Conserved Protein Domain Family
MnuA_DNase1-like
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cd10283: MnuA_DNase1-like 
Mycoplasma pulmonis MnuA nuclease-like
This subfamily includes Mycoplasma pulmonis MnuA, a membrane-associated nuclease related to Deoxyribonuclease 1 (DNase1 or DNase I, EC 3.1.21.1). The in vivo role of MnuA is as yet undetermined. This subfamily belongs to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds.
Links
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Statistics
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PSSM-Id: 197338
Aligned: 56 rows
Threshold Bit Score: 133.678
Created: 18-Jan-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:putative catalytic site [active site]
Evidence:
  • Comment:based on other EEP superfamily members with structure, and on site-directed mutagenesis of bovine pancreatic deoxyribonuclease I (DNase I); highly conserved in the EEP superfamily
  • Citation:PMID 9000637
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1               #                                                                #        
NP_326525      74 IRLGHWNVLNQSgntpt-------------------------------knlaISKVILHNKl---dLVGLTEITNe---- 115  Mycoplasma pu...
ZP_03925788  1294 VKVATFNVLNYFtdlgedqvkcksykdrndnpvgtdkcavrgaytkaafadqKAKIVSAISlldadIISLEEIENsqrfg 1373 Actinomyces c...
NP_927023     301 LKVASFNVLNYFttlgsrgaa-----------------------ndkeferqQGKVVAALKaidadVVGLIEIQNng--- 354  Gloeobacter v...
ZP_05846722   514 HSIASFNVLNYFtdlgqdqgncgsykdregnpvtadkcdvrgayseqafkdqQAKIVKAINtldvsVLGLEEIQNsakfg 593  Corynebacteri...
NP_051603     487 LRVGGANVLNYFttyggstdrgan-----------------nagelarqrakMATTLTTLNa---dVLSLMEVQNng--- 543  Deinococcus r...
YP_830176     531 LAGCTFYTDRDGnpitvrggcdar-----------------gaanaenlkrqQDKIVAAIGksgadVVSLMEVENsaqfg 593  Arthrobacter ...
ZP_05859856    25 FSLGTFNIEYFAvtgqkry--------------------------tpedcahLAQTIQDSRa---dLLSLQEIEGd---- 71   Jonquetella a...
ZP_06392409    25 LVIGTFNIEYFNvsgkkay--------------------------sqedcsyLARLIKESDv---dLLALQEIEGd---- 71   Dethiosulfovi...
YP_001221535  319 VRIAGFNVLNYFttlgergaa-----------------------taeelrkqRAKIVTAITgldaqVVTLMEIENstrfg 375  Clavibacter m...
ZP_01620435    34 LSIISYNVESDDlddt--------------------------------dphlVAEDIREIVga--dLWGLSEVAD----- 74   Lyngbya sp. P...

Feature 1                                                  #                                      
NP_326525     116 ----NGVKTIINElnks-ssdkWNYIVSQKKRgttgssgqaEHVGIIYke-------------nKLTLEPFDDqekskgk 177  Mycoplasma pu...
ZP_03925788  1374 hdrdATLEDLVAAlnekmgagtWKAVASPANIpnn---gdaIRTAFIYkpa----------kvkAEGESLILDhpd---- 1436 Actinomyces c...
NP_927023     355 ---lIALDNLTAAlnkaygrtvFDVVIPPLRGtgt----ddIQVGIIYkp------------erVKPVGPSRSdpe---- 411  Gloeobacter v...
ZP_05846722   594 kdrdAALKHLVDElnaa--ggkWEYVKSPATVakn---edvIRTAFIYqpd----------kvePVGESKILDvea---- 654  Corynebacteri...
NP_051603     544 ---dTALNDLVAAlnekagagtYAAVTTGSVGtd------aIKVAIIYkpsk---------vtpVGQFMTDNNs------ 599  Deinococcus r...
YP_830176     594 kdrdDALAKLVEAlnip-tpgiWDYVRTPANAppla-dedmIRTAFIYkkaa---------aepVGESVIHNDtva---- 658  Arthrobacter ...
ZP_05859856    72 ----GAMTYLVARhl-----pgWRFAGNDTASs--------QDLYFLWkdsavqm--lsgpdvyFANASFQHDgst---- 128  Jonquetella a...
ZP_06392409    72 ----ATMRFFVTKfl-----pgWAYSGNDTGGr--------QDLYFLWrkdsvrildgpvvygaNGSFRFEGKsy----- 129  Dethiosulfovi...
YP_001221535  376 epadTATADLVRGlndaagkpvWDYVRTPAELqstp--tdeIQNAIIYrtda---------vtpVGQAATQIDetv---- 440  Clavibacter m...
ZP_01620435    75 ----QAAADIFTEavav-pgsdFKSIFGTTGSl--------DKLQIIYnqn-----------rlDLLDHEELDni----- 125  Lyngbya sp. P...

Feature 1                                                       #                                 
NP_326525     178 fyenklwddpfkkgqkidYVRPPFGAKFStkgn---vknDFSVVFVHSdspgvsitkankeenasgyagqghkevaealr 254  Mycoplasma pu...
ZP_03925788  1437 ---------------ftgVARSPLAQKFVpvvderhnakPFVLIVNHFkskgsvakghgeqeg--dfdgqgnnnplrvkq 1499 Actinomyces c...
NP_927023     412 ----------------piFDRPPLAQTFQarrs--gprsTFTVVVNHFkskgscpdpgpdada---dkgqgcwnlrrvaq 470  Gloeobacter v...
ZP_05846722   655 ---------------fdqIARQPLAQQFKnkga--kdeqAFVAVVNHYkskgsvargdadtg-----dgqgnnaklraem 712  Corynebacteri...
NP_051603     600 -----------------vFSRPPVAQTFRdkt----tggVFSVIANHLkskgscptsgdvd------tgqgcwnqlrvrq 652  Deinococcus r...
YP_830176     659 ----------------faSARKPLAQVFKpvga--sddkKFIAIANHFkskgsaatpedtd------kgqgasnlarteq 714  Arthrobacter ...
ZP_05859856   129 ---------------frlFDRPPLVATFKdka----sgfQFTLVNVHLksqstrgksdvvs-------akayndakraaq 182  Jonquetella a...
ZP_06392409   130 ----------------rlHDRPPMVGLFLdie----gdrRFHMVNVHLksqstrgkddqdr-------akryndfkrgaq 182  Dethiosulfovi...
YP_001221535  441 ----------------wgNAREPVAQSFRgg------drTFTVVANHLksksgsgtqpad--------gqgffnadrvaq 490  Clavibacter m...
ZP_01620435   126 -----------------gGSRSPLVAHFKfls----tgqEFLFTVNHFnrgses---------------------krnqq 163  Lyngbya sp. P...

Feature 1                                 # #                                                     
NP_326525     255 TKEVMEYFDSIDgv--nnELFFMGDTNIkvgnea-----kafkpLLQSG-YKSLIkd-----vkENSTSLaqrw----ge 317  Mycoplasma pu...
ZP_03925788  1500 AAALAEFAKANFae---vPTFLLGDFNAysked-------pivtLGNAG-FEKLTg-------eGHSYVFkg-------- 1553 Actinomyces c...
NP_927023     471 ARKLLAFVKTLNd----pDVLVVGDLNAygged-------pikaLGAGG-LVSLNlrip--aaeRYSYVFeg-------- 528  Gloeobacter v...
ZP_05846722   713 SSQLVKWLSEDAdfk-dkPQFILGDFNAyaked-------airiIEEAG-YTNLEtkf----daGHSYQFgg-------- 771  Corynebacteri...
NP_051603     653 AQALLGFVDTVKqksgdqDVLLLGDFNAygaed-------pikvLQGGG-FESLNlrip--aedRYSYQFng-------- 714  Deinococcus r...
YP_830176     715 AKSLLAFSNDLQaskgtdKVFLMGDFNAyaked-------pinvLTAAGyINQDEkarnadgsaKHSYLFgg-------- 779  Arthrobacter ...
ZP_05859856   183 LEALDRLVSSLNg-----PIFITGDFNYe---------------SPKTA-FRLLTlp-----dgLYSYDAt--------- 227  Jonquetella a...
ZP_06392409   183 IDGINGIVGSLKg-----PVFILGDYNVd--------------dPKGTN-FPLLSl-------pKGSYSYdd-------- 227  Dethiosulfovi...
YP_001221535  491 AKAVARFAGELEassgsdLVYLLGDFNAyseed-------piqvLRDAG-FVDLVaak---apgERTYSFdg-------- 551  Clavibacter m...
ZP_01620435   164 AENLRDWAAAQSl-----PVIAVGDYNFdfdldkkkgnkafdlfVRKDV-MTWIKpn------cLKTNSCpltgtqcdpk 231  Lyngbya sp. P...

Feature 1              #                                                                   ##     
NP_326525     318 yANTYDKIFYkgdlkve-nskfydLWKVFDdkilnkeefkkaidk------------nsknnseiyyvrsaISDHTLIWT 384  Mycoplasma pu...
ZP_03925788  1554 rSGSLDHVLAnegak-----alvsDTGVKVw---------------------------------------eINAHEPVML 1589 Actinomyces c...
NP_927023     529 qSGYLDHALAtpsl-------dkqVTGITEwhvnsdeppvidynteys-----rrnpaakkddryeptpyrSSDHDPVVV 596  Gloeobacter v...
ZP_05846722   772 rVGSLDHVLAnekat-----ematGADVWDinadesvafeysrr-------------nynvvdfyepnvfrASDHDPIKV 833  Corynebacteri...
NP_051603     715 lFGYLDHALAsqnl-------saqVSGITEwhvnsdepviadyntefkkvagctgtnctgidlfdptnpfrASDHDPVLV 787  Deinococcus r...
YP_830176     780 lVGSLDHVLAtp-----------gADSVVTgadiwninsvesvaley-------srynsnvtnyyapdqfrASDHDPVVV 841  Arthrobacter ...
ZP_05859856   228 -RSSLDHIGYagltfsrppalreaESSIPRrspg----------------------------------rsqHPDHDIVLL 272  Jonquetella a...
ZP_06392409   228 rKSRLDYIGYlgieksdswrlfevETSIPArstk----------------------------------rsqSPDHDMVLL 273  Dethiosulfovi...
YP_001221535  552 eVGSLDHVLAtraga-----aavtGVGVWDinapewaareyg------------------gaatdgssafrSSDHDPVKV 608  Clavibacter m...
ZP_01620435   232 yASILDYVFVsqmak-----kwpcESDILFvqnqvc-----------------------------qkekegFSDHYPLMA 277  Lyngbya sp. P...

Feature 1           
NP_326525     385 DL 386  Mycoplasma pulmonis UAB CTIP
ZP_03925788  1590 EY 1591 Actinomyces coleocanis DSM 15436
NP_927023     597 GL 598  Gloeobacter violaceus PCC 7421
ZP_05846722   834 GF 835  Corynebacterium jeikeium ATCC 43734
NP_051603     788 GL 789  Deinococcus radiodurans R1
YP_830176     842 GL 843  Arthrobacter sp. FB24
ZP_05859856   273 DF 274  Jonquetella anthropi E3_33 E1
ZP_06392409   274 DL 275  Dethiosulfovibrio peptidovorans DSM 11002
YP_001221535  609 GL 610  Clavibacter michiganensis subsp. michiganensis NCPPB 382
ZP_01620435   278 NF 279  Lyngbya sp. PCC 8106

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