1RQ8,1JO0


Conserved Protein Domain Family
CRS1_YhbY

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smart01103: CRS1_YhbY 
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Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly.
GFP fused to a single-domain CRM protein from maize localises to the nucleolus, suggesting that an analogous activity may have been retained in plants. A CRM domain containing protein in plant chloroplasts has been shown to function in group I and II intron splicing. In vitro experiments with an isolated maize CRM domain have shown it to have RNA binding activity. These and other results suggest that the CRM domain evolved in the context of ribosome function prior to the divergence of Archaea and Bacteria, that this function has been maintained in extant prokaryotes, and that the domain was recruited to serve as an RNA binding module during the evolution of plant genomes. YhbY has a fold similar to that of the C-terminal domain of translation initiation factor 3 (IF3C), which binds to 16S rRNA in the 30S ribosome.
Statistics
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Structure
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PubMed ReferencesClick to see Conserved Features Help

smart01103 is a member of the superfamily cl00663.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1RQ8_A       2 LTGKQKRYLRSLA--HNIDPI--FQIGKGGINENMIKQIDDTLENRELIKVHVLQNNFDDKKELAETLSEATRSELVQVI 77   Staphylococcus a...
NP_565462  243 LTKEEVRELVTSC--LKTTRQ--LNMGRDGLTHNMLNNIHDLWKRRRVCKIKCKGVCTVDMDNVCEQLEEKIGGKVIYRR 318  thale cress
NP_186786  166 LPPAELRRLRTVG--IRLTKK--LKIGKAGITEGIVNGIHERWRTTEVVKIFCEDISRMNMKRTHDVLETKTGGLVIWRS 241  thale cress
NP_200300  143 LTEDEVTELIERY--RHSDCTrqINLGKGGVTHNMIDDIHNHWKKAEAVRIKCLGVPTLDMDNICFHLEEKSGGKIVYRN 220  thale cress
AAK68804   159 LTEAERKFLVELCqrNKTKRQ--VNLGRDGLTHNMLNDVYNHWKHAEAVRVKCLGVPTLDMKNVIFHLEDKTFGQVVSKH 236  thale cress
NP_173754  203 LKRWEKGMLIKPH--MHDNRQ--VNLGRDGFTHNMLELIHSHWKRRRVCKVRCKGVPTVDMNNVCRVLEEKTGGEIIHRV 278  thale cress
NP_188947  221 LPESELRRLRNLT--FRTASK--MRIRGGGVTQVAVDAIKEKWKSAEIVRLKIEGASALNMRKMHEILEKKTGGLVIWRS 296  thale cress
CAB45335   244 vPEHELKRLRNVA--LRMVER--VKVGSAGITQALVEAIHEKWEVDEVVKLKFSEPYSLNMKRTHEVLENNLEANPEIHR 319  thale cress
NP_188468  243 veDSELRRLRRDG--MYLRVR--INIPKAGLTQAVMEKIYDTWRKEELVRLKFHEVLARDMKTAHEIVERRTGGMVIWRA 318  thale cress
NP_193187  222 LSEFELNRLRNVM--FRTKSK--MRVTGAGVTQAVVDAIQEKWKGSEIVRLKIEGSSALNMRRMHEILERKTGGLVIWRS 297  thale cress
1RQ8_A      78 GSMIVIYR 85   Staphylococcus aureus
NP_565462  319 GGVLFLFR 326  thale cress
NP_186786  242 GSKILLYR 249  thale cress
NP_200300  221 INILVLYR 228  thale cress
AAK68804   237 SGTLVLYR 244  thale cress
NP_173754  279 GGVVYLFR 286  thale cress
NP_188947  297 GTSISLYR 304  thale cress
CAB45335   320 sveardyv 327  thale cress
NP_188468  319 GSVMVVYR 326  thale cress
NP_193187  298 GTSIALYn 305  thale cress
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