4CPG


Conserved Protein Domain Family
SGTA_dimer
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pfam16546: SGTA_dimer 
Homodimerization domain of SGTA
SGTA_dimer is a short N-terminal domain at the start of SGTA or small glutamine-rich tetratricopeptide repeat-containing proteins. It is the homodimerization domain of the SGTA, a heat-shock protein (HSP) co-chaperone involved in the targeting of tail-anchor membrane proteins to the endoplasmic reticulum. This N-terminal homodimerization domain mediates the association with a single copy of Get4 or Get5 proteins, providing a link to the rest of the GET pathway.
Links
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Statistics
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PSSM-Id: 465168
Aligned: 78 rows
Threshold Bit Score: 59.4551
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4CPG_A         19 KRLAYAIIQFLHDQLRHGGLSSDAQESLEVAIQCLETAFGVTVEDSDLAL----PQTLPEIFEA 78  
PDM61262     1087 KNLAVSFIQFIRHKVSANQCTDDQIEALEVAVQCLESAFALTDANYAFQP----SKSLLALFTA 1146
2_pfamImport    3 KNLIVAFLQFIRAKSGQGPISQEQAETLEIAIQCLEGTFNIDDGSYAFQP----SRPLIDLFTE 62  
Q21746         24 QNLVVSFLQFIRQKVSQNQATAEQAEALEVAIQCLEHSFGLDDASYAFQP----SRPILELFKS 83   Caenorhabditis elegans
XP_002198289    5 KRLAFSIIQFLHTQLQSGSMSPDAQESLEVAIQCLETAFGVSMEDQSLAV----SQTLPEIFEA 64  
EEN47402        7 gKMVFAIIDFLNDQLHSGQLSGDAAESLEVAIQCLETAYGIEYKDAACVArlhtKPPLYELFLs 70  
XP_002404605    5 KRLVLSIVQFLRQQLQTADLSSDAKESVEVAVQCLETAYGVSIDDLSNDSll-vSRTLLDIFRE 67  
XP_024114501    5 KRLAYSIIQFLHDQLQSGGLSSDAQESLEVAVQCLETAFDVSTDDQSLAV----PVTLPEIFAS 64  
1_pfamImport    3 RRLAYSIIQYLHDQLQHGDLSPDAQESLDASIQCLETAFEVTVEDKYLAV----SQTLPEMFEA 62  
EPY52792        4 KKVATAVIDFLNQATATSAVSDEEKESLEVAAQCIKDSFKVEPNEITPGS----GKRLVDAYEA 63
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