4Z0R,5OFB,5OFB,5OF9,2L7P


Conserved Protein Domain Family
zf-CW
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pfam07496: zf-CW 
CW-type Zinc Finger
This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.
Links
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Statistics
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PSSM-Id: 462181
Aligned: 151 rows
Threshold Bit Score: 34.9769
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4Z0R_A        10 VWVQCEneNCLKWRLLSSEDsAKVDH-D----E-PWYCFMNT-----DSRYNN---CSISEED 58  human
EEC20158      67 FWAQCT--RCHKWRRLPKGDdLTPEVvE------TFTCSDIPtyddseskiED---CDIPEDP 118
8_pfamImport   1 YWVQCT--QCGHWRSLTNDVeLTSDViR------SYTCIMKVpn-ssVKPMIKy-sCSQPNEQ 53 
ERE77441     138 YWVQCTkpECGKWRQLTKEIqLTPHMaR------TYRCGIKln--tiTKTDIPd-hCSLPEDL 191
XP_006011444 147 YWVQCIkpECRKWRQLTKEIqLTSVLaK------TYRCGMKln--nnVKNEGPd-qCSFPEDM 200
XP_012820859 138 YWVQCTklECGKWRQLTKEIqLTTQMaK------TYKCGMKmn--nsVKTEGSd-qCSMPEDL 191
XP_023352089 140 YWVQCTkpDCGKWRQLTKEIqLTSQM-A----Q-TYRCGTKPntsvkVEGSDQ---CSQPEDL 193
XP_005452898 160 YWVQCTkpDCRKWRQLTKEIqLTASL-A----A-TYRCGMKFn----NIKSEEpdqCSQPEDL 212
XP_022527712 168 YWVQCTkpDCGKWRQLTKDIqLTASL-A----A-SYRCGMKLn----NVKTEGpdqCSQPEDM 220
XP_002971718   4 YTVQCS--RCGQWRLVPSE--EVYESiRarvlEnPWVCEDAKiwrp-------dacCDIKGDI 55
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