Conserved Protein Domain Family
GT29_ST3GAL3
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cd23981: GT29_ST3GAL3 
beta-galactoside alpha-2,3-sialyltransferase 3
ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).
Links
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Statistics
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PSSM-Id: 467709
Aligned: 7 rows
Threshold Bit Score: 439.358
Created: 28-Nov-2018
Updated: 27-Apr-2023
Structure
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Aligned Rows:
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putative active
Feature 1:putative active site [active site]
Evidence:
  • Comment:based on homology to other members of the family
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                ###                    ##                    #                          
Q11203       156 RCRRCIIVGNGGVlanksLGSRIDDYDIVVRLNsAPVKGfekDVGsKTTLRITYPEgamqrpeqyerdSLFVLAGFKwqD 235 human
Q5ND64       137 SCKRCIIVGNGGIlsnksLGSRIDQYDVVIRLNeAPVKGyskDVGsKTTMRITYPEgaiqkpenyednSLFVFSAFKplD 216 Japanese medaka
AFN40456     139 SCRRCIIVGNGGVlanksLGLKIDDYDVVVRLNsAPVKGfekDVGgKTTLRITYPEgaiqkmeqyekdSLFVLAGFKwqD 218 chicken
NP_001177325 141 NCRRCIIVGNGGVlanksLGSKIDEYEVVVRLNsAPVKGfekDVGsKTTLRITYPEgaiqkleqyekdSIFVLAGFKwqD 220 African clawed ...
XP_014342857 156 SCKRCIVVGNGGVlanksLGSKIDEYDVIIRLNgAPVKGyekDVGaKTTIRITYPEgaiqkaegyekdSLFVFAGFKpqD 235 coelacanth
XP_007885248 167 TCKRCIIIGNGGIvanksLGSKIDDYDVVIRLNeAPVKGfekDVGsKTTLRITYPEgaiqkperyekdSLFVFAGFKpqD 246 elephant shark
KFZ64172      24 SCRRCIIVGNGGVlanksLGLKIDDFDVVVRLNsAPVKGfekDVGgKTTLRITYPEgaiqkmeqyekdSLFVLAGFKwqD 103 chuck-will's-widow

Feature 1                                                                         ###            
Q11203       236 FKWLKYIVYKervsasdgfwksvatrvpkepPEIRILNPYFIQEAAFTLiglpfnnglmgrgniPTLGSVAVTMALHgCD 315 human
Q5ND64       217 FKWLKQMVYKekvrgmegfwksvaqyvprapADMRILNPYFIQEAAFQFiglpfnnglmgkgniPTLGTVAITMALHnCD 296 Japanese medaka
AFN40456     219 FKWLKYIVYKekvsasdgfwksvatrvprepHEIRILNPYFIQEAAFSFiglpfnnglmgrgniPTLGSVAITMALHnCD 298 chicken
NP_001177325 221 FKWLKYIVYKekvsasdgfwksvatrvprepHEIRILNPYFIQEAAFSFiglpfnnglmgrgniPTLGSVAITMALHnCD 300 African clawed ...
XP_014342857 236 FKWLKCIVYKekvnladgfwksvatiipkepHEIRILNPYFIREAAFTFiglptnngmmgkgniPTLGTVAITMALHnCD 315 coelacanth
XP_007885248 247 FKWLKYIVYKekvspsdgfwksvatavpkepKDIRILNPYFIREAAFMFiglpvnngmmgrgniPTLGTVAITMALHnCD 326 elephant shark
KFZ64172     104 FKWLKYIVYKekvsasdgfwksvatrvprepHEIRILNPYFIQEAAFSFiglpfnnglmgrgniPTLGSVAITMALHnCD 183 chuck-will's-widow

Feature 1             ##         ###               #            
Q11203       316 EVAVAGFGYDmstpnAPLHYYETVrmaaikeswtHNIQREKEFLRKL 362 human
Q5ND64       297 EVAVAGFGYDmnmpyAPLHYYETVrmstikeswtHNIPKEKEFLRKL 343 Japanese medaka
AFN40456     299 EVAVAGFGYDmsspnAPLHYYENIkmsaikeswtHNIQREKEFLRKL 345 chicken
NP_001177325 301 EVAVAGFGYDmnlpnAPLHYYETIkmaaikeswtHNIQKEKEFLKKL 347 African clawed frog
XP_014342857 316 EVAVAGFGYDlnnpnAPLHYYESIkmlaikeswtHNIGREKEFLRKL 362 coelacanth
XP_007885248 327 EVAVAGFGYDmntpnAPLHYYETIkmsaikeswtHNIAKEKEFLKKL 373 elephant shark
KFZ64172     184 EVAVAGFGYDmsspnAPLHYYENIkmsaikeswtHNIQREKEFLRKL 230 chuck-will's-widow

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