Conserved Protein Domain Family
OPA3

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pfam07047: OPA3 
Optic atrophy 3 protein (OPA3)
This family consists of several optic atrophy 3 (OPA3) proteins. OPA3 deficiency causes type III 3-methylglutaconic aciduria (MGA) in humans. This disease manifests with early bilateral optic atrophy, spasticity, extrapyramidal dysfunction, ataxia, and cognitive deficits, but normal longevity.
Statistics
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PSSM-Id: 462072
Aligned: 135 rows
Threshold Bit Score: 71.0026
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_014172718                    7 FKLAALFVRHISKYGANQIKIQAHE-----HQRFR-RQAARYGQAIHQLNMRL----NVAVLRNyd-aeKRarekaeaae 75 
XP_001615794                    5 FKIGIVLIRQVSKPISGYIKKKAIE-----NKKFK-SICIYCGKKYYFFEQYI----QKKFYNAna-tnVN--------- 64 
Q4N9R1                          5 YKVLCVFIRQISKPFANYLKRRAAH-----NERFR-NICIYFGNKSFAFERSI----SRRFYNSev-teCD--------- 64  Theileria parva...
EDO05638                        5 FKLLTVFIKQISKPLASYLKKRASK-----NERFR-KLCVTIGNRSYAFDRYV----TRRFYNPeq-gePD--------- 64 
XP_008206277                    9 SALLTQLFRQLTKPASQRIVDYAAR-----HPSFRrYLLLAPGRLYHRLESHLerlkAAPMVASka-ekKP--------- 73 
EGI68336                        9 ANLIGQILRQITQPLSKAIVKRVKK-----RPLIRkYVLMQLGHFYYLCENLI----EWRQISVi--------------- 64 
WGS:AAGF:cds.TTHERM_00348870A   5 LKALSLVGKVFSRPIVVIFKVGIQK-----IGGTPrETLVRWGNIIYNWEAWI----NRRFLGYeg-kvKE--------- 65 
WGS:AAGF:cds.TTHERM_00191250A   5 FKLFSLFVRILARPVIARTKAHTSSkl--qNQKFR-VFFVWLGNKAHRINVYI----NRTFLKLnn-qdFK--------- 67 
A0CNE2                          5 LKLISLIVRVFARPIITSRKEVSIEkvlmsKQRFLtQQIQNLGNYYYYTDQKI----DRMYLNQnl-hdEY--------- 70  Paramecium tetraurelia...
A0BUL1                          5 FKVFSLIVRVFARPVIARTKAAHLKkaqsgHTTWIkQFYVRLGNFQHKWDQKI----DSKFMGIdkkssDF--------- 71  Paramecium tetraurelia...
XP_014172718                   76 aptvktkeqaereerlkqkeaadrakygttakeahpatvimrtsdasipaasaaaatatsstsssadstrgpthftsvwk 155
XP_001615794                      --------------------------------------------------------------------------------    
Q4N9R1                            --------------------------------------------------------------------------------     Theileria parva...
EDO05638                          --------------------------------------------------------------------------------    
XP_008206277                      --------------------------------------------------------------------------------    
EGI68336                          --------------------------------------------------------------------------------    
WGS:AAGF:cds.TTHERM_00348870A     --------------------------------------------------------------------------------    
WGS:AAGF:cds.TTHERM_00191250A     --------------------------------------------------------------------------------    
A0CNE2                            --------------------------------------------------------------------------------     Paramecium tetraurelia...
A0BUL1                            --------------------------------------------------------------------------------     Paramecium tetraurelia...
XP_014172718                  156 RKFRALPEAKAVDL---------FADVVGAAFILVIASALVLYEYYRSASKP--DanlANLERIKDLngqLTELRAAEDE 224
XP_001615794                   65 -YSSYISESKSVNV---------GSELLGETIIFLVAAIIIVAEYKRNSLKE--A---KKETVLNHK---LETLKLQVLE 126
Q4N9R1                         65 --KVTLSPEKSVNI---------GSELLGECFIFTVAAGLITAEYVRGALKE--S---RKEYRLKQR---LDNIDSRQGE 125 Theileria parva...
EDO05638                       65 -TTPWISPEKSVVI---------GTELFGEIIVFGVATLLVLSEYARGIRKE--S---KKEAKLQER---LGTLEAQQSR 126
XP_008206277                   74 -KVKALKDEEAAML---------GSQLMIEIVIFALLALILTCDWLRSQRKS--A---LEEDRRRAE---FAELERQKSE 135
EGI68336                       65 TKKRPIDDDRTMEV---------GTSLLLEAIIFGFLGGVVIYETQKAADRAciA----EELQIQE----FNDIKAKKDR 127
WGS:AAGF:cds.TTHERM_00348870A  66 ---VLLSDEKALEN---------FANFFIEVVIVYGVIGYITISQGIQKHRE------MQEEKERK-----DRLEEEVYY 122
WGS:AAGF:cds.TTHERM_00191250A  68 --VQDLSEPAALEL---------GVETFYEVIIYACILGLPIIEIYRAQVES--N---EKSEKQKQV---MEGIHTRLQN 128
A0CNE2                         71 ---DKLNDEDALKLvilitiilqGTEFLLEMIIYTILILVSLFEIYKTYFEQqeR---------------LQNMNNTIKN 132 Paramecium tetraurelia...
A0BUL1                         72 -FFKPLNDELALEK---------GVEFFYEILIYALLITLPTYEMYSAQQDS--K---KKSEQNTQK---LNNLMKQIEE 133 Paramecium tetraurelia...
XP_014172718                  225 H 225
XP_001615794                  127 L 127
Q4N9R1                        126 L 126 Theileria parva
EDO05638                      127 I 127
XP_008206277                  136 A 136
EGI68336                      128 L 128
WGS:AAGF:cds.TTHERM_00348870A 123 L 123
WGS:AAGF:cds.TTHERM_00191250A 129 L 129
A0CNE2                        133 L 133 Paramecium tetraurelia
A0BUL1                        134 N 134 Paramecium tetraurelia
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