Conserved Protein Domain Family
Herpes_U30

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pfam04523: Herpes_U30 
Herpes virus tegument protein U30
This family is named after the human herpesvirus protein, but has been characterized in cytomegalovirus as UL47. Cytomegalovirus UL47 is a component of the tegument, which is a protein layer surrounding the viral capsid. UL47 co-precipitates with UL48 and UL69 tegument proteins, and the major capsid protein UL86. A UL47-containing complex is thought to be involved in the release of viral DNA from the disassembling virus particle.
Statistics
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PSSM-Id: 282392
Aligned: 7 rows
Threshold Bit Score: 811.722
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P03189   29 LARVTRQlLLSGDDPAARLRALMPLELGIFGLGDLAQPVLVRDFLNTLTLMSGHaYPAAVLRHHAYYLLRAASFS----- 103  Epstein-Barr virus ...
Q01055    6 LTELTKN-LEAASNELLKTKVLMDMELNYLSIEQLESAQNITDFLNILKQTSSQ-YSTFIHQHFLFYLLKLSTFS----- 78   Herpesvirus saimiri...
F5HEU7    7 LEKLTKG-LSGGGGSLHQTKLLMEFQLRGLPVPALLNSSTTEQFLNTVAQLPTD-LSKFIRDYRVFALVRAAYFL----- 79   Human herpesvirus 8...
Q66665    7 LDRLAQR-LSDAENLFKKVRVLVDLESAPLSLRSLSDPVRIASFLNTLSDRGNE-YLAFIRHRPAFYLLRVASFGe---- 80   Equid herpesvirus t...
O36413    8 LLKITQN-IQNVTSKLAKLREILDLEMKMIDATELCNQQLVVKFLNSLPQEQGG-LIEFVTTHYVYFLFKNCTLSpqfle 85   Alcelaphine herpesv...
Q6SW85    9 FKKLIEQlRARATDKAEALNTVSQLEIGAVDAQDVTASA-VRAFVGALPSSGYH--FGFVRQNVVFYLLSHATVQta--r 83   Human herpesvirus 5...
P52437  155 LEFILSS-LKNSTSPESLLAATAKIELLSLAADSVTHNR-VIAFINRLTPKKYH--FDLIRQYAVFYFLNSTTLTs---e 227  Human herpesvirus 6...
P03189  104 RRSFGLGHLEAALD------------------------------VLASSL-------PPtta----spaTDDPLDGSRLI 142  Epstein-Barr virus ...
Q01055   79 TLNYDLESIKQYMN------------------------------ILNNVCdvattihATs---------SSNFLNNQTVI 119  Herpesvirus saimiri...
F5HEU7   80 EPPSSIDPLEAAR-------------------------------ALGRLVdil-ssqPPqntapaqpptSDDTLNNCTLL 127  Human herpesvirus 8...
Q66665   81 QVPLGAGDLQGAVG------------------------------LLTSAVrafkdlkPPpegt---papANNLLENSNIL 127  Equid herpesvirus t...
O36413   86 RGTEHEEVVSKCLH------------------------------LLKSAVecmsqitSDlfg-----cqGSGLLSNRNIL 130  Alcelaphine herpesv...
Q6SW85   84 DPLYAAEQLHEQLDrflrhqhdgggdedrlpfyhngatltafqkLLQTLReiqtviaEQsggt---aaaADLIASNNAST 160  Human herpesvirus 5...
P52437  228 NKLLSAELLYEELSqipsssssgtele----nlnnaevlyvfdrILNSIKmlknelsSPigklraqpaaNDPGTDKTIKY 303  Human herpesvirus 6...
P03189  143 AE---------------TRALAAAYRRIIEEGSGEvlAVSGPTATFAFVEELVADTYLA--RWD----A-FPREglsfya 200  Epstein-Barr virus ...
Q01055  120 NH---------------IKQYITSNATFTGLSEPI--VPNNVISTFRCVEEVVHVCFQC--YWHfpfqAqIPQI------ 174  Herpesvirus saimiri...
F5HEU7  128 KL---------------LAHYADQIAGFKTPALPP--VPPGIIGLFTCVEQMYHACFQK--YWA----AaLPPMwilt-- 182  Human herpesvirus 8...
Q66665  128 TR---------------LSQFIAHLRSL-DLSQPVtfTPPASLVTLRCIEEITFSFWHA--HWT----A-PPEVslp--- 181  Equid herpesvirus t...
O36413  131 SE---------------LQLFLTWAQNVNRNSTELtsLPTTPVQTFLCAEEIMSLLYLS--KLY----NtIPSVqfnm-p 188  Alcelaphine herpesv...
Q6SW85  161 ERrgkkggsssggqqplVRRVITQLETAATEARPY--------VNCRAVAELLDLTYQRliYWAc---TlMPYVlfr--- 226  Human herpesvirus 5...
P52437  304 SK---------------IQSIIQKINSFTHENSLL--------ANCRAVVELIDDLYRKlySWFlhvlT-FEDIqf---- 355  Human herpesvirus 6...
P03189  201 fnaAKTTLGRWLVTV--------YAETNRYpwaaagqgqptaadiKAMAVELVEHSgggagggegeesgGGLFHRPESlS 272  Epstein-Barr virus ...
Q01055  175 ---PNGALEKWLLTQhfkflnldYTAFNSL---------------KDQATYLITHE-------------KHLFVPLSS-S 222  Herpesvirus saimiri...
F5HEU7  183 ydpPTSPLQDWLIVA--------YGNKEGLllpsg------ipseEVLAKTLVTEH-------------HELFVSRSNsT 235  Human herpesvirus 8...
Q66665  182 kpnPQSKLERWLALS--------YAAALGAardnap---khrrelRALAKSLLTTE-------------RDLFAPVSVvT 237  Equid herpesvirus t...
O36413  189 nfqTMGVLEQWTISL--------YTSTVGLptgpy-----qlpnaTELACALVSRH-------------ADLFISPTHvS 242  Alcelaphine herpesv...
Q6SW85  227 -rdTDTELDTVLLMHffy---thYRSVNGDlavefq-----------nyvknsVRH-------------MSSFVSSDIdG 278  Human herpesvirus 5...
P52437  356 --pGDTFLDRLLKMDycf---tyYPSSNRHlidlfe-----------------------------ktldnqTFTNLDKfF 401  Human herpesvirus 6...
P03189  273 SVVASLPLARRRAVEILGVYAEASGGQTPPvaavPVLAFDAARLRL-LEPSGALFYDYVYEALLWDQTYGVPDSV----I 347  Epstein-Barr virus ...
Q01055  223 EYSLTLPLAKNQALNIYTSFTTNTITKSNV----PVLAFSAKELTD-ATPELFFLYDFIIEALYHEHSYNVPQNI----I 293  Herpesvirus saimiri...
F5HEU7  236 ETAVTMPVSKERALAIYRVFAKGEVVAENT----PILAFTDVELST-LKPHYLFIYDFIIEALCKSYTYSCTQAR----L 306  Human herpesvirus 8...
Q66665  238 ETSLTLPLAKERAREIF-SMVDDALPGDAAargaPVLGFRDADLNA-ASPEYVFLYEHVFEALLHDQTYGCARRT----V 311  Equid herpesvirus t...
O36413  243 QPLLTFPFAKKRANLIFQSYLNN--PQASItetgPLVQLREADLQT-LDTTFFFLYDYIFEALSNNQAYSCSAAT----V 315  Alcelaphine herpesv...
Q6SW85  279 DQKPGAE---HMRDVSYKLFVGNLQARDASglmfPIISTRISTVNLyLSPERMFFHPGLISRLLSEEV--SPRAN----L 349  Human herpesvirus 5...
P52437  402 DTSGNSPELLYQKTFSLKIFSKNLTAQDNGlyiyPLLKTDLSILDF-LGTENILFHRGLIYHILHQKTIPQERENdlnkI 480  Human herpesvirus 6...
P03189  348 EAFLAGMAAEMEALAARVQEAAGSRAsFSPAAIEQVAT------VLLSAGLNETVAGDYAMMLASVPRVSRSR-WRWLEA 420  Epstein-Barr virus ...
Q01055  294 EQFISKNTQFMTDLCNTIQIKCSNKS-LTSSEIRHIKE------LLESCGLTEECCHRLQTSVLISNVSFTSNsWKGYET 366  Herpesvirus saimiri...
F5HEU7  307 ESFLSRGIDFMTDLGQYLDTATSGKQqLTHSQIKEIKY------RLLSCGLSASACDVFRTVIMTLPYRPTPN-LANLST 379  Human herpesvirus 8...
Q66665  312 EAFLERCLKFLVNLGSYVQTACSNKShLSPPEIEGVRA------AFHACGLTREACHTFSTMLAIAPAGGAASrLKHLHA 385  Equid herpesvirus t...
O36413  316 NNFIARCVDSLTDLGSNL-LEASTASrGPSNNIDAFKG------FLLRAGLTEKNCSDFKTLLLLNKSNGHTQ-WKQFPK 387  Alcelaphine herpesv...
Q6SW85  350 DAY-ARVCDRVLE-----------DHlHTPRRVQRLLDltqmvmRLVELGFNHDTCAAYAQMALIQPASQKSSlF--VSE 415  Human herpesvirus 5...
P52437  481 NQFFATVIQQVIE----------TKSsCLPASLSQLLDti---fHFNRIGLNMETCRTYIEILSNHMATPDTQpI--INT 545  Human herpesvirus 6...
P03189  421 TAALLESLSGFALHFFRLLPTASPTSRFARVARAAYLRAEAEAVDRRARRTSGpstpaaapaatavgvgaaadpWD-AVT 499  Epstein-Barr virus ...
Q01055  367 FISLISQLVLFSDFFYKCLFYFSPTSIGHSKITEILNTVSAIESETLSHANKFs--------------------WK-LAN 425  Herpesvirus saimiri...
F5HEU7  380 FMGMVHQLTMFGHYFYRCLGSYSPTGLAFTELQKILTRASAEQTERnpwrhpg--------------isdiplrWK-ISR 444  Human herpesvirus 8...
Q66665  386 TVQHLEQITVFGRHFYECLRRCSPTSISHRLVREVLRTAQVEQNSAtpwtaga--------------aegsalgWP-VHS 450  Equid herpesvirus t...
O36413  388 LLRLVTQLTLTAHYFYACLQQYSPTSLARCKITDTLKMAAAEQMVEyqasgsg--------------kqskpfeWT-IPG 452  Alcelaphine herpesv...
Q6SW85  416 IREKLIQIIYNFYTFFMCLYVYSPTFLFDHRRRLILEQHRSTLIGSKEELQHV---------------------WSnVTL 474  Human herpesvirus 5...
P52437  546 FTINLTHIVFTAHVFFICMENFSPTFIFYNRKKLILEQQRAILIIERNDYSTL---------------------WKqISD 604  Human herpesvirus 6...
P03189  500 PLRIFIVPPPAAEYEQVAGDLS-SELLRSLLWVRYSRLWQ----------APAPAPALPCKPPLLPgeqgrrq-----wt 563  Epstein-Barr virus ...
Q01055  426 MLSFFIPKAPSKIILETYTHIS-PYLMKSAFSIWAKKTWNytw-----ldATSPHPTQTHTFKHAPv------------- 486  Herpesvirus saimiri...
F5HEU7  445 ALAFFVPPAPINTLQRVYAALP-SQLMRAIFEISVKTTWGgavpa-nlarDIDTGPNTQHISSTPP-------------- 508  Human herpesvirus 8...
Q66665  451 YLRIFLPRPPEDDLAATFKAASeSNFMKSLIGVSVKRDWDlnkf--------------yvlSKKAPggggngeggsgggn 516  Equid herpesvirus t...
O36413  453 ILSFFIPQPPTELLQVMSDNIS-SPYMQSFFWISAHRAWQlkpht-ilqrELSPTPL-----PSSP-------------- 511  Alcelaphine herpesv...
Q6SW85  475 NVNTHFAVQYTEEDFEAHTKGA-TEAEREYLYRDLHSKWGvhlf--tlrpSRGAAGAASPLPPLDG-------------- 537  Human herpesvirus 5...
P52437  605 HIECLFNVSLSESFFKEYTKGG-NEDQKQFLYKNLFEKWGnvffpftysvSTSNNSTAHH-------------------- 663  Human herpesvirus 6...
P03189  564 aavaaAPRTDVEAYCRSLRAGQTArADPAYV---HSPFFPAAFIEFQIWPALRRVLSNELPKTRSLAALRWLVSFGSDLA 640  Epstein-Barr virus ...
Q01055  487 -----ISQSEVQKYCENLQLGTTE-YDSRIV---NSHLFAEEFITHHIIPTLTAILQNKVQKNRALFQLRWLIVFASDEA 557  Herpesvirus saimiri...
F5HEU7  509 -----PTLKDVETYCQGLRVGDTE-YDEDIV---RSPLFADAFTKSHLLPILREVLENRLQKNRALFQIRWLIIFAAEAA 579  Human herpesvirus 8...
Q66665  517 ggagtVSRKQVRKFCEGLNPGDAD-YALEVV---QSKYFAPEFARAVLLPELEAMLRGRVRRHVMLFRLRWLVLFAFEDA 592  Equid herpesvirus t...
O36413  512 -----CNEEDVKKYCREIQVGDTA-YQLNIV---KCDTFELEFIKTHAFPILQNIFSMDLHIHRAMVQLRWLITFAADAP 582  Alcelaphine herpesv...
Q6SW85  538 -----VTRSDILRECALVNLNEGRvNYASLLafsHHPEFPSIFAQLVVVTEFSEIFGIPQGLFQAVGSPRLFAL------ 606  Human herpesvirus 5...
P52437  664 -----ITTLELRDICKEVYQSDSPdAYESLLpysTHPSFKTLFVKIYVIPMVSHITNLTFDKLQS--DCRLLTL------ 730  Human herpesvirus 6...
P03189  641 lpsPELTRARRP-LELIYATVWEIYdgappmpgespqavglrplnlegegkagdagaegaEDEEgggpwglsshdAVLRI 719  Epstein-Barr virus ...
Q01055  558 ---KGLYRIRRP-LGLLYFQIIEIF-----------------------------------HDSNaa-------aaAILNV 591  Herpesvirus saimiri...
F5HEU7  580 ---TGLIPARRP-LARAYFHIMDILee--------------------------------rHSQD-----------ALYNL 612  Human herpesvirus 8...
Q66665  593 ---AGLAHIRRP-LTLAYFQLTEIFgq--------------------------------gGVGSgagaagggdggALGNL 636  Equid herpesvirus t...
O36413  583 ---PFLSTLRKP-LILLYFQINDIIsq--------------------------------nRVDT-----------SFINM 615  Alcelaphine herpesv...
Q6SW85  607 ---IQLCRVLLPeQVTLYQNLVSIY--------------------------------------------------NLTTF 633  Human herpesvirus 5...
P52437  731 ---IHACKLLLPsQHLLLHYMAWLY--------------------------------------------------AFSIN 757  Human herpesvirus 6...
P03189  720 MDAV--------REVSGIISETIsaseraaeaPPL--AWPTSLFSLLFTLRYSTTAESLGLATRRFLVSGET----LSED 785  Epstein-Barr virus ...
Q01055  592 LDYL--------NEIQQLIQYYV---------PTY--TTPIKFIQELFSIKYKPQSTELSKSIQKFIAETET----CVKD 648  Herpesvirus saimiri...
F5HEU7  613 LDCI--------QELFTHIRQAV---------PDA--QCPHAFLQSLFVFQFRPFVLKHQQGVTLFLDGLQT----SLPP 669  Human herpesvirus 8...
Q66665  637 LDHF--------HEAWTAARELV---------PEAggEVPHELLTNIYRSLHAPAAREQLAAAAAFLKEIKP----LVEG 695  Equid herpesvirus t...
O36413  616 LDYT--------KDVLTAVQEAV---------PSA--EFSPNLINYLFLTHFSSSLKILMDTVNEFVTETTT----VAES 672  Alcelaphine herpesv...
Q6SW85  634 VKHIdaavfktvRDCVFDIATTLehlsgvpvtPNV---------DLLAELMARSVAHNLYTTVNPLIEDVMRssagSLRN 704  Human herpesvirus 5...
P52437  758 VDHIdlgtftviKSVIFKIADHInvmthtiysPET---------NLLVSILLNAYTNYLQKYVNPWIKQTITanfsLIQT 828  Human herpesvirus 6...
P03189  786 ISRLTGAAWRLCSRPLLYDAETGRVQIPlateeeeeavvavkeksvssSPRHYSTDLQTLKSVVEGI---QDVCRDAAAR 862  Epstein-Barr virus ...
Q01055  649 ILPFIQLGTNMCNTTYYHIENTYNINIQ--------------------GQSPARLDTKALTHAIKAI---QGLTKESWTT 705  Herpesvirus saimiri...
F5HEU7  670 VISLANLGDKLCRLEFEYDSEGDFVRVPva-----------------pPEQPPHVHLSHFKKTIQTI---EQATREATVA 729  Human herpesvirus 8...
Q66665  696 TWNMMRIASVLCHARYNYLSASGHLRVPfg-----------------eKPGYVDVPVPVFKETVKIM---ESSLHETLVI 755  Equid herpesvirus t...
O36413  673 VASLARVGATICHSVFSFNTRNDTLEFPiag---------------enGDEIFQISVPAFKSTVANL---QQNCYDVIVL 734  Alcelaphine herpesv...
Q6SW85  705 YLRHTRLCFGLARGRARLSEDGVTVYVEv------------------qGQYGLRVPTTRFVEQLRELvrrDRLLAENLRG 766  Human herpesvirus 5...
P52437  829 YITFTKQCASILATKCNINLDNLFIYITi------------------gTDKIVTTSFCSFIATCRNLvrqHEEFEKSLQT 890  Human herpesvirus 6...
P03189  863 WALATADTATLRRRLLVpALRESRGIADHPLWAHTSEplrPDLEELNERVEHALELGYSLTGALRRSVAYRFRDYtFARL 942  Epstein-Barr virus ...
Q01055  706 ISQSYKELQTAYIQLAT-ILETIEKISQHSIAIKVSN---PNFIKLNNTFLQCFKKYNTIANLITNSHSFNLTRY-FRQI 780  Herpesvirus saimiri...
F5HEU7  730 MTTIAKPIYPAYIRLLQ-RLEYLNRLNHHILRIPFPQ---DALSELQETYLAAFARLTKLAADAANTCSYSLTKY-FGVL 804  Human herpesvirus 8...
Q66665  756 LSQACQDLQRFYAACLG-ILDQNQFLATHPVQLDLSE---PDFQAVKETLLGCLRRYREVASLAAGSCCFSLTRH-FGAL 830  Equid herpesvirus t...
O36413  735 LNESSRELHASYLDLQV-ISSDIDSMRNHSIKFDHAS---LNFKGMKDFYIKCFALQNKLASKIANTCCYSLTRR-FAPL 809  Alcelaphine herpesv...
Q6SW85  767 LNERLLSVRVRVRQ----ISSDTEEVSRHA-----------KGHRTVAQMSKALKKTASKIKMLETRVTLALEQA----- 826  Human herpesvirus 5...
P52437  891 IQISEITLTGMLRNIITsVSSSKELLTNEAL----------------QKFIDTVQRISQHVNETYHSISVNLEKC----- 949  Human herpesvirus 6...
P03189  943 FQPPAIDAERAEAIVRRD--ARPPPVFI-----PAPRRLPQGga-----------dTPPPLSMDDILYLGKSICKALvdv 1004 Epstein-Barr virus ...
Q01055  781 FEPELIPITTVQKILNFNdeTDDPQPFLdslsqPLYSHTNAP--------------KKSELTSEDFNRLLEFANPVF--- 843  Herpesvirus saimiri...
F5HEU7  805 FQHQLVPTAIVKKLLHFDeaKDTTEAFLqslaqPVVQGQRQGaa-----------gGSGVLTQKELELLNKI-NPQFtd- 871  Human herpesvirus 8...
Q66665  831 FDPPLITEAVVRKVLEFSeeRDTTDAFIeslqqPIAKVEEEDwdd---------apPKHALNDYDLTALREI-NESFplp 900  Equid herpesvirus t...
O36413  810 FEPELISLQTVENILNFSdtVDDPSVFLsginqPMGCVPPNCqq-----------gAVEKLSKQDVLDIREL-APDFte- 876  Alcelaphine herpesv...
Q6SW85  827 QRSNGAVVTAVQRALAVFdvLSRENLERrgaqlCLTEATSLLhrhralapmtwpagTGVAAAAEADGALREFLEAPW--- 903  Human herpesvirus 5...
P52437  950 KTSNDILIESLKKIIYIVdvLSSNAILNtslasRCLEAANLAvsn--------nsfTILEIKKDAVAVFKPFITQLFe-- 1019 Human herpesvirus 6...
P03189 1005 ldhhpaapETTP-----IK-TYTPAMDLNPEQIT 1032 Epstein-Barr virus (strain B95-8)
Q01055  844 --------ETAPs---sIKlHYSDTFNTPQVNIN 866  Herpesvirus saimiri (strain 11)
F5HEU7  872 ------aqANIPp---sIKrSYSNKYDVPEVSVD 896  Human herpesvirus 8 strain GK18
Q66665  901 kqhgnnppETTPs----IKlSYTDSVNVSQITLD 930  Equid herpesvirus type 2 strain 86/87
O36413  877 ------gaSSAPanatvIKhNFTGTFDKVSIDLD 904  Alcelaphine herpesvirus 1 strain C500
Q6SW85  904 --------ESAPq---pPRlRMTPDTDHEESTAg 926  Human herpesvirus 5 strain Merlin
P52437 1020 --------SMKPttslhKKlMSTQKLTTDHIPfl 1045 Human herpesvirus 6 (strain Uganda-1102)
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