6KTR,1PWA,2P23


Conserved Protein Domain Family
beta-trefoil_FGF19
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cd23331: beta-trefoil_FGF19 
FGF domain, beta-trefoil fold, found in fibroblast growth factor 19 (FGF19) and similar proteins
FGF19 is involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. It stimulates glucose uptake in adipocytes. Its activity requires the presence of beta-Klotho (KLB) and FGFR4. FGF-19 interacts with fibroblast growth factor receptors, FGFR1, FGFR2, FGFR3, and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by alpha-Klotho (KL), KLB and heparan sulfate glycosaminoglycans that function as coreceptors. FGF19 contains a FGF domain with beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.
Links
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Statistics
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PSSM-Id: 467017
Aligned: 11 rows
Threshold Bit Score: 216.918
Created: 6-Apr-2021
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
trimer
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:trimer interface [polypeptide binding site]
Evidence:
  • Structure:6KTR; Homo sapiens FGF19 in complex with Fab, contacts at 4A
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        ####                                   #                                        
6KTR_C        20 IRLRHLYTSgphglsSCFLRIRADGVVDCARGQSaHSLLEIKAVAlRTVAIKGVhSVRYLCMGaDGKMQGLLQYseEDCA 99  human
1PWA_A         8 IRLRHLYTSgphglsSCFLRIRADGVVDCARGQSaHSLLEIKAVAlRTVAIKGVhSVRYLCMGaDGKMQGLLQYseEDCA 87  human
2P23_A        20 IRLRHLYTSgphglsSCFLRIRADGVVDCARGQSaHSLLEIKAVAlRTVAIKGVhSVRYLCMGaDGKMQGLLQYseEDCA 99  human
O35622        50 TRLQYLYSAgpy-vsNCFLRIRSDGSVDCEEDQNeRNLLEFRAVAlKTIAIKDVsSVRYLCMSaDGKIYGLIRYseEDCT 128
O95750        42 IRLRHLYTSgphglsSCFLRIRADGVVDCARGQSaHSLLEIKAVAlRTVAIKGVhSVRYLCMGaDGKMQGLLQYseEDCA 121 human
XP_005996281  43 VRLKHLYTSskhgliSYFLQINDDGKVDGTTTRScYSLLEIKSVGpGVLAIKGIqSSRYLCVEkDGKLHGSRTYsaDDCS 122 coelacanth
NP_990005     44 IRLRHLYTAskhglfSCFLRIGGDGRVDAVGSQSpQSLLEIRAVAvRTVAIKGVqSSRYLCMDeAGRLHGQLSYsiEDCS 123 chicken
NP_001296288  35 VRLRHLYAAr----hGLHLQINTDGEISGSHMQSsDSLMEIWPVDtGCVAIKGVaSSRFLCMErLGNLYGSHIYtkEDCS 110 zebrafish
XP_012670272  40 IRLKHLYAAr----dGLHLQIRKDGNVDGSPQQSaLSLMEIRPVDnGCVAIKGIaSSKFLCLErDGRLYGSNSYvrDDCA 115 Atlantic herring
KPP72196      22 VRLRHLYSSr----qGVNLQINGDGTVNGSSVQSlHSLLEIKSFDwGLVAIKGLaSSYYLCMEeSGRLYGSRTYtrEDCS 97  Asian bonytongue
XP_018112825  43 IRIRHLYTArrfghdSYYLRIHEDGRVDGDRQQSmHSLLEIRATAvGIVAIKGYrSSLYLCMGsEGKLYGMHSYsqDDCS 122 African clawed ...

Feature 1            #                                        ####
6KTR_C       100 FEEEIRPDGYNVYRSEKHRLPVSLS-SAKQRQLYKNrgflPLSHFLPML 147 human
1PWA_A        88 FEEEIRPDGYNVYRSEKHRLPVSLS-SAKQRQLYKNrgflPLSHFLPML 135 human
2P23_A       100 FEEEIRPDGYNVYRSEKHRLPVSLS-SAKQRQLYKNrgflPLSHFLPML 147 human
O35622       129 FREEMDCLGYNQYRSMKHHLHIIFI-QAKPREQLQDq---KPSNFIPVF 173
O95750       122 FEEEIRPDGYNVYRSEKHRLPVSLS-SAKQRQLYKNrgflPLSHFLPML 169 human
XP_005996281 123 FKEDILPDGYTIYVSKKHGSVVNLS-NHKQKRQRNRrtlpPFSQFLPLM 170 coelacanth
NP_990005    124 FEEEIRPDGYNVYKSKKYGISVSLS-SAKQRQQFKGkdflPLSHFLPMI 171 chicken
NP_001296288 111 FLERILPDGYNVYFSSKHGALVTLS-GAKNKLHSNDg--tSASQFLPMI 156 zebrafish
XP_012670272 116 FVEQILPDGYNVYSSRKHGTLLSLSvGTRSQARGHDkglsSHAQFLPMA 164 Atlantic herring
KPP72196      98 FRECIMPDGYSIYVLARNGVGVRLR-RGRQRTQVRDkgvtLPSQFLPMA 145 Asian bonytongue
XP_018112825 123 FEEELLPDGYNMYKSKKHGIAVSLS-KEKHKQQYRGkgylPLSHFLPVI 170 African clawed frog

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