2R5O


Conserved Protein Domain Family
Wzt_C-like

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cd10147: Wzt_C-like 
Click on image for an interactive view with Cn3D
C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins
The Escherichia coli ABC protein Wzt consists of 2 domains, a conventional ABC domain that binds ATP and utilizes its energy to transport molecules across membranes, and a C terminal domain which is responsible for its target molecule specificity. Wzt is part of the ATP-binding-cassette (ABC) transporter complex, responsible for the transport of the O-antigenic polysaccharide (O-PS) portion of lipopolysaccharide (LPS), a major component of the outer membrane of Gram-negative bacteria. This CD includes Wzt proteins from two Escherichia coli serotypes O8 and O9a, WztO8 and WztO9a; these proteins are specific for their cognate polysaccharides (O8 or O9a O-PS).
Statistics
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PSSM-Id: 199902
Aligned: 325 rows
Threshold Bit Score: 49.6666
Created: 5-Apr-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:putative carbohydrate binding site [chemical binding site]
Evidence:
  • Comment:based on site-directed mutagenesis of Escherichia coli Wzt

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         #                                                          #              # 
2R5O_B     39 EEYRWGQg--------gAKIIDYHIQSagv-dfPPSLTg--nQQTDFLMKVVFEy-dFDCVVPGILIKTldGLFLYGTNS 106 Escherichia coli
EDS73368  284 AREEQGNqeeilekkdiLEFIKTRMLDini-nnRNRINfnygSTVIIEIEYEVKkpiENDLICCFSIRDieEREVFATNK 362 Anaerofustis sterc...
EFC20764  253 REAAHGGgfqi---vngFELLSLSMHSpdg-rrLTRVRv--nEPVNIRIHYRNTd-aLDQPKFGIGVHTsdFLYLTTYDS 325 Desulfovibrio sp. ...
EFO33990  277 AEGWEGQrp-------cTILQWIETFDsdg-tpSRTFEt--gDTMFIRIGYEVNq-kIEAGYFTIFFIDdlGDRVQVIYS 345 Roseibium sp. Tric...
EGK01934  279 NAQKDKD----------IILHAAELIDesgnkiDNVIDv--hTAFNLRLQIEFRk-rINAPKITFHFKNmrDQFVWFNDI 345 Dysgonomonas gadei...
AEI48002  266 PEEAPGTd--------eVRFRTVRIDPeyq-dqKHYIDv--rTPVNVHIEFWNMa-dRADLNLSLHLYAftGECIFNVGT 333 Runella slithyform...
ACU04231  271 PDTAPGNe--------sVRIKRVEMLPqyp-dsSNIIDi--rTPLLIEFEFWYLpaeEMDLGVNIILNTvmGECVFNVAS 339 Pedobacter heparin...
ADB38589  266 PEEAPGNd--------lVRVRRIELVPeyl-ddLTHIDv--rTSMKFRFEFWNLm-dHANLNLSLHLNSmtGECIFNIGT 333 Spirosoma linguale...
ACT93987  267 IESAPGNd--------qVRVKSFKLFPeyq-ddLTHIDv--rTPINFQFEFWNLv-eGASLNLSMHLYTftGECIFNVGT 334 Dyadobacter fermen...
EGK05888  268 SEVNFNKqie-----enLIVESAYITNekn-evANKILt--gEKWKVRIKYKVKdggIRNVVFACGLCTalDIPINTTWS 339 Dysgonomonas mossi...
Feature 1                                                 #              # ##                 
2R5O_B    107 flasegreNISVs----rGDVRVFKFSLp---VDLnsGDYLLSFGISAGNpqtdmTPLDRRYDs------IILHVTKsmd 173 Escherichia coli
EDS73368  363 qn-----kDNIVds---sIGRHIFRFILp--nLRLlpGNYKIAGEFWNNE-----AGLHFKFAs-----lRRLNIVSney 422 Anaerofustis sterc...
EFC20764  326 --------RHEIqmetvePGEHEAVCHIt--rLPFtpGVYSLRLGVSSGGv---eKTIFYGENl------LNFQVVGeer 386 Desulfovibrio sp. ...
EFO33990  346 l-------HDDKel--eiGTRGVIECRId--dLRLvsGEYSLTLDFGQIIdg-hlKFLDCVPDa------TQVRIALgny 407 Roseibium sp. Tric...
EGK01934  346 n------dVNKGmd--ipHEKGLYEFIIpieqPLLkpDTYSVSVGITNEDnr--qTNHFGYILkmeivdfAGIRATRa-- 413 Dysgonomonas gadei...
AEI48002  334 s------sQSFE------KGLVSATLEIp--gNFLndGSYVISIMVVKDTs----TVLFQLPDa------LSFEVEDhre 389 Runella slithyform...
ACU04231  340 t------sKQYT------KGVIKGKCTIp--gDFLnnGSYSIDLSFVKNTs---sPLFDFEEC-------LSFEVEDfre 395 Pedobacter heparin...
ADB38589  334 qs-----kPFGKg-----LIAGECTIPG----FFLndGSYTISMMIVKDTv----TPLFVMEEg------ITFDVEDyr- 388 Spirosoma linguale...
ACT93987  335 q-------AENFa-----KGLVSGTCEIp--gNFLndGSYVVSMMIVKDTs----TVLYNMEEa------LVFDIEDyre 390 Dyadobacter fermen...
EGK05888  340 a------pQSQS------KGEYEIEFLCd--eLFLqrGTYKIVIGISRGN-----ESLFYNDSs------LQFDVVFipk 394 Dysgonomonas mossi...
Feature 1                        
2R5O_B    174 --------fwGVIDLKSSF 184 Escherichia coli
EDS73368  423 -------kggGVYAIPYKT 434 Anaerofustis stercorihominis DSM 17244
EFC20764  387 frn--vagseGLILLDAKW 403 Desulfovibrio sp. FW1012B
EFO33990  408 lgklglrqnqGALAQRSQW 426 Roseibium sp. TrichSKD4
EGK01934  414 ----------GYLYTETKW 422 Dysgonomonas gadei ATCC BAA-286
AEI48002  390 gvt-wygkwpGYVRPQLNF 407 Runella slithyformis DSM 19594
ACU04231  396 nta-wygdwvGSVRPKFKV 413 Pedobacter heparinus DSM 2366
ADB38589  389 ---------eGIAWYGKWP 398 Spirosoma linguale DSM 74
ACT93987  391 nvt-wygkwpGYIRPQLNF 408 Dyadobacter fermentans DSM 18053
EGK05888  395 v------ineNLIKVDGTT 407 Dysgonomonas mossii DSM 22836

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