1EWK


Conserved Protein Domain Family
PBP1_mGluR_groupI
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cd06374: PBP1_mGluR_groupI 
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ligand binding domain of the group I metabotropic glutamate receptor
Ligand binding domain of the group I metabotropic glutamate receptor, a family containing mGlu1R and mGlu5R, all of which stimulate phospholipase C (PLC) hydrolysis. The metabotropic glutamate receptor is a member of the family C of G-protein-coupled receptors that transduce extracellular signals into G-protein activation and ultimately into intracellular responses. The mGluRs are classified into three groups which comprise eight subtypes.
Links
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Statistics
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PSSM-Id: 380597
Aligned: 12 rows
Threshold Bit Score: 739.927
Created: 4-Jun-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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ligand bindingdimer interface
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:1EWK; Rattus norvegicus mGluR subtype 1 binds glutamate, contacts at 3.5A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                #                                     
1EWK_A       4 RSVARMDGDVIIGALFSVHHQppaek----vperkCGEIREQYGIQRVEAMFHTLDKINadpvllPNITLGSEIRDSCWH 79   Norway rat
CDS18160    29 KLKVRIPGDIMIGALFPIHEQptvet----afsrqCGNVREQYGIHRIETLIRTIQMINenenilPRIRLGVDARDTCWY 104  Echinococcus gra...
EEN46338     5 RQVARMEGDLIIGALFSIHEKprgpag---isareCGDIREQYGIQRVEAMFQTLDRINsdptilPNITLGCEIRDSCWH 81   Florida lancelet
EFX66273    25 RKTAILEGDMTIGYLFSMHEQpdqks----ahmrtCGRIWEEYGIQRAEATFQTIERINkdpailPGIRLGVEIRDDCWY 100  common water flea
NP_989469   32 RVVAHMPGDIIIGALFSVHHQptvdk----vherkCGEVREQYGIQRVEAMLHTLDRINldptllPNITLGCEIRDSCWH 107  chicken
Q13255      36 RSVARMDGDVIIGALFSVHHQppaek----vperkCGEIREQYGIQRVEAMFHTLDKINadpvllPNITLGSEIRDSCWH 111  human
OCT77909    51 RSVARMDGDIIIGALFSVHHQppadk----vperkCGEIREQYGIQRVEAMFHTLDQINmdqnllPNITLGTEIRDSCWH 126  African clawed frog
EEZ98591    30 RISAFLNGDFIIGALFPVHHQpsskkrtvaslgikCGEIRELYGIQRVEVTFQTLDKINkdpnllPNLTLGVEIRDECWY 109  red flour beetle
OWF48826    32 RRIARKEGDVIFGALLPMHKKppett----vytrsCGKIWEQYGIHRLEIFLETVDKINaspdilPNVTVGYDIRDSCWY 107  Yesso scallop
ELT88339    17 RRIIRMDGDIIIGALFPVHRQpplki----aftsqCGEFWEQYGIHRIEMFLRTLDAINndpnilPNVTLGCDIRDSCWY 92   Capitella teleta
CEF65085    29 MLVAEIPGDIQIGALFPVHRQiqg--------sesCGEIWESYGIQRIEASFLALKYLNk----rLPFKLGIEIHDTCWS 96   Strongyloides ratti
OQR71791    44 FYKSIDPEDFLLGLIVPVHSQpnlte----vnplrCGDVLEQEGIQRVEMALRTVAEINkrpdllPNTTLGIHIRDSCNY 119  Tropilaelaps mer...

Feature 1                                                                      #               
1EWK_A      80 sSVALEQSIEFIRdslisirdekdglnr-----------clpdgqtlppgrtkkPIAGVIGPGSSSVAIQVQNLLQLFDI 148  Norway rat
CDS18160   105 aPIALEQCMDFIRtafiyreyedclqmtng-------sngkclppgvspssieiPIAALIGPGSSEMTKQVHQVLQLFSI 177  Echinococcus gra...
EEN46338    82 dTVALEQTIEFVRhtistqtqhssaqk-------------cpdgtvlsspvyeqPIVGLIGPGSSSVTIQVQNLLQLFNI 148  Florida lancelet
EFX66273   101 aPVALEQTLEFIRdavaaspvapssgnnktyhshitpptisttptaanqtkrrkVLVGVIGPGSSAVSIQVQNLLQLFHI 180  common water flea
NP_989469  108 sAVALEQSIEFIRdslisseeeegmvr--------------cvdgssssfhskkPIVGVIGPGSSSVAIQVQNLLQLFNI 173  chicken
Q13255     112 sSVALEQSIEFIRdslisirdekdginr-----------clpdgqslppgrtkkPIAGVIGPGSSSVAIQVQNLLQLFDI 180  human
OCT77909   127 sSVALEQSIEFIRdslismrdqkdgask------------cldatptphgrikkPIAGVIGPGSSSVAIQVQNLLQLFDI 194  African clawed frog
EEZ98591   110 aPVALQQSIELIRdaitpvssyldsc----------------hnlttsdagqrgPLIGVVGPGSSSVALQVQNLLQLFHI 173  red flour beetle
OWF48826   108 sPIALEQSIDFIKdslanldaeearqn-------------nstpkgdcktenrkPIVGLIGPGSSHNTIQVQNLLQIFHI 174  Yesso scallop
ELT88339    93 sPVALERSIDFIKnsiasvessnlts---------------aaanpqchkprekPIAGLIGPGSSTVTIQVQNLLSLFNI 157  Capitella teleta
CEF65085    97 eRVTINSLIRMLKenvaqnkcct---------------------tpgcekknnaVISAVLGPGKSSTALSAQNLLQVFKI 155  Strongyloides ratti
OQR71791   120 pPIALEQTINYIRasvwhdsdyqetpypwsqs----hsietyslkkctvpekrrNLVSVLGPATCTGTTQVQNLLQLFGI 195  Tropilaelaps mer...

Feature 1           ###                                                #                       
1EWK_A     149 PQIAYSATSIDLSDKTlYKYFLRVVPSDtLQARAMLDIVKrYNWTYVSAVHTEG-NYGESGMDAFKELAAQEgLCIAHSD 227  Norway rat
CDS18160   178 PQIGYSATAAELSNIAeYQYFLRVVPSDdLQVEVIVSLLKrYGWTYVALVNSNG-FYGDRGIAALRYRMDEIgICSETER 256  Echinococcus gra...
EEN46338   149 PQIAYSATSKDLSDKArYKYFLRVIPPDtLQAQAMADIVMhYNWTYVSTLHTTG-NYGQSGAEVFKALVKKEgVCIATSD 227  Florida lancelet
EFX66273   181 PQIGYSATSRDLSDKNrFGYFLRVVPPDeLQAMAMLQIVQrYNWTYVSAVSTEG-SYGESGLQVFREYADREgICLAKEY 259  common water flea
NP_989469  174 PQIAYSATSMDLSDKTlFKYFMRVVPSDaQQARAMVDIVKrYNWTYVSAVHTEG-NYGESGMEAFKDMAAKEgICIAHSY 252  chicken
Q13255     181 PQIAYSATSIDLSDKTlYKYFLRVVPSDtLQARAMLDIVKrYNWTYVSAVHTEG-NYGESGMDAFKELAAQEgLCIAHSD 259  human
OCT77909   195 PQIAYSATSIDLSDKTlYKYFLRVVPSDiLQARAMLDIVKrYNWTYVSALHTEG-NYGESGMEAFKEMAALEgLCIAHTD 273  African clawed frog
EEZ98591   174 PQVGYSTTSRDLSDKSrFNYFLRVVPSDyYQAQVILDIVRyYGWTYVSAVNTDE-NYGQSGIQAFRELAEEAdVCIARED 252  red flour beetle
OWF48826   175 PQIGFSATSMELSNKNlYGYFLRVVPSDkYQAQAMLDIVIrYNWTYISTVHTDG-NYGARGLAEFHNLARNSsVCIANTE 253  Yesso scallop
ELT88339   158 PQIGYSATSLDLSDKSlYKFFLRVVPSDkLQARALIDVVRhFNWTYISTVYTEG-NYGFSGITEFQNMATEAnICEAVSD 236  Capitella teleta
CEF65085   156 PQIGYSSTSIELSDKErFAYFTRVVPSDvWQARAIFEVIQhFNWTYVAVVYSAG-NYGEKGYEELLKITNEN-VCIAHSE 233  Strongyloides ratti
OQR71791   196 PQIGYSATAKIPAEYS-KYFLSMIPNDDyQSQAMLDILVR-FNWTYVYTIYSDDdDYGPMGIDRFKTKAYSRgICVAQKY 273  Tropilaelaps mer...

Feature 1                                                                       #              
1EWK_A     228 KIysnageksFDRLLRKLRERlpk---arVVVCFCEGmTVRGLLSAMRRLgvv----geFSLIGSDGWADRDEVie---- 296  Norway rat
CDS18160   257 SIdnketeeaFLELAQDIFNPdrk---akVVVCFCQGeTVAGLLKAMDTLhlq---gkgYMLIGADGWSDRQDIlgplvd 330  Echinococcus gra...
EEN46338   228 QVeydadndrYDNVVRNLQSTps----ahVVVCFCQGnTVRGLLAAMERLntt----gqFLLLGSDGWADRKELta---- 295  Florida lancelet
EFX66273   260 SIlsngveheYDRLLTRIMEEpk----arVIVCFCEGeTVNAILKAIRRFnqt----ghFLLVGSDGWADRLDVvq---- 327  common water flea
NP_989469  253 KIysnageqsFDKLLRKLRSHlpk---arVVACFCEGmTVRGLLMAMRRLgla----geFLLLGSDGWADRYDVtd---- 321  chicken
Q13255     260 KIysnageksFDRLLRKLRERlpk---arVVVCFCEGmTVRGLLSAMRRLgvv----geFSLIGSDGWADRDEVie---- 328  human
OCT77909   274 KIysnageknFDRLLKKLRERlpk---arVVICFCEGmTVRGILMAMRRLgvs----geFLLIGSDGWADRDEVie---- 342  African clawed frog
EEZ98591   253 SIlsnapdegFDKVILNLKQDpn----ayVVVCFCEGlTVRGLLKATRRLnmt----nhFLFIGSDGWADRGDVtr---- 320  red flour beetle
OWF48826   254 SApsrkdphvFDALIRRMLVTkn----arVIVCFCEGaTVTSLYNATRRVkga---qghFLILGSDGWADRPDVve---- 322  Yesso scallop
ELT88339   237 KVgnnaedaaYDKVIKNLKGKpn----arVVVCFCEGmTIRGLLKAAKRLgae----ghFLFIGSDGWNVRKDVve---- 304  Capitella teleta
CEF65085   234 KVkplapeeeFRRALKQIINLkiv---pkAIVCFCEGeVAKAMLAAQRYLiskdkniekFQWIGSDGWADRKDVva---- 306  Strongyloides ratti
OQR71791   274 VLsprsrtsdYETTVRKMMNAhvrptgarVIVAYLEKtILMRFLHTLKHLnat----hkFLILASDSWGTDPEVvr---- 345  Tropilaelaps mer...

Feature 1                                                                                      
1EWK_A     297 ------gyEVEANGGITIKLqspeVRSFDDYFLKLrl--dtNTRNPWFPEFWQHRFQCrlpghlle-------------- 354  Norway rat
CDS18160   331 pktgerafSRLAQGSLSIKIhspkVEDFDEYFTNLtpq-thHNISPWFTEFWEQKFDCaitpssd--------------- 394  Echinococcus gra...
EEN46338   296 ------vnPREAAGSITIKPwspqVESFDEYYQNLnp--wnNARNPWFQEFWQWKFDCrivgham--------------- 352  Florida lancelet
EFX66273   328 ------gyEAEAEGGISIRIhsppVASFDRDYFALkpdaptRARNPWFQEFWEHRFDCllsahpadss------------ 389  common water flea
NP_989469  322 ------gyQREAVGGITIKLqspdVKWFDDYYLELrp--etNHRNPWFQEFWQHRFQCrlegfpqe-------------- 379  chicken
Q13255     329 ------gyEVEANGGITIKLqspeVRSFDDYFLKLrl--dtNTRNPWFPEFWQHRFQCrlpghlle-------------- 386  human
OCT77909   343 ------gyEAEANGGITMKLksaeVMSFDDYYLALrl--dtNSRNPWFAEFWQHRFQCripghpqe-------------- 400  African clawed frog
EEZ98591   321 ------gfEEEAWGALSIRIhspyVKSFDEYYWSLkp--hnNTRNPWFREFWESRFSCsldgppdddsasvdtlnstqss 392  red flour beetle
OWF48826   323 ------siEDAAAGGLSMKLhspiIPAFDKKFKALnp--flNDRNPWFKEFWQEKFSCtipgdeda-------------- 380  Yesso scallop
ELT88339   305 ------hiEPSAMGGLSIKLyspeIEDFNRHYFSLrp--knNSRNVWFREFWQERFECyiegpdr--------------- 361  Capitella teleta
CEF65085   307 ------glEDEAAGSFTIRIhsprIEAFEKHYFNLnp--enNSVNPWFRDFWQQKFECqfvipke--------------- 363  Strongyloides ratti
OQR71791   346 ------slEDVAEGCMTLSFprppDAAFREHFTTLkp--etNSYNPWFREFWEDRFKCtlpgrqdtp------------- 404  Tropilaelaps mer...

Feature 1                               #                                                      
1EWK_A     355 ---npnfkkvCTGNESLEENYVQDSKMGFVINAIYAMAHGLQNMHHALCpgh---------------------vglCDAM 410  Norway rat
CDS18160   395 ----nlrkpcTGEESLKNVPMYQDNKLSLLNLAIYVVAIALHRVQEIVCgvgr--------------------pgiCPGL 450  Echinococcus gra...
EEN46338   353 ----ektfgdICTGNESLHNYVQDTKLGFVINAIEAMAHGLHDMQTSLCgdy---------------------vglCPQM 407  Florida lancelet
EFX66273   390 fisspsskklCTGEESLRGRYKQDTKMGFVIKATMAMAWALHHLQQSLCgans--------------------sglCPAM 449  common water flea
NP_989469  380 ---npkynktCTSQMTLRTQHVQDSKMGFVINAIYSMAYGLHNMQLSLCpgy---------------------vglCDAM 435  chicken
Q13255     387 ---npnfkriCTGNESLEENYVQDSKMGFVINAIYAMAHGLQNMHHALCpgh---------------------vglCDAM 442  human
OCT77909   401 ---nhsfkkiCKGNESLEENYVQDSKMGFVINAIYAMAHGLHDMHTALCpgh---------------------vglCDAM 456  African clawed frog
EEZ98591   393 tvnktdsrklCSGEESLLDKYRQDSKLSFVIKAVYSLAHALHDMQQDKCgpgt--------------------tgtCEKL 452  red flour beetle
OWF48826   381 ---kaefinkTCTGREIHQDFVQDSKLGFVVNAMYTMAKALHNMHQDICgdy---------------------pglCPEM 436  Yesso scallop
ELT88339   362 ---dlrydteCDGEERLQDGFEQDAKLGFVVNAMYTMAHALHQMRNDLCtnts-------------------evglCAEM 419  Capitella teleta
CEF65085   364 ---eiglkkqCTGNESLKIGYEQDPKLSQVSNAIRVLGEALEKMYKDRCgldk-------------------nfteCTAM 421  Strongyloides ratti
OQR71791   405 -kilkyhrwcTGNETLNDGSFREDPKLDYLRRSIYLVAYGLHRMIEDHCgsaqygtapdeitdgeqgsehnatraeCVSK 483  Tropilaelaps mer...

Feature 1                                                                                      
1EWK_A     411 KPIDGRKLLDFLIKSSFVgv-sGEEVWFDEKGDAPGRYDIMNLqyte---------------anryDYVHVGTWHEg--- 471  Norway rat
CDS18160   451 LPVNGSLLRQELLKSNYTds-nGDTIFFDENGDPPGSYDLMNYqhtfne-----------rgeevfDYVQVGRWKHg--- 515  Echinococcus gra...
EEN46338   408 RNVNGTLLLDHILSTTFLgv-nNGTVMFDKNGDPPGRYDIMNFqdfg---------------agdyGYVKIGSWKYg--- 468  Florida lancelet
EFX66273   450 LPIDGSLLRDHLLNVSFAy--gTETVQFDSNGNPPGWYDIMNYqrhqqqpnnsnnkaqqqqqqqqyGYVQIGSWRNg--- 524  common water flea
NP_989469  436 KPIDGRKLLESLMKTNFTgv-sGDMILFDENGDSPGRYEIMNFkkmg---------------kdyfDYINVGSWDNg--- 496  chicken
Q13255     443 KPIDGSKLLDFLIKSSFIgv-sGEEVWFDEKGDAPGRYDIMNLqyte---------------anryDYVHVGTWHEg--- 503  human
OCT77909   457 KPIDGSKLLEFLIKASFLgi-sGEDVWFNEKGDAPGRYDIMNLqqie---------------pnryDYMLIGTWHEg--- 517  African clawed frog
EEZ98591   453 LPFNGSLFKSYLMNVTFEy--dEDIIEFDENGDPPGRYDIMNYqkld---------------dgsfDYVQVGNWHNr--- 512  red flour beetle
OWF48826   437 IPLEGRKYKEYLLNVSMVty-sNDDLHFDKNGDPPARYDIMNFqkfgeg------------anvtyGYVKVGEWNTg--- 500  Yesso scallop
ELT88339   420 SPVNGTIFLQYLLNVSFTsy-sGDSLMFNRNGDPPGRYEIMNFqrlltd-----------ngtyyyDYVHVGDWDSg--- 484  Capitella teleta
CEF65085   422 HTINGTLLFKYILNVTFIde-fQQVITFDQNGDAPAWYDILNYvgk------------------ngGYKLAGSFRQfpsg 482  Strongyloides ratti
OQR71791   484 MYVNAAAFVAYLNRTSFVwppgSSNASETIQVNPPGVYNIYNFrkvk---------------ersyDYVQIGTWKGg--- 545  Tropilaelaps mer...

Feature 1               
1EWK_A     472 --VLNIDDY 478  Norway rat
CDS18160   516 --QLITLQE 522  Echinococcus granulosus
EEN46338   469 --QLSVDDD 475  Florida lancelet
EFX66273   525 --TLDMPDW 531  common water flea
NP_989469  497 --ELKMDDD 503  chicken
Q13255     504 --VLNIDDY 510  human
OCT77909   518 --ILSIDDE 524  African clawed frog
EEZ98591   513 --SLWWNQS 519  red flour beetle
OWF48826   501 --HLDMNDS 507  Yesso scallop
ELT88339   485 --NLTMNRE 491  Capitella teleta
CEF65085   483 nySLKFHKK 491  Strongyloides ratti
OQR71791   546 --LQLWEDP 552  Tropilaelaps mercedesae

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