Conserved Protein Domain Family
Trypan_glycop

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pfam00913: Trypan_glycop 
Trypanosome variant surface glycoprotein (A-type)
The trypanosome parasite expresses these proteins to evade the immune response. This family includes a variety of surface proteins such as Trypanosoma brucei VSGs such as expression site associated gene (ESAG) 6 and 7.
Statistics
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PSSM-Id: 395732
Aligned: 24 rows
Threshold Bit Score: 173.733
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q387P2  13 ILLTLAVIKT--IESASKGPITHAAWSPLCTLSKDKQKLYNRANKLQDDISNFFQTAAKASIKAA---IVAVKLNSADA- 86  Trypanosoma brucei
Q387P1   9 VCVIVLLSMRpgSDGAGQAGLLKTVWQPVCGLSEELDVVGGNSLRIIDDILSAATNQTNTAIRLR---IYALKNIEEKP- 84  Trypanosoma brucei
Q38CQ2  36 ALAIMLPLSAekAAAAAGDSLKAAAWQPVCQLAEALNKVPSNSKLRLRALITTTQGQRLAAAKLG---VYALLAEEAQE- 111 Trypanosoma brucei
Q57Y75  15 AILVLLTALPqwVVPAAHMGLLKATWQPLCALTKELDEVPGEALQEVMAILSKASELEKEAMMLK---IYSALTESESE- 90  Trypanosoma brucei
Q57XH3  10 GLLVIADTLRs-GHAAGTYGVTKASWQPLCEATTDLRTIPSDVAANLKAGVTKVKNMILDSTRAA---IYSQLQKGTKE- 84  Trypanosoma brucei
Q380Y2  14 SLVAGAAIQK--AEAAAGQGIHEEDFNPLCAVSDELKKSEGYAKHLISELDAAASVGINQALRLK---IYAETLSTATQr 88  Trypanosoma brucei
Q38G20  24 SLLLLALASAs-SSSASHVAVKSELWKPQCELAKELRKTAGITISKLSAKLTAIDNLNKMSMRLL---LFGQRTSPLDN- 98  Trypanosoma brucei
Q57TR9  19 TVAVALLYVAv-TASASYEVLDFTTWPAHCSLAVTLRKVHGGMLTKLESQISYRNKLEEMEAKLR---IYGLKGATAEEq 94  Trypanosoma brucei
Q57Z50   8 FLLILCVCSCwhLSSADTEAIKETAIREVCELSKTLKGTPFAITQRWKHIEALISTFERLLRRLElinLLCCEDEDSVS- 86  Trypanosoma brucei
Q380W1  17 TLLTLCFTTIlrLAKPSTNGFNEAKITQLCGTAMAIQDTAAVAIGRLQKLHRQEQAAAEARNKLL---LAALVVPTVNDt 93  Trypanosoma brucei
Q387P2  87 MKAAMGLQAKIKADVTAKMAAAEQC-RTISTVVTLRSAYLHGRIAEFIEMMTAMRGKTn-EHACLSKQGDGTD---RAAG 161 Trypanosoma brucei
Q387P1  85 VKEISALASYYAARGHAAIMDMQATeLAKHIAAVRSATYLKGRIDEGINMLEQVKGGQ---NGCLVATAADDTt-eVRTG 160 Trypanosoma brucei
Q38CQ2 112 SKAAVVLAAWYSRLADLNDNLLKTTlVDTTIDAVASSIYVKGRADEALNILAQAKTTS---NGCLLTDDSGTLa--AHGP 186 Trypanosoma brucei
Q57Y75  91 AKKATTVAAHMRRLAHSQRQYFMTIdAQKFLAASKASAYAKGRLDEFLQVAGSMKDSS--NRGCLLAGSNQNGl--KLTD 166 Trypanosoma brucei
Q57XH3  85 AARVITISLYMLGAALRAVSYLESTdIINGVDLAAKSAYLKGHIDEFLKVAEKTTRSG---EHCLLAAGDTGAa--TFAG 159 Trypanosoma brucei
Q380Y2  89 TKLRTLANAYIDYCIAEFTDTVNNC--QTALGYTAATNYVAAGVDAVMDLLIGAEAGAagANGACTRTGDATSs----TA 162 Trypanosoma brucei
Q38G20  99 QVTALALALAAQKKAAKIQSTVSDS-VKTGLLATQYSGELAGGIVSAVHFLKHASDGA---HYCLNSNGKKGDg--RPAV 172 Trypanosoma brucei
Q57TR9  95 TTVELLAETAALMRVSKQNKEQTNL--QTAVTAVGFASEGAAAISSYLMTIDSLTHNT--QTYCLSDSAAELSp--TG-- 166 Trypanosoma brucei
Q57Z50  87 -----ILKLYTQSQIASLEVLMKAL-MERGPNAAAFAAYAAGRLDEFVAVFTQSVGKTprTNACVIADSGMRRwdqAAAN 160 Trypanosoma brucei
Q380W1  94 ILFTAAARAAENCRVDATTKAAGNV--AAGVTAAANGAHVAGRLTELVAILQATTKSDt-ARKCITQANTRTTk------ 164 Trypanosoma brucei
Q387P2 162 ETITKQQatCKLHSEE-------LTKHSEELT---ELTATGYPKLTLPTGLTTSE-QGGDtnpNCIFLTTTA----NELN 226 Trypanosoma brucei
Q387P1 161 TRIGGVE--CKLKLSE-------LSKTTWSKA---NIDETGYPNLKEGGTTSGTAvQPTDsnnVCRLLHHSSa---HGLG 225 Trypanosoma brucei
Q38CQ2 187 AKIGETP--CSRKLEPpvldtyeNLDE--------VMDANGWKSSHATTAKADLA-GSGGd-kTCKLLTV------DGAG 248 Trypanosoma brucei
Q57Y75 167 GALDGVQ--CKNSASQ-------VAATTRATK---TITAAGISGPIHGQESSNRI-QHSAn--ECRLFGKTHa---NGLG 228 Trypanosoma brucei
Q57XH3 160 ESLNRVN--CPTT----------MVDTTPTKAslkKLSSKGHKGAMTPSNGGSHE-HQASgtyRCRLFSKSNa---NGLA 223 Trypanosoma brucei
Q380Y2 163 KTKSQLNaaCTERYKAdrphnpaKKPTAANVR----------LAPRSGTALTSTN-HQ-----TCALTSTQS----DCLF 222 Trypanosoma brucei
Q38G20 173 DTTG-----CATLTATe-----vSTETGFNKG---DINDDGFVKLTALTTTDGAG-QTG----TCGVFETAS-------- 226 Trypanosoma brucei
Q57TR9 167 ---------CRHGKSS--------DYEAGNGPdndDIVDSGFTKIAGQTNTANTG-KKS----KCGLFRHEAnpesNGGI 224 Trypanosoma brucei
Q57Z50 161 G--------CEHNV---------VGNAAQN-----FLDLEVLLKTTLLTRGNQKG-ESK----QCPLTKSDL----SGYA 209 Trypanosoma brucei
Q380W1 165 -LTSPAEfgCPTTITDeyapklnLDSS--------EITNKGLAKYSGPTQLQDAT-GNN----VCAFMLGSNa--dNTAL 228 Trypanosoma brucei
Q387P2 227 -GNGGFKEAIPLAAG---YLlrkeDMTANSKQainqlQTVDEPASAKTTVRPYVELW---KAFKQLTNCEAMFSAAYTL- 298 Trypanosoma brucei
Q387P1 226 -NSANLDTAVKSLAG---YI----TTGATAA------PTLAARASLTTTKTSATGAWv--DAYERAGKYRPKLNTEYSS- 288 Trypanosoma brucei
Q38CQ2 249 fGAAKLDADLELGGG---LW----VVNKDDKQ-----IKTVEIKKGSSTATKTGNMYq--HAWHKLQALDSAEQETKPN- 313 Trypanosoma brucei
Q57Y75 229 hTAALENPKLVWAGG---YI----TIDTSSGDdg--kVTLTQLTPAGTQTRPEAKPWq--DCIEAVGAMPTAGSPAYTN- 296 Trypanosoma brucei
Q57XH3 224 hSGGNVEDGIKWAGG---YY----SLHSTPDNp----LTVADLRETPDTPREASTAWq--QVFTAISKAPNSESATYTN- 289 Trypanosoma brucei
Q380Y2 223 hSGHVNTRTIDFLDG---LV----GLKKDG-------LKTKAFDPSTAQEATHLALFtekTALQTLNAIEGKAGAAAGN- 287 Trypanosoma brucei
Q38G20 227 -GSGSTTAGIQISAGakvHLaf-gAIEGTTSQqp-trPALNKFEGANLEAEQTFFg----KAHKSLKALTLDTTENALE- 298 Trypanosoma brucei
Q57TR9 225 -FITAASSKPSFGYG---ML----KIEAEDQS-----TGLKLSGIKARAGDEDQKFWs--SCHAAVKAAQDMQDEPPLK- 288 Trypanosoma brucei
Q57Z50 210 -TVDDAPDRIKWAGG---LL----TVHKMYGW----------KEDGWSTNGRNVEFIk--EAAEQFKEIKKVLEKQLPNg 269 Trypanosoma brucei
Q380W1 229 wQYSGSATPATVGAD---LI----TVSPHTGSgatatIAVANALGTDYQAPDSATAAk--KLFTAIGKVMKLPESTCPE- 298 Trypanosoma brucei
Q387P2 299 -PTAEALVD--------SPEVKTAIKNHFLRKEGQYEDskdskdVNPIVKRLYKPDDEHYPKKFWQETAKKDTPQAATGK 369 Trypanosoma brucei
Q387P1 289 -DTSPLDKR--------PDLVKAVRSTETKLEGEGEEP------AAKLVTAYFGGTEPNKLDAFLKLVEQDKIPKGIAGL 353 Trypanosoma brucei
Q38CQ2 314 -ATEGAEAT--------SELQAAITNTLHNGQEGAAGQ------PETAVLAVFPKPTGTSINNLLHRANEAQLPEKIAGV 378 Trypanosoma brucei
Q57Y75 297 -DTAVLATS--------ESAADLFGRVQKNIEDGTLSN------TKTEITAMFGDQPEVQVNKLLSNAANYQLKEKIGGK 361 Trypanosoma brucei
Q57XH3 290 -NSKAIDSD--------TEATELLSQVLHNEKGENAED------IKKMRDDIFTTKLASVVDSTFANIHNAKLPAKISGI 354 Trypanosoma brucei
Q380Y2 288 -KSTEQLAT----------LSTLASRAAASQEKKDSEG-------AELKTQEFGDAGSKINQALWHVVEKLEVAKEALPE 349 Trypanosoma brucei
Q38G20 299 -DPKAMLKQlateaeamEALYTVLSGASPNKKPTEFSA------QNQQLKIRYFGADGEKTEKLWEQITAGKTIGAGEDP 371 Trypanosoma brucei
Q57TR9 289 -VDQTLLAVlvgstemqYILKLEAAASQQKGPEEVTID------LASAKKTYFG-SDNNKLEPLWTKIKGENIVDLTNAK 360 Trypanosoma brucei
Q57Z50 270 lDSIDALNAflkreepdAMMKDAIKTHQGWEEEKDDKT------IIEKIKEIFGIGEPCAKIEFIETLIRTNVSARESGC 343 Trypanosoma brucei
Q380W1 299 -TTEKAISEalttttikAEVKDLLIKLGKVTNTMADQA------ARSLIGQAVK-DDNAASTARVNQVNKLKVKKIDGGK 370 Trypanosoma brucei
Q387P2 370 AELSKLDDIV--TEEELAQVLSYYT 392 Trypanosoma brucei
Q387P1 354 QKDTFIGQIT--NTEQLNQILSYYV 376 Trypanosoma brucei
Q38CQ2 379 NAKTKLRSIV--DTHKFQQIEGALI 401 Trypanosoma brucei
Q57Y75 362 NKGTKLNEIG--TAAELEAVLAAVD 384 Trypanosoma brucei
Q57XH3 355 DKGKSLGEIT--APSDLAALLAALL 377 Trypanosoma brucei
Q380Y2 350 ASDRKLGSIN--SFQELTRVTGYYE 372 Trypanosoma brucei
Q38G20 372 HKFSNLSEVS--TADDLSKALFFYT 394 Trypanosoma brucei
Q57TR9 361 GTTKELGTVT--DTTELHKLLSYYY 383 Trypanosoma brucei
Q57Z50 344 TKQIDLFQLTtrQMEEVKERRLDQL 368 Trypanosoma brucei
Q380W1 371 PKEVKIETLT--DPPEITTALLiai 393 Trypanosoma brucei
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