Conserved Protein Domain Family
BPL_N

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pfam09825: BPL_N 
Biotin-protein ligase, N terminal
The function of this structural domain is unknown. It is found to the N terminus of the biotin protein ligase (BPL) catalytic domain. This domain is essential in BPL activity.
Statistics
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PSSM-Id: 462915
Aligned: 87 rows
Threshold Bit Score: 299.05
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
KIS68258       2 SDVLVYSGPGVSTSALHHTLKTLRTLLT-TYDVKTVDAKTLALDPWQKGTALVVLPGGRDLPYVSELArpftrniddnia 80 
EPB92499       1 MNVLIYNGNGTSLNAVNQTYTTLKAILGhAYDIMKVDATTLKSEPWEETCSLLVVPGGRDSPYCQDLD------------ 68 
EPB90018       1 MNILVYNDLGASPNSVKHTYNTLKTILGhVYDIIQIDRKVLQNEPWEVGCVMLVMPGGRDMPYCEALN------------ 68 
XP_009267554   1 MNILIYDDQGCSATSIAHLKSQLTRFLSpCYSIQSVSAAVLANEPWEEYTAAVVIPGGRDLPYLHSLR------------ 68 
EIM23741       1 MNVLIYDGPGTSPTSVRRLQQEMVTNLVdKYSIQLVSPEILANEPWEEHTRAIVIPGGRDLPYLQCLN------------ 68 
KDE03003       5 VNILVYNGSGVSAASLAFTVASLKAYAShHYDVQLVSPKTLRSDPWTETCALLVFPGGRDLLYLFDLQ------------ 72 
CEL58996       3 LDVLVYQGPGVSEASLYHTLATLNTLLRpNYTVRAVDAKLLETEPWGPSCALLAIPGGRDLPYVEHLA------------ 70 
CCA70934       1 MNVLVYSGPGVSETSLYCTISTLKDILGtSFAIQTVSPKVLETEPWAPTCALLVIPGGRDLPYLSALG------------ 68 
XP_002174237   1 MNVLIYSGTGTSKIALTRTYQSLLRMVVpHYALRYVDVRTLDNEPWTSSTALLVIPGGRDLGYCKDFT------------ 68 
O14353         1 MNVLIYNGNGASKICLLRTFQSLLPFVVpLYAMRFVDASTLEKEPWPASTALLVMPGGRDMGYCSSFN------------ 68  Schizosaccharom...
KIS68258      81 pssapeRTASRQLRNYVES-GGNFVGICAGAYYASSHCTFEKG-TDMEVDGERPfLRFFPGTCQGTVYPGFVYESDKGAR 158
EPB92499      69 ------GQGTTKIKDYVHG-GGHYVGFCAGAYFASKNIEFEKG-KELEVVGQRE-LGFYPGISRGTMFPGFVYNSEKGAR 139
EPB90018      69 ------GRPNARIRAFVEQ-GGRYLGLCAGAYYASTNIEFEKGrALMEIIQPRE-LGFYPGLCRGTTYPGFVYNSESGAR 140
XP_009267554  69 ------GTLIARLKRYIFN-GGRYLGVCAGAYFACKRVEFAVGdESLAIVGDRP-LNLIDALAVGPALPNFQYNSERGAH 140
EIM23741      69 ------GKAMRKIKEYVNN-GGKYFGVCAGAYFACRSIEFAKNdPQLAIIGDRP-LKFVDGVAVGPTFDGFEYNSENGAH 140
KDE03003      73 ------GEANRRIEQWVTNhGGKYLGFCAGAYYASKEIEFERG-TRLEVVGQRE-LGFFPGMCKGAVFAGFEYDSEAGAR 144
CEL58996      71 -------KAIPKIKEFVEK-GGAYLGICAGAYFGSARVEWEVG-TPLQVVGERA-LKFFPGTSRGCAYPGFEYESEAGAQ 140
CCA70934      69 -------PAMKTIATYVRK-GGSYLGICAGAYFASGRIEWEMG-TPLEVQGERP-LKFFPGLSRGCMYPGFQYESENGAR 138
XP_002174237  69 ------EKTYQKVKEFVRR-GGSYLGICAGGYFASGKVDFRMEdSKLNVVGPRK-LAFFPGTCKGPTYPGFVYDSESGAR 140
O14353        69 ------ETIYRKITDFVKR-GGAYLGLCAGGYFGSAVVDFRMPdSDLNVVGKRK-LQFFPGTCAGPTFPGFTYDSEDGAR 140 Schizosaccharom...
KIS68258     159 IVDIERvt--------gHsQKDQWRCHYNGGGAF-M--NADTWAEr--gVEVLACYTkaqtDDLLLDIDLnggtawkrpn 225
EPB92499     140 AVSILH-------------QKQSFKAYYNGGGYF-V--RPQEHDQ----VKVVCTYQ----DSGLCQDED---------- 185
EPB90018     141 SVTVDLgretlspyyhgEgVPQEINMYYNGGGYF-V--HPEKFDN----VTVLCRYK----EPSNLPESEp--------- 200
XP_009267554 141 LAEVEVeasthkhthtrTqAHDKLLLYLNGGCAFdI--GSTSTQDtdtdTSILATYS----HN----------------- 197
EIM23741     141 LVQLNYn------------DGSSGGCYLNGGCSFnV--DPAK-------GEVLARYA----HD----------------- 178
KDE03003     145 EVSIALernvw--rdhwSsSPEKLEVWYNGGGHF-VlaENSIMSEqrsrIGVLARYEq--iEG----------------- 202
CEL58996     141 LLDITAtih------geDsEQTFEGIYYNGGGVF-E--DADTPQMralgVLVTARYPn---------------------- 189
CCA70934     139 TVSVRM-----------SdGRIRNGLYYNGGGEF-I--LSNDTPN----VTPLAFYDdsekP------------------ 182
XP_002174237 141 AAPLALspdl----svpGaTDGIVKIYWNGGGSF-V--DAHKYEN----VRILARYNdlpeSQn---------------- 193
O14353       141 RASIIVdgm--------qssPVHTHIYFNGGGSF-L--ETENYSN----VKVVARYQetdfE------------------ 187 Schizosaccharom...
KIS68258     226 ydGQAAVVLCSVGL--GKALLFGTHPEFPLlatstPVLlAenGQvdAQEHKDHKeRARQLRLHEQRRLQWLHELFTqRLG 303
EPB92499     186 --EVAAGVQCRVGS--GSALLFGFHPEYDV------------SMvdLSDNDNKEqITRELEASLPTCREFLGQLLS-DIG 248
EPB90018     201 --HPAAVVHCSVGQ--GHALLIATHPEYDI-----SSQ-DllLAdgNTVTQAVRnILCELTLSEVERKRFLRASFA-LIG 269
XP_009267554 198 --GSVAALQRRYGN--GRVVVTGVHPEFSLkcppaSLV--------AGEQHLQH---LELDQLEQARIAHLRTLLN-ALA 261
EIM23741     179 --GSIAAYHI------GDVVVTGLHPEFSIralpaSML-------------VVNeDPKSVAKMEQARINHFRKLLG-ALK 236
KDE03003     203 --RPIAGVVCDVGNkgGKAILWSVHPEHPS----------------LATNSSKAsSSLDFDTKEALRRALLRSTLA-LLD 263
CEL58996     190 --GKPGAVTCAVGR--GTAALWGLHPEYAI---------SkePYrtALQNSSQK-DPSDVATRESRRLELMRGVLA-GLG 254
CCA70934     183 --NTVAAVSCRVEE--GNAVLWHVHLEYPT---------TseLVksAAARVFQTlSESDVTKVESERKEIMLESLR-ILR 248
XP_002174237 194 -nEQASVISMNVGR--GRVILTGVHPEFET----------------DGCEGHEK-------RDETLRLEFLRCLLQ-DLN 246
O14353       188 --KSAAIIYVKVGK--GNVVLTGIHPEFSA----------------EGSPILDK-------RDEKTRLELLSYILK-LLG 239 Schizosaccharom...
KIS68258     304 LRSElpqwaasaavsaagdaaagntiAAGtaieTDEPKLQPIFLAL 349
EPB92499     249 LKVKkv--------------------------eQSVPDLTPIYLAT 268
EPB90018     270 LSVVp--------------------vENTivqeNKVPDVTPLYLSG 295
XP_009267554 262 LHLKpi-------------------------deAKPVGLLPMLLVG 282
EIM23741     237 LELSpi-------------------------eeSKPKGLLPLVLTS 257
KDE03003     264 VQVS----------------------EEA----APPPKLLPLFLAS 283
CEL58996     255 LTIPgg-------------------aASTklsdTPLPQL---LCAS 278
CCA70934     249 LKTS----------------------NPPeiptNPLPQY---ICAT 269
XP_002174237 247 IKIN-----------------------EDynseQWKPSLH--YLIT 267
O14353       240 LKVP-----------------------KDts-kCGQPTLTDQYLFP 261 Schizosaccharomyces pombe 972h-
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