Conserved Protein Domain Family
DUF1863

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pfam08937: DUF1863 
MTH538 TIR-like domain (DUF1863)
This domain adopts the flavodoxin fold, that is, five parallel beta-strands and four helical segments. The structure is a three-layer sandwich with alpha-1 and alpha-4 on one side of the beta-sheet, and alpha-2 and alpha-3 on the other side. Probable role in signal transduction as a phosphorylation-independent conformational switch protein. This domain is similar to the TIR domain.
Statistics
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PSSM-Id: 430330
Aligned: 24 rows
Threshold Bit Score: 73.5911
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9A8E1         8 YKAFISYSHHDRKaaEWLH----RSLESyrppAGlraglGEASGNALKPIfRDRDELsaaaDLSEAI-RDALDRSDTLII 82  Caulobacter vib...
Q2LRS2        24 HRVFVSYHHNGDQ--AYYDkftkLFANGyeiiTDts--------------iERQIGSdsvtYQQQVIrEQHITGSSITIV 87  Syntrophus acid...
Q2NGB5         3 SNIFLSYYHEDKE---YSDkfqeLFQNLntktIR-----------------LTNNDYssdeYISNIInENNITNTTTTIV 62  Methanosphaera ...
Q21ZJ7         6 KNVFISHVHADDA---GLGklktLLAKSgmdiRDssi------------nsSNPNNAkspdYIKSEIlAPQINWAGTLLV 70  Rhodoferax ferr...
Q122B7         5 RNIFISHIHADDS---RLQplkdLLNQSgfeaRDgsi------------nsSNPNNAsspdYIKSSIlAPRIQWASVLVV 69  Polaromonas sp....
Q6MN07         5 DQVYVCFDADEDM--DYYRtmkmWVGNkni-------nfDFNNAHDLNTLrDGSSEE----TIKRKL-RERMNNAGLLVV 70  Bdellovibrio ba...
Q6LJM5         2 KRIFISHNHRDSK---TINliksIYCNPnhnlNFankslAAPIFNDHQHInRRPPTDsaskPVKQEI-SRLLNESDKLLV 77  Photobacterium ...
WP_011770797   2 KRIFISHNHRDTA---SINliksLNSNPnnnlLFknkslSSPIYNDYNHInRRSPNDnasnPVKKEI-SSLLAQSDRLLV 77  Psychromonas in...
WP_011714671   7 YQLFISHSWTYRD---TYEklveLFDE------HpnfiwVNHSIPKDDPIhNAENDK----KLYEAI-KDKMYPVNCVVM 72  Magnetococcus m...
WP_020457801   7 YDLFISHAWKYND---DYYrlvdLLNK------ApnfkwRNYSVPQHDPV-IDPDDPvdqkTLIEEL-KGQIRPVNCVLI 75  Acetivibrio the...
Q9A8E1        83 LCSSHA-ATSRWVDKEVAhfltlrgadhmisviapgapeglplmellppalraalpegveplavdlrqdadgrrlAKLK- 160 Caulobacter vib...
Q2LRS2        88 LCGAET-WKRRWIDWEIH---------------------------------------------------------MTLN- 108 Syntrophus acid...
Q2NGB5        63 LVGPKT-YKRKHIDWDIY---------------------------------------------------------AALK- 83  Methanosphaera ...
Q21ZJ7        71 YVSPKT-KDSDWVNWEIE---------------------------------------------------------YAVK- 91  Rhodoferax ferr...
Q122B7        70 LISQNT-QHSEYVNWEIE---------------------------------------------------------YAEK- 90  Polaromonas sp....
Q6MN07        71 LVGEKTrNLYKYVRWEIE---------------------------------------------------------IALK- 92  Bdellovibrio ba...
Q6LJM5        78 LIGPDT-HSSLWVQWEINa-------------------------------------------------------fTSKH- 100 Photobacterium ...
WP_011770797  78 LVGPDT-HSSLWVQWEINa-------------------------------------------------------fISKH- 100 Psychromonas in...
WP_011714671  73 LAGVYS-THSKWINNEIK---------------------------------------------------------IAKQf 94  Magnetococcus m...
WP_020457801  76 LSGMYA-AYSFWIQKEID---------------------------------------------------------ISVD- 96  Acetivibrio the...
Q9A8E1       161 IAARLLGVSLDRLVqrDARRRlr--lMTAVSGVALAI 195 Caulobacter vibrioides
Q2LRS2       109 KEHALLGIALPTATrnSAGQIi---vPDRLHANIISG 142 Syntrophus aciditrophicus SB
Q2NGB5        84 QKSSLIGICLPNRNdyRLNNLiletyPPRLHDNVTSG 120 Methanosphaera stadtmanae DSM 3091
Q21ZJ7        92 QGKRIVGVWEHGTKdcEV--------PSALAEYADAM 120 Rhodoferax ferrireducens T118
Q122B7        91 QGKRIVGVWDHGAGqcDI--------PEALDKYADAI 119 Polaromonas sp. JS666
Q6MN07        93 DGIPIVVANLNGKRsfDDHRC-----PAILDNELALH 124 Bdellovibrio bacteriovorus
Q6LJM5       101 SSSNILMMRIPDNQt----------aGAPANARHLSI 127 Photobacterium profundum
WP_011770797 101 GSNHVLLMRIPNDSt----------sGTPANAKHFPI 127 Psychromonas ingrahamii
WP_011714671  95 YGKPIIAVEPWASEk----------tSQPVKNNANAI 121 Magnetococcus marinus
WP_020457801  97 YGKPIIGIKPWGQEr----------iPKAVSDVAIEI 123 Acetivibrio thermocellus
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