Conserved Protein Domain Family
SLC6sbd_BGT1
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cd11511: SLC6sbd_BGT1 
Na(+)- and Cl(-)-dependent betaine/GABA transporter-1, and related proteins; solute-binding domain
BGT1 is a relatively low-affinity transporter of gamma-aminobutyric acid (GABA), and can also transport betaine. GABA is the main inhibitory neurotransmitter within the mammalian CNS. Human BGT1 is encoded by the SLC6A12 gene, and is similar to mouse GAT2. Mouse GAT2 plays a role in transporting GABA across the blood-brain barrier. In addition to being expressed in cells of the central nervous system, BGT1 is expressed in peripheral tissues, including kidney, liver, and heart. An association has been shown between the SLC6A12 gene and the occurrence of aspirin-intolerant asthma, and BGT1 is a drug target for antiepileptic drugs. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.
Links
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Statistics
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PSSM-Id: 212080
Aligned: 4 rows
Threshold Bit Score: 1041.04
Created: 20-Jul-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:Na binding site 2 [ion binding site]
Evidence:
  • Comment:based on Aquifex aeolicus LeuT (SLC6) with structure
  • Comment:One of two Na+ binding sites in Aquifex aeolicus LeuT. It binds the Na+ ion designated Na2, and appears conserved in Vibrio parahaemolyticus vSGLT and other SLC5 proteins
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                        #  #                                                            
NP_003035     35 DRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIPVFFLEVALGQYTSQGSVTAWRKICPL 114 human
XP_001093673  35 DRGQWNSKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIPVFFLEVALGQYTSQGSVTAWRKICPL 114 Rhesus monkey
XP_416378     99 ERGQWSSKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYLIFLFTCGIPLFLLETALGQYTSQGGVTAWRKICPI 178 chicken
XP_002193195 110 ERGQWRNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYLIFLFTCGIPLFFLETALGQFTSQGGVTAWRKICPI 189 Taeniopygia gut...

Feature 1                                                                                        
NP_003035    115 FQGIGLASVVIESYLNVYYIIILAWALFYLFSSFTSELPWTTCNNFWNTEHCTDFLNHSGAGTVTPFENFTSPVMEFWER 194 human
XP_001093673 115 FQGIGLASVVIESYLNIYYIIILAWALFYLFSSFTSELPWTTCSNVWNTEHCVDFLNHSGAGTVTPSENFTSPVMEFWER 194 Rhesus monkey
XP_416378    179 FEGIGYSSQVIETYLNIYYIIILSWALFYLFSSFTTVLPWASCNNPWNSDLCVDFLNSSDWDNRTVPANATSPVVEFWEK 258 chicken
XP_002193195 190 FEGIGYASQVIVGYLNVYYIVILSWALFYLFSSFTSVLPWANCNNPWNSDLCVDILNRSSLDNRTLPSNATSSMIEFWEK 269 Taeniopygia gut...

Feature 1                                                                                        
NP_003035    195 RVLGITSGIHDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGAYQGIIYYLKPD 274 human
XP_001093673 195 RVLSITSGIHDLGALRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLVRGVTLPGAYQGIIYYLKPD 274 Rhesus monkey
XP_416378    259 RVLGLTDGIHKLGTVRWELALCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYAMLVILLVRGVTLPGAAEGIVFYLKPD 338 chicken
XP_002193195 270 RVLGLTDGIHKLGTVRWELALCLLLAWIVCYFCIWKGVKSTGKVVYFTATFPYVMLFILLVRGVMLPGAAEGIIFYLKPD 349 Taeniopygia gut...

Feature 1                                                                                        
NP_003035    275 LFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALCFLNSATSFVAGFVVFSILGFMSQEQGVPISE 354 human
XP_001093673 275 LFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCVALCFLNSATSFVAGFVVFSILGFMSQEQGVPISE 354 Rhesus monkey
XP_416378    339 VSRLADPQVWMDAGTQILFSYAICQGCLTALGSYNKYTNNCYRDCIMLCFLNSATSFVAGFAIFSVLGFMAREQGVPIAE 418 chicken
XP_002193195 350 MSRLADPQVWMDAGTQILFSYAICEGCLTALGSYNKYTNNCYRDCIMLCSLNSATSFVAGFAIFSVLGFMAREQGVPISE 429 Taeniopygia gut...

Feature 1                                            #  ##                                       
NP_003035    355 VAESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASIDMFPRQLRKsgRRELLILTIAVMCYL 434 human
XP_001093673 355 VAESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASVDMFPRQLRKsgRRELLILTIAVTCYL 434 Rhesus monkey
XP_416378    419 VAESGPGLAFIAYPTAVTMMPVSQLWSCLFFLMLIFLGLDSQFVCVESMVTALIDMFPGVFRKkgRRELLILAIAVICYL 498 chicken
XP_002193195 430 VAESGPGLAFIAYPTAVTMMPVSQLWSCLFFLMLIFLGLDSQFVCVESMVTAIIDMFPGVFRKkgRRELLILAIAVISYL 509 Taeniopygia gut...

Feature 1                                                                                        
NP_003035    435 IGLFLVTEGGMYIFQLFDYYASSGICLLFLSLFEVVCISWVYGADRFYDnIEDMIGYRPWPLVKISWLFLTPGLCLATFL 514 human
XP_001093673 435 IGLFMVTEGGMYIFQLFDYYASSGICLLFLSVFEVVCISWVYGADRFYDnIEDMIGYRPWPLVKISWLFLTPGLCLATFF 514 Rhesus monkey
XP_416378    499 LGLLLVTEGGMYIFQLFDYYAASGTCLLFLAIFEVICVGWVYGANRFYDnIEDMIGYRPWPLIKICWLVFTPGLCLAVFL 578 chicken
XP_002193195 510 LGLLLVTEGGMYIFQLFDYYAASGTCLLFLAIFEVICIGWVYGANRFYDnIEDMIGFRPWPLIKICWLVFTPGLCMGVFL 589 Taeniopygia gut...

Feature 1                                                                     
NP_003035    515 FSLSKYTPLKYNNvYVYPPWGYSIGWFLALSSMVCVPLFVVITLLKTRGpFRKRLRQLITP 575 human
XP_001093673 515 FSLSKYTPLKYNNvYVYPPWGYSIGWFLALSSMVCVPLFTVITLLKTQGsFKKRLCQLITP 575 Rhesus monkey
XP_416378    579 FSLIKYAPLKYNNsYVYPPWGYVLGWLMALSSMVCIPLYIIFILLRTKGsLKQRLAQLISP 639 chicken
XP_002193195 590 FSLIKYKPLKYNNsYEYPSWGYVLGWLMALSSMVCIPLYAIFILLKTKGsLKQRLMQLISP 650 Taeniopygia guttata

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