4FXQ


Conserved Protein Domain Family
ADPrib_exo_Tox

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pfam03496: ADPrib_exo_Tox 
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ADP-ribosyltransferase exoenzyme
This is a family of bacterial and viral bi-glutamic acid ADP-ribosyltransferases, where, in Swiss:Q93Q17, E403 is the catalytic residue and E401 contributes to the transfer of ADP-ribose to the target protein. In clostridial species it is actin that is being ADP-ribosylated; this result is lethal and dermonecrotic in infected mammals.
Statistics
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PSSM-Id: 427336
Aligned: 21 rows
Threshold Bit Score: 137.497
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4FXQ_A         236 AESWGVQTFKNWKENL-----------------------TISEKDIITGYTGSKYDPINEYL--RKYDgeiiPNIG-GDL 289 Bacillus cereus
YP_009167566   377 KNSWNAAKTKFLKRMIysfsgigagpmiditiardgskyTPSQKRGIREYCGSGYTDINNLLlgRYNPer-yDVMSeKEI 455
ABR68092       276 AHSWGMKIYEDWAKNL-----------------------TASQREALDGYARQDYKEINNYL--RNQGgs-----gnEKL 325
AIA96500       266 GDSWGKKNYKEWSDSL-----------------------TNDQRKDLNDYGARGYTEINKYL--R-EGgt-----gnTEL 314
EDT15235       261 GDLWGKENYSDWSNKL-----------------------TPNELADVNDYMRGGYTAINNYL--ISNGplnnPN---PEL 312
KEI06358       226 SEAWGEKNYGDYVSKL-----------------------SQEQLGALEGYLHSDYKAINSYL--RNNR-----VPNnDEL 275
Q977Y7         207 ANEWGSQYYDNWLKSL-----------------------NDSERNAIRQYTGNDYKKINNYL--RGVN----DSLD-GID 256 Clostridium a...
A0FKE4         241 QNQFGLEAEQYLGEQPhg-------------------lySDAEVMALGLYTNGEYQHLNRSL--RQEK----QLDAgQAL 295 Aeromonas ver...
P12726         374 QNSWNAIKTKIIRRELrgyaltagwslhpivenkdsskyTPAQKRGIREYVGSGYVDINNALlgLYNPdertSILTaSDI 453 Escherichia v...
TMHRI:Sez_0628  46 TNRWRSQTAF-----------------------------TEAEKKMMYQYTHASASPINLAL--EQVMgdtsQLD--AQL 92 
4FXQ_A         290 DKKskkalekienqIKNLDAALQKS-KITENLIVYRRVselqfgkkyed----ynlrqngiinEEKVMELESNFKGQTFI 364 Bacillus cereus
YP_009167566   456 ESA-----------INNLDSAFENGdRIPEGITVYRAQ-------------------------SMTAPIYEALVKNKVFY 499
ABR68092       326 DAQ-----------IKNISDALGKK-PIPENITVYRWCgmpefg-------------yqisdpLPSLKDFEEQFLNTIKE 380
AIA96500       315 EEK-----------IKNISDALEKN-PIPENITVYRYCgmaefg-------------ypiqpeAPSVQDFEEKFLDKIKE 369
EDT15235       313 DSK-----------VNNIENALKLT-PIPSNLIVYRRSgpqefgltl-------tspeydfnkIENIDAFKEKWEGKVIT 373
KEI06358       276 NKK-----------IELISSALSVK-PIPETLIAYRRVdgipfdlpsdfs-fdkkengeiiadKQKLNEFIDKWTGKEIK 342
Q977Y7         257 PKI-----------IEDIKSGLKKA-SVPHDMKVYRGTdlnplr--------------nlidvGKDGSLDFSSLVGKTFK 310 Clostridium a...
A0FKE4         296 IDQ-------------GMSAAFEKStPAEQLVKTFRG--------------------------THGGDAFSGVTEGQVGH 336 Aeromonas ver...
P12726         454 EKA-----------IDNLDSAFKNGeRLPKGITLYRSQ-------------------------RMLPSIYEAMVKNRVFY 497 Escherichia v...
TMHRI:Sez_0628  93 QQS-----------VALLDSATHKL-TIPWNIIVYRYVyetfltelgiseeelaryyhdktfdPQILSAIK---PGARYT 157
4FXQ_A         365 QHNYMSTSLVQD-------PHQSYSNDryPILLEITIPEGVHGAYIAD--M----------------------------- 406 Bacillus cereus
YP_009167566   500 FRNFVSTSLTPIifgrfgiTHAGIGLLepEARNELTVDKNEEGITINPneIraykenpeyvkvqigwaidgahkvnvvyp 579
ABR68092       381 DKGYMSTSLSSE-------RLAAFGSR--KIILRLQVPKGSTGAYLSA--I----------------------------- 420
AIA96500       370 EKGYMSTSLSSD--------ATSFGAR--KIILRLQIPKGSSGAYVAG--L----------------------------- 408
EDT15235       374 YPNFISTSIGSV-------NMSAFAKR--KIILRINIPKDSPGAYLSA--I----------------------------- 413
KEI06358       343 NLSFSSTSLKST--------PLSFSKS--RFIFRLRLSEGTIGAFIYG--F----------------------------- 381
Q977Y7         311 DDGFMSTALVKE---------SSFDYM--NVSWEINVPKGTEAAYVSK--I----------------------------- 348 Clostridium a...
A0FKE4         337 DTAYFSTSRDPK-------VATSFGGS-----GTISTVFGRSGIDVSD--I----------------------------- 373 Aeromonas ver...
P12726         498 FRNFVSTSLYPNifg-twmTDSSIGVLpdEKRLSVSIDKTDEGLVNSSdnLvgigwvitga----------dkvnvvlpg 566 Escherichia v...
TMHRI:Sez_0628 158 KQGFMSTTAIKN---------AAMPHR--SVELRIRIPQGSQAAFVQP--Y----------------------------- 195
4FXQ_A         407 -SEY-PGQYEMLINRGYTFKY----------DKFSIVKptreeDKGKEYLKVNLSIYLG 453 Bacillus cereus
YP_009167566   580 gSLGiATEAEVILPRGLMVKV----------NKITDASnndgtTSNNTKLIQAEVMTTE 628
ABR68092       421 -GGF-ASEKEILLDKDSKYHI----------DKATEVI-----IKGVKRYVVDATLLTN 462
AIA96500       409 -DGFkPAEKEILIDKGSKYHI----------DKVTEVV-----VKGIRKLVVDATLLLK 451
EDT15235       414 -PGY-AGEYEVLLNHGSKFKI----------NKVDSYK-----DGTVTKLILDAT-LIN 454
KEI06358       382 -SGF-QDEQEILLNKNSTFKI----------FRITPITsiinrVTKMTQVVIDAEVIQN 428
Q977Y7         349 -SYF-PDEAELLLNHGQEMII----------KEATVG------SDGKLNIVLD-LNLKR 388 Clostridium acetobutylicum
A0FKE4         374 -SVE-GDEQEILYNKATDMRVllsakdergvTRRVLEEaklgeQSGHSKGLLDALDLAR 430 Aeromonas veronii
P12726         567 gSLApSNEMEVILPRGLMVKV----------NKITDASyndgtVKTNNKLIQAEVMTTE 615 Escherichia virus T4
TMHRI:Sez_0628 196 -SFY-PYEMELLFPRQCTLEI------------IGANL-----SDDHTRLLIETR-LLP 234
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