Conserved Protein Domain Family
MFP2b

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pfam12150: MFP2b 
Cytosolic motility protein
This domain family is found in eukaryotes, and is approximately 50 amino acids in length. These proteins are found in nematodes. They complex with MSP (major sperm protein) to allow motility. Their action is quite similar to the action of bacterial actin molecules.
Statistics
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PSSM-Id: 403393
Aligned: 10 rows
Threshold Bit Score: 550.898
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003141621   8 EDTWAFGPIGSPFPDNPVHALDQPNQYVALWYKHGKPIHGRAWNNGGVLECSFPYKNAELTGAKDLGGQIQILQYK---- 83 
4_pfamImport   1 EDTWAFQPIGAPFPPSPVKCMGEQNMYVALWYKHGKPIHGRSWNNGGVVECSFPYKEAELTTKQQLEGQIQVLQYL---- 76 
XP_003148592   8 EDIWAFGPIGSPFPDNPVRATGQQNMYVALWYKHGKPIHGRAWNNGGVIECSFPYNKAELTGAKDLGGQIQVLQYK---- 83 
1_pfamImport   1 EDTWAFQPIGAPFPENPVKVLGQQNMYVALWYKHGKPIHGRAWNNGGVVECSFPYLKAELTGAKDLGGQIQVLQYK---- 76 
XP_003139314   8 EDEWAFGPIGSPFPDNPVRVLGQPNMYVALWYKFGVPIHGRAWNNGGVLECSFPYKKAELTGTKDLGGQIQVLQYK---- 83 
2_pfamImport   1 DDIWTNQKVGTPFPTNVVKAPGETNKYVALWYRHGKPIMGRAWNDSGVMQCTFVLEDKVFTGS-DVGGVIQLLLLE---- 75 
3_pfamImport   1 DDIWTLQKVGTPFPPNVAKAPGETNKYVALWYKHGKPVMGRAWNDSGVVKCMFVLDDKIYSGA-DVGGSIQLLILD---- 75 
XP_003117292   7 DDIWTFQKVGTPFPSNVAKAPGETNKYVALWYKHGKPVMGRAWNDSGVVKCTFVTDNKIYSGP-DVGGSIQLLVID---- 81 
Q94401         6 EDSWAFQPIGSPFPEAPVRVPNQNNQYVALWYKHGKPIHGRAWNNDGVVECSFPYNKAELKGKLDLGGQIQILQYK---- 81  Caenorhabditis ...
XP_001898624   6 EDTWAYNTIGSPFPDNPVRVKGQQNMYVALWYKFGKPIHGRAWNNNGNVECSFPYSKVELTGARDLGGQIQILTCSeqdp 85 
XP_003141621  84 -GDHNLLGFWYEWIKYKDRFE-KTEE-RQKLKCGDSLPILWKnRKAGPLMGYLD-ATELAHFSHDGKTEILQGTVLDDMY 159
4_pfamImport  77 -GDHNNQGFWYEWIKYKDRIE-KIDDkHQLVRCGDSFPIFWK-RAEGNLLGYVDnKTEEAWFSFNGKVIKQLGPQLNEMY 153
XP_003148592  84 -GDHLTLGFWYNWIKYKDRFE-KFEKgAELLRCGDSFPIFWNdRNEGPLLGYVDnKTEIARFSHDGKVEEVSGGALNDML 161
1_pfamImport  77 -GDHRNLGYWYNWIKYSQRFD---GEhREILRCGDSIPLLWAnRPQGAILGYVDnKTEIARFSHDGISEDKSGGELADMM 152
XP_003139314  84 -GDHNTLGFWYEWIKYKDRFE-KTDI-RQIVHCGDSMPILWQdRPEGALLGYLDnKTELAHFSHNGKAESLQGTPLSNMW 160
2_pfamImport  76 -PPNKKKSFHYDWVSFKKAKSlTSEGkYEMVRCDYNSPVYWAeHG---FLGCINtQLQIAHFV-DNDSKILTTNKTEDLQ 150
3_pfamImport  76 -HIEKSKSFHYDWVNFKKAQSlTIEGkYEMVRCEYSASMYWPeHG---LLGCVNtEKLVAHFV-DNEMQIKTTKKLEHLL 150
XP_003117292  82 -PGEKPCPFHYDWVNYKKAQSlTIEGkYEMVRCEYSASVYWPeHG---LLGCVStNRLVAYFV-DNDSQIISTKKMDDLL 156
Q94401        82 -GDYNSLGYWYEWLPLKQRHE-NNEGiREIVRCGNSVPVLAKlKDGTDKLGFLDlNTEVALFSNAGTTEKYEGGATANFM 159 Caenorhabditis ...
XP_001898624  86 vEQFKKSGFWYEWRPYKDR---ENDQlLQLVRCGQSTPVLMPtKDGNTFLGYIDmGKDVANVGYKGKNETLAGGEIQNLL 162
XP_003141621 160 IIVRNLKggppgceckkCyvppppppkpeeppppPPPGPPPP--RIMRDEWMDLRMGDPWPT-RKLVQALGKTLDTIPKE 236
4_pfamImport 154 IITRNCIggpphcpcavCg---------------AAPPPPKPvpRVERDEWMDIREGDPWPT-RQLVKALDKTLDTLPGV 217
XP_003148592 162 IIVRELKggppncvcheC-----------------SAGPPKPvvRVTLDEWADFRYGDPWPTtGKPVQALNRALSTLSDE 224
1_pfamImport 153 IIVRELKggppncecpvC-----------------AKLPPKPviRVMLNEWADFRAGDPWPA-RKMVKALDKSLDTLAGE 214
XP_003139314 161 IIVRNTKggpptcgckqCykpp---------ppkPPPGPPPP--RVMIDEWIDLRAGDPWPKdKKLIKALNKNLDTHPGE 229
2_pfamImport 151 VL---------------Ckisg---------sreSADKAAALnkMTNVNDWEDFNWGSYWPInKNVMSI---PKQL---G 200
3_pfamImport 151 VL---------------Ckiagsrd--atekekeKGSTGSASklLTVVNDWEDFNWGSAWPSnKNVMSI---PKNIPSAG 210
XP_003117292 157 VL---------------CkiagakeahapekdkeKSSVGYSLrlSTHINDWEDFNWGSPWPTnKNVMST---PKNISPVG 218
Q94401       160 TIFRNLR-------------------------------PPPTglKVYDDLWYDLRYGDNFPS--NAVPADGRALNTETG- 205 Caenorhabditis ...
XP_001898624 163 VLFRNIK-------------------------------APPTgiKIYEDTWIDLKYRDPFPTaKNPIPGGGRKLKNDDGS 211
XP_003141621 237 DPDQYVALWYQQGEPIMGRIWkDSNGKVAAAFGWNGHEYR-DKVGSLQVLVELGHNVRGYDYSWQPFSVCGTFGEKEWLP 315
4_pfamImport 218 NPDQYVALWYMQGEPVMGRVW-NEGGKVAANFSWFNNEYC-KNVGSIQLLIYLPDSVRGFDYGWIPFPEAAQFGDKAWHP 295
XP_003148592 225 NPNQYVALWYQSGEPVMGRIW-NDGGKIAACFGWGGHEYR-KNIGSIQVLFELPEQIRGFDYAWKPFKEAAQFGAKEWIP 302
1_pfamImport 215 SPDQYVALWYQAGEPVMGRVW-NEGGKIAANFSWNGKEFK-TNIGSIQILFELSEHVRGFDYGWIPYQQAATFGEKEWHP 292
XP_003139314 230 NPEQYVALWYQQGEPVMGRIW-NNNGKVAACFGWNNNEYR-EKIGSLQILVELPDFVRGYDYDWKLFSVCASFGEKEWFP 307
2_pfamImport 201 VPDQYVALWYRHGKPIMGRAW-PKNGKIDASFVDANREFTgPTVGSLQLLIALPPTTVGYDYVWMNYTLAMDYRDKDFVP 279
3_pfamImport 211 I-DQFVALWYRHGKPIMGRAW-QSNGRIEASFVDAKREFTgATVGSLQLLISLPPTTVGYDYVWMTYTQAIDYRDKDYVP 288
XP_003117292 219 F-DQFVALWYRHGKPIMGRAW-PKNGRIEASFVDSNREFTgATVGSLQLLISLPPTTVGYDYVWMAYGQAVDYRDKDYVP 296
Q94401       206 PHMQYVALWYKHGDPVFGRSYpSSAGKTMAHFGKNNQENAgPEVGSMQLLTVPEASCMGLEYKWMPLSEGKSSG---WTT 282 Caenorhabditis ...
XP_001898624 212 ETYSYVALWYKHGEPVFGRAYpDPAGKTLASFGWNGQENAgAELGSMQMIVIPQPENLGFEYKWMSYKEVKG-GAGAFKP 290
XP_003141621 316 VYVdy-kGIISPCVITWE-GKQILGKVDIRNEKASAAFSGKENIMIGPKVQ-SQLVLCRKAR 374
4_pfamImport 296 VHVnnhkGDISVGVVNVAgGKQILAKVDVRNEKYGYGYQGKEHSATAKNCAdNTIVLCRKAK 357
XP_003148592 303 VHVdhhkGNISPAVLIID-GKEILGKADIRNERATVGHGGTEKVYVGPAVH-TCVVLCRKAK 362
1_pfamImport 293 VHVahhkGDISPAVIVID-GKQILGKVDIKNERACAGHGGKEVMHVAGAVH-SSVVLCRRAK 352
XP_003139314 308 VYVdr-kGIISPCVCTID-GKEILGKVDIRNEKASAAFSGKEHVMVGPSVQ-KQMVLCRKAR 366
2_pfamImport 280 VHL----SYVVPALVPVG-TKLLLGQVNMKTECATVAIDGKVTKLEGGPVK-SISVLCRREM 335
3_pfamImport 289 VHL----SYICPAIVPVD-GKFFLGQVNMKTECATVALNGSVTQLDGGPVK-SIMVLCRKEM 344
XP_003117292 297 VHL----SYICPAVVPVN-GKLILGQVNMKTECATVALDGTVTQLDGGPVK-SIFVLCRREM 352
Q94401       283 VHI----GNSAPCILKDDkGLEVLGNLDLTIEKASAGYGGKEKIMTGAAVA-KLKVLFKRRL 339 Caenorhabditis elegans
XP_001898624 291 LHV----GDCVPCVLKTAkGAELLGNLHMKMEKATAGFGGKDSAVVGPAVM-NFLVLCRNgh 347
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