Conserved Protein Domain Family
TFP_LU_ECD_PATE2
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cd23578: TFP_LU_ECD_PATE2 
extracellular domain (ECD) found in prostate and testis expressed protein 2 (PATE2) and similar proteins
PATE2 (also called PATE-like protein M (PATE-M)) is a member of the prostate and testis expression (PATE)-like family of proteins that likely play important roles in reproductive and neuronal physiology. They are expressed mainly in the male genital tract and involved in sperm-oolemma fusion and penetration, but not sperm-zona binding. PATE2 contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).
Links
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Statistics
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PSSM-Id: 467108
Aligned: 16 rows
Threshold Bit Score: 77.7507
Created: 1-Mar-2021
Updated: 27-Apr-2023
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q6UY27        27 TEIMCYeCKKyhlglCYGVMtsCSLkh----kQSCAVENFYILtrkgq-smyhYSKLSCMtsCEDinf-lgfTKRVELIC 100 human
XP_007495138  27 PEVVCSvCQKfkkgsCMHSLgtCSTkl----qKICRSQSYFQYseeakewsftHSKLECVedCGKpiv-lraWYRVVNLC 101 gray short-tail...
NP_001347990  26 LLRHCNlCSHhdglkCRNGMksCWKfdlwtqnRTCTTENYYYYdrftglylfrYAKLNCKp-CAPgmyqmfhDLLRETFC 104 house mouse
XP_003764436  26 ADKNCNlCTVfhmgfCYTGMksCAAsa----gDHCATKNIYVIqntge-aryhYSKLTCKsnCVNedm-tskRKRVEILC 99  Tasmanian devil
XP_007495140  32 EGLICHvCKTfvngrCLEGEdtCLMdl----vSGCEARVFFKTfhnv--wyniSASLNCNtrCKEssg-vvqGRSFKVFC 104 gray short-tail...
XP_020856226  32 EGVACHvCKRfvngrCLESKdsCVKev----pSGCETKVFYLIvnhv--wqstYARLNCNsvCKEteg-idnGMHFKIFC 104 koala
ELR46877      27 WFQLCRrCEFhngysCNHVIgsCWKfkianlkRACVTDNFYYYdrvadrynyrYSVLSCRt-CEEgsfmlfhDLYRETFC 105 wild yak
NP_001254709  22 QERICMsCHMfvngkCVESEgkCTMed----gGACRTRDIYLFnargg-flynHTMLECSksCKAsee-syfHLKISTFC 95  Norway rat
KFO31377      18 GLRYCHeCKHfdgdiCQTGMksCWKfnvlmynKSCSTENFYFYdrntgrylfrYTVLSCRp-CAAgivqvfhDLLSETFC 96  Damara mole-rat
NP_001161060  23 EPTFCTsCDEyidktCTRNLgvCHAry---pdFACQTKEVYIQlntge-ylykYSVLGCPrrCVEyvr-firFEKNIFSC 97  house mouse

Q6UY27       101 CDhSNYCN 108 human
XP_007495138 102 CSdKNRCN 109 gray short-tailed opossum
NP_001347990 105 CIdRNYCN 112 house mouse
XP_003764436 100 CReQHYCN 107 Tasmanian devil
XP_007495140 105 CE-TDYCN 111 gray short-tailed opossum
XP_020856226 105 CN-QDYCN 111 koala
ELR46877     106 CT-EDNCN 112 wild yak
NP_001254709  96 CKsQDFCN 103 Norway rat
KFO31377      97 CTeDNFCN 104 Damara mole-rat
NP_001161060  98 CN-ESYCN 104 house mouse
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