Conserved Protein Domain Family
FRG1

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pfam06229: FRG1 
FRG1-like domain
The human FRG1 gene maps to human chromosome 4q35 and has been identified as a candidate for facioscapulohumeral muscular dystrophy. Currently, the function of FRG1 is unknown.
Statistics
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PSSM-Id: 368803
Aligned: 10 rows
Threshold Bit Score: 202.65
Created: 22-Mar-2022
Updated: 13-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CAK36887      96 ASALENMIEGDPRTAEPHDV-------RQVWIASKIaGIEGWSLKGSNGRYLTSD--KHGILSANASAISQHEIYTIses 166
Q6DDA8        66 GAYIHALDTGLFTIGAPHKDddg-pspPEQFTAIKL-SDSRIALKSGYGKYLGIN--SDGLVIGRSDAIGAREQWEP--- 138 tropical clawed...
Q566W5        65 NSYIHALDTGLFTVGSPHKEdeg-pdpPEQFTAIKL-SDSRIALKSGYGKYLGIN--SEGVVVGRSDAIGSREQWEP--- 137 zebrafish
EDO44060      69 GSYVEALNNGLFTAGEPREDgvnspapVEVFTAVPV-SEVKLAIKSGYGKYMSVN--TMGDITGRAEAIGPQEQLEL--- 142
Q7QC94        71 QAYVKALDNGLFTLGAPHNEgdp-pdpEEIFSAVLI-NEQKVAFKSGYGKYLKVE--KDGMITGRSDAVSALEQFEP--- 143 Anopheles gambi...
Q9VWA8        72 RSYLKAMDNGLFTLGAPHNAgdg-pdpEEIFTAFPI-NDRKVAFKSGYGKYLKIE--KDGMVTGRSEAVGGMEQWEP--- 144 fruit fly
XP_018644975  95 ACYLSATDEGLVVIGPPRKYgep-papEEIFTAMQV-SDTKVAFKSGYGRYLGVStkSDAILGATADAVGVFEQFEP--- 169
O18282        78 RTYVAAMDNGKFTIGFPHPEgeg-pnpEEIFALVKTpDDSKISLKTGFGRYVGVD--SEYQLVAMAEAIGSREQFVL--- 151 Caenorhabditis ...
Q2UKA8        84 ASEIENLIEGDPGTAEPHDV-------RQVWVATRVaGTEGISFKGQHGKYLGCD--NYGILSAASSAISHQESFVV--- 151 Aspergillus oryzae
Q0UA03        83 ASALENMVDGDLGTAEPHDV-------RQVFVANRVaGTEGLSLKGHHGRYLSCN--KYGILSANATAMSPEESFIV--- 150 Parastagonospor...
CAK36887     167 gaggggffVFGTGTGASSAsqggdgvddkekkeKKQTYLVART-------VASKTTASGTKVEIRGDETTlddgeedGGG 239
Q6DDA8       139 --------VFENGKMALLA--------------SNSCFVGCNEegd--liAQSKTAGEGEMIKIRSCVER-------DGK 187 tropical clawed...
Q566W5       138 --------VFQNGKMALLA--------------ANSCFISYSEsgd--ivAKNKTAGEEEMIKIRSCTER-------EVK 186 zebrafish
EDO44060     143 --------LFDGDKVALQA--------------YNGCFLSVSDsgs--lsASKKKAGEKEIFSIRADKPK-------S-K 190
Q7QC94       144 --------VFEQGKTALLA--------------ANGCFVSVDPedd-alvAIKKKVGSDEVCTIRSCAGR-------EDI 193 Anopheles gambi...
Q9VWA8       145 --------VFEEQRMALLS--------------ETGHFMSIDPqdd-acvALRKKVGQHEICKVRSNASR-------D-V 193 fruit fly
XP_018644975 170 --------IFQDGRSALLG--------------ANNCFLSADPitd-divFKSQQAKTNEMVIFRSNKPL-------IHD 219
O18282       152 --------VFQEGKTAFQAv-------------SSPLFLSTVPnkeghiyVASRTATENEMVNIRTDAIQ-------E-G 202 Caenorhabditis ...
Q2UKA8       152 --------IPS-EMPGSFClqt--------gggDKETFVSVTE-------GKSSKAASGRVVEVRGDATSl------SFE 201 Aspergillus oryzae
Q0UA03       151 --------IPVPDNPSAFSlq-----------tARDKFLSIDE-------SSAST------AEVRGDVETi------TFN 192 Parastagonospor...
CAK36887     240 TNIRVRMQARFKPRIQASKEIKARE----KIGRKELegivgrRLDDDEVKRLRKARKEGDFHEVVLDVRVRGKHDKF 312
Q6DDA8       188 SEDEIPKEDKGNVKQCEINYVKKFQ----SFQDNKL------KVSLEDNKDLKKARKEGNFHETLLDRRSKLKADRY 254 tropical clawed frog
Q566W5       187 RKDDIADEDRGDVKNCELNYVKKFQ----SFQDRKL------RLNEEDSGSLKKARTDGKFHEALLDRRSKMKADRY 253 zebrafish
EDO44060     191 PKTDSQVEDEEDVTNLELSYVKKFQ----SFQDRKI------KLSKEEQSNLKKARLDGRLHEEMLDRREKMKSDKF 257
Q7QC94       194 SSKELPVEESGDLDQVELNYVKKFQ----KFQDKKI------RVSKEDKLTLKKAKEDGALHEALLDRRSKMKADRY 260 Anopheles gambiae ...
Q9VWA8       194 VIDTEPKEEKGDLGEVEKNYVKKFQ----KFQDKKM------RINQNDVKELEQAKAQGSLHETLLDRRSKMKADRY 260 fruit fly
XP_018644975 220 PLLDIPEEEREGLKKAEVNYVRKFQ----SWQDQKL------RLSKEDFSDVKRARHSGNLYECLLDRREKMKSDRY 286
O18282       203 PVDWRSVEDRKNARECETAYVKMYQhskvDLKNRHI------AIDVKDKKGVKKAQADGSAHELLLDRRMKMKSDRY 273 Caenorhabditis ele...
Q2UKA8       202 TTMRIRMQARFKPRIKASKETKAKE----KISRKELeeivgrRLDDDEVRRLKRARKEGNFHEEVLDVRVRGKHDKF 274 Aspergillus oryzae
Q0UA03       193 TTFRIRMQARFKPRLKASKEEKAQA----KISKKELediigrRLNDDEVRRLKKSRREGNFHETALDMKVKSSHDKY 265 Parastagonospora n...
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