6IAN


Conserved Protein Domain Family
IFT81_CH

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pfam18383: IFT81_CH 
Intraflagellar transport 81 calponin homology domain
This is the N-terminal domain found in IFT81 proteins. Crystal structure analysis revealed that IFT81-N adopts the fold of a calponin homology (CH) domain with structural similarity to the kinetochore complex component NDC80 with microtubule (MT)-binding properties. Functional analysis show that IFT74 and IFT81 form a tubulin-binding module required for ciliogenesis. It is suggested that IFT81-N binds the globular domain of tubulin to provide specificity, and IFT74-N recognizes the beta-tubulin tail to increase affinity.
Statistics
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PSSM-Id: 465736
Aligned: 17 rows
Threshold Bit Score: 146.241
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6IAN_C        17 EVLQYIVDNVNK-LLSRHYSLVEFDAIQGTDLLQILADIFGTLSPAQ--QIDXGV-APTDEAAASXLEFLtKTLGYRVPP 92  Trypanosoma bru...
ESN96098       3 ENLKFIVSELNKpPFNRNFSLISFDSLEELSLLQLLTDIFAEIEPSQ--KLDVRD-ETPDATAIRIFQML-RIFKYKIPA 78 
XP_015792662   2 ESIKFIISELNKePFKKNLNLVTYDNLTGEQRIQILFDIFHVIDETI--TSDILEiSDGEEVVIKIMEML-RILKYTPPS 78 
EYB93695       4 DSLNFIIQNLNSpPFNCNTSLIAFDLWSPTTLLQQLSDVISWITQTD--NVDVTK-ETPDETALRLLYYL-KILKFNPPT 79 
CEF70549       4 ENIRKLVTFLNApPFSKNLNLITFDSLKNDKLLQLLSDVLQWITNDS--IIDIRS-ESAEETAIRIFNAL-RLIRFRAPK 79 
KFB46856       3 EDLKLIVVELNK-LLETDYNLITFDSLSPESLLQVLVDVCHAFGAIE--KIDVRE-NDPEDTNLQVMDAL-RKVQYRPAE 77 
EDS26152       3 EDLKLAVLEVNR-LLETDYNLITFDSLAPESLLQVLVDVFQAFGAIE--KLDVRE-NDPEETNAAVMEAL-RKIQYRPPG 77 
KZC11374       3 ENMKFIVTEVNR-LLGRNYNMIYFNSLTPEELLQVLREVLIKIQDQNdtNVDSRN-ETPEEMAVYILSVL-RVLNYQPQT 79 
XP_012057678   3 ENVKFIVTEINK-LLGRNYSIIGFNTLNTEDLLQILCSVLMKIQQQDdsDIDIKL-NSPEENSMYVLTAL-RILNYQSDV 79 
XP_019698797   3 ENVKFIVTEVNK-LLGRNYNLIGFNALSAEDLLLVLCSVLMKIQQRDesDVDVRI-ESPEESSIYILTAL-RILNYQPNV 79 
6IAN_C        93 XL--ADSFPTSFSRAEPTVIYPTLYWVLSNXQQNEKRVYLARFLQRLE 138 Trypanosoma brucei brucei TREU927
ESN96098      79 ND--QNAFRQGIVEGKKLTIHPIMAWVLGKIPELKERAYLGRYLVKVE 124
XP_015792662  79 NIe-PSLFRQNLISGERNTYTHIFNYLLSKLTELKQRAYLARFLVKIE 125
EYB93695      80 DIddLEEWRSGLVEGAKRSVYPVLFYIFSNVEILKQRAYLAKYLVKVE 127
CEF70549      80 DLdeLQDWRTGIIEGEKCYIYPILYWVFTNQEKIRERVYLSHYLTKVN 127
KFB46856      78 DIddPGAFRRGMVRGEKRLIHPILRWILENSERVKKAAYLAKFLIPLE 125
EDS26152      78 DIddPGAFRRGLVRGEKKLIVPILRWTFDNRERVKKSSYLARFLIPLD 125
KZC11374      80 D---PVSFRQGLIRGDPETIHPILTWLLSHVDIVRKRAYLSRFLVKVE 124
XP_012057678  80 E---PILFRQGLVRGEVEIIHPILKWLLMHMDTVQKRAYLSQFLVKVE 124
XP_019698797  80 D---PVTFRQGLARGEVDIIHPILMWLLTHIDVVQKRAYLSRFLVKIE 124
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