Conserved Protein Domain Family
mthyl_TIGR00027

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TIGR00027: mthyl_TIGR00027 
methyltransferase, TIGR00027 family
This model represents a set of probable methyltransferases, about 300 amino acids long, with essentially full length homology. Members share an N-terminal region described by Pfam model pfam02409. Included are a paralogous family of 12 proteins in Mycobacterium tuberculosis, plus close homologs in related species, a family of 8 in the archaeon Methanosarcina acetivorans, and small numbers of members in other species, including plants. [Unknown function, Enzymes of unknown specificity]
Statistics
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PSSM-Id: 272862
Aligned: 17 rows
Threshold Bit Score: 248.383
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
AAM54088      19 SWTSLGNAGARAQESARAD--RLFDDPLARAFLDAAG-------TGNPLLPDRGGGDPGLLg--QITDVIVVKTVFFDAV 87  Actinosynnema p...
CAB99159      22 PSAALWTAAAHAAECLRPA--PIVRDPWAADFLHAAG--------FDGGP-----PGDGPlq-rLLPDWQVVRTRFFDDY 85  Streptomyces co...
AAS02539      28 ADTALLVAAIRAHETTRDD--RLFADPFAARLAGDRG----------RELLAGALAATGES----ATAQIVVRTRFWDDA 91  Mycobacterium a...
AAM03623       6 AKTGVGPTALVAIEQHFPEnqRIIEDDLAYRILPLGMrafvwlmRFDSLRAWMIRVTEKDTp--GIWGGMMCRKRYIDEK 83  Methanosarcina ...
AAM06141      15 SKMAEGIALHRALESQKPEgeRICYDPYAIYFISQETle---pfSDPQKARAAHEYYERLFp--GFASSVRIRVRYFDDF 89  Methanosarcina ...
AAM05854      62 IKTAEGMALVRAIEAQKPEdvRICYDPVALSLVNRIRf-------tLSKLVIDSGIYGLIFr--GAIEFITARERYIDDF 132 Methanosarcina ...
CAD89781       9 DRTAEGVAMWRAIGAKESDarVRNPDFMAAGFLSPVSra---llTVSPLRSWMTSYYGNKLp--GAYGYATARTLHLDAI 83  Melittangium li...
WP_003913284  23 GYTALLVAGWRALHTTGPK--PLVQDEYAKHFITASAd-----pYLEGLL---ANPRTSEDg-tAFPRLYGVQTRFFDDF 91  Mycobacterium t...
WP_010999881  13 CRTALVMATKRAIESDRSD--HLFDDPFAALLSGDTG--------KAWREKWEQQDSDNPLgttLRIQFVAVRTRFFDDF 82  Nostoc sp. PCC ...
WP_011030923  19 GLTALLVAAARAIETHRPD--ALAQDIYAEHFVLGARas---ahWPVRLDRAPGGDTSPLWg--RFARYFGLRTRVLDDF 91  Streptomyces co...
AAM54088      88 LARAAA-AGVRQVVLLAAGLDARAFRLPWPE-GVVVFEVDLPDVLGFKERVVREVGAEPSCDRRVVAADLR-SDWVAALV 164 Actinosynnema p...
CAB99159      86 ALAAAR-SGCRQVVLLGAGLDTRAFRLDWPT-GVHVFEVEDAAVLAFKEYVLD-WSRLSCGRRTVVEADGT-ASWGEELG 161 Streptomyces co...
AAS02539      92 LLEAA--QQISQVVILAAGMDARAYRLAWPD-GTVVYELDQPEVLAAKDGVLA--GERPACRRVAVGVDLA-QDWPAALR 165 Mycobacterium a...
AAM03623      84 LVESVn-Q-VDAVVNLGAGFDTRAYRFPSLS-ETPVWEVDQPENIRSKQTRLSGLFGTVPSHVRLVPIDFDrEELGFVLA 160 Methanosarcina ...
AAM06141      90 VKKSId-DGLEQLVVLGAGYDTRAYRIEGLKgEIKVFEVDHPDTQYVKIKNIKEIFGFLPNHIIYVPVDFEtENFGERLM 168 Methanosarcina ...
AAM05854     133 LKACLn-EGLDQVVILGAGFDTRAYRIAGIE-KMRVFEVDHPETQEVKLKRLKKVINPMPDHVTFVQVDFNtQMLGKRLL 210 Methanosarcina ...
CAD89781      84 FARALd-EGAEQVVLLGAGYDSRAYRFRERLsKVRLFELDLQATQERKKKRIKTLFGGLPEWVTYVPINFDaQRLEDVLP 162 Melittangium li...
WP_003913284  92 FNCADE-AGIRQAVIVAAGLDCRAYRLDWQP-GTTVFEIDVPKVLEFKARVLSERGAVPKAHRVAVPADLR-TDWPTPLT 168 Mycobacterium t...
WP_010999881  83 IL-SVL-PEAKQLVFLGAGLDTRAFRLSFPP-KTRLYELDLPELIQYREAILQD--KKANCHRHAIAADLT-QPWSHLLL 156 Nostoc sp. PCC ...
WP_011030923  92 LLRSVRsAGIRQVVLLGAGLDARAFRLDWLS-DCVIFEIDRDGVLAFKHRVLDTLSAEPGARRVPIGTDLR-ADWAGALT 169 Streptomyces co...
AAM54088     165 AAGLDREAPVAWLAEGALGLLDEAGCEELMAAVLGASAAGSRFALDHT-----HD-GWKAGEA--LGgylEGT---GVCL 233 Actinosynnema p...
CAB99159     162 AAGFDPGRPTAWLCEAPLYFLRPPEVAAVVAVMTELSAPGSMFGAECVn---sAT--TSSPFV--AP---FMD---ALST 228 Streptomyces co...
AAS02539     166 RAGLDPSAPAVWLIEGLLQYLDEAAVTALFDRVDALSARGSVLLYDVVgkallES-EFMAPVL--ES----------MAR 232 Mycobacterium a...
AAM03623     161 SYDYSADKRTFFIWEAVTQYLTETGIRTTFDFLAKAE-RGSRLVFTYVrkdflDGrVMYD--W--EKvykKY-----VKD 230 Methanosarcina ...
AAM06141     169 EKGYDRSLKTLFIMEGLVVYIPPEAVDEALSFIAENSGKGSTILFDYFpesvvDGsCELEV-G--KNmrnYAA----KQG 241 Methanosarcina ...
AAM05854     211 ASGYDEQGKTLFIWQGVTMYLTPEGIDSTLAFIANHSGTGSSVIFDYFynetlHd-------M--KTvrwITR----VIG 277 Methanosarcina ...
CAD89781     163 AAGFDRTKRTFFLWEGVSMYLTEEAIDQTLGFVARNSPPKSSIAFDFVdqgalKGnSPRHPGV--QQwidVLT----ELG 236 Melittangium li...
WP_003913284 169 AAGFDPQRPSAWSIEGLLPYLTGDAQYALFARIDELCAPGSRVALGALgs-rlDH-EQLAALEtaHPgvnMSG---DVNF 243 Mycobacterium t...
WP_010999881 157 EQGFDVHLPTLWLMEGLLMYLDEAQVNQLLKTIGQLSAEGSFLGADLVs----vK-SWQVGAK--HP----------NGM 219 Nostoc sp. PCC ...
WP_011030923 170 ATGFDATAPTAWLVEGLLFYLPHAAETALIDTVDRLSAPGSALAYEVk----lEK-DLMAYRD--SPlyvSTRrqlGIDL 242 Streptomyces co...
AAM54088     234 ADLVKGGPREPGGaWLARHGWRVAEY-DVVAEAARHGRP 271 Actinosynnema pretiosum subsp. auranticum
CAB99159     229 IGLGWNWQIADPErWWAEHGWDAAAA-DPYTLPYAVERL 266 Streptomyces coelicolor A3(2)
AAS02539     233 SGAPWRFGTDDPGgLCERLGWSATVT-DVAEPGNRYQRW 270 Mycobacterium avium subsp. paratuberculosis K-10
AAM03623     231 KIWLFGMDPEEWPkFLERYGWKVVEHvGYEELAGRYIRP 269 Methanosarcina acetivorans C2A
AAM06141     242 EPFKFGIKESAVEtFLSERGFSQIHNvTAEDYKRIYFSG 280 Methanosarcina acetivorans C2A
AAM05854     278 ERLIFGIDEGQIEpFLIRRGFREVHNaTTGELKRLYFTG 316 Methanosarcina acetivorans C2A
CAD89781     237 HPMTFGIDENATDvFLRKRGFEVVSQiGSAEMERKYLTK 275 Melittangium lichenicola
WP_003913284 244 SALTYD-DKTDPVeWLVEHGWAVDPVrSTLELQVGYGLt 281 Mycobacterium tuberculosis
WP_010999881 220 ISKHWRFGTDEPEqLFAAYGWNASVI-QPGDIRANYGRY 257 Nostoc sp. PCC 7120
WP_011030923 243 LDLFSREPRPDSAaRLRDRGWTASVH-TPFDFTRRHGRG 280 Streptomyces coelicolor
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