Conserved Protein Domain Family
PDS5

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pfam20168: PDS5 
Sister chromatid cohesion protein PDS5 protein
This entry represents the Sister chromatid cohesion protein PDS5. The large PDS5 molecule is exclusively alpha helical, composed of a large number of HEAT-like repeats and helical extensions/additions that deviate from the HEAT repeat pattern.
Statistics
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Structure
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PubMed ReferencesClick to see Conserved Features Help

pfam20168 is classified as a model that may span more than one domain.
pfam20168 is the only member of the superfamily cl48339
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
OQO26920       69 DEMAS--------LEQF---GEE-DAARD-QLIPKATELTSSMLLMHKDKGVRAYALACIVQTFRLLAPNAPYNP-KQLk 134 
ESO11948       27 DELVKrlklltraFQDMsqdDND-------EFKQLAIYLASEYFLEHNSKDVKLLVACCIADIFRVFVPDAPYTEpEQLk 99  
XP_013405627   27 EELVKrlkalaraFQDMgqdDNE-------KYTELALHLASEFFIDHSSKDVRLLVACCIADVFRIFAPEAPYTNqDQLk 99  
2_pfamImport    1 DELVRrlktcaqsFQSM---NQD-DDNK--NYVILAIHLAQEAFLEHSSKDVRLLIACCIADVFRVYAPDAPYKDpEHLk 74  
OQR67831       23 DDLARrlkecaqaFQNL---NQE-DDNS--RYSQLALHLASEFFLEHHSKDVRLLVACCIADVFRVFAPEAPYKDtEQLr 96  
XP_015792482   38 DDLIRrlkdiamaFQQM---SQE-EDNT--CYIPLALFLATNFFLEHQSRDVRLLVACAIADVFRVYAPNAPYQNpSLIk 111 
CRK92889       23 DELIRrlkalsltLQAM---GQD-DENFS-RYTPLAVHLVKDFFLSHDSKDVQLLVACCIADILRVFAPEAPYKEpDQIk 97  
XP_002611624   27 DELIRrlkvlaktFADM---DQD-QEEEKqRYEPLALHLASEHFLHHESKDVKLIVGCCIADIFRIYAPEAPYKDpIQLk 102 
Q29RF7         39 DEMIKrlkmvvktFMDM---DQD-SEDEKqQYLPLALHLASEFFLRNPNKDVRLLVACCLADIFRIYAPEAPYTShDKLk 114  human
KNC87110      126 DELLKrlkallvdLQKQ---KQHeTVSS--EIAHFAETLVDTSLLKHKDKDVKIYVACCLAEVLRLYAPQTPYND-EVLv 199 
OQO26920      135 eiftlfvttvlpalarpSDPYQQQHLAALESLSAVRSIALLADIPGA-DALIVQLFANCFD-VLSGNmkgataeniPKAV 212 
ESO11948      100 eiflflid-qlkglkdpESPLFKRYFYLLENLAWVKSFNISLELPDS-SEILFRLFKTTLElINDRH---------NNKV 168 
XP_013405627  100 eiflflik-qlrglddpEAPQFKRYFYLLENLAWVKSFNICIELEDN-QEIFCSLFKLMFD-IINDKh--------TAKV 168 
2_pfamImport   75 aififlih-qlrgledpKDPAFKRYFYLLENLAWVKSFNICIELDDN-QEIFCQLFKLLFKiVNDDH---------STKV 143 
OQR67831       97 sifeffiq-qlqglkdpKNPTFKRYFYLLENLAWVKTFNICLDL-ECnQTIICNLYTLILGiVNDYH---------SAKV 165 
XP_015792482  112 riflffiq-qlrglqdpKDPTFKRYFYLLENLAWVKSFNICIELDDS-QSIFCQLFNLIFKiVNDNH---------SDKV 180 
CRK92889       98 eifeflir-qlnglkdpKDPAFKRYFYLLENLAYVKSFNMCFELVES-QEIFCSLFSLIFK-IVNDEh--------SEKV 166 
XP_002611624  103 eiflflvk-qlrglediNGALFKRYFYLLENLSWVKSFNICFELEDC-GEIFNQLFETLFSiVHRGH---------SNKV 171 
Q29RF7        115 diflfitr-qlkgledtKSPQFNRYFYLLENLAWVKSYNICFELEDC-NEIFIQLFRTLFSvINNSH---------NKKV 183  human
KNC87110      200 avfrffis-qlrglanhQSPYFTLAFSLLEVLAFVHSFVLCIELPEA-TELFCSLVSTLKEtVSSNH---------SNKL 268 
OQO26920      213 EYHMTNVLVTLVQECEKLPSGVVEIILAQFLRadpatlaqagkrdiRDMANISPAYNMARSVCSGCASEMKGAIGQYFSA 292 
ESO11948      169 SVLMLDILCPLLSEADAIPQEVLDIFLACIIE--------------PFKTQNRPAFEMARDLIRRTTSVLEPYIELFLSN 234 
XP_013405627  169 KNFMLDMMCPLIAEADSVSQKLLDIILVNIIE--------------PWKSQNRQAYDLAKDLIKRTSNAIEPYIQTFFNN 234 
2_pfamImport  144 KNFMLDMMCPLISEADSVSQELLDVILSNIIE--------------PRKTQNKNAYNLAKDLLKRTAPTIEPYIQAFFNN 209 
OQR67831      166 RSFMVEMLCPLINEADGVSQKLLDTLLAYIVP--------------PKKSSHKVASQLSHEILKKTSSALEQHLHLFFNN 231 
XP_015792482  181 KNFMLDMLTPLIIEADAVSSKLVEIILWQLID--------------PKKKGNKQACWLATQILKKANKTMEPYLITYFNN 246 
CRK92889      167 KSFMQEILVPLLSESDSISNELLDIIFINIIE--------------PNKTQRKNAYNLAKDLIKKTTDSLTMYVQAFLNE 232 
XP_002611624  172 RTFMLDMMSPIITEGDSVSQDLLDIILMRIIE--------------PQKSKLPEAYELARDLIKRTSQAIEPYIQTFFNN 237 
Q29RF7        184 QMHMLDLMSSIIMEGDGVTQELLDSILINLIP--------------AHKNLNKQSFDLAKVLLKRTVQTIEACIANFFNQ 249  human
KNC87110      269 VSYMADMVAGSLKEMDSIEPELLIAILESLLP--------------DNKKENPIQFSLSRLILQKAETAMQGDLTRFFRE 334 
OQO26920      293 VLLSasevseepakhggskmrgrkrthaesedesddgmltpPAEVDFDNAERAHRLLRELWRAASEVVETVVPQLQPQMK 372 
ESO11948      235 CLIQs------------------------------------SKSEKSSLSGRVYDLIQELNNISPSLLQNVLPQLELKLK 278 
XP_013405627  235 ALML-------------------------------------GKTSESEVSDHIFKLIYELNMISPSILLAVLPQLEFKLK 277 
2_pfamImport  210 SLIL-------------------------------------GKAPDTDIGKHLYDLIYELNSISPSVLLAVLPQLEFKLK 252 
OQR67831      232 YLVL-------------------------------------GKTGGSTLIPSMYDIIYELSHILPQAMAGVLPQLEMKLK 274 
XP_015792482  247 AITHgvhanagelsddeede------tqrtslrpgskssnqTVSKENQTVNQLCDLLYELNQICPSVMDGILPQLEFKIR 320 
CRK92889      233 ALMQd------------------------------------KPDKSYQSSKRIYDLIYELNVIAPSLLLSVLPQLECKIK 276 
XP_002611624  238 VLVL-------------------------------------GKTSESDASGRIYDLIYELNLIAPNVLLSVLPQLEFKLR 280 
Q29RF7        250 VLVL-------------------------------------GRSSVSDLSEHVFDLIQELFAIDPHLLLSVMPQLEFKLK 292  human
KNC87110      335 ILTGa-----------------------------------nKSRAELVHGGNVYALLGEISDIAPNAILYVYPLLKQMLE 379 
OQO26920      373 A-ENVRL-------RAMAVQTVGDMVAGIGaagpappiplapaaypshssdrsnvppasqsaiyrpiapHAFSSTYGDCY 444 
ESO11948      279 SaDDAE--------RMAATKLLTKMFAAPN---------------------------------------SDLALQHKQLW 311 
XP_013405627  278 S-NDEGE-------RKAVTKLLARMFSDTD---------------------------------------SDLAVQNKPLW 310 
2_pfamImport  253 S-NDEKE-------RLDVTRLLARMFSDKD---------------------------------------SELAVQHQSLW 285 
OQR67831      275 C-KENNE-------RLEVTKLVARMFSEKN---------------------------------------SELAGQYPALW 307 
XP_015792482  321 S-NEERE-------RCEFTKLLARLFSDKN---------------------------------------SRLAEQYPELW 353 
CRK92889      277 S-SNEGE-------RLKAVALLARMFSEKD---------------------------------------SKLGKQHTVLL 309 
XP_002611624  281 S-NDGDE-------RLNVTRLLARMFSDKE---------------------------------------SQLSSQNKPLW 313 
Q29RF7        293 S-NDGEE-------RLAVVRLLAKLFGSKD---------------------------------------SDLATQNRPLW 325  human
KNC87110      380 VnYDPQIkdekqqkRYQATQLLCRMFCRD----------------------------------------STMIETHRGLW 419 
OQO26920      445 LEFVSRHNDKAAVVRCAWAVAAARILLTSAGGIgldsdqeMRLL--RLLNGMLVDTDEKVRLAVIEAIAM--FDFDTIAH 520 
ESO11948      312 NAFLGRFNDIDLNIRRMTVQSCQDIIINHAELV-------TEEAagKHLKHRQHDSDENVRMDVVKVIVA--SAKAELKH 382 
XP_013405627  311 LCFLGRFNDISASVRTICVQYSQQFLINHPALR-------GDMT--ENLKQRQHDQEENIRYDVVQSIIA--AAKKDLPG 379 
2_pfamImport  286 NCFLGRFNDISVAVRTRCVQYSMHFLLNHPELT-------KDIT--EQLKLRQHDPEETVRYEVVMAIVS--AAKKDFSS 354 
OQR67831      308 NALVGRFNDIKLQVRMRCVQYSMHFLLNQPSLR-------NDIT--QALKTRQHDPNESVRFEVVMAIVE--AAKKNFEA 376 
XP_015792482  354 KSFLGRFRDISVTVRMRCVQYSMHFLINHPELR-------EDIT--EQLKQRQHDPDENVRYEVVMAIIS--AAKKGIEN 422 
CRK92889      310 NHFLGRFLDIAVAIRIKCVQSTMHFLVNHTNLR-------PEII--NVLNGRQHDSDESVRYEVVNSIVE--TARRDYII 378 
XP_002611624  314 NCYLGRFKDVNVAVRVECVKFANKLLINHQNMM-------EEVT--EQLKARCHDPDESVRYEVVSSIIK--AAKESLRN 382 
Q29RF7        326 QCFLGRFNDIHVPVRLESVKFASHCLMNHPDLA-------KDLT--EYLKVRSHDPEEAIRHDVIVTIIT--AAKRDLAL 394  human
KNC87110      420 EQLLQRLKDIEPAIRAEVVAHCSQFVTRHPRHA-------SDIV--NRIGERVLDPAESVRMGTVQAVCStaMANPSVVS 490 
OQO26920      521 KVGKLggvaaqgsILRQIADRIKDPKAPVRVAAIELLADIWgva-----------sgAIGe------------GSEQMSN 577 
ESO11948      383 VPDD---------LLECVKERTLDKKFKVRREALVGLGQIYkk------------chEVG-------------GDVR--- 425 
XP_013405627  380 INDE---------LLGFVKERTLDKKFKVRREALLGLGHLFkkv-----------msKSEdt----------eENKELRK 429 
2_pfamImport  355 VSEE---------LLTFVKERTLDKKFKIRKEALLGLSVIYkqc-----------mtTGG-------------LSKQTVD 401 
OQR67831      377 VSIE---------LLNIVKERTLDKNFKVRREALLGLAHIYkn-------------lTCGsh---------etEDPNIVE 425 
XP_015792482  423 INED---------LLSFVKERTLDKKFKIRREALFGMAQLYkqy----------niaQLGggdddrqsstdtnTNNSALK 483 
CRK92889      379 VAESPe-------LLAILKERSQDKKFKIRRAALNGLAYIYnkh-----------lqAVQas---------eaTIESPLD 431 
XP_002611624  383 VSQE---------LLSLVQDRMLDKKFKIRREANQGLALIYreh-----------ctTPG-------------QEDEMIR 429 
Q29RF7        395 VNDQ---------LLGFVRERTLDKRWRVRKEAMMGLAQLYkky-----------clHGE-------------AGKEAAE 441  human
KNC87110      491 KE-----------VFERLCCRSKDKKPEVRDLAIKQIGEVYktlllchagetlnsagMIGs------------HERELFA 547 
OQO26920      578 LFAAIPSEIVNAVY----VNNPQI--NASILEVLHKSLVPtAYpmmtatydtvagtgvvvdsqlggdpaadVNALRVERI 651 
ESO11948      426 RVAWIRNKVLHAYY----Q--LSIddKILVERILNTSLVPySM----------------------------DPPSRMKQL 471 
XP_013405627  430 RVDWMKDRVINGYY----QTNIED--RLVVERIFNTCLVPyML----------------------------DVKERMKRL 475 
2_pfamImport  402 CVSWIKNKVLHVYY----Q--TALedRLLVERILHTCLVPyQL----------------------------DTEDRMKKL 447 
OQR67831      426 CVAWIKNKVLHIYY----Q--SELedRLIVERILHTCLVPyQL----------------------------SYDLRTFKL 471 
XP_015792482  484 MLNWIKNKCLHNYY----Q--TQLddRLLVERILHTCLIPyNL----------------------------PLQQRMKIL 529 
CRK92889      432 TANWIQIKILNGYY----HATLED--QLLIERLLITNLVP-YTl---------------------------PASEKMKAL 477 
XP_002611624  430 ---WIKNKLLHVYY----QTSPED--RLLVEHAVTHCLVPyTM----------------------------DTKERMRRL 472 
Q29RF7        442 KVSWIKDKLLHIYY----Q--NSIddKLLVEKIFAQYLVPhNL----------------------------ETEERMKCL 487  human
KNC87110      548 VYGAIPEFVFTAYAtsgaS--PIDstQRVAETVIQNCLIDnKA----------------------------SAEERALQV 597 
OQO26920      652 LVFVRCLDDRATaaffnlqrLQCQGAAQLCALLRLSEAShSSDDSSt---------------------------dEKTKA 704 
ESO11948      472 YLLYSNLDEHAIralqeifkTQAGLRNIVKNILDLQQKG-DSPDVG---------------------------------Q 517 
XP_013405627  476 YYLYATLDQSAIkalnellkMQYSLRCHVRGLLDLHSRDlQTADSV---------------------------------S 522 
2_pfamImport  448 LQLYSTVDDHAVkafnellkCQNIVRSHVRSLLELI----GDESNEek--------------------------eKNMTQ 497 
OQR67831      472 YQLFATCDEHAVkalieilkCQCAIRQQIKQVVHLLGS--GAMDAE-------------------------------KQE 518 
XP_015792482  530 YTFYVTIDAHAArafnellrQQQSVRKQVKEVLDLIKN--GEKDEK--------------------------------DP 575 
CRK92889      478 YKLFATIDDHAMkafvelqkNQMKMRKTVMDWIKLHKIK-ETPETQ---------------------------------K 523 
XP_002611624  473 FRLYATLDDYAVkslnevfrSQHMLRNHMKQLLDLLEE--DPEETEveetkkmiasktnllatifhcelfcesclVRCKK 550 
Q29RF7        488 YYLYASLDPNAVkalnemwkCQNMLRSHVRELLDLHKQ--PTSEAN--------------------------------CS 533  human
KNC87110      598 LNMYMSLSETGIkaytqlikHKINLLGVVKKYCDLRI---GLKKAEd---------------------------rEETDI 647 
OQO26920      705 QIDAIVTSLTK--MTTDSN---VAKEHLRIYLK--HNHRRGNQLIRFC--------------CDAVSDYRKVCKAMKEFR 763 
ESO11948      518 AINTKILALSR--HLPEPE---KACQQLHKFFKs-IQESKIRQSLQNL--------------INAQCECKKAEEHVKEII 577 
XP_013405627  523 LMMSKVYFLSR--NLPDSN---KALEHVKKFNQilRDDKRIRTHLQDL--------------VSPGCPCKMAEEHVKEIL 583 
2_pfamImport  498 KIAVLASVLCIkkSLPEPV---KTQEFIKKFVTtlQMDKRLMSQMEVI--------------MKHDCSCKEAEESVREIL 560 
OQR67831      519 ELMKRVQHMSR--NLPEPV---RAQEYLIKFADllRANPATYQHMVLI--------------LDGGATCAEAEKSVKEVL 579 
XP_015792482  576 TVRSKIQLCAK--NLPEPV---KADEFLTKLCHnlCHNPVLRHHMDTIvsstsfphinedgsISPPPSCSVIETSVKEIL 650 
CRK92889      524 EVTKKMNMLMK--LFPDPL---KSQEYLVKFSAhlRKDKMILMDMETI--------------LRRDVDNKACTEAMTSIL 584 
XP_002611624  551 YARERIKPWSY--CFREPVgtsKAQEQVKKFVDilGKDERIHGFMQTL--------------VDPKCTCEKAPETMREIQ 614 
Q29RF7        534 AMFGKLMTIAK--NLPDPG---KAQDFVKKFNQvlGDDEKLRSQLELL--------------ISPTCSCKQADICVREIA 594  human
KNC87110      648 KAKQLLDTIAK--NLGGNV-----STNFDKLLK--IHKSKDLSLFKLI--------------LK-AQQVSTTPEKRREIL 703 
OQO26920      764 KKMEEsp---sPLPSTLSTMEVVLDMFSMLLYNRTHVPAML---------AFARTDDKGLGEAATK-------------- 817 
ESO11948      578 KKLGNs----tPQNLLYATVKQLLERIAPLMIDNLSILALIiliqkviqsKLDGNDEDDDEEDEEKqgrkerlhqksgln 653 
XP_013405627  584 KKIGGqgqvpaAQQGIYGTVKVLLERIAPVLIDQEAISHLM---------TLVDEAIRGLGEMNDEiksas----lagmk 650 
2_pfamImport  561 KKLGNp----vMTNVFYMTVKKMLERVAPVMIDRAAIEVLI---------DLVSKMLSDIREDDLEtckpe-----rglk 622 
OQR67831      580 KSLGLp----vQTNSFFVTIKQMLERVAPVVVDSTGIKQIL---------GYVQDSLQGTGEIDIQcnvpqs--ayrgle 644 
XP_015792482  651 KSLGYp----vQTNSFYVIIKQLMERIAPVMIDFQGLIVLF---------NYVSDSLLGEGEMDMRlgleps--gkrglq 715 
CRK92889      585 KKLGTp----iMTNIYYNTVKILLSRIASVMIDREA--------------HFLHDS------------------------ 622 
XP_002611624  615 KKIGHfgq-kgPASPFYDTVKNLLEKVSPLIIDPSAVDQLF---------KLLNDTMEGLGDEDLGdsgqe-----rglq 679 
Q29RF7        595 RKLANpk---qPTNPFLEMVKFLLERIAPVHIDSEAISALV---------KLMNKSIEGTADDEEEgvspdta-irsgle 661  human
KNC87110      704 SDAVT-------KVKEKDVVKAIFSRTSLVIFSQDLVTHQL---------AILRALANEDTEFENVefvt-------vcs 760 
OQO26920      818 VIKDLSNTAPKVFELHIK---EYCEML--KQN-VpteatpndpSATHVLKTISDFV--Q-------HDASAM---PND-- 877 
ESO11948      654 LLLLLSQNFAGSFQMNDIy-tYLLEFIkyDDDv----------VVDMTMQILKNVG--A-------GIDQTF---PEV-- 708 
XP_013405627  651 LLYTLSYVYPGAFQTEATf-tHLIALLkhEDE-G---------VSDLTLQIFCNTG--Y-------ALQEKF---PNI-- 705 
2_pfamImport  623 LLYTLSWVFPGAFQCRDIy-sRFLQFLqlGDEl----------AAEMTLQIFANIG--S-------KLEFDQ---PET-- 677 
OQR67831      645 LLHTLSGVFPNAFMNEEIf-eTIYHFLgfDCPr----------TQVQVLLVLSNVG--K-------DLETHF---PNI-- 699 
XP_015792482  716 LIHALSSVFPAIFYGKEIftnYLLPFLwkSSDnPq--------IGEIVLQILTNVGgvQgsisssnNGEQNSvltATPww 787 
CRK92889      623 VLRPMMALL------------SFELNF----------------VAASIFKALTHLG----------RFKSLIdshPEV-- 662 
XP_002611624  680 LILMLSPIYPESFQSEDIf-gQLLSYLkkENPi----------VVDTALQIFSNTG--A-------VIEENF---TMI-- 734 
Q29RF7        662 LLKVLSFTHPTSFHSAETy-eSLLQCLrmEDDk----------VAEAAIQIFRNTG--H-------KIETDL---PQI-- 716  human
KNC87110      761 FLKMLAQVSPVHFEAQPIl-eNLIDFLkaESNe----------IVDAGLQLLALMG--E-------SLRHGN---AKS-- 815 
OQO26920      878 --R-ELYKALSA-YTLYGsPPKAAKHAVRVMLa--------------------sDDKKEMYTEEILEKCLK----DFTYG 929 
ESO11948      709 --HsSLLPVLQK-MIKVG-TTKQAKHAVRCIDv--------------------lCKDKVEIFGQLFQQLQQ----CMNLE 760 
XP_013405627  706 --YsSLLPVLTS-MVKIG-SPKQAKHAVKGIAvl-------------------cSNKEVIY-AQMMEHLKK----SLNHE 757 
2_pfamImport  678 --SvILVPILKR-FASEG-SMKQAKYAVRCLVt--------------------iCRDRYMIFEHSLEELKK----HLTLE 729 
OQR67831      700 --AqRLQPVVQN-FVENG-TPKQAKYAVQCLYn--------------------mVFHKERVLGVVIDHLKQ----HLTLA 751 
XP_015792482  788 atEdDFIATLVDkFVLKAsSTKQAKYAIQCLNaii-----------------gdDEEKLRIFAQILDQIKEv---GLTLD 847 
CRK92889      663 --LeDLAPICKH-FAFNG-TPKQAKHAIRCLFvnsnsnsitnadkdnesveetnRKRIKKQIDHIFQEIVDatnqNLNVS 738 
XP_002611624  735 --KsALLPVLQA-KAKSG-TPRQAKHAIRCVNti-------------------fPGVRDSIFNQIFEHLRK----KLSFN 787 
Q29RF7        717 --RsTLIPILHQ-KAKRG-TPHQAKQAVHCIHa--------------------iFTNKEVQLAQIFEPLSR----SLNAD 768  human
KNC87110      816 --LlESTHPLMHdMVLTG-TPRQSKLAVRVWAa--------------------aTVNPDAAFDELLSELTS----PARLT 868 
OQO26920      930 SHG--F-LARLASLSQVVLLSNTEL-DTaMQETVTDTAVGKILREIR--------TTAEEVDADWTD----E--PDRELS 991 
ESO11948      761 SSN--L-LTSIVAIGHLCQLCPSKFvEP-TDNIISMFIMKEVLMQDR--------TVGRKKTEDWCE----EkhISEETL 824 
XP_013405627  758 SVN--F-LTALVAIGHIAFYCPQHVaGD-LRSIVSKFIVKDLLMQDR--------SKPKSSSESWYG----DhmVSEETQ 821 
2_pfamImport  730 STY--F-CTALVSVGHIAYYCPDLFgSQ-MKNIVSKVVVKDLLMQDR--------DNQRSDGDGWCS----EdeLSDETK 793 
OQR67831      752 SAN--F-ETALVSLGHIALLLPETFyQQ-MKSVVSKVVVKELLMADQ--------EEPRMSELQWCE----YeaLPHETR 815 
XP_015792482  848 SPY--F-RIHLVTIGMVATCGGHVFfPKlLRSIIQKYVVQNLLMKDQrleeevqaQEESEKNRDLSDptvsYefCCEEVK 924 
CRK92889      739 SEHy---RTAIVSFGHIAYNLPERFnIP-LKNIVSRKIVKDLLIGDLp------dVRQHKAVGDWCD----EeqLSEEIR 804 
XP_002611624  788 SPN--F-LTALTSIGHLSLLAPALFsQQ-MKNFVAKFIVKDLLMQDR--------NEKKATTSSWCE----DdqVSFETQ 851 
Q29RF7        769 VPE--QlITPLVSLGHISMLAPDQFaSP-MKSVVANFIVKDLLMNDR--------STGEKNGKLWSP----DeeVSPEVL 833  human
KNC87110      869 FDHalI-CTTLSALSTIAVVAPRAF-DV-NSGPAVLFVVKDLLQNNR---------TAETGDTDHKE-----------ID 925 
OQO26920      992 AKLLALTILVNNVRGQV---------Hgdmse--daksALETR----AIPVY-KLLNTIIQKEGELSKTpttIS---TPN 1052
ESO11948      825 IKLESVKMIGRWLLGLK---------D-----------QNNCK----VSPIM-RMLYTMILCEGDLMER---GH---INK 873 
XP_013405627  822 AKIHGMKLICRWLLGLK---------T-----------NMNNL----GQSTL-RLLHTCIIHDGDLMER---GN---INK 870 
2_pfamImport  794 AKIEGMKLMVRWLLGLK---------------------TSTNS----AISSL-KLLTTVILHDGDLMEK---GK---IAI 841 
OQR67831      816 CKLAGIKMMGRWLVGLSnmhqaqqqgGpqlpeqeteveQSTQAmtanAASTL-RLLITMLKNQGDLMER---EH---VSD 888 
XP_015792482  925 CKIEGIKLMVRWLYGLK---------LntliaspesqqEVVAVyqnaAMNTM-RIMTAIVQNNGDLN-----EKglaGTT 989 
CRK92889      805 CRVEGLKAIARWLVGMK---------D------------NVVA----AQKTF-RMLCAFINKAGDILDK---GQ---LSE 852 
XP_002611624  852 AKIIALKLIVNWLLGMK---------N-----------NDGNS----CTSTF-RLLHAMIKNKGDLMQK---GK---VSQ 900 
Q29RF7        834 AKVQAIKLLVRWLLGMK---------N-----------NQSKS----ANSTL-RLLSAMLVSEGDLTEQ---KR---ISK 882  human
KNC87110      926 AKVLGVKLLVKRLIGMD---------Aras-----iasEEEENksvdAFKITnKLLRALIANKRFCR-----DP---MSE 983 
OQO26920     1053 sHKAKLRLSAAVQIVKLCCH-----------------PTL-DALFSdIDFNRLTTVVQDPRPEVRNGFAKAIQKYLVAGK 1114
ESO11948      874 pEMSRLRLHAGCCMLKVAQE-----------------PAY-ADAIKlEQFETMALLINDPCVEVRQIFVSKLHRGLMNLR 935 
XP_013405627  871 pETSRLRLAAGCCMLKLAQE-----------------NVF-AELIThEQFQALALLINDSCFEVRARFAQKLHKGLYSMK 932 
2_pfamImport  842 aEKSWLRYMAGCCILKLCQE-----------------PTY-SDILTpEQFNTVARLLNDECKDVRDRFSQKLHKGLISLK 903 
OQR67831      889 cEKSYLRLWAAAAILKVCSC-----------------TVY-ADVITqPQFQRLVGVITDPVDEVRERFSAKLHKRLMSLQ 950 
XP_015792482  990 hEKARLKLAAAAAMLKIVGNdsitatsqgdttaivaaSSPsSAVITpTQWHTLATILLAEEEYVRDRFALKLHKGLISLS 1069
CRK92889      853 aEKAWLRVAAGNAMLKI-CEqkgvgdeynaeqfltlsTLMvKKKFDdNFSSNLAFFQNDPVLQVRELFLKKLHKGLYKGI 931 
XP_002611624  901 pEQAHLRLAAGCAVLKLAQE-----------------RVF-AELLTlEQFQMVASLMNDKCLEVRQKFTNKLHKGLMRLR 962 
Q29RF7        883 sDMSRLRLAAGSAIMKLAQE-----------------PCY-HEIITpEQFQLCALVINDECYQVRQIFAQKLHKALVKLL 944  human
KNC87110      984 eDDAKLRLVGASGYLKVAMC-----------------KSY-KPLLPaSQMDLLALTMEDPEESVREGFSKKLIRGLFSMK 1045
OQO26920     1115 ----LQPRFNALIFMYAFEPSK-TAKDAVAKWAKARGNTL----------------EKLNSRAMRTTFARFLSLLAHHLD 1173
ESO11948      936 ----LPIQYMGIMCLGALDPIK-ERRSLIKQMLAANINRRrdyirqn---pscatsCTVYSILPDYVLPYSLHLLAHDPD 1007
XP_013405627  933 ----LPLRYMSIFSLAANDPFK-ERKQAVKQYISLNIQKRreyikq-----hsaaaNKLFSLLPEYVLPYTIHLLAHDPD 1002
2_pfamImport  904 ----LPLDFMAIFALAGNESTK-DLRTQLTHNLQANVNKRrdylkq-----hsvtnDKIFQFLPDYVLPYAIHLLAHDPV 973 
OQR67831      951 ----LPLQFMALLSYGGIEQRR-PLKAKMRHYLLANIQRRreylka----npiaasPKLLTVLPDYVVVYVIHLMAHDPL 1021
XP_015792482 1070 ----LGLEFLALFCLGGYYQHEnPFKNKLRSYLVLNIAKRrdlvk-------sksvTNLKAVLPDCIMPYVIHLLAYMPF 1138
CRK92889      932 phkcLPLDFMGIYSMCGRETDK-KLGEQMKSNYEVDVNHRreyvktfsnggiegalGQLANILPDYILPFAVTVLSHSNL 1010
XP_002611624  963 ----LPLEYLSIFSLAAREPHA-GLRRQIKACINKNIAQRrqyitq-----hsgaqAKRMSLLPDYVVPYTIHLLAHDPR 1032
Q29RF7        945 ----LPLEYMAIFALCAKDPVK-ERRAHARQCLLKNISIRreyikq-----npmatEKLLSLLPEYVVPYMIHLLAHDPD 1014 human
KNC87110     1046 ----LDINFLALVPIAALDPNE-NLQKSARASYVKIVEKYkqisaql--kasgtneQVLHRFRPELSLPVLLSVIAHREE 1118
OQO26920     1174 FSMKP--EELADNVEYILFYLKN-VATV------ENLPHIHH--LAQRLKSVQDGINPAqs------------------- 1223
ESO11948     1008 LVAYDnvPALRSIKDCLLFLLEPlLTKN------DTVSFEFYskILANIKNTVDAQCPDsee----------------an 1065
XP_013405627 1003 LTTYKnvPALINIRECLWFVMEP-LIKS------ENQSYNFFrkIFEMIKQTRDAQGPTnee----------------mn 1059
2_pfamImport  974 YKKYDnvKTLQSIKECLWFLMEPlMMNN------ENYSFGFFkkLLENIKQTKDAQNPAdem----------------qn 1031
OQR67831     1022 YDEPAdvEALNRIKECLWFQLEPhCSKN------DNYSFSYFkkLLEGIKRSKDRQNPTnea----------------an 1079
XP_015792482 1139 YTQFDnvDQLEVVKNCLMFIIEPiALKN------EQFSFSYYkkTFENIKTCVDRVSASavpeadengsnstptmatmtn 1212
CRK92889     1011 LEDRTniDELKIAEKCLSFILEPlINNK------DTFCFSLYknMIEKMKNAKSAYQPHndt----------------in 1068
XP_002611624 1033 FYDRQkvEQLKDIKECLWFIMEPlIMRS------ENQNYIFLkkLIEVIKSTSDAQCPDntn----------------an 1090
Q29RF7       1015 FTRSQdvDQLRDIKECLWFMLEVlMTKN------ENNSHAFMkkMAENIKLTRDAQSPDesk----------------tn 1072 human
KNC87110     1119 DGSEE--ERIQSAVKILTFCLDV-LTHHekgsqgESYDYLHT--IVARVKNCKDVLKEEs-------------------- 1173
OQO26920     1224 eRlyvlselAEAIIRK--FAEEKGWNLQLFSGK-DNLPRGPFI 1263
ESO11948     1066 kKlyatcdlAMNLL----LTKMSCFSIKNFPAE-PVLPTKLFK 1103
XP_013405627 1060 cKlyavcdlGHGLL----ISKSTNFVFKDGPAK-PVLPMKLFS 1097
2_pfamImport 1032 mKlyavcdlALSIV----LSKTTNFVLVEHPVE-PKLPSKLFT 1069
OQR67831     1080 hRlyavcdlTLALI----MSKTANFGLREVPQE-ARLPAKLFV 1117
XP_015792482 1213 yKiycacdlALGLI----MSKTQNFLLKDFPVQ-PSLPGKYFM 1250
CRK92889     1069 eKlwtlcdlSLHLI----LTKLKNVDTREYSLDqVNIPRMYFQ 1107
XP_002611624 1091 eKmyavcdlAHNLLVL--KATNVTW--KEHPVT-PDLPCKLFT 1128
Q29RF7       1073 eKlytvcdvALCVINS--KSALC---NADSPKD-PVLPMKFFT 1109 human
KNC87110     1174 eDlyvvcdlATLMITNcaHRNIKNWIIQPFPSK-IKLPSGFFS 1215
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