Conserved Protein Domain Family
MR_like_2

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cd03327: MR_like_2 
Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues, a Lys-X-Lys motif and a conserved histidine-aspartate dyad. This subgroup's function is unknown.
Statistics
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PSSM-Id: 239443
Aligned: 13 rows
Threshold Bit Score: 480.292
Created: 7-Oct-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative metalputative active
Feature 1:putative metal binding site [ion binding site]
Evidence:
  • Comment:based on the homology to other subfamilies

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       
NP_394216     3 KIKSLEKISeenvtqqvfpytkptdy----------------ykdmigevspaeaamitKIVFVKMETEd-gIRSYISVT 65  Thermoplasma aci...
CAG87577      8 KIKSVKTYIlngkgiggdyhnverghwlidns----isnpmskfpeyrssrvswginvlGSFCVEIEATd-gTRGFATGF 82  Debaryomyces han...
NP_754675     9 KIKQVRAWFtggataekgagggdyhdqganhwiddhiatpmskyrdyeqsrqsfginvlGTLIVEVEAEn-gQTGFAVST 87  Escherichia coli...
XP_362731     9 TIKAVRSFViggvgsggdyhnvegghwlidsp----istpcsrweeyrksrtswginvlGSFFVEIEASd-gTVGYATGF 83  Magnaporthe gris...
ZP_00280149   5 TIRHVRAFIvrgggadyhdqpgghwiddhis-------tpmarypeyrqsrqsfginvlGTLVVEIEASd-gTVGFAVTT 76  Burkholderia fun...
AAW42009      7 TIVKLETFIpsahgsggdyhrqggdhwivqgn----iscpmhkyeeykvsrtswgigvlGSIFVKVHASd-gTVGYATGF 81  Cryptococcus neo...
ZP_00523953  27 KITAVEIWQlhghrdtvrgidqqyqanplfi------ydelrpkpyadaaqgttqnsavSALYLKIKTDg-gVDGLYGPI 99  Solibacter usita...
ZP_00218133   2 KIRSVRARVfqwkgktvppqgnfcsna---------------mdllyapqetmstfrfhSWTVVEVETDd-gIVGLGNVA 65  Burkholderia cep...
NP_342750    15 KIDKIYVVTterisrqnfpyvkptdy----------------yreylgslspfqsafmdKVCFIRMDLDdnvTYSILETS 78  Sulfolobus solfa...
NP_250905     2 KIKSVRTRVfewkgkvvppqahfctna---------------sdilfekgdamgsfrfhGWLVVEIETDd-gLVGIGNCA 65  Pseudomonas aeru...
YP_165074     3 KIKSVRTRVwnwtgptvpptgnfctna---------------sdvlwdkgdamssfrfhQWLTCEVETDd-gTIGIGNAA 66  Silicibacter pom...
ZP_00520860   2 KITEIRTRVvewrgktvppqphfctnp---------------mdildlpadsmgsfrfhGWLIVEVFTDa-gIVGIGNAA 65  Solibacter usita...
EAM93924      2 KVESIKIIGrekvkqpvykyvkptdy----------------ykdilgevspteaaminEVCTLEMKAGe--YSSYYNTT 63  Ferroplasma acid...
Feature 1                                                                                       
NP_394216    66 ep----vWKYLEgISKYVNlfdvseiSKAWDFLYRitlpngr-sglalhAISAVNLLMYDAYSKELGIPVYRLIGGstrk 140 Thermoplasma aci...
CAG87577     83 ggp-pacWMVQNhFLRFLEeadprdiNILWDKMFRasmfygr-kgitiaVISVIDLALWDLMGKIRNEPVYKLIGGatrd 160 Debaryomyces han...
NP_754675    88 age-mgcFIVEKhLNRFIEgkcvsdiKLIHDQMLNatlyysgsgglvmnTISCVDLALWDLFGKVVGLPVYKLLGGavrd 166 Escherichia coli...
XP_362731    84 ggp-pacWLTHQhFERFLIgadprrtNHLFEQMYRasmfygr-kglpiaVISVIDLALWDLLGKIRKEPVYQMIGGatkd 161 Magnaporthe gris...
ZP_00280149  77 gge-igaFIVEKhLARFLEgqlvtdiEKMWDQMYFstlyygr-kgvvlnTISGVDLALWDLLAKVRKEPVYQLLGGpvrd 154 Burkholderia fun...
AAW42009     82 ggp-pacWLIEEhFKRFIVgqdprdtNKMWDQMFRasmfygr-kglplaAISVVDLAIWDLLGKIRGEPIYKMIGGrtkk 159 Cryptococcus neo...
ZP_00523953 100 dne--vaIVVDQqLRAFLMgkdalaqEKLWDQLYRsnrhar--rgaflmAISAVDNTLWDLRGRFFKTPVYRLLGGptra 175 Solibacter usita...
ZP_00218133  66 laphvakVIIDQyLAPLVIgqdpwdyEYLNQRMYRathawgr-kgigmaAISAVDIAIWDILGKSVGKPVFKLLGGrtke 144 Burkholderia cep...
NP_342750    79 es---vcNFVMSnLADLVRglpvsriNMVWDLLYRytlpigr-sgiaihAISVINLLMYDAYAKLLGVPVYELLGGkard 154 Sulfolobus solfa...
NP_250905    66 laprvakEIVDLyLAPICIgedpfdnEYIWQKMYRrthawgr-kgigmaAISAVDLAIWDIMGKAVNKPVFKLLGGrtke 144 Pseudomonas aeru...
YP_165074    67 laptvvkKAIDDwFAPMVIgedpfdyAYLWEKMYRrshawgr-kgigmtAISAVDLAIWDLMGKLTGKPVFKLLGGrtke 145 Silicibacter pom...
ZP_00520860  66 lsprvtkQLIDVyLKPLLLgkdpfdyEFLWQHMYRqtmafgr-kgvamvAISALDIAIWDILGKAAKQPVFKLLGGrtkq 144 Solibacter usita...
EAM93924     64 sd----vASFVMeFSGKLKefniseiNMAWDMLYRlslplgr-sgvmmhALSAVNIMMYDIYSKSLNVPAYKIMGGatrk 138 Ferroplasma acid...
Feature 1                                                                             #         
NP_394216   141 QIRAYASHlhpd-kdenLEAEAKHYleeGYTDMKMRFiaspsdp-yaveknLHLVKIIRDVvgysVNLAGDFWMslnynF 218 Thermoplasma aci...
CAG87577    161 KLEFYCTGs--------KPEAAKEM---GFWGGKVALpygpdeghkglqknVKFLRDHREKvgpdFPLMVDCYMslnvlY 229 Debaryomyces han...
NP_754675   167 EIQFYATGa--------RPDLAKEM---GFIGGKMPThwgphdgdagirkdAAMVADMREKcgedFWLMLDCWMsqdvnY 235 Escherichia coli...
XP_362731   162 RLNFYCTGp--------EPTAAREM---GFWGAKVPLpycpdeghvgmkknIEFLRKHREAvgpdFPLMVDCYMslnvsY 230 Magnaporthe gris...
ZP_00280149 155 ELVFYATGa--------RPDLAKEM---GFIGGKLPLqhgpaegdaglrqnLDKLAEMRSRvgddFWLMYDCWMsldvpY 223 Burkholderia fun...
AAW42009    160 DIPLYLTGp--------RPEVAKKL---GFWGSKVALphgppdghegirknVEYLKACKEAvgpdYPVQVDCYMsldvpY 228 Cryptococcus neo...
ZP_00523953 176 SIEAYGSClgyslepdkAQSRAVQLkkeGYRYQKWFLaygpgdgpeglkknVDLVRVLREAvgdeTELMFDVYSgwdlsY 255 Solibacter usita...
ZP_00218133 145 KIPCYYSKlyrt-dlreMQDEAQRYlkeGFRAFKMRFgygpahgqqgvtenLKSVAAIREVigydNDLMLECYMgwnleY 223 Burkholderia cep...
NP_342750   155 KIRAYASHlhpt-skdeLEKEARSYveeGYAAMKMRFccgpsdp-lgvdknVELVKVIRDSvgysVDLAGDAWMswnlnF 232 Sulfolobus solfa...
NP_250905   145 KIWTYASKlyandnldaFLEEAQGYlnqGFTALKMRFgygpkdgptgmrrnIEQVRALRELagpdIDIMLECYMgwtleY 224 Pseudomonas aeru...
YP_165074   146 KIPVYYSKlysg-pidtMQAEAEEArknNYPGYKMRFgwgpkdgmagmrenLKRVEAVREVigydVDLMLECYQgwnldY 224 Silicibacter pom...
ZP_00520860 145 KIPVYASRlysq-pldqLAAEAKLYkdqGYRAMKLRFgwgpvdgaagmqrnVELVRTVREVvgseIDVMADAYMgwtldY 223 Solibacter usita...
EAM93924    139 RIRAYASHlhpt-dlkeLRKEAEEYvsqGYKTMKMRFisgpsdi-ngleknIELVKTIRDAvgydVELAGDAWMswnynF 216 Ferroplasma acid...
Feature 1                         #                           #                                 
NP_394216   219 AYKMIRALEky--dLAWIEEPLlpDDFEGYSRLTkk--veIPISAGEHHYhvFDFKRLLd-aGVTILQPDATWVGGITPM 293 Thermoplasma aci...
CAG87577    230 AIDLAKATEdl--nINWFEEVLhpDDIEGYAQLKraf-prIKWTTGEHEYtrYGFRKLIegrNIDILQPDVMWVGGLTEI 306 Debaryomyces han...
NP_754675   236 AIKLAHACApy--nLKWIEECLppQQYEGYRELKhnapagMMVTSGEHHGtlQSFRTLSe-tGIDIMQPDVGWCGGLTTL 312 Escherichia coli...
XP_362731   231 TIELAEKCKdl--dINWWEECLspDDTDGFEQIKrah-ptLKFTTGEHEYsrFGFRKLVegrNLDIIQPDVMWLGGLTEL 307 Magnaporthe gris...
ZP_00280149 224 ATRLAQAAHey--gLKWIEECLppDDYWGYAELRrnvprgMMVSTGEHEAtrWGFRMLLemqCCDLIQPDVGWCGGITEL 301 Burkholderia fun...
AAW42009    229 TIALVKACEkagveINWWEEVLhpDDFDGHIKLKeal-pyVKFTTGEHEYskYGFRKLIenrAVDIIQPDVMWLGGLTEL 307 Cryptococcus neo...
ZP_00523953 256 ALSWARQVEry--rPRWIEEATqaEKIDSFAALRkg--tsIPIASGEHIQgrWEVYNYLkegALSVVQCDPEWCGGTTEL 331 Solibacter usita...
ZP_00218133 224 AKRILPKLEky--qPRWLEEPViaDDIDGYAELNql--trIPISGGEHEFslYGFKQLLdrkAVSVVQYDTNRVGGITMA 299 Burkholderia cep...
NP_342750   233 ALKMARRLEky--eLSWIEEPLlpDDFESYSYLSkr--tdIPISAGEHHYhvYDFKRLLd-sGVRILQPDAVWVGGITPM 307 Sulfolobus solfa...
NP_250905   225 ARRMLPKLAef--ePRWLEEPViaDDIEGYVELKkm--giMPISGGEHEFtgHGFKDLLerrAVDVIQYDTNRVGGITAA 300 Pseudomonas aeru...
YP_165074   225 TKRMLPKLVky--ePRWLEEPViaDDVEGYRELNam--niVPISGGEHEFsvIGCKDLIekkAVSVLQYDTNRVGGITAA 300 Silicibacter pom...
ZP_00520860 224 ARRMLPLLEsf--hLRWLEEPVipDDIHGYAALKal--grIPIAGGEHEHtsYGFRELLeakAVDYIQFDTNRVGGITQA 299 Solibacter usita...
EAM93924    217 ALKMVKKLEry--dMAWVEEPLmpDDFDAMKMLSwk--tgIPISEGEHHYhvYDFKRLLd-aGIRILQPDAVWTGGITPM 291 Ferroplasma acid...
Feature 1                                                                                       
NP_394216   294 KKIAGLAesygAQIIPHag-nIYNLHFIisepeaitpMAEYltryrdw------meqhivnVPRATGARFVLN--DDPGF 364 Thermoplasma aci...
CAG87577    307 LKVAAQAaaydIPVVPHas-gPYSYHFVvsqq--ntpFQEYlanspdstsvlpvfgglftdEPVPVNGYLDVStfDKPGF 383 Debaryomyces han...
NP_754675   313 VEIAAIAksrgQLVVPHgs-sVYSHHAVitft--ntpFSEFlmtspdcstmrpqfdpillnEPVPVNGRIHKSvlDKPGF 389 Escherichia coli...
XP_362731   308 LRVSAMAaaydIPVVPHas-gPYSYHFVmsqp--ntpFQEYlanspdgksvlpvfgdlfldEIIPSKGFLTPKdlDQPGF 384 Magnaporthe gris...
ZP_00280149 302 IKISALAdahnVMVVPHgs-sVYSYHFVvtrh--nspFAEFlmmapkadevvpmftpllldEPVPVNGRMKVP--DAPGF 376 Burkholderia fun...
AAW42009    308 IKVAAMAaaydIPVVPHgs-gPYSFQAImsfp--nsdFCEYianspdgksiepsfgnlflnEVLPRNGRVDLT--DEPGF 382 Cryptococcus neo...
ZP_00523953 332 QKICVLAsifdVPVIPHghslHAALHLIasqspavcpLAEYlilkmrs------yyhfeknPPAPKNAHFDLP--AGPGY 403 Solibacter usita...
ZP_00218133 300 HKINALCeaysVPVIPHag-qMHNYHLTmstl--aspMSEYfpmfdvevgn-elfyyifdgEPVAENGFVQLRd-DVPGL 374 Burkholderia cep...
NP_342750   308 KRITGLAeaygGVVIPHts-nIYNLHFIisepesvspMAEYltkykwl-------edrminPPKPIKGYFELG--EEKGF 377 Sulfolobus solfa...
NP_250905   301 RKINAMAeawsVPVIPHag-qLHNYHLTmast--aspMAEFfpvfdvevgn-elfyyvfkgEPQPVDGYIQLDd-HKPGL 375 Pseudomonas aeru...
YP_165074   301 QKINAIAeafqVPVIPHag-qMHNYHLTmana--ncmISEYfpvfdvevgn-elfyyifegDPAAVDGFLDLDd-NIPGL 375 Silicibacter pom...
ZP_00520860 300 RKVQSLAeafsVPVVPHag-qMHNFHVVmasl--nspMAEFfpvvdveign-elfwyifegEPTPMDGYIDLRd-DVPGL 374 Solibacter usita...
EAM93924    292 KKIIALAetygAIVVPHtg-nIYNLHVIgsepesvtpVAEFltkyrew------meqhmegTLFPEKGYFTLS--DKPGF 362 Ferroplasma acid...
Feature 1            
NP_394216   365 GIRYD 369 Thermoplasma acidophilum DSM 1728
CAG87577    384 GLTLN 388 Debaryomyces hansenii CBS767
NP_754675   390 GVELN 394 Escherichia coli CFT073
XP_362731   385 GLTLN 389 Magnaporthe grisea 70-15
ZP_00280149 377 GVRLN 381 Burkholderia fungorum LB400
AAW42009    383 GLELN 387 Cryptococcus neoformans var. neoformans JEC21
ZP_00523953 404 GIEFD 408 Solibacter usitatus Ellin6076
ZP_00218133 375 GLTLK 379 Burkholderia cepacia R18194
NP_342750   378 GLKYD 382 Sulfolobus solfataricus P2
NP_250905   376 GLEIS 380 Pseudomonas aeruginosa PAO1
YP_165074   376 GISIT 380 Silicibacter pomeroyi DSS-3
ZP_00520860 375 GLTIK 379 Solibacter usitatus Ellin6076
EAM93924    363 GLEYK 367 Ferroplasma acidarmanus Fer1

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