Conserved Protein Domain Family
L_thr_O3P_dcar

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TIGR01140: L_thr_O3P_dcar 
L-threonine-O-3-phosphate decarboxylase
This family contains pyridoxal phosphate-binding class II aminotransferases (see pfamAM:pfam00222) closely related to, yet distinct from, histidinol-phosphate aminotransferase (HisC). It is found in cobalamin biosynthesis operons in Salmonella typhimurium and Bacillus halodurans (each of which also has HisC) and has been shown to have L-threonine-O-3-phosphate decarboxylase activity in Salmonella. Although the gene symbol cobD was assigned in Salmonella, cobD in other contexts refers to a different cobalamin biosynthesis enzyme, modeled by pfam03186 and called cbiB in Salmonella. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]
Statistics
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PSSM-Id: 273466
Aligned: 47 rows
Threshold Bit Score: 268.676
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_011318570   6 HGGNLAWA--AALAGCPA-DA-IVDFSASISPLG-P-----Pqsa--iaAIQS--QIS--N--LRH----YPDPDYSELR 63  Anabaena variab...
WP_010897752   6 HGANPKTL--ATQMGTSLtGE-AIDFSVNTNPFG-P-----PpqllaylRKQL--DQG--L--FTQ----YPDQEASELA 66  Bacillus halodu...
WP_011357873   9 HGGSPA----------SS-GA-MLDFSINISPVL-P-----P-------IGPVvvEPS--E--LMR----YPSIDGAGIR 55  Pelodictyon lut...
WP_011362038   9 HGGAPIK------------SN-QPDFSVNISPIM-P-----P-------IGSL--SLSdfA--LHN----YPSIDGSGIR 54  Chlorobium chlo...
EXY12896       5 HGDD--------SYKYRH-PI-RSNFSSNVYNKV-NldglrA-------HLCG--RIS--A--ISA----YPEPEPYTLE 56  Bacteroides fra...
WP_010932619  11 HGDRSGDR--LA-----S-AI-SLDFSVNLAPIE-P-----P-------LQEL--FST--SipLAP----YPSMDGHGVR 60  Chlorobaculum t...
WP_011231745   6 HGANPLAL--YEQCGLAP-PDeYIDFSVNTNPYRlP-----P-------SAWP--NGE--E--WIRwageYPDSEAKALR 64  Geobacillus
WP_005873516   5 HGDDLYRH---------G-PI-RANFSSNVYNAT-E-----Rqgl--ldHLHR--RLD--S--IGS----YPEPEPYSLE 55  Porphyromonas g...
WP_011324351   2 dpdsidavdrvphgssDD-PD-VLDLSANINPEV-Pdg-crA-------VYRE--AFA--D--ARS----YPNDSYPEYR 60  Natronomonas ph...
WP_010903155   2 HPDAVRDAgrVAHGGSDD-PD-VLDFSANTTPRT-P-----Pgt---raAYAA--ALD--D--AAR----YPDDDYPAFR 60  Halobacterium s...
WP_011318570  64 LALGHFHQLPLEWILPGNGSAELLTL-AGRELAQL-A-ATVLiTPAFGDYYRTLRAYHARVLEF----------Plvsve 130 Anabaena variab...
WP_010897752  67 RAIAIKEHVPPSSVLVANGAAQIIYT-IAQLWHKQ-R-VAIV-EPTFSEYEEACLANDCSVERI----------Mlppp- 131 Bacillus halodu...
WP_011357873  56 SFYVDRFKLDPNSVLPLNGAAEGIYL-LPRAHGLR-R-VLIP-APSFYEYERACRIAGAEVVWMelseadgfamP----- 126 Pelodictyon lut...
WP_011362038  55 DFYVARFGLDGDTVLPTNGAIEAIYL-VPRALGVR-R-VLTL-TPSFHDYERASLVAGATVSHL----------Pldaet 120 Chlorobium chlo...
EXY12896      57 ARLADRHALPAASVCVTNGATEAIYL-IAQTFRGT-N-TAIL-MPTFSEYADACRMHGHKVTSL----------Y----- 117 Bacteroides fra...
WP_010932619  61 EFYAARFGLDPVCVLSTNGAIEGLYL-IPRALGIK-R-VLVP-QPSFFDYGRACRLAGAEVVPLalsesgsfafP----- 131 Chlorobaculum t...
WP_011231745  65 ELVAKQEQIRPGQVLVTNGAAEAIYL-LAALLAGR-R-VGIL-EPTFSEYRRACLAYGCEVKSLlaees-rgfsY----- 134 Geobacillus
WP_005873516  56 KGLADYHGIAADSISVTSGATEAIYL-IAQAFRGS-S-SAVV-VPTFSEYADACRLHGHRVDFI----------S----- 116 Porphyromonas g...
WP_011324351  61 AAAADYVGCAADDVVPTAGGLAAMRLaIGTVVGPGdR-VLVP-APSFGEYAREVRLAGGEPDIV----------D----- 123 Natronomonas ph...
WP_010903155  61 AAAADHVDCARDTVVQTPGGLAGIRLaIETRVTPG-DtVLVP-APSFSEYAREVELQGATPVFV----------P----- 123 Halobacterium s...
WP_011318570 131 srvlgTECHLTqlhtqhSGL--STNYALLLNNPHNPTGKLFTREAILPLLEQFa----LVVVDEAFMDFV---PPDeeqS 201 Anabaena variab...
WP_010897752 132 --wslDLDRMT------AVL--KRTDLLFICHPNNPTGVAYRKEQLIELLELAkqfgtTLVIDEAFYDFM---EVPi--T 196 Bacillus halodu...
WP_011357873 127 -----SFERLV------SAM--DGVDALFLANPNNPTGTELPPGMLPGLASRFpe--kWFIVDEAFIQYTaafPRN---S 188 Pelodictyon lut...
WP_011362038 121 gfalpSLEQFA------TALqeAEADALFVGNPNNPTGTAIEPEVIMALASRFpw--mWFIVDEAFIQFTanfPHN---S 189 Chlorobium chlo...
EXY12896     118 -----TLDAVP-----------EDVHMVWLCNPNNPTGEVRDKKYLTELIAKHpr--vCFVIDQSYEYFT---LKE---L 173 Bacteroides fra...
WP_010932619 132 -----GIDKLA------DAL--AGCDALLAGSPNNPTGTLIPKELLLALACRFpe--kRFIVDEAFIQFT---EAFp--S 191 Chlorobaculum t...
WP_011231745 135 -----DIDQAA------AWA--AECDAVFFCHPNNPTGTVMPERDLRSLVAAAdqagtYIVVDEAFYPFW---RG----G 194 Geobacillus
WP_005873516 117 -----KPEE---------AS--SRYDMVWLCNPNNPTGRVWKTSELYRIVRECps--tIFIVDQSYEYFS---IA----E 171 Porphyromonas g...
WP_011324351 124 -----YGTLLD------RSP--EEYAMAVVCTPNNPTGDCYDADTLRAFADRCaevgtVLLADEAFLGFT---DRA---S 184 Natronomonas ph...
WP_010903155 124 -----HDALLD------ADP--SEHTLAIACTPNNPTGDRYDDDALRAFAARCraantELLVDEAFLGFT---DAP---S 184 Halobacterium s...
WP_011318570 202 LIPV-VA--EYPNLVILRSL---------TKFYSLPGLRLGYAIAHPDRLQKWQLWRDPWPVNTLAAAAAIAALEDREFQ 269 Anabaena variab...
WP_010897752 197 FTAQ-AA--ANEGIIVVRSM---------TKMFTIPGLRLGYAISAPSVIEKLKSKIPPWSVNGLADKAGQFCLRETMFV 264 Bacillus halodu...
WP_011357873 189 LMRE-VM--AMKNVVVVHSL---------TKFYALPGLRLGAVVAHPDVIERLLFHKEPWTVNAVAEQVAGRLAGCGTWE 256 Pelodictyon lut...
WP_011362038 190 LMKQ-VS--ALRNIIVVHSL---------TKFYALPGLRLGAVVAHPDVINRLLDVKEPWTVNAIAEEVARRLLHCSDYD 257 Chlorobium chlo...
EXY12896     174 FTAQeAA--GFPNVILLHSM---------TKRYAIPGLRLGYVTAHPGLIGRLRTNRMPWSVNQLAIEAGLYLLSEGIPA 242 Bacteroides fra...
WP_010932619 192 NSLM-TEikAFRNIAVVHSL---------TKFYAIAGLRLGAVIAHPSMIRQLYGYKEPWTVNAVAEHVAGQLLHCGEYE 261 Chlorobaculum t...
WP_011231745 195 FTAM-RWldRYPRLIVLRSL---------TKIHHLAGVRLGYVAADEAVIASLKTHQPPWSTNCIAQQLALRFMAMESFV 264 Geobacillus
WP_005873516 172 VLDT-KE--AV-------SLpnllllhslTKRFAIPGLRLGYLTAHASLTERIRVCRMPWSVNALAIAAGEYLVQQGFPT 241 Porphyromonas g...
WP_011324351 185 LAGR-------EGVVVARSL---------TKLFGLPGLRAGFAVATGELGDRLQTARPAWSLGGPAAAVGAHAMADTAFV 248 Natronomonas ph...
WP_010903155 185 IAGT-------PGVVVARSL---------TKLFGLPGLRAGFLVAVGDRLTTLRTARRTWNLGAPAAAVGAHAMRQSEFV 248 Halobacterium s...
WP_011318570 270 VQTWQWLPPAREELFQGLTAIPGLTPQASAANFLLV--E--TQQ--SSl--eL---QQKLLQQ-H-QILIRDCLSFKELG 336 Anabaena variab...
WP_010897752 265 RDSAQRIAAARAEMQAGFRHLGF-DVSPSVVNFFVI--S--DPR--ESigmlA---MLKGLLD-R-GFVLRHTENFPGLD 332 Bacillus halodu...
WP_011357873 257 ESLRKMLAAERERIQRECSSIEGLTLYGGSANFFLA--R--STR--SL----Dv--LLPQFTR-K-GIHLRDARNFRGLE 322 Pelodictyon lut...
WP_011362038 258 AEVRSIIAAERLRMSAQFARSGEIVLVGGAANFFLA--R--WIG--GC----SldvLFARLAE-R-NLYVRDCRNFRGLE 325 Chlorobium chlo...
EXY12896     243 GLSMKDYLAECARLKSSLEAIGGLEVWPTDTHFMLVclR--FGK--AA----A---LKEYLAReE-GILIRDASNFEGLD 310 Bacteroides fra...
WP_010932619 262 REVHAIVREGRKQIADGLAGNSVITLHGGAANFFFA--S--VAD--EFsl-dA---LFDVLAE-R-GILVRDCRNFEGVP 329 Chlorobaculum t...
WP_011231745 265 KWTKERIAAERERVFRSLPAGRY-AVSPSVVNFYLL--RplSGR--TE----D---LFFYLLQ-Q-GIVPRHTMNFPGLD 330 Geobacillus
WP_005873516 242 SIPLAELRVETERLRTAIGSMAGYEVEPTDTHFMLV--R--CRHhsAA----D---LKAVLAD-QyGLLIRDASNFEGLD 309 Porphyromonas g...
WP_011324351 249 SDTRRRIDRERAHLRDRLAAHGF-EVFPSEAPFLLC--D--VGG--PP----Dg--LLAACRE-H-GVVLRDATTFRGLD 313 Natronomonas ph...
WP_010903155 249 AETRRHVASERARMRAALS--DAFDVHPSSAPFLLL--D--VGP--RPv--dA---VMAAASA-E-GIRLRDATTFRGLD 313 Halobacterium s...
WP_011318570 337 DRFFRLAVRSHTDNQRLTKALK 358 Anabaena variabilis
WP_010897752 333 GRYLRVAVKDQDTNRKLLQAVK 354 Bacillus halodurans
WP_011357873 323 GEWFRFAVRTPDENTRLIALFR 344 Pelodictyon luteolum
WP_011362038 326 ANYFRFAIRTPAENERLLEALl 347 Chlorobium chlorochromatii
EXY12896     311 ERFFRIATQTPEENDELVGAIA 332 Bacteroides fragilis str. 1007-1-F #8
WP_010932619 330 PKYFRFCIRTSDENRRLIEALN 351 Chlorobaculum tepidum
WP_011231745 331 GRYVRLAVKTQVENDRLLEALA 352 Geobacillus
WP_005873516 310 THCIRIATQTREQNDWLIDALR 331 Porphyromonas gingivalis
WP_011324351 314 -RHVRIAVRTREATETLCETLD 334 Natronomonas pharaonis
WP_010903155 314 -SHVRVAVRTPDENDRLLAALA 334 Halobacterium salinarum
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