4M48


Conserved Protein Domain Family
SLC6sbd_SERT-like

?
cd11497: SLC6sbd_SERT-like 
Click on image for an interactive view with Cn3D
Na(+)- and Cl(-)-dependent monoamine transporters, SERT, NET, DAT1 and related proteins; solute binding domain
This subgroup represents the solute-binding domain of transmembrane transporters that transport monoamine neurotransmitters from synaptic spaces into presynaptic neurons. Members include: NET which transports norepinephrine, SERT which transports serotonin, and DAT1 which transports dopamine. These transporters may play a role in diseases including depression, anxiety disorders, attention-deficit hyperactivity disorder, and in the control of human behavior and emotional states. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.
Statistics
?
PSSM-Id: 271388
Aligned: 12 rows
Threshold Bit Score: 876.258
Created: 8-Jul-2011
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
 
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:Na binding site 2 [ion binding site]
Evidence:
  • Comment:based on Aquifex aeolicus LeuT (SLC6) with structure
  • Comment:One of two Na+ binding sites in Aquifex aeolicus LeuT. It binds the Na+ ion designated Na2, and appears conserved in Vibrio parahaemolyticus vSGLT and other SLC5 proteins

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                    #  #                                                             
4M48_A      8 RETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLAVGGIPLFYMELALGQHNRkGAITCWgRLVPLF 87  fruit fly
NP_998737 119 RETWSKKIDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLIPYTIMAIFGGIPLFYMELALGQYHRnGCISIWrKICPIF 198 chicken
AAB67676   69 REHWGKKIDFLLSVVGFSVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNReGAATVW-KICPCF 147 bullfrog
Q01959     60 RETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNReGAAGVW-KICPIL 138 human
NP_523846  74 RETWGQKAEFLLAVIGFAVDLGNVWRFPYICYQNGGGAFLVPYCLFLIFGGLPLFYMELALGQFHRcGCLSIWkRICPAL 153 fruit fly
AAK94482   29 RESWGKKIDFLLSVIGFAVDLGNVWRFPYVCYKNGGGAFLIPYLIMLIFGGLPLFYMELALGQFQRcGCFTVWkRLCPML 108 California sea hare
ABA39884  143 REIWDSKIDFLLAVIGFAVDLGNIWRFPFICYRNGGGAFLIPYLVMYIFGGLPLFYLELALGQYQRsGCLTVWkRICPLF 222 Schistosoma mansoni
ABG91820  108 RETWNKKADFLLSIIGFAVDLANVWRFPYLCYTNGGGAFLIPYFTMLICGAVPLFLMELIMGQYQRqGAITVW-KIAPLF 186 common earthworm
NP_491095 100 RDKWATKMEFLLAVVGYAVDLGNIWRFPSVCYKHGGGAFLIPYFIMLMIGGLPMFYMELVLGQFHRsGCVSIWrKVCPLF 179 nematode
EFX85431   71 RETWAKKAEFLLAVIGFAVDLGNVWRFPYICYKNGGGAFLIPYVVMMVFGGLPLFYMELALGQFHRsGCLTLWkRICPAL 150 common water flea
EEN68333   60 RGTWDKKTDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLIPYLTFFLIGGLPLFYMELILGQFNRtGAISVWeHVCPIL 139 Florida lancelet
AAZ08593  178 RETWGTGADFLLSIIGFAVDLANVWRFPYLCYRNGGGAFLIPYTLMLIFGAVPLFYMELILGQYNRqGPITLW-KICPLF 256 cabbage white
Feature 1                                                                                     
4M48_A     88 KGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASF----TNSLPWTSCNNIWNTPNCRpf---------------------- 141 fruit fly
NP_998737 199 KGIGFAICIIDLYVASYYNTIMAWVFYYLVSSF----TTELPWTSCNNAWNTGNCTtyf--------------------- 253 chicken
AAB67676  148 KGVGYTVILIALYVGFYYNVIIAWSLYYLASSF----TSELPWTTCGNVWNTPNCTdptlln------------------ 205 bullfrog
Q01959    139 KGVGFTVILISLYVGFFYNVIIAWALHYLFSSF----TTELPWIHCNNSWNSPNCSdahpgds----------------- 197 human
NP_523846 154 KGVGYAICLIDIYMGMYYNTIIGWAVYYLFASF----TSKLPWTSCDNPWNTENCMqvt--------------------- 208 fruit fly
AAK94482  109 KGIGMAICIIATLVSWYYNTIVAWAVYFLFSSF----TNSPPWLSCNNTWNTPNCTtfsdrilpytekcetevlsynhtm 184 California sea hare
ABA39884  223 SGVGFGICIIASYTAWYYNTIIAWALFYMIDAM----KPHIPWDGCNNWWNTNSCVtvyerlinhsilnashk------- 291 Schistosoma mansoni
ABG91820  187 KGIGICQCLIAFYVAFYYNVIIAWSLYYLVSSF----AYVLPWTTCNNTWNTMNCIdgsama------------------ 244 common earthworm
NP_491095 180 RGIGYGICCICTFIAIFYNAIIAQAVYFAIVSLskiwDSEVPWASCGNPWNTPRCSddlnv------------------- 240 nematode
EFX85431  151 KGVGYAICIIDFYMGMYYNTIIGWAVYYFVASF----TSELPWTSCDHPWNTNSCAlvg--------------------- 205 common water flea
EEN68333  140 KGVGYAVIIIAFFVDLYYNVIITWSFFYLFASF----TTKLPWTSCDNEWNTPDCIdqltddfvn--------------- 200 Florida lancelet
AAZ08593  257 KGVGFCAVMVAFYVSFYYNVIIGWALYFLVSSA----RSELPWLHCNNLWNTDQCWdasrqnt----------------- 315 cabbage white
Feature 1                                                                                     
4M48_A    142 -------------------------------------esQGFQS------AASEYFNRYILELNRSEGIHDLGAIKWDMA 178 fruit fly
NP_998737 254 ------------------------------------skdNISWAlhs-isPAEEFYTRQVLQVHRSNGLDDLGGISWQLT 296 chicken
AAB67676  206 ----------------------------------asffgNGTKYskykltPATQFYEREVLHLHESAGIHDLGLPRWQLT 251 bullfrog
Q01959    198 --------------------------------sgdssglNDTFGt----tPAAEYFERGVLHLHQSHGIDDLGPPRWQLT 241 human
NP_523846 209 -------------------------------------seNFTELat---sPAKEFFERKVLESYKGNGLDFMGPVKPTLA 248 fruit fly
AAK94482  185 lnttammndteagvsihlvnatqykravcrlvkevdtsgNFYATa-----ASTEFFERNVLELQHADGISSVGGVKTTLA 259 California sea hare
ABA39884  292 -----------------------yelnelvnlsiaslkiNGSGKvf---sSTEEYFYRRVLQIQYAEGYNNVGPIRWEIS 345 Schistosoma mansoni
ABG91820  245 ----------------------------------ngstsNESTT------AAAEFFERGVLGLQESSGIGDIGLPRKYLV 284 common earthworm
NP_491095 241 -----------------------------------tisrNGTPLt----tPSEEYYLYKVLEVQKSTGFDDLGGVKTSMA 281 nematode
EFX85431  206 ------------------------------------pvdNGTFVr----sPAQEYFERNVLENYRSDGMDDLGPIKWSLA 245 common water flea
EEN68333  201 ------------------------------gtdgfnatvNETRRgi---sPAAQYYEREVLQLYKSEGIGDFGDLQWKLA 247 Florida lancelet
AAZ08593  316 ---------------------------------tnktdiSYQGPlsh-ftPASEFFHRAVLEMQYSEGLNDLGFPKWQLT 361 cabbage white
Feature 1                                                                                     
4M48_A    179 LCLLIVYLICYFSLWKGISTSGKVVWFTALFPYAALLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWADAATQVFFS 258 fruit fly
NP_998737 297 LCLLLIFIIVYFSIWKGVKTSGKVVWVTATFPYVILFILLVRGATLPGAWRGVLYYLKPEWQKLLATEVWVDAAAQIFFS 376 chicken
AAB67676  252 LCLFAVLIVLFFSLWKGVKTSGKVVWITATLPYVVLFVLLIRGVTLPGSFKGISAYLHIDFKRLKEPGVWIDAATQIFYS 331 bullfrog
Q01959    242 ACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSVDFYRLCEASVWIDAATQVCFS 321 human
NP_523846 249 LCVFGVFVLVYFSLWKGVRSAGKVVWVTALAPYVVLIILLVRGVSLPGADEGIKYYLTPEWHKLKNSKVWIDAASQIFFS 328 fruit fly
AAK94482  260 LCLFGVFFIVYFALWKGIKSSGKAVWITATLPYVVLLILLCKGCTLPGAGDGIVYYLSPQWEKLLNLEIWIAAAAQIFFS 339 California sea hare
ABA39884  346 LCLMAVFTIVYFSLWKGVKSSGKAVWVTATLPYVILSILLIRGLTLEGSLTGIKYYLTPNFSSLLSISVWSDAASQIFFS 425 Schistosoma mansoni
ABG91820  285 LCLFGVFIMIYFSLWKGVHSSGKVVWVTATMPYVVLSILLVRGLMLPGASIGIMYYITPKLERLGDPKVWIDAAIQIFYS 364 common earthworm
NP_491095 282 VCLLAVFIMVYFALWKGPQSSGKIVWVTATAPYIILSILLIRGLLLPGAKNGLYYYVTPDFEKLKDPAVWSAAATQIFFS 361 nematode
EFX85431  246 LCVFAVFVLVYFSLWKGVRSTGKAVWITAVAPYIVLIILLFRGASLPGAGDGIRYFLTPQWSKLAETKVWTDAASQVFFS 325 common water flea
EEN68333  248 LCMLGVFLLLYLSLWKGVRSSGKVVWVTATMPYIVLTILLIRGATLPGASEGIKYYLTPNFDRLMDSQVWIDAAQQIFYS 327 Florida lancelet
AAZ08593  362 ICLGIVYITLYLSLFKGVKSSGKVVWMTATMPYVVLSILLARGLLLPGATRGIAYYLHPELSRLKDTQVWVDAAVQIFYS 441 cabbage white
Feature 1                                                                                     
4M48_A    259 LGPGFGVLLAYASYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHtlg-vrIEDVATEgPGLVFVVYPAAIAT 337 fruit fly
NP_998737 377 LGPGFGVLLAYASYNKFHNNCYQDALVTSTVNCLTSFVSGFVIFTVLGYMAEmrnedvSEVAKDMgPSLLFITYAEAIAN 456 chicken
AAB67676  332 LGAGFGVLIAFASYNKFDNNCYRDALLTSTINCVTSFISGFAIFSILGYMAQknn-vkIEDVATEgPGLVFIIYPEAIST 410 bullfrog
Q01959    322 LGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQkhs-vpIGDVAKDgPGLIFIIYPEAIAT 400 human
NP_523846 329 LGPGFGTLLALSSYNKFNNNCYRDALITSSINCLTSFLAGFVIFSVLGYMAYvqk-tsIDKVGLEgPGLVFIVYPEAIAT 407 fruit fly
AAK94482  340 LGPGFGVLLALSSYNKFHNNCYRDALITSATNCLTSFLAGFVVFTVLGYMAHvqh-rtVETVARQdVGLIFVVYPEAVAT 418 California sea hare
ABA39884  426 LGPGFGVLLALSSYNKFHNNCYRDAMITSFINCATSFVSGFVVFSVLGYMCFrmg-ktMEDVANEgPGLVFIAYPEAIAT 504 Schistosoma mansoni
ABG91820  365 VGAGFGVHIAFASYNKINSNCYRDCLATVCVNSFTSLFSGFVIFSYLGYMSIrqk-kdISVVAAEgPGLVFVVYPEAIAT 443 common earthworm
NP_491095 362 LGPGFGVLLALSSYNDFNNNCYRDAVTTSIINCATSFFSGCVVFSTLGYMSLltnkpiNEVVGEHdASLIFIVYPQALAT 441 nematode
EFX85431  326 LGPGFGTLLALSSYNKFHNNCFYDALLTSSINLATSLLAGFVIFAVLGYMAEirn-vsIDQLGLEgPGLVFVVYPEAIAT 404 common water flea
EEN68333  328 LGAGFGVLIALSSYNKFHNNCYRDALVTSSVNCMTSFFSGFAIFSVLGYMSQkrg-vpIDKVATEgPGLVFVVYPEAIAT 406 Florida lancelet
AAZ08593  442 VGAGFGVHLSYASYNTFHNNCYRDCLVTTLVNCFTSFFSGFVIFTYLGFMSHkqg-vpISSVATEgPGLVFQVYPEAVAT 520 cabbage white
Feature 1                      #  ##                                                          
4M48_A    338 MpaSTFWALIFFMMLATLGLDSSFGGSEAIITALSDef-----------------pkIKRNRELFVAGLFSLYFVVGLAS 400 fruit fly
NP_998737 457 MpaSTFFAIIFFLMLLTLGLDSTFAGLEGVITGVLDefp----------------hvWSKRREFFVLGLIIICFLGSLAT 520 chicken
AAB67676  411 LrgSTFWAVVFFIMLLTLGIDSAMGGMEAVITGMADdf-----------------siVKKHRKAFTFAVAFITFLLALLC 473 bullfrog
Q01959    401 LplSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDef-----------------qlLHRHRELFTLFIVLATFLLSLFC 463 human
NP_523846 408 MsgSVFWSIIFFLMLITLGLDSTFGGLEAMITALCDeyp----------------rvIGRRRELFVLLLLAFIFLCALPT 471 fruit fly
AAK94482  419 LegTSFWAVIFFFMLIMLGLDTTFGGLEAIITGILDew-----------------tfLRRHRELFVAGLMLWCFLGGLVT 481 California sea hare
ABA39884  505 LagSTFWAIIFMLMLITLGLDSTFGGLEAIITAIMDsv-----------------paLSGRREVFVLAVVIYCFIGALPS 567 Schistosoma mansoni
ABG91820  444 LpgSVGWSILFFVMLITLGIDSAMGGLEALLTGLSDewks-------------vikrYRFGREALTGMVVFGAFLFALPN 510 common earthworm
NP_491095 442 MdySCFWSFIFFVMLITLGIDSTFAGIEAFITGFCDes-----------------rfLSKNRKWFVLVICIIYYFLSFPA 504 nematode
EFX85431  405 MagSTFWSMIFFFLLITLGLDSTFGGLEAMITGLCDeyp----------------vlLGRRRELFVGILLVFIYLCALPT 468 common water flea
EEN68333  407 LpgSTAWAIIFFLMLITLGIDSSVTWFSTCLCVIAClkkkmggteailtglsdefpiLTRKRELFTGVILFVEFSLALIN 486 Florida lancelet
AAZ08593  521 LpgASLWAMLFFFMLIMLGLDSGMGGLECVITGLLDaara--------------sgaRWLRREHFTLLVVCLSFCIACIN 586 cabbage white
Feature 1                                                                                     
4M48_A    401 CTQGGFYFFHLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIFLLFITVYLLIGY 480 fruit fly
NP_998737 521 LTFGGAYVVKLFEEYATGPAVLTVVFLEAVAVAWFYGITQFCNDVKEMLGFAPGWYWRVCWVAISPIFLLFVTCSFLSNP 600 chicken
AAB67676  474 ITNGGIYVVTLLDTFAAGTSILFAVLIEAVGVSWFYGVDRFSDDIYRMLGFRPGLYWRLCWKFVSPAFLLFVVITSIVTH 553 bullfrog
Q01959    464 VTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSIVTF 543 human
NP_523846 472 MTYGGVVLVNFLNVYGPGLAILFVVFVEAAGVFWFYGVDRFSSDVEQMLGSKPGLFWRICWTYISPVFLLTIFIFSIMGY 551 fruit fly
AAK94482  482 TTYGGIYVIQLMDTYGAPISILLIVFLEAVAVSWIYGVDRFSHDIETMLGTAPGPFWRVSWTYISPLFLLVLFILSLMTS 561 California sea hare
ABA39884  568 TTCGGYLVLTMLDRHGAPISILFIVFCECVALCWFYGTKRFCNDVQMMLGFKPGIFWQICWAYISPIFLLGIFIANIVSY 647 Schistosoma mansoni
ABG91820  511 VTNGGMYLVTIWDRFAAGTAILFGVFSQAVAVSWFYGMEQFCKDAEQILGFRPNLYWRLTWKFISPIFILGIVISSVVSF 590 common earthworm
NP_491095 505 ISYGGQFVIPFLDEYGVSLSVLFIVTCEMIAVCWFYGVDQFSKDIRAMLGFYPGIYWRVCWTCSPVFISVIFIMTVYNSS 584 nematode
EFX85431  469 TTYGGMYLVDLLNVYGPGIAILFLVFVEAMGVSWCYGTQRFSDDIESMLGFQPGPFWKITWAYVSPIFILLIFICTLIDP 548 common water flea
EEN68333  487 VSQGGMYMFHMLDQYAAGTSILFAVLFEAIGVSWLYGMRQFKQDVEEMLHFTPGLWWRFCWKFVSPLFLLFITIFSIVQY 566 Florida lancelet
AAZ08593  587 VTPGGIYMFHLLDTYAAGISLLCSALFEAVAVSWFYGLKRFSDDVEEMLGFRPGLYWRICWKFISPIFIIGVVVFGLLYQ 666 cabbage white
Feature 1                                                            
4M48_A    481 EPLTYADYVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPGsLRQRFTILTTPW 535 fruit fly
NP_998737 601 PELRLFDYNYPYWTTVVGYCIGTSSIICIPIYMAYRLIITPGtLKERILKSITPE 655 chicken
AAB67676  554 SPLSYDDYNFPPWANRTGWAIALSSMLLVPIYSVYKFFTVPGtFEQKLGYCITPE 608 bullfrog
Q01959    544 RPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGsFREKLAYAIAPE 598 human
NP_523846 552 KEMLGEEYYYPDWSYQVGWAVTCSSVLCIPMYIIYKFFFASKgGCRQRLQESFQP 606 fruit fly
AAK94482  562 PPPQYGDYVYPYWSLAVGWLIVCITLVSIPIFIVISFFNSKGtFKERIYQMITPT 616 California sea hare
ABA39884  648 ETQPVSVLGVVYEPTTWVIVLSWAIVFSSPIFIPILMIYKLLkAKGTFVERLRFL 702 Schistosoma mansoni
ABG91820  591 EPLEYKTYTMGNYTFPVWANVVGWGIALSSMSFIPIVAVYQLcSFRGPWIQRLAL 645 common earthworm
NP_491095 585 FKPIQMASYTFPWWSVILGWFLRLLSVLAIPVFAIIYLLSGTgTLYERFRWAITP 639 nematode
EFX85431  549 VPLDTQDYTYPAWSIKVGWVLTAIPLSCIPIYMIYKLIITKGtFVQRLVKMFTPE 603 common water flea
EEN68333  567 RPLAYETYVYPPWGVGLAWCLSASSMVFIPGYAIFKLLKLQGpFRERIAYAITPA 621 Florida lancelet
AAZ08593  667 QPLQYQNYMYPQWAVVLGWGLACSSILMIPIVAIYKLISTPGnCRQRIACCISPI 721 cabbage white

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap