1NBA


Conserved Protein Domain Family
CSHase
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cd01015: CSHase 
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N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This CSHase-containing pathway degrades creatinine via N-methylhydantoin N-carbamoylsarcosine and sarcosine to glycine. Enzymes of this pathway are used in the diagnosis for renal disfunction, for determining creatinine levels in urine and serum.
Links
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Statistics
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PSSM-Id: 238497
Aligned: 7 rows
Threshold Bit Score: 241.537
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:catalytic triad [active site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            #                                                                          
1NBA_A       46 AVIHIDLANAWTQpgh-pfsCPGMETIIPNVQRINEAARAKGVPVFYTTNVYrnrdassgtndMGLWYSKIPTETLPADs 124 Arthrobacter sp.
NP_105355    45 AAVFIDLQEEHRQdkr--ylVEGFAGILANVQRLQEAARANHVPLQHWAYIVdldkq--drpfHPLGADGKSAFSDKSDp 120 Mesorhizobium loti
ZP_00096473  27 ALVVVDLVEAYLQpgs--plYAGIEAALESAVRLTDAARNAGIPVIFTNVEYqpg-----gtdGGVFYRKVPALRVFEKg 99  Novosphingobium ...
ZP_00031011  38 GLLIVDFVNGFADpav--fgGGNIAAAIGNTRPVLAAARRRQWPVAHTRIVFadd-----dadSNIFALKVPGMLTLKEr 110 Burkholderia fun...
NP_746071    26 ALLMIDFMQGYTTpga-plyAPGVVAAVEQAAGLLALARDCGTLVVHTNIRYqpph----fadGGVWVRKAPVMKDMVEg 100 Pseudomonas puti...
ZP_00017899  27 ALLVIDFIKAYTTpgsplyaAPGVPDAVRASQPLLAAARAAAIPIIYTTVAYasd-----grdGGIFVQKVPALRQLTHe 101 Chloroflexus aur...
BAC00809    127 ALLVIDLIRGFTDtrs--plAGELDSQLQATQQLLADARDADVPVIFSTVAYdad-----lqeAGKWIRKIPSNSWLVEg 199 Rhodococcus sp. YK2

Feature 1                           #                                #                          
1NBA_A      125 -yWAQIDDRIAPADGEVVIEKNRASAFPGTNLELFLTSNrIDTLIVTGATAAGCVRHTVEDAIAKGFRPIIPRETIGDRv 203 Arthrobacter sp.
NP_105355   121 --LTEICHEVAPARDEALLVKAEASAFRSGPAADQLKAAgIEWLVVAGVWTEACIDATVKDAVARGFRVLLVKDACGSGs 198 Mesorhizobium loti
ZP_00096473 100 spLGAFPAVLSPREDEIVITKRYASAFFATHLASTLTSLgVDTVLICGTSTSGCIRATALDACQHGFLPFVVRDACGDRh 179 Novosphingobium ...
ZP_00031011 111 dhNSAIVDELAPQSGEMVVRKTVPSAFFGTSLAAWLAQRgVQTLIVAGAVTSGCVRASVVDAMQYGFRPVVLSDCVGDRa 190 Burkholderia fun...
NP_746071   101 npLAAFCEAVAPQAGEVVLSKQYASAFFATSLAPLLHAQgVDTVVLAGCSTSGCIRASAVDAMQHGFRTIVVRECVGDRh 180 Pseudomonas puti...
ZP_00017899 102 spLIAIVDELAPQPDDLVIEKKYASAFFGTHLAATLTALrIDTLIMIGCSTSGCIRASAVDGMQHGFRVIVPRECVGDRa 181 Chloroflexus aur...
BAC00809    200 seWVELDERLGRRENEMLLVKKYASCFFGTDLAARLISRgVDTVILLGCTTSGCIRATAVDACSYGFHTVVVEEGVGDRa 279 Rhodococcus sp. YK2

Feature 1                                   
1NBA_A      204 pgVVQWNLYDIDNKF--GDVESTDSVVQ 229 Arthrobacter sp.
NP_105355   199 aaMHQTGILNLANRLygGAVTDTDGACR 226 Mesorhizobium loti
ZP_00096473 180 qaPHEANLFDLQAKY--AEVIGEAEALA 205 Novosphingobium aromaticivorans
ZP_00031011 191 iaPHEANLFDMEQKY--AAVMESCVLLD 216 Burkholderia fungorum
NP_746071   181 sdPHEANLFDIDSKY--GDVVTRQDAMQ 206 Pseudomonas putida KT2440
ZP_00017899 182 pePHLANLFDIDGKY--GDVVSVSEVLA 207 Chloroflexus aurantiacus
BAC00809    280 elPHLASLFDIDNKY--GDVVSLEDASA 305 Rhodococcus sp. YK2

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