Conserved Protein Domain Family
isochor_syn

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TIGR00543: isochor_syn 
isochorismate synthases
This enzyme interconverts chorismate and isochorismate. In E. coli, different loci encode isochorismate synthases for the pathways of menaquinone biosynthesis and enterobactin biosynthesis (via salicilate) and fail to complement each other. Among isochorismate synthases, the N-terminal domain is poorly conserved. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]
Statistics
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PSSM-Id: 273127
Aligned: 13 rows
Threshold Bit Score: 369.389
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9S7H8       198 IRAYGGMRFDPngkiavewepfgAFYFSVPQVEFNEFGGSSMLAATIA--WDDElswtleN---AiealQETMLQVSSVV 272 thale cress
P44613        93 FPLVGGLQFQG------------TAQFVLPKMLVEQDNKGTLVSFFVK--NEQSa-----N---D----TLAHLKTFENL 146 Haemophilus inf...
Q51508       108 PRLCGGFRFDPrgpreehwqafaDASLMLAGITVLREGERYRVLCQHL--AKPGe-----D---AlalaAYHCSALLRLR 177 Pseudomonas aer...
AAO79805      56 GFVIAPFRIDKs----------------CPIVLIQSDRTGQPLPMEIV--AE--------E---EqdlqSYPE------- 99  Bacteroides the...
BAM51880      76 PYIFCGFSFFDrpsnr---npfaNSFLFLPQIQVVKTSQHCLLSWQIS--LDGNt-----N---VtdlvDFIGRMLSAIR 142 Bacillus subtil...
WP_031824805   3 LRVVGGFQFSShksdde-wrefgLNHFVLPEVLISTDNNGTFLTYTVK--RESFt-----V---EalndLMDLFNNISDI 71  Staphylococcus ...
WP_010933498 131 ARYIGGFCFNNlqkqnklwsafsPGLFILPLVSIEYRDGQTLMTCSLW--LEPGn-----DrqkGleqlLAALSAVSAGD 203 Chlorobaculum t...
EHC49658      47 LRIWGLNAFEPk-----------EGYLLLPRLEWRRSGGTATLRLHLH--SDVSl-----R---DdarlAKAFLASLVGI 105 Salmonella ente...
WP_002364946  98 ALLFGGLPFDTeqtpteawgelgEGWFYLPSILFTFSGSRIYGTLNFSgsSEQEv-----E---ErwstLVAQFDRLLAT 169 Enterococcus
WP_010902776  89 PRLFGGFSFFDthtaagvwqgfpPARFVLPAIQLTSVGDETWLTA-IE--AGPDa-----T---VasasASLADARDAVD 157 Halobacterium s...
WP_002966563  74 PIVVGAIPFDPgep----------scLYVPEEMDWQERE--------P--ASGAs-----A---AampqLAGQRSV---- 121 Brucella
WP_010905536  83 ylfhsqtfFDDikgel--wenfgGETIAFKHYFVVNKENSYTLTCDSP------------R---EipeiTIPKFK----- 140 Lactococcus lactis
WP_005874579  49 VPCFVAAPFDSee-----------eaYFIPGEFECEGD----LTDKAV--RD-------------------LKDAVFSGI 92  Porphyromonas g...
Q9S7H8       273 MKLRNRSLGVSVLSKn----HVPT--KGAYFPAVEKALEMIN-QksSPLNKVVLARNSRIITDTD--IDPIAWLAQLQRE 343 thale cress
P44613       147 TALSALPKQIPLHTE-----LRAN--ERTWCDWVNQALVEIK-S--GELTKIVLANETTFHLKQA--INAYDFLAESEKQ 214 Haemophilus inf...
Q51508       178 QPARRRPSGPTAGAQgdasaQERR--Q--WEAKVSDAVSSVR-Q--GRFGKVVLARTQAR-PLGD--IEPWQVIEHLRLQ 247 Pseudomonas aer...
AAO79805     100 -------ESFHTLCTg------------KYATCFHTFIEALR-D--ATFDKLVLSRSLTIGKNPE--FSPSAVFRAACQR 155 Bacteroides the...
BAM51880     143 RAQPARDTHTPSMVVkaprlTGIE--VAKLSKAIASSLEEIA-Q--QRLSKVVLATALDLDYGSR--LNVAHCLQRLRQQ 215 Bacillus subtil...
WP_031824805  72 D----VDEQIGEITRn----EDIY--KDDWRQLVVEAIESIN-N--E--EKIVLARRRLIKFDKD--ISIPYILKQAYSK 134 Staphylococcus ...
WP_010933498 204 APETAGIPEMTQVS------YCPD--KAQWIENCETILRNFD-E--GKLDKVILARQTELSFAGK--VPAIRFLLDYPFP 270 Chlorobaculum t...
EHC49658     106 KPVPALRLSLTSEQHw------PD--KDGWVKLIQQATHTIA-Q--EAFDKVVLARATDLQFSRP--VNAAAMMASSRRL 172 Salmonella ente...
WP_002364946 170 C--EELPAVAETKIDk----EEVA--VTEWLQAVNETVAVLReD--GPLKKVVLARQLAVSSPEK--IRSNQVLVNLMAQ 237 Enterococcus
WP_010902776 158 SLPAMQAAGPRPGVTd----TTPTpgRDAWTAGVQDAVDRIQ-S--GPLRKVVLATALRADLAEP--ATPCALLERLRQR 228 Halobacterium s...
WP_002966563 122 ----------------------PD--EAGFKHAVEHAIINFR-L--SDVRKAVLSVMRELTFADD--IDVDAMLANLRAQ 172 Brucella
WP_010905536 141 -------HQLTEKAS--------D--FSAWQELFYAIQKNFA-D--GKSRKIVASRELEFTSQTS--FELESIIQNLLDN 198 Lactococcus lactis
WP_005874579  93 R--------MPCPESg-----DMD--KEAYRTAFEEIMRRID-S--GVLEKVVLSRTLTLKRGDSgfSDVFSYWELLRRA 154 Porphyromonas g...
Q9S7H8       344 GHDAYQFCLQPPGAPAFIGNTPERLFQRTQLGVCSEALAATRPRAASSARDMEIERDLLTSPKDDLEFSIVRENIREKLN 423 thale cress
P44613       215 NQGCYHFLWAENSHSVFVGSTPERLFAREYNLLLTEALAGTASVSESEEETQSQANWLLNDEKNLKENWLVVEDISQNLR 294 Haemophilus inf...
Q51508       248 HADAQLFACRRGNA-CFLGASPERLVRIRAGEALTHALAGTIARGGDAQEDARLGQALLDSAKDRHEHQLVVEAIRTALE 326 Pseudomonas aer...
AAO79805     156 YIHSYIYLCYTPQTGVWLGSTPEIILSGEKNEWNTVALAGTQPLQNGK-------LPQVWDDKNRQEQDYVASYIRRQLL 228 Bacteroides the...
BAM51880     216 YGDCYLFSWGNGQGDCFVGASPERLLSLHNQQLVTDALAGSAPRDVDVQGDRQLGQELLHNPKELREHQAVLDYLLQRLR 295 Bacillus subtil...
WP_031824805 135 EKNSYIFLLE-SQDSIFFSQTPEQLIKVNNKILSTKAVAGTIKRSQDEDEDTKNVEAFLKDNKNLIEHRFVVDSILHDIK 213 Staphylococcus ...
WP_010933498 271 ENTAYRFYFEPVEGHAFISFTPERLYRRDGDMLETEALAGTVTKEALKADDSIASELLLNSEKDIREHRFVKDTIYRELQ 350 Chlorobaculum t...
EHC49658     173 NLNCYHFFMAFSADTAFLGSSPERLWRRRETALRTEALAGTVANHPDNHKAWQLGEWLMKDDKNQRENMLVVEDICQRLQ 252 Salmonella ente...
WP_002364946 238 QQNTYLFALE-AKDTSFIGATPERLLLGTKETFATACIAGTIKTGQTPEETKTLGAQLLQDRKNTGEHQIVVERLAKELA 316 Enterococcus
WP_010902776 229 YPACFRFLVAPADGGVFLGATPERLASLRGGRVETVALAGSVGRGDSPAADARLADRLRESDKLRHEQGVVVDTIARRLE 308 Halobacterium s...
WP_002966563 173 NHDGYQFRVPLPGGGALVGVSPELLIHKDKGKIVSNPLAGSAKRMADPEADRKNADRLAKSEKDHYEHRLVIEDIRARLQ 252 Brucella
WP_010905536 199 NPNAFIFAYQKGK-RIFLGASPEILVQKENDQLLSYALAGTFPKTMENA-----GQKLLTDPKNLLEHDIVVQKIKRNLL 272 Lactococcus lactis
WP_005874579 155 YPHAFVFLYFIPGKGVWAGASPELLLDYTKGRVKTMALAGTRPVSFEGE------LLKPWTQKEIREQGVVRDYIREVLE 228 Porphyromonas g...
Q9S7H8       424 GICDRVVVKPqKTVRKLARVQHLYSQLAGRLTKEd-DEYKILAALHPTPAVCGLPAEEARLLIKEIESFDRGMYAGPIGF 502 thale cress
P44613       295 KQVESFDVSN-VELKPLRKVQHLIRKIRANLTAHy-ADVNILKAIHPTAAVSGLPQQQAKMILSEIETFDRGWYAGTLGV 372 Haemophilus inf...
Q51508       327 PFSEVLEIPDaPGLKRLARVQHLNTPIRARLA-DagGILRLLQALHPTPAVGGYPRSAALDYIRQHEGMDRGWYAAPLGW 405 Pseudomonas aer...
AAO79805     229 SLGIRSTESG-PYPAYAGALSHLKTDFHFSLKDNk-NLGDLLKVLHPTPAVCGLPKEEAYRFILENEGYDRKYYSGFIGW 306 Bacteroides the...
BAM51880     296 ALGLSPQASS-LKLLKLANIQHLWTQIQAPLPPHi-HPLALVQQLHPTPAVAGVPVAIAEDLIRRHETFDRNLYAAPLGW 373 Bacillus subtil...
WP_031824805 214 PYITELHYDKtPKILKNDHLYHLYTEIKAPLKDd--SYISLIDHLHPTPALGGYPKEFAMDFIEQKEFGTRGLYGAPVGY 291 Staphylococcus ...
WP_010933498 351 PVCSDIDMQEkVGVLQLNRLAHLLAKCKARLLPEfsNDSTVLRQLHPTPAVGGVPREKAMSLILSIEPFCRGWYAAPVGW 430 Chlorobaculum t...
EHC49658     253 NCTHSLDVLP-PQVLRLRKVQHLRRCIWTALNQAd--DTLCLHQLQPTAAVAGIPREPARCFIEQHEPFEREWYAGSAGY 329 Salmonella ente...
WP_002364946 317 KMTTSENSIQaPIILENRDVQHLYVPISGQRKPGi-SFLESVMQLHPTPALGGEPKELAVEWIRQYEPGSRGLYGAPIGW 395 Enterococcus
WP_010902776 309 GIGDVAVGDR--DVRQLSTIQHLETPISAAVSADt-HVLDVIETLHPTPAVNGLPPADALATIRDTETFDRGWYAAPIGW 385 Halobacterium s...
WP_002966563 253 PICTELDIPErPSLIHTAALWHLSTRIEGRLHDPdmTALQLACLIHPTPAVCGFPTERARRLIRFVEPFERGLFTGMVGW 332 Brucella
WP_010905536 273 EKAETVTV-GtTELMELKNVYHLRTILSAKNSEL--SLIDWTKQLHPTPALGGEPRHEALEFLRKHENHERGLYAAPLGL 349 Lactococcus lactis
WP_005874579 229 NHCRSVEMSEt-RTFMAGNICHLCTDFTALT--Gd-GLESLLKALHPTPALGGFPRKEALACIREVEVHERKFYGGYLGP 304 Porphyromonas g...
Q9S7H8       503 FGGEE--SEFAVGIRSALVEKGLgALIYAGTGIVAGSDPSSEWNELDLKISQFTKSI 557 thale cress
P44613       373 MSDVC--SEFCVAIRSAFIEGHR-IRVFAGAGIVAGSQPLEEWKEIERKAAGLISLF 426 Haemophilus influenzae Rd KW20
Q51508       406 LDGEGn-GDFLVALRSALLTPg-rGYLFAGCGLVGDSEPAHEYRETCLKLSAMREAL 460 Pseudomonas aeruginosa PAO1
AAO79805     307 LDPEGr-TDLYVNLRCMHIEDEQ-LTLYAGGGLLASSELNDEWQETEKKLQTMRRIL 361 Bacteroides thetaiotaomicron VPI-5482
BAM51880     374 LDSEGn-AEFIVGIRSALLSRNR-ARLYAGAGIVAGSDPLKEVAEIELKLQTLWRSL 428 Bacillus subtilis BEST7613
WP_031824805 292 IDIYDd-CEFIVAIRSMLIKKAQ-ATLFAGCGIVKDSDPDSELAETNLKFTPMMNAL 346 Staphylococcus aureus
WP_010933498 431 LNRDA--AEFAVGIRSALVNDDR-VYLYSGAGLVRGSNPESEWEEVDQKIGDILAIT 484 Chlorobaculum tepidum
EHC49658     330 LSTRQ--SEFCVTLRSAKVTANV-VRLYAGAGIVRGSDPEQEWQEIDNKAAGLRTLL 383 Salmonella enterica subsp. enterica se...
WP_002364946 396 ISGNDdsGEFAVALRSGVFAGQQ-GVLYAGCGIVADSQAELEREETKIKFQPMLRGI 451 Enterococcus
WP_010902776 386 IDADGd-GTFGVGLRSGVVDDDS-VTLFAGNGIVGDSTPDAEWEEVQLKYRPVLDEL 440 Halobacterium salinarum
WP_002966563 333 SDAEGn-GEWVVTIRCGTVKGNL-VRLFAGAGIVEASSPDSEWAEVQTKLGTMLRAC 387 Brucella
WP_010905536 350 IDSKGn-GTMIVGIRSALIVDKK-LYAYAGCGIIPSSDALEEFRETKVKLKTILEAL 404 Lactococcus lactis
WP_005874579 305 VGKDA--ARLYVNIRSMELFPGA-FRLYVGGGINGDSVFEDEWEETSDKAATLLNVL 358 Porphyromonas gingivalis
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