Conserved Protein Domain Family
bHLH_TS_amos_like
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cd19715: bHLH_TS_amos_like 
basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster protein Amos and similar proteins
Amos, also termed absent MD neurons and olfactory sensilla protein, or reduced olfactory organs protein, or rough eye protein, is a bHLH transcription factor that promotes multiple dendritic neuron formation in the Drosophila peripheral nervous system.
Links
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Statistics
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PSSM-Id: 381558
Aligned: 6 rows
Threshold Bit Score: 104.915
Created: 3-Oct-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative DNAputative dimer
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Comment:Based on the structure evidence that Mus musculus myoD (1MDY) basic region binds DNA.
  • Citation:PMID 8181063
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                #   # ### #    #                 ####                   
Q9Y0A7       132 GGEVLKKRRLAANARERRRMNSLNDAFDKLRDVVPSlghDRRLSKYETLQMAQAYIGDLVTLLS 195 fruit fly
XP_002433775 119 PPVVVKKRRLAANARERRRMHGLNVAFDKLRQVVPSigdDRKLSKYETLQMAQSYITALSELLI 182 black-legged tick
OWF45654     131 GREVLRKRRLAANARERRRMESLNVAFDQLRDVVPSigdDQKLSKYETLQMAQSYINALKDLLI 194 Yesso scallop
EFX77712     232 APQVMKKRRLAANARERRRMNNLNSAFDRLRDVVPAlgnDRQLSKYETLQMAQSYITALWELLQ 295 common water flea
KOF97312     208 GKDVLKKRRIAANARERRRMSSLNVAFDNLRAVVPA---HGKMSKYDTLQLAQVYIMKLREILE 268 Octopus bimaculoides
ELU02810      10 SKDVLRGRRQAANARERRRMNSLNVAFDELRGVIPGlsdDRKLSKYDTLQMAQSYIDALKEVLS 73  Capitella teleta

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