPAGEGKTTTSVGL 81 
YP_001006249  28 LPSLSN--MSSETNLLPIQQIAPQLGLSADDLIPYGHHMAKVDISALR--PSGPQGKLILVSSITPTPLGEGKTVTTIGL 103
YP_205176      1 MKSDIE--ICQTATLTRMKTIASNLGLHDDDITPQGPFKAKVNIDALKRLKSEPNGKLILVSAITPTPLGEGKTVTTIGL 78 
WP_015871391   1 MISCCEpmPSSQPALLPIATIAAKIGIATEALIPYGHYAAKVDMRQLT--PRPPRGKLILVSSITPTPLGEGKTVTTLGL 78 
NP_716196      1 MLTDME--ISRRAHLKDIAQLGAEFGLLPEEMQLFGNTKAKVDLQVQQRLAGQPKGKLIIVTAVTPTPHGEGKTVTTIGL 78 
WP_013344858   1 MQSDLI--ISQQAKLLPIADVAERAGILADELIPQGEAKAKVKFSLLQRLDNAPRGKLVVVTAITPTPLGEGKTVTTIGL 78 
NP_800344      1 MQSDIE--ICRNTPLSSIDVIAEKAGLLPEEFDTHGKYKAKVHPKCLARLNDNQNGKLVLVTAITPTPLGEGKTVTTIGL 78 
WP_011219410   1 MKSDIQ--ICRDTALTPIDQIALMAGIEPQDLTPQGTLKAKVKPSILNRLADKPEGKLVLVTAITPTPLGEGKTVTTIGL 78 
WP_025801039   1 MTSLSE--QMHAPQLKPISQIAEQLGIPTTYLIPYGHYAAKIDIKAIK--PEQGTGQLVLVSSITPTPLGEGKTVTTIGL 76 
WP_106911001   1 MKTDSQ--ICQEAALLPVSDVAQKAGFLPDEVLTLGEHKAKIRLQTLQRTAQQPDGKFVLVSAITPTPLGEGKTVTTIGL 78 
4IOJ_A        82 TDALARLGKRVMVCLREPSLGPSFGIKGGAAGGGYAQVVPMEDINLHFTGDIHAVTYAHNLLAAMVDNHLQQGN------ 155
YP_001006249 104 SQGINRLGYRGVACIRQPSLGPVFGVKGGAAGGGAAQVLPMEKLNLHLTGDIHAISAAHNLAAAALDARLYHEQrlgavf 183
YP_205176     79 AQGLAKLGESVSACIRQPSMGPVFGVKGGAAGGGYSQVAPMEELNLHLTGDIHAITAAHNLASAAIDARIYHEQrlgydv 158
WP_015871391  79 SQGLNHLGHSAIACIRQPSLGPVFGVKGGAAGGGASQVLPMEQLNLHLTGDIHAISAAHNLAAAALDARLFHEQrlgdaf 158
NP_716196     79 TQSLKALGNKVCACIRQPSMGPVFGVKGGAAGGGYAQVVPMQELNLHLTGDIHAVSSAHNLGAAAIASRLYHEMrlgkae 158
WP_013344858  79 SQGLKAIGQQVMACIRQPSMGPVFGVKGGAAGGGYSQVAPMEELNLHLTGDIHAVSAAHNLAAAAIDARVYHEQrhgekf 158
NP_800344     79 AQGLAKLKQSVMACIRQPSMGPVFGIKGGAAGGGYSQVAPMEELNLHLTGDIHAVTAAHNLASAALDARLFHEQregyda 158
WP_011219410  79 AQGLAKINKRVIACIRQPSMGPVFGVKGGAAGGGYSQVAPMEKLNLHLTGDIHAVTAAHNLAAAALDARLYHEErhgyea 158
WP_025801039  77 SQGLNFIGKKALACIRQPSLGPVFGVKGGAAGGGVAQVLPMEQLNLHLTGDIHAITAAHNLAAAALDARLFHEQrlgekf 156
WP_106911001  79 AQGLAALGEKTIACIRQPSMGPVFGVKGGAAGGGYSQVAPMDELNLHLTGDIHAITAAHNLAAAALDARLYHESrlgaeh 158
4IOJ_A       156 --------VLNIDPRTITWRRVIDLNDRALRNIVIGL---GGKANGVPRETGFDISVASEVMACLCLASDLMDLKERFSR 224
YP_001006249 184 s-qqtgmpLLNIDAQQILWPRVVDHNDRALRHIQVGV---GGGTHGVERHDHVEITAASELMAILALSESLHDMRQRIGR 259
YP_205176    159 fseknelpALRIDPQHVVWKRVMDHNDRALRMVTIGKnedGKTINGYEREDGFDITAASELMAILALATDLQDLRQRIGR 238
WP_015871391 159 t-aqsglqRLDIDPLRIVWKRVMDHNDRALRSIDVGV---GGGNNGVPRHDGFDISAASELMAILALSDGLADMRTRIGK 234
NP_716196    159 ferqsglsYLDIDPKGIRWHRVVDHNDRCLREIEVGL---G-ENNGPAYTSGFDITAASELMAILALSRNLTDMRVRIGK 234
WP_013344858 159 e-aktglpNLNIDPERVVWDRVVDMNDRTLRRVTIGLnapGSTANGLERESGFDITAASELMAILALANDLADLRARLGK 237
NP_800344    159 feartglkALKIDVESITWKRVMDHNDRALRMVKIGLnehGKTINGFERNEGFDISAASELMAIIALAKNLKDLRQRIGK 238
WP_011219410 159 fsdktglpALRIDIKNIVWKRVMDHNDRALRMITVGKneaGKAINGLEREDGFDISAASEIMAILALSKDLADMRQRIGR 238
WP_025801039 157 t-ehtglkRLDIDPEHILWKRVIDHNDRALRSIDIGV---GGGNNGVPRHDGFDITAASELMAILALSESLTDMRQRIGR 232
WP_106911001 159 ftertglpRLDIDPQQIVWNRVMDHNDRALRKIRIGInppGSHANGIERESGFDITAASELMAILALAQDLPDMRQRLGR 238
4IOJ_A       225 IVVGYTYDGKPVTAGDLEAQGSMALLMKDAIKPNLVQTLENTPAFIHGGPFANIAHGCNSIIATKTALKLADYVVTEAGF 304
YP_001006249 260 IILAHSTSGQAITADDLGVAGAMTALMKETIHPTLMQTSEQTPVLIHAGPFANIAHGNSSVLADRLGLQLADYVVTEAGF 339
YP_205176    239 IVVAYNLDGEPVTTEDLQVAGAMTVTMKFAINPTLMQTLEGVPTFVHSGPFANIAHGNSSIIADNIALKLTDYTVTEGGF 318
WP_015871391 235 VILAYSLQGAPITAEDLQVAGAMTVVMKAAIHPTLMQSSEQTPVLIHAGPFANIAHGNSSVLADRLALQLADYVVTEAGF 314
NP_716196    235 LVLALNRQGEAVSADELGVAGAMTAIMADAVKPTLMQTLNGAPCLIHAGPFANIAHGNSSVIADDIALKLADFVVTEGGF 314
WP_013344858 238 VVLAYSHDGKPVTAEDIQVAGAMAAILRDAAQPTLMQTLEGVPTLVHAGPFANIAHGNSSIIADRMALRLADVVVTEGGF 317
NP_800344    239 IVVAYDLDGQPITTEDLQVAGAMAVTLKEAIAPTLMQTLEGVPTLIHAGPFANIAHGNSSIIADEIALKLSRYTVTEAGF 318
WP_011219410 239 VVLAYNIDGNPITAEDLQVAGAMTVTMCEAIEPTLMQTLEGVATLIHAGPFANIAHGNSSIIADRIALKLSEFTVTEGGF 318
WP_025801039 233 IILAYTLQGHAITTEDLEVAGAMTVLMKEAIHPTLMQTSENTPVLIHAGPFANIAHGNSSVLADRLALQLADYVVTEAGF 312
WP_106911001 239 LILAYNHAGEPITAEALGVAGAMAAIMKDAINPTLMQTLEGVPVLIHAGPFANIAHGNSSIIADKMALKLADYTVTEAGF 318
4IOJ_A       305 GADLGAEKFYDVKCRYAGFKPDATVIVATVRALKMHGGVPKS--------DLATENLEALREGFANLEKHIENIGKFGVP 376
YP_001006249 340 GSDMGMEKFFNIKYRQSGITPSCVVLVATLRSLKANSGVFDIkpgqplpaEILNTNIPLLSQGCANLKWHINNAKSYGLP 419
YP_205176    319 GSDMGFEKACNIKAPLSEKSPDCAVLVATLRGIKANSGLFPLspgqslpkELFAPNKEALDAGLDNLLWHINNCAKYGLP 398
WP_015871391 315 GSDMGMEKFFNIKYRQSGIAPSCVVLVATLRSLKANSGQFNMkpgqalpeEVKQPNADLLRTGCENLGWHIANARRYGLP 394
NP_716196    315 GSDMGFEKFCNIKARQSGLIPSAAVLVTTLKALKANSGLASDt-------DINAPDQARLEAGFANLNWHINNVVQYGLP 387
WP_013344858 318 GSDMGFEKACNIKARAAGKGPDAAVVVATLRGLKANSGQYDLrpgqalpqAIFEPDAAALEAGFANLKWHIENVQRYGVP 397
NP_800344    319 GSDMGFEKACNIKAAAANKAPDCVVIVATLRGLKANSGHYDLrpgmaipdSIFSPDQAALVAGFENLKWHIKNVHKYGIP 398
WP_011219410 319 GSDMGFEKACNIKAQQADRGPDCAVVVATLRGLKANSGLYDLrpgqalpdAIFSPDEKALIAGFDNLKWHIRNAAQYGLP 398
WP_025801039 313 GSDMGMEKFFNIKCRQSGIKPSCVVLVATLRSLKANSGKFNMkpgqslpeEVKHANLPLLTEGASNLAWHIGNASRYGLP 392
WP_106911001 319 GSDMGLEKACNIKAQVAGKAPDCVVLVATLRGLKANSGRYNLkpgqaippSLFSADPEALEAGFANLQWHMNNVQKYGLP 398
4IOJ_A       377 AVVAINAFPTDTEAELNLLYELCA--KAG----AEVALSEVWAKGGEGGLELARKVLQTLESrPSNFHVLYNLDLSIKDK 450
YP_001006249 420 VVVAVNCFPDDSPEELAFLADYAL--SAGa---IACEISEAFAKGGAGTTALAQRVIDACAH-ASPPVLAYPDNASLEQK 493
YP_205176    399 VVVAINRFPEDTQEELDSLLNWVSnlDMN----VDVAISEAFVKGGNGTLELAEKVIKACQQ-ETQFTPLYTSEMSLFDK 473
WP_015871391 395 VVIAVNRWPEDTPQELAILRDYAL--SAGa---FGVEFSEAFALGGRGAARLAACVTDACSQ-AAQVNLLYPDAMPLAEK 468
NP_716196    388 VVVAINRFASDTDAELNWLMEAVR--GTAa---FGCELSEAFSQGEDGAMALAQTVIRACEQ-PSEFRLLYPDNMELEAK 461
WP_013344858 398 AVVALNRFPQDTDEELAWLKGQVE--ALG----ARVAISEAFAKGGAGATELAHQVMDALAQ-PADFQFLYEAEQSIEAK 470
NP_800344    399 AVVAINQFPQDCEQELTALQDLIHafDPN----VKVAISTAFAQGGEGTRDLAQYVVDACEK-TTNFRPLYQKHQSLQEK 473
WP_011219410 399 VVVAINRFPQDTDVELELLKNMVA--DTDfstyVGVAISEAFGKGGEGATELAQAVVKACET-PANFKPLYSLSQSLEEK 475
WP_025801039 393 VVVAINHFPEDSAEELEFIRQFAM--EHGa---FGVEISDAFSAGGKGTAQLAECVTAACRS-GGEVSLLYPDDMSLADK 466
WP_106911001 399 VVVAVNRFPQDTDEELQWLCHRIE--ETG----CRVALSDAFSQGGQGALALAQAVMQACEQ-PATFTPLYQPAAPLLDK 471
4IOJ_A       451 IAKIATEIYGADGVNYTAEADKAIQRYESLGYGNLPVVMAKTQYSFSDDMTKLGRPRNFTITVREVRLSAGAGFIVPITG 530
YP_001006249 494 IEILAQR-YGAREVTFTPQARQQLDSITAAGFGHLPLCIAKTPLSISADASLKNVPHDFVLPVTACAVSAGAGFVRIYAG 572
YP_205176    474 LNAVAIKGYGAERIELSEKAQQQLATFEKLGYQSLSVCMAKTPASISTDGNIKGAPTDFIVPIRELKLCAGAGFIYALCG 553
WP_015871391 469 LQTLAHS-YGASHAELTVQAQQELDALEQAGFGHLPLCMAKTPLSISADPALKNAPRGFVLPIRSLQVSAGAGFIRAYAG 547
NP_716196    462 LSTLAELGYGAAGINLSAVAKQQLQELSALGYAHLPVCMAKTPLSISHDPQLKGVPQGFIVPVRELVLNAGAGFITALVG 541
WP_013344858 471 LLTMAEAGYGGNGIELSDKARADIARLEALGFGHLPVCMAKTPLSISHDPALKGAPSDFVVPVRGLRLCAGAGFIYVLTG 550
NP_800344    474 LMSVCEAGYGATNVEMSELATKQLAHFEKLGFNELAVCIAKTPLSVTTDSSVKGAPVGFTVPIRELRLCAGAGFVYALSG 553
WP_011219410 476 LMAVAEVGYGARSIELSDCAKEQLATLKKHGHDNLAVCLAKTPLSITTDPGIKGAPSDFVVPVRELKLCAGAGFVYALCG 555
WP_025801039 467 LQTLAKNGYGALRAELTPAAQDTMQQLELAGFGHLPLCMAKTPLSISADPALKNVPRDFVLPVTDLKVSAGAGFIRVYAG 546
WP_106911001 472 LNAVARRGYGAKCVELSPQAQAQLAHIEQLGQQELYVCLAKTPLSISHDPALKGAPQDFVLPIRELNLCAGAGFVYALCG 551
4IOJ_A       531 AIMTMPGLPKRPAACNIDIDADGVITGLF 559
YP_001006249 573 DIMTMPGLGTQPAYYHIDIDDEGCIRGLS 601
YP_205176    554 NVMTMPGLPEKPAFMNLDIDGDGNIVGLS 582
WP_015871391 548 NIMTMPGLSTLPAYRHIDIDADGNTVGLS 576
NP_716196    542 NVMTMPGLGLTPGYLKIDIDVDGEIIGLG 570
WP_013344858 551 NVMTMPGLPERPGYLNIDIDANGNITGLD 579
NP_800344    554 SVMTMPGLPDKPAFMNLDLDEDGNIIGLS 582
WP_011219410 556 NVMTMPGLPEKPAYMNLDIDADGNIVGLS 584
WP_025801039 547 NIMTMPGLSTLPAYRHIDIDNAGNIVGLS 575
WP_106911001 552 NVLTMPGLPEHPAYLGIDITADGTIVGLG 580
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