Conserved Protein Domain Family
DUF4647

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pfam15504: DUF4647 
Domain of unknown function (DUF4647)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 282 and 480 amino acids in length.
Statistics
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PSSM-Id: 464752
Aligned: 9 rows
Threshold Bit Score: 614.952
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q8BHW4        22 MNVADESQWDEAVCTLSGCQHPQCWASLRRIERGHPRILDPSPKSPRETEDKLPTLTIVNITDTCLWTQKRVAqQQPSEF 101 house mouse
2_pfamImport   1 MDLPEESQWDETTCQLAVCQHPQCWATIRRIERGHPRILGPPCKTALHDEDKLPVLTTVNMADSCLWAKRHAH-HHLSGF 79 
XP_014948454   1 MDLPDKSQWDETTCDLAVCQHPQCWATIRRIERGHPRLLDSSSKSFVDAEDKLPVLTIVNIADSCFPAKRVIRrRHLPGF 80 
XP_023366233   1 MDLPDDSQWDETTCDLALCQHPQCWATVRRIERGHPRILSSPCKTLQPDEDKLPELTIVNMSDSCFFS------RHLSKF 74  small-eared galago
XP_009243047   1 MDLPDESQWDETTCGLAVCQHPQCWATIRRIERGHPRILGSSCKTPLDAEDKLPVLTVVDISDSCFAP------RHLPEC 74  Sumatran orangutan
NP_001019517  22 MRVVDESQWNEAVCTLAGCQHPQCWASLRRIERGHPRILDTSSKSPWESEDKLPTLTVVNIMDTCLWAKKRVVqRQASEF 101 Norway rat
XP_023401112   1 MDLPDANQWDETTCASAVCPHPQCWAALRRIERGHPRLLGSPCKTPLDTEDKLPMLTIVNISDSSLRPKRLAQ-RCLSGF 79  African savanna...
XP_008271637   1 mdlpdetqwdettcnlalcqhpqcwasfrrierghprilgspcqtpvgpeDKLPMLTVVNISDSCFRAKRLAR-RPLLAS 79  rabbit
XP_006088057  20 MDLPDESQWDETTCNLAACQHPQCWATIRRIERGHPRILGSSYKTPLDVNDKLPVLTIVNLSDSCFQARRRPH-GHLPGL 98  little brown bat
Q8BHW4       102 TFPKDRPSLSKPA---SKRQS--------------------------------RSPKALRDKDVTSRSPRPLK------- 139 house mouse
2_pfamImport  80 TFTRPRALLCPGAkfdSKLQG--------------------------------RPRKDLPDKDLIDHPDRSPK------- 120
XP_014948454  81 TFTKAHSLLS--SkfdSKFQG--------------------------------RPWKDLPDRDLMNRTDRSPK------- 119
XP_023366233  75 TFSKARSLLCRGSkskSKFQG--------------------------------RPQKGLPVKSWINSTNKPSK------- 115 small-eared galago
XP_009243047  75 TFTKAHSLLSRSSkfySKFHG--------------------------------RPPKGLPDKSLIHCTNRLPK------- 115 Sumatran orangutan
NP_001019517 102 TFPKERSLLLKPA---SKCHG--------------------------------RSWKSLRDKDATSHS-RPPK------- 138 Norway rat
XP_023401112  80 TFAKTHSLLSRGSkfdSKFQGrkdfshntnlifsvncllylffilgnfhflglKSMKGLPEKGLISSTNTPPK------- 152 African savanna...
XP_008271637  80 AVSKAHALLSRESkfdSKFQD--------------------------------RPQKGLPD-DLSSLTERAPK------- 119 rabbit
XP_006088057  99 TFTKPHSLLSQRSkfdSKFQG--------------------------------RPRKDLPDKDLIIYTNRSPKgshklek 146 little brown bat
Q8BHW4       140 LSVLNLNEAKLPLSENVSNMVVTWVPEETEKDVs--PVQKTDVSS---------WPGKKRRKKLRKKSKPSLYypgrQY- 207 house mouse
2_pfamImport 121 LSVLNLNETQLPNPQDVRNMVVIWIPEQPERHMs-pAEKKPVLRS---------QDWMRRRMISTTGFSSLLS----PCr 186
XP_014948454 120 LSVLNLNETKLPCPQDVGNMDVIWIPEKHVSPA----EEKHLICS---------QDGNMNRKKSPGKHKSEL-------- 178
XP_023366233 116 LSVLNLNDTPLPCSEDVSNMVVIWVPEESEKSVslpek--rdltS---------QHRKNKVKTWAGKKGSSPSfsrkQYp 184 small-eared galago
XP_009243047 116 LPVLNLNETQLPCPEDVRNMVVLWIPEETEIHV-----------S---------QHGKKKRKNSAVKSKSFLGlsgnQSa 175 Sumatran orangutan
NP_001019517 139 LSVLNLNEAKLPFSGDDRNMVVTWVPEEMAKKT---IQEKAGVPS---------RSVKKRRKKWGETSKPSLYyrgrRY- 205 Norway rat
XP_023401112 153 VSVLNLNETSPLCPQDVRNMAVIWIPEEPEKHKrspAEKKPDVTN---------QDGREKRKKSAVENKSALGflekQGm 223 African savanna...
XP_008271637 120 LSVLNLNEIEIPSSKDVRNMVVVWIPEEQEKPV-----------S---------QHEKKKRKKSTVKNKLSLGlpgkQHt 179 rabbit
XP_006088057 147 LPVLNLNETQIPHPQGVSNMVVVWIPKEPGASV-----------SpaeqyvapsQDGKKKRKTSTV--SSVVls-gkQDr 212 little brown bat
Q8BHW4       208 ---SRSPAAIVPPPSPEHHLEQlspEAIPLWAQVGMLPQDLLEECILAHEKSIIGPEVKIELSKMRKSLPLERRRPESAI 284 house mouse
2_pfamImport 187 kvrRKPLGMIVPPPSPIQFLEQ---QSVPLWNQFDMLPQDLLKDLLPNEGKTMPSLEMRTQLAMMKKKAPLEKSRPDSAI 263
XP_014948454 179 ------PGIIVPPPTPAHLYEQlssESLPLWNQFDMLPQDLLKDLLLDKGKTILYPEIRTQLAMMRKKPPLEKSRPDSAI 252
XP_023366233 185 etqSRMLKMIVPPPTPVPLSEQlasDCIPSWDPFHVLPQDLLEELLSDEGKTMLSPEMKIQLAMMKKSLPLEKNRPDSAI 264 small-eared galago
XP_009243047 176 etrVGTPGMIVPPPTPVQLSEQfssDFLPLWAQSEALPQDLLKELLPGGKQTMLCPEMKIKLAMMKKNLPLEKNRPDSAI 255 Sumatran orangutan
NP_001019517 206 ---LRSPAVLVPPPSPVHFLEQlhsEAIPLWAQVDMLPQDLLKECILSHEKSTACPEVKMELSKMKKSLPLEKSRPDSAV 282 Norway rat
XP_023401112 224 gtqLGRQEVLVPPPSPVHLLKQlhtDSILPWDQIDMLPQDLLKDLLTDEGKIIPSSNMKIELAMMKKSRPLEKSRPESAI 303 African savanna...
XP_008271637 180 raqLRAPAITVPPASPVHLYEQfssESMPVWAPVDMLPLDLVADLFPGGGRDMPCPELKIQLAMVKKTLPLEKDRPDSAL 259 rabbit
XP_006088057 213 etkLSTPGMLVPPPSPVRFFEQlspEFLPFLNQFDTLPQDLLNDLLLDEGKRSPCLETKTQLA-TRKKNPLKKSRPESAI 291 little brown bat
Q8BHW4       285 SSKMYLTIQRLTLQRPSLRYPARLRKLCPNLKQgE----------G----LAGHGSS-------------DSLMQQG--- 334 house mouse
2_pfamImport 264 SAKMFLTVHRLTLQRPALRYPKHSKKLYHNLNT-E----------G----HKKQQQW-------------QQKQQQR--- 312
XP_014948454 253 SAKMYLSVHRLTLQKPALRYPEHLKKHCSNLKT-D----------G----HRK-----------------QQRQQQR--- 297
XP_023366233 265 SSKMFLSVHRLTLQRPALRYPEFSKKLRCNLKT-E----------DgfagWQQEQQRqq----------eQQQQQQR--- 320 small-eared galago
XP_009243047 256 SSKMFLSIHRLTLESPALRYPERLKKL-HNLKT-E----------G----YRKQQQWqqrqqqwqqrqqqQQQQQQR--- 316 Sumatran orangutan
NP_001019517 283 SSKMYLTIQRLTLQRPSLRYPDCLKKLRHNLKR-D----------S----WK------------------QQEE------ 323 Norway rat
XP_023401112 304 SSKMFLSVHRLTLQKPGLRHPEHLRKLHNNLMSkA----------S----LS------------------EAARSPGpkk 351 African savanna...
XP_008271637 260 SSKMFLTTHRLTLQRPSLRYPEHWKKLQYSLKI-E----------G----LRKQQWW-------------QQQQRKG--- 308 rabbit
XP_006088057 292 SAQMFLSVHRLTLQRPSLKYPAHLKKLYYNLNI-EdrlssaarspG----LRKQ----------------QQKQQQR--- 347 little brown bat
Q8BHW4       335 -----------KAKTFPPK---Q--------EPKKKAKRNVKGQYGEETTSGHFfhd-----svGL----RISG------ 377 house mouse
2_pfamImport 313 -----------KVKTPPKR---Q--------EAKKKSKNSGKGFHFQRSVWGHL----------GH----RTLP------ 350
XP_014948454 298 -----------KVKTAARK---Q--------EAKKRCRSEPESHNSSRKHP-------------GR----KTLR------ 332
XP_023366233 321 -----------RVQTPTK-------------EAKNKARNGPGIQGTSNKRLSTIayd----plfGL----RTLR------ 362 small-eared galago
XP_009243047 317 -----------KVKTPIKK---Q--------EAKKKAKSDPGSQSTSHKHPVTTihg----plyGY----RTLP------ 360 Sumatran orangutan
NP_001019517 324 -------------KTSTKK---Q--------EAKKKAKRDVEEQYGEETMSSDSfhdpsfhdhvGL----RISR------ 369 Norway rat
XP_023401112 352 qqqqkqqqqqrKVKTLTKK---QvkgqgivlEVKKKTKSDPGSQNTLHERK-------------VIavydPVSGhsslpd 415 African savanna...
XP_008271637 309 --------------------------------AKKKAKGDAKRWDMSRQHSVNIvcd----------------------- 333 rabbit
XP_006088057 348 -----------KLKTPMKEpkkP--------EAKKKSKKDPGSQSTSRKSL-------------GH----RTLP------ 385 little brown bat
Q8BHW4       378 ---QEDQQTPWEEED-IEKTSAETHVSLEEVyEFD---KYyTEYYATPESAV-LYET--VYQN------------LDDde 435 house mouse
2_pfamImport 351 ---SQESDKKQPQQT-KSEEPTLRKVRALEPfRMVsvlRYcIAHHLKADTAVaGRSSdsEGRV------------LKT-- 412
XP_014948454 333 ---GQQSDKKRQQQQmKTRGPPSKQDSTERP-QTNiaeKF-LDSSRSKKSPE-LSQIeyTKKD------------IKTqm 394
XP_023366233 363 ---GQKSHMKQQQ------------NSTERS-KMDyskKC-VDFSLSMESLG-SPERelTNKN------------ISApv 412 small-eared galago
XP_009243047 361 ---GQNSDMKQQQQM--EKGTTLKQDSTERP-KMNyydH--ADFHHSVKSPE-LYETepTNKD------------ISApv 419 Sumatran orangutan
NP_001019517 370 ---REIERKLLKGEVgMEKTSLERRVSVEEPmAYEfgsYYtASYYTSPESAL-LYET--IYQD------------LNDge 431 Norway rat
XP_023401112 416 eesDTKQQEQMEIEGpTLKQLRVYQGHTARAlFKDateEPgMD--HLEKYPDsF--T--RHSStelvktestkedIGTqv 489 African savanna...
XP_008271637 334 --svcESDGMLQEEG-----------------------------------PE-LSELepAYEN------------NSTaa 363 rabbit
XP_006088057 386 ---GGESDNNQQLQM-EKNGPILKQDSTERP-QMGnaeND-LDSFSSKQNPE-LSKTesTNKD------------FGPqm 446 little brown bat
Q8BHW4       436 etmvgikaSSKDRNLKNLSAMMDGIGWNPELKLLRILQATEEEDEE 481 house mouse
2_pfamImport 413 --------CSPSFSVLHLSLLGEGCRWNPELKLLRILQATDNEDEE 450
XP_014948454 395 e----illEDRMRTPKSASSVS----WNPELKLLRILQATDEEDEE 432
XP_023366233 413 katlepqaSRSED------------SWNPELKLLRILQATDDEDDD 446 small-eared galago
XP_009243047 420 eavpeaqaARRKKISFNFSEIMARTGWNSELKLLRILQDTDDEDEE 465 Sumatran orangutan
NP_001019517 432 eteleveaFSKDNNPKSLSAVMDNISWNPELKLLRILQATEEENEE 477 Norway rat
XP_023401112 490 efelesqtSSEEKTPRNLSASIDGTIWNPELKLLRILQATDDEDEE 535 African savanna elephant
XP_008271637 364 e----avlEARRETSKRLAGSVTGVSWNPELKLLRIIQATDDEEQE 405 rabbit
XP_006088057 447 e----evpVAHEEPSKDLSSSISRASWNPELQVMRISQAAEYEAEE 488 little brown bat
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