Conserved Protein Domain Family
FemAB

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pfam02388: FemAB 
FemAB family
The femAB operon codes for two nearly identical approximately 50-kDa proteins involved in the formation of the Staphylococcal pentaglycine interpeptide bridge in peptidoglycan. These proteins are also considered as a factor influencing the level of methicillin resistance.
Statistics
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PSSM-Id: 426751
Aligned: 21 rows
Threshold Bit Score: 374.685
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q8G7I3  16 ITPAELDAFSAAQVQ-GSFQQTSQMAAMGAFNG-PVDYVGVKRG-DKLIAACYVVYTRSRFGL-EGSVWCGPLCDYDNPQ 91  Bifidobacterium longum
Q2FVL5   6 LTSDEFNAFTTKH-F-SHYTQSAIHYNHRVDLKgDVHLVGVKDDnGQVIAGCLLTEARTLKFFkYFYTHRGPVMDYTNQS 83  Staphylococcus aureus...
Q5HLI6   6 LTSEEFEQFTSEN-F-SHYTQSSIHYNNRSKTKgDVHLVGVKDDqEDVIAACLLTEARSLKFFkYFYTHRGPVMDFNNLV 83  Staphylococcus epider...
Q2FYR1   6 LTVTEFDNFVQNPSLeSHYFQVKENIVTRENDGfEVVLLGIKDDnNKVIAASLFSKIPTMGSY-VYYSNRGPVMDFSDLG 84  Staphylococcus aureus...
Q2FYR2   6 LTAKEFGAFTDSMPY-SHFTQTVGHYELKLAEGyETHLVGIKNNnNEVIAACLLTAVPVMKVFkYFYSNRGPVIDYENQE 84  Staphylococcus aureus...
Q830W0   8 IPAEVHDTFVKNHPL-CNLLQSSSWAKVK--DNwGSEIVGVYEKdTLVASSLVLIKPLPA-GFtMLYTPRGPVMDYTNER 83  Enterococcus faecalis
Q8E152   8 ISEKEYDAFAIASSQ-TNLLHSSKWAQVK--SNwQNERLGFYKDdQLVAVASILIKSLPL-GFtMLYIPRGPIMDYSNKE 83  Streptococcus agalact...
Q8E153   5 ITAVEHDRFVSESNQ-TNLLQSSNWPKVK--DNwGSQLLGFFDGeTQIASASILIKSLPL-GFsMLYIPRGPIMDYSNLD 80  Streptococcus agalact...
Q8DV07   8 ISKEEHDNFIKNSSQ-TNLLQSSSWAKVK--DEwENERIGFYQDsKLVASASILIRPLPL-GMtMFYIPRGPVMNYQDKD 83  Streptococcus mutans
Q5M449   8 LSTSEHDRFVIDSPQ-TNLLQSSSWAKIK--DSwGNDRLGFYQDdKLVAVASVLIQPLPL-GFsMIYIPRGPIMDYQDKE 83  Streptococcus thermop...
Q8G7I3  92 VVEAMTEALRRSAKAHHAISVSCWPAAVYRLHDLDGKPT---SDPDTTMMDNMARFGWKHGGFTVGYEs-VVNRWNFVKG 167 Bifidobacterium longum
Q2FVL5  84 LVAFFFKALTSYLKKHNCLYVLVDPYLIENLRNADGEIVk--SYDNRAFVRTMDKLGYKHQGFPVGYDsmSQIRWLSVLD 161 Staphylococcus aureus...
Q5HLI6  84 LVRFFFKSLTAYLKKHNCLYVLVDPYVLENLRQPNGEIIe--SFDNRALIKTMEELGYKHQGYTVGYDtmSQIRWLSVLN 161 Staphylococcus epider...
Q2FYR1  85 LVDYYLKELDKYLQQHQCLYVKLDPYWLYHLYDKDIVPFe-gREKNDALVNLFKSHGYEHHGFTTEYDtsSQVRWMGVLN 163 Staphylococcus aureus...
Q2FYR2  85 LVHFFFNELSKYVKKHRCLYLHIDPYLPYQYLNHDGEITg--NAGNDWFFDKMSNLGFEHTGFHKGFDpvLQIRYHSVLD 162 Staphylococcus aureus...
Q830W0  84 LVSYFMAELKKFGKKKRALFIKMDPAVHYQDFHLGEEHQp--HAEATSIIETLKEAGAKYQGLTMDMGatIQPRFQANIY 161 Enterococcus faecalis
Q8E152  84 LVNFVLKTLKNFGRKKRAVFAKFDPALLLRQYHLKEENVaeeIDESRQAIDNLKSAGAQWIGPTKAISetIQPRFQANIY 163 Streptococcus agalact...
Q8E153  81 IVTKVLKDLKAFGKKQRALFIKCDPLIYLKMVNAKDFENspdEKEGLIAIDHLQRAGADWTGRTTDLAhtIQPRFQANLY 160 Streptococcus agalact...
Q8DV07  84 LVNFVLTSLKKFAKRKRALFIKFDPFILLNHHQIDEEAIn--NPQAQTIIDTLKHLGCEWLGQTSDMGetIQPRFQANIY 161 Streptococcus mutans
Q5M449  84 LLAFVITSLKKYAKTKRALFVKFDPSLFVTKNLISQEVNi--NEDTLSIAKDIQALGVEWTGLTEDMAenIQPRFQANIY 161 Streptococcus thermop...
Q8G7I3 168 LDCIHNEKELLaSFSKYRRKNIRIAQDSGLRVRRLERGELSTFVKLCDMSAARQGFKSRDLAYYERLFDTFGDLIEFKVV 247 Bifidobacterium longum
Q2FVL5 162 LKDKTEDQLLK-EMDYQTRRNIKKTYDIGVKTKTLTIDETQTFFDLFHMAEEKHGFKFRELPYFEEMQKLYDDHAMLKLA 240 Staphylococcus aureus...
Q5HLI6 162 LKDKSEDQLLK-EMDYQTRRNIKKTYEMGVKVKTLPIEETNTFFELFKMAEEKHGFKFREEPYFVEMQKTYEDHAMLKLA 240 Staphylococcus epider...
Q2FYR1 164 LEGKTPETLKK-TFDSQRKRNINKAINYGVKVRFLERDEFNLFLDLYRETEERAGFVSKTDDYFYNFIDTYGDKVLVPLA 242 Staphylococcus aureus...
Q2FYR2 163 LKDKTADDIIK-NMDGLRKRNTKKVKKNGVKVRFLSEEELPIFRSFMEDTSESKAFADRDDKFYYNRLKYYKDRVLVPLA 241 Staphylococcus aureus...
Q830W0 162 REDFSEE-----QLSKSTKKMIKTAEKKGVVVQQGHVDFVDEFEKVIQSTMERQHISLRNSDYFKKLLNIYPEDSFIMLA 236 Enterococcus faecalis
Q8E152 164 TKANIEE-----NFPKHTKRLIKDAKHRGVQIYRANIDDLPKFATVVALTENRKGVALRNENYFHQLMTIYGEDAYLYLA 238 Streptococcus agalact...
Q8E153 161 ANQFGLD-----KMSKKTRQAIRTSKNKGVDIQFGSHELLEDFAELMKKTEDRKGINLRGIDYYQKLLDTYPNNSYITMA 235 Streptococcus agalact...
Q8DV07 162 AEGFSEA-----NLSKKIRQSIRTAKNKGVSIRFGGYELLADFSDLMKKTEDRKSIHLRGIDYYRKLLDNYPQHSFITLA 236 Streptococcus mutans
Q5M449 162 KEDFTEE-----QLSKSTKQAIRTARNKGISVQFGGTELLDQFADLMKKTEARKNIHLRGIDYYEKLLTTYPESSYITLS 236 Streptococcus thermop...
Q8G7I3 248 ETHFDEYLDTLQSKLNAASKDKRNLERLLQRAQQqpegtakkgasdPATLEKRIATADKKIAALEKTIGEVNGIIASDGP 327 Bifidobacterium longum
Q2FVL5 241 YIDLNEYLKTLQLKQQQLTAELSGVEEALEESPN------------SKKNKTKRTQLEQQLNSNKRKIDNTIEQIEQDGA 308 Staphylococcus aureus...
Q5HLI6 241 YIDLQDYLDTLQTKHQNLNQQLKDVEKTLEENPN------------SKKNKTKHTQVKQQFDSNARKIRQTKEKIAEEGQ 308 Staphylococcus epider...
Q2FYR1 243 YIDLDEYVLKLQQELNDKENRRDQMMAKENKSD---------------KQMKKIAELDKQIDHDQHELLNASELSKTDGP 307 Staphylococcus aureus...
Q2FYR2 242 YINFDEYIKELNEERDILNKDLNKALKDIEKRPE------------NKKAHNKRDNLQQQLDANEQKIEEGKRLQEEHGN 309 Staphylococcus aureus...
Q830W0 237 QVNLKERLDSTRQRYDKNQKDLSNLKE---------------------NQVKKRHNLEELDASLTRELKELEENIAEAGE 295 Enterococcus faecalis
Q8E152 239 KVNLPKRLAQFKEQLLQIQKDLSETPS---------------------HQKSRLTRLNQQEASVKQYILEFQEFSKKYPD 297 Streptococcus agalact...
Q8E153 236 SLDVAKRLEKIEKECQIAQSERIKSLEL--------------------NREKKVKQHQGTIDRLNKEIDFLKEAQKAYDR 295 Streptococcus agalact...
Q8DV07 237 SLNLKERLTELESQRKKAQNNLAKFGDN--------------------VKPSKIDNTKKEIERLSDEIAFLQEHLSQGKD 296 Streptococcus mutans
Q5M449 237 TLDLPARLKDLNKQLEKNIADAAKFTEK--------------------TKPGKIENNKQEYKRLSEEIAFLQEKVDAGNK 296 Streptococcus thermop...
Q8G7I3 328 Vi-PVEAGVYFWHPNEVVCLSSGEDDRFMDYYPSSLIHFEAMLDCIARGVERFNFYGISGIFDANDpsyGVWQFKTRFGG 406 Bifidobacterium longum
Q2FVL5 309 Vl-NLASALFIYNEHEVYYLSSGSNPKYNAYMGAYHLQWEMIKFAKAHHIDRYNFYGITGDFSESSedyGVQQFKKGFNA 387 Staphylococcus aureus...
Q5HLI6 309 Vl-HLAAALYIYNDHEVYYLSSGSNPKYNAYMGAYRLQWDMIQFAKEHNIDRYNFYGVTGDFSENAedaGVQKFKEGFNA 387 Staphylococcus epider...
Q2FYR1 308 Il-NLASGVYFANAYEVNYFSGGSSEKYNQFMGPYMMHWFMINYCFDNGYDRYNFYGLSGDFTENSedyGVYRFKRGFNV 386 Staphylococcus aureus...
Q2FYR2 310 El-PISAGFFFINPFEVVYYAGGTSNAFRHFAGSYAVQWEMINYALNHGIDRYNFYGVSGKFTEDAedaGVVKFKKGYNA 388 Staphylococcus aureus...
Q830W0 296 Iv-TVAGALAVTFGPTSEILYAGLDDRYKRYMPTYVTWRDAIQECFNRGCESCNMGGLEGSLND-----GLIKFKANFNP 369 Enterococcus faecalis
Q8E152 298 Ep-VIAGILSIRFGNVLEMLYAGMDDSFRKFYPQYLLNARVFEDAFKNDIVSANLGGVEGSLND-----GLTKFKSNFNP 371 Streptococcus agalact...
Q8E153 296 DiiPLAATLTLEFGNTSENIYAGMDDYFKSYSAPIYTWFETAQRAFERGNIWQNMGGIENDLSG-----GLYHFKSKFEP 370 Streptococcus agalact...
Q8DV07 297 Tv-PLSGTLSLEFGKTSENVYAGMDDEFRRYQAAIYTWFATANHAFERGSHWQNMGGIENDLSG-----GLYNFKSKFKP 370 Streptococcus mutans
Q5M449 297 Iv-PLSGTLVLEFGNTAENIYAGMDEDYRRYQPAILTWFETANHAFERGAEWQNMGGIENSLDG-----GLYNFKSKFNP 370 Streptococcus thermop...
Q8G7I3 407 FVEELPGKFTLPVDGLRFGVSEAAH---K 432 Bifidobacterium longum
Q2FVL5 388 HVEEYIGDFIKPIKPLLYKVQTYLN---H 413 Staphylococcus aureus subsp. aureus NCTC 8325
Q5HLI6 388 KIYEYIGDFIKPIKPLFYKVKQELE---S 413 Staphylococcus epidermidis RP62A
Q2FYR1 387 QIEELIGDFYKPIHKVKYWLFTTLD---K 412 Staphylococcus aureus subsp. aureus NCTC 8325
Q2FYR2 389 EIIEYVGDFIKPINKPVYAAYTALK---K 414 Staphylococcus aureus subsp. aureus NCTC 8325
Q830W0 370 TINEFIGEFDLPVNKLLFKASEYAY---K 395 Enterococcus faecalis
Q8E152 372 MFEEYIGEFNLAINPLLYKLANLAYtirk 400 Streptococcus agalactiae serogroup V
Q8E153 371 IIEEFIGEFNIPVNRLLYKASNYVYalrk 399 Streptococcus agalactiae serogroup V
Q8DV07 371 EIEEFIGEFNLPVSP-LYKLANIAYtirK 398 Streptococcus mutans
Q5M449 371 RIEQFIGEFNLPVSP-FYGLANFAY---K 395 Streptococcus thermophilus LMG 18311
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