1FSZ,1OFU,1W5F,1W5E,4M8I,3VO8,3WGJ,2R6R,4DXD,3VOA,3WGL,1W58,1W5F,3VO9,2RHH,2VAM,3WGK,1RLU,1RQ7,2Q1X,2VAW,4E6E


Conserved Protein Domain Family
FtsZ_type1
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cd02201: FtsZ_type1 
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Filamenting temperature sensitive mutant Z, type 1
FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at the site of bacterial cell division, which is required for constriction of cell membrane and cell envelope to yield two daughter cells.
Links
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Statistics
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PSSM-Id: 276961
Aligned: 273 rows
Threshold Bit Score: 205.711
Created: 8-Feb-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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nucleotideSulA
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:nucleotide binding site [chemical binding site]
Evidence:
  • Structure:1FSZ: Methanocaldococcus jannaschii FtsZ with bound GDP (defined using 4.0 A contacts)
  • Citation:PMID 9722999
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             ###  #                                                                  
1FSZ_A     38 AKITVVGCGGAGNNTITRLKMEGi----eGAKTVAINTDAQQLIRTk-aDKKILIGKkltrgLGAGGNPKIGEEAAKESA 112 Methanocaldococcus...
EGS28836   44 IKLKVIGIGGAGNNAVQMMELEKy----pSVEFIVANTDAQALAKNk-cPNKLALGKes-rgLGAGSDPEVGQARAKESS 117 Mycoplasma anatis ...
EGV00052    8 VKVKVIGIGGAGNNAINLLLEEDl----pNVELWIANTDYQDLEKSk-cTNKLYLKGds-egYGAGGDPKIGKKAAEDSI 81  Mycoplasma columbi...
EFF41843   25 ISLKVIGVGGAGNNAVELMLKDKy----pNIEFIVANTDAQALTKNs-cSKKIALGSkdsrgLGAGSDPDVGKKRANESS 99  Mycoplasma alligat...
P47466     18 LKIGVFGIGGAGNNIVDASLYHYpnlaseNIHFYAINSDLQHLAFKtnvKNKLLIQDhtnkgFGAGGDPAKGASLAISFQ 97  Mycoplasma genital...
P75464     18 IKIAVFGIGGAGNNIIDDMLRMHpelqtaNVQFFALNTDLQHLKTKryvQNKAVIQFeeskgLGVGGDPQKGAVLAHHFL 97  Mycoplasma pneumon...
ENY70177    6 IKIKVIGIGNAGLNICESLIERQn----tNIEIYAADTDKNKLNKTk-iTNKIILGTsl-ngSGTGGDPKLGAQAAEESS 79  Mycoplasma bovigen...
BAH69713   15 VKLKVIGVGGAGNNAINLMLDENl----pNVELLVANSDRQDLVKSl-cPNKILLGDst-rgFGAGGDPKVGRECALESI 88  Mycoplasma ferment...
AIA29532    8 IKIKVIGVGGAGNNIVSSLVSKEl----eNIDLIVANTDFQVLNNCp-vEKKIYLGDst-kgLGTGGDPEIGAQCAKESI 81  Mycoplasma califor...
AAZ43752   36 IKLCVIGVGGGGNNAVKMIQAAGf----sNVNFIIANTDDQALSLNp-cENKISLGKdt-rgLGAGSDPEIGEKSARESV 109 Mycoplasma synovia...

Feature 1                      ## ####                        #   #    #                      
1FSZ_A    113 EEIKAAIqdsdMVFITCGLGGGTGTGSAPVVAEISKKIgalTVAVVTLPFVMEGk-vRMKNAMEGLERLKQHTDTLVVIP 191 Methanocaldococcus...
EGS28836  118 RKIEEKIkdadVVIITAGLGGGTGTGAAPVVAEIARNNgalTIAIVTTPFSTEGk-kRTRIAKEGIEKLKEKVDSYIVLS 196 Mycoplasma anatis ...
EGV00052   82 REIDDVLqdtdLLIITAGLGGGTGTGAAPVIAKAAKDKgivTLAIVSTPFTIFEgsrRKKIALEGLEELKNSTDSYIVLS 161 Mycoplasma columbi...
EFF41843  100 REIEDNLkgsdVVILTAGFGGGTGTGATPVIAQIAKNVgalTIAVITTPAKYEGk-kKLNIALREIEVLKKSVDAYIVIS 178 Mycoplasma alligat...
P47466     98 EQFNTLTdgydFCILVAGFGKGTGTGATPVFSKILKTKkilNVAIVTYPSLNEGl-tVRNKATKGLEILNKATDSYMLFC 176 Mycoplasma genital...
P75464     98 EQFHKLSdsfdFCILVAGFGKGTGTGATPVFSKFLSNKgvlNLSIVSYPAMCEGl-kAREKAAKGLERLNQATDSFMLFR 176 Mycoplasma pneumon...
ENY70177   80 EQIAQIIddcnMLIIVSGFGGGTGTGASETIAKLARNKnilTLAIITLPMADIVgkrKLELANNYLEKLTQCVNSYMVID 159 Mycoplasma bovigen...
BAH69713   89 KEIQKSLentdIVIISAGLGGGTGTGAAPVIAEAAKKMgilTVAVVTTPFELIEgkhKSLIAQEGLKKLSEVVDSYIVIS 168 Mycoplasma ferment...
AIA29532   82 DEIEKSIegadIVVVVAGLGKGTGTGSGPVIAQTAKQKgilTLAMVATPFEQFEgsrVSAIANQGLRQLKDSVNAYMVLS 161 Mycoplasma califor...
AAZ43752  110 DEIEEALkgadVVLVTAGLGGGTGTGAAPVIAEAAKKMgalTIGIVTTPFSYEGp-kRKRIAKNGIQELSKVVDSYIVLS 188 Mycoplasma synovia...

Feature 1     #               #  ##  #                                                        
1FSZ_A    192 NEKLFeivpnmplklAFKVADEVLINAVKGLVELITKDglINVDFADVKAVMNN------------GGLAMIGIGESDSe 259 Methanocaldococcus...
EGS28836  197 NERLLqqygdvpiddAYTKSNVYLKNIINTIHDILYRIgtINIDFADMRRILEK------------SGLTLIGLGQASGk 264 Mycoplasma anatis ...
EGV00052  162 NDKLMqsnlegnsedAFKFANITLKNSIKAIWEVIFEKftINIDFNDLRKVLKN------------GSQTFISIGKGFGn 229 Mycoplasma columbi...
EFF41843  179 NQKLDelfgefpiedAYKASNNSLKTTIIAIHDILYRTgkINIDYADVRKILDD------------SGLAVVALGTASGk 246 Mycoplasma alligat...
P47466    177 NEKCTn--------gIYQLANTEIVSAIKNLIELITIPlqQNIDFEDVRAFFQTkktnq--dqqlfTVTHPFSFSFDSKd 246 Mycoplasma genital...
P75464    177 NDRCTd--------gIYQLANVAIVKTIKNIIELINLPlqQNIDFEDIRSFFKKpaqrleneanlfRVTNTFTFSFDAHn 248 Mycoplasma pneumon...
ENY70177  160 NNRMLqqnaelpmyqAVKMANVAVETTIDVIDDIISNVsdLNIDFSDIKSALIN------------GGKIVVASGKSQNg 227 Mycoplasma bovigen...
BAH69713  169 NQKLVenyrnlpvqeAFKVSNYTLKNSIKIIRDIIFETgfINLDFNDLRQVLLD------------GKETIIGIGNGFGk 236 Mycoplasma ferment...
AIA29532  162 NEKLVqqnidfpfsqAFKMIDEIVAKCLSTITQIINQPtkINVDFNDFKAILQN------------GGKIVIGSGKAQGd 229 Mycoplasma califor...
AAZ43752  189 NDKLAenfgdlpiedSFQLANITLKNIILAFHDILYRIgtINIDYADVVKILGG------------SGLAVVGIGQATGk 256 Mycoplasma synovia...

Feature 1                                                                                     
1FSZ_A    260 krAKEAVSMALNSPLLDvd---idGATGALIHVMGPedLTLEEAREVVATVSSRLDp-------nATIIWGATIDENle- 328 Methanocaldococcus...
EGS28836  265 nrATKAVEKAFQNNLYSte---icGAERFLINIQYDksATLNEIKTAVDEVNKFLNtnss--ideDDIIIGQERIEGet- 338 Mycoplasma anatis ...
EGV00052  230 daWKKAVEQALLNQLNEfe---lsDPKKIIIIFKMKq-SSFKEIEEAKKLIDQYLNvkd----ddVEILLGIKYLENvde 301 Mycoplasma columbi...
EFF41843  247 drAEKAINKAFANNLYTyn---fqGAKRFLVNIQHDakATGRDMSKAMDTIRQHLGvded--dedVDIIFGHETIPDvs- 320 Mycoplasma alligat...
P47466    247 -sIEQFAKQFKNFEKVSyfdhsivGAKKVLLKANINqkIVKLNFKQIQDIIWTKIDny------qLEIRLGVDFVTTip- 318 Mycoplasma genital...
P75464    249 -tIEHFSHKLKNFEYEGffdhkveGAQKVILKVLVNqgLYPLDLTQIQEIIWAKIDnh------nLEVQLGVDFTDAnp- 320 Mycoplasma pneumon...
ENY70177  228 dkVTNAFEAARDSSSFIdk---ptSFATLLTNCTVDtkISYADILELRKKIIEEYQlp-----edIDGKFGIDYKEHeds 299 Mycoplasma bovigen...
BAH69713  237 drAIKAVDDALMTPLFQse---ikNCQKVAILFQCDkrASLDDIETAKNRIDEYLAnn-----leAQTFIGLQYIDTqdr 308 Mycoplasma ferment...
AIA29532  230 nkIQSVFANATESANIIdk---pqSFSHVIFHCLLDqhSAYSEIIALKNSLIEHFNmds---tidTRLAIGNYESPDskd 303 Mycoplasma califor...
AAZ43752  257 drATKAVEKAFEQNLYEyp---ikSANKILVNIQHDkkATLHEINTAIKKVHEILSqnrsddqeeYDCIIGQEAVETkdn 333 Mycoplasma synovia...

Feature 1                  
1FSZ_A    329 --ntVRVLLVITG 339 Methanocaldococcus jannaschii
EGS28836  339 --dlFKVSVIAGR 349 Mycoplasma anatis 1340
EGV00052  302 rdksFSLTVIASG 314 Mycoplasma columbinum SF7
EFF41843  321 --eyFKVSIVAAG 331 Mycoplasma alligatoris A21JP2
P47466    319 ---nIQIFILSEH 328 Mycoplasma genitalium G37
P75464    321 ---sVQLFFLMEK 330 Mycoplasma pneumoniae M129
ENY70177  300 rddyLKFSYILTQ 312 Mycoplasma bovigenitalium 51080
BAH69713  309 -eeiFRISIIASN 320 Mycoplasma fermentans PG18
AIA29532  304 --dsLQFSFIATE 314 Mycoplasma californicum
AAZ43752  334 -aevFKVSVIAGE 345 Mycoplasma synoviae 53

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