Conserved Protein Domain Family
UbiB

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TIGR01982: UbiB 
2-polyprenylphenol 6-hydroxylase
This model represents the enzyme (UbiB) which catalyzes the first hydroxylation step in the ubiquinone biosynthetic pathway in bacteria. It is believed that the reaction is 2-polyprenylphenol -> 6-hydroxy-2-polyprenylphenol. This model finds hits primarily in the proteobacteria. The gene is also known as AarF in certain species. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]
Statistics
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PSSM-Id: 273909
Aligned: 12 rows
Threshold Bit Score: 606.601
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q8PQT0         4 ILRASRIGRVILRYRLDALLEG-T-PAERWLRLAKPFVPRASAEIAA--QsrgarLRLALQELGPIFVKFGQILSTRRDL 79  Xanthomonas axo...
AAD21549       8 FWRLFRWSRILSKHGVLKTVEKsT-IVPLSLRLIIRLLRIGYRVPNPp-D-----YTGAFVALGPAAIKFGQTLATRPDL 80  Zymomonas mobil...
P27854         6 VRRLYFIIRTFLSYGLDELIPK-M-RITLPLRLWRYSLFWMPNRHKD--KllgerLRLALQELGPVWIKFGQMLSTRRDL 81  Escherichia coli
Q9JVQ5         4 LKRLTVIVGTFYRYRLAGLCAS-L-MGSGWICALLKMMPQSSKLKNEppa---vrLRLALESLGPIFIKFGQVLSTRPDL 78  Neisseria menin...
CDH87787      34 YFRLIRIGWVLARENAFAAVPS-E-HLPPLARFVQKLAGLLASREARl-GarsgrLARAVERLGPSYVKIGQFLATRPDV 110 Sinorhizobium m...
WP_010962936   5 ILRLLHIITVLTRYNILP-------------YLLPPSKKSINKIQgh-------kLKCALEKLGPVFIKFGQSISSRTDV 64  Wolbachia endos...
WP_010977614   5 FFNLIRIFRIISKKQILIDSRS-PkYCRFIGYILALFFAPVSLIKKSr-EdygkrLIDCLSDLGPIYIKFGQTLSTRADL 82  Rickettsia conorii
WP_010921536   7 FWRLTGAGWALVRADALIPRELeP-LLPPSAKLAGRVLRLFAGPAARk-GrpgerLAAVLERQGPAAIKMGQFLSTRADI 84  Caulobacter vib...
WP_004401600   4 LRRYREIIFVFIKYGFGAIIDN---IGILKHINVRRKILKQTNDENIakLsrgerLRLALEELGPTFIKMGQILSTRSDI 80  Thermoanaerobac...
WP_011025524  13 YKRYRDILKILTKNGFGFIVD----------ILSRGGRVPFYLLRGHdvMeigerIRNTLEELGPTFIKLGQLISTRADL 82  Caldanaerobacte...
WP_003481867  11 LGRLQEIASVLIRYGFGDVVRR---IGLADVLERAGRLLHWQNAEGRlrMsaamrVRRALEELGPTFVKLGQVLATRVDL 87  Xanthomonas
WP_011715035   1 --------MILAQHNVMEPFARr--YVPMRLLSWLVQLNPVIWRHCRr-TplhirLRLALEELGPTFIKFGQTLSTRLDI 69  Magnetococcus m...
Q8PQT0        80 IPADVAEELTLLQDRVKPFDGQAARLIVEA-------ALGL-PVSV---------------AFASFDTVPLASASIAQVH 136 Xanthomonas axo...
AAD21549      81 IGEETAAQLACLQDSVPPLPFKDIRIVIEN-------ALGC-PIEK---------------SFRFFNEIPIGSASIAQVY 137 Zymomonas mobil...
P27854        82 FPPHIADQLALLQDKVAPFDGKLAKQQIEA-------AMGGlPVEA---------------WFDDFEIKPLASASIAQVH 139 Escherichia coli
Q9JVQ5        79 IPHDYAVELAKLQDKVPPFDARLSREQIEK-------SLGQ-SIEK---------------LYAEFETEPIASASIAQVH 135 Neisseria menin...
CDH87787     111 VGAELAADLSLLQDRMATFPESASRAAIEA-------SLGR-PVGE---------------LFLEFSE-PIAAASIAQVH 166 Sinorhizobium m...
WP_010962936  65 LNEDITNNLLLICDRLPSFSHKIAVKTIES-------EFNC-KLSD---------------IFSSFSEKPIAAASISQVH 121 Wolbachia endos...
WP_010977614  83 VGTEIAGYLRLLQDKLPPFDGGVARRLITSlrgdiyvDEAI-SASKqkiatqsmtvshdalPFLHLDDTPIAAASISQVH 161 Rickettsia conorii
WP_010921536  85 FGAAFADDLSRLKDRLPAFPLSVAKAEIAR-------NLGK-PLDE---------------IFAEIGE-PVAAASLAQAH 140 Caulobacter vib...
WP_004401600  81 LPKDIIKELEKLQDKAPAFSFDEVKSVIQN-------EFGE-SLEE---------------AYAEFEPTPLAAASIAQVH 137 Thermoanaerobac...
WP_011025524  83 IPHDILIELSKLQDEVAPEEFESIKKVLES-------ELGG-NIEE---------------FFSYFEEKPLASASIGQVY 139 Caldanaerobacte...
WP_003481867  88 LPPEWIEELSELQNAVPALPFDQIRPQLVA-------ALGM-EPES---------------VFARLDEQPLAAASLAQTH 144 Xanthomonas
WP_011715035  70 LPDEIGQELKRLQDDVPPFDLATVRQSIEE-------DLKR-PLHE---------------LFRSFDEKPVASASIAQVH 126 Magnetococcus m...
Q8PQT0       137 AATLPPDangvrREVVVKVLRPEIERQIDADIALLHSLATLVERTHPRADKIRPREVVAEIEGTLAAELDLQREGANASV 216 Xanthomonas axo...
AAD21549     138 QAETLDG-----VTVAVKVLRPGIKLAFRKATETYEWAATKIESLNDEFIRLRPKLVVKTFRQWTIRELDLRREAASASE 212 Zymomonas mobil...
P27854       140 TARLKSNg----KEVVIKVIRPDILPVIKADLKLIYRLARWVPRLLPDGRRLRPTEVVREYEKTLIDELNLLRESANAIQ 215 Escherichia coli
Q9JVQ5       136 KARLHSG-----ERVAVKVLRPNLLPLIEQDLSLMRFGAAWVERLFSDGRRLKPLEVVAEFDKYLHDELDLMREAANAGQ 210 Neisseria menin...
CDH87787     167 PAVVMRDgt--rERVAVKVIRPGVRQRFVADIEAMYLVSRMQERFLPYTRRLRPVEVTKTLEQTTKVEMDLRLEAAALSE 244 Sinorhizobium m...
WP_010962936 122 RAVTTEG-----KEVAVKVLRPNIEKTFSRDIKMLSWLAEIAEKFSEQSKRLRPIELVKTFAEICRLELDLRFEAAHSSE 196 Wolbachia endos...
WP_010977614 162 KAQLITG-----EYVAVKILRPGIHKKYNRDIKLLYFLAKIISKFSK-AKRLKPIKVVDKFHETMKFELDLRLEAAAASE 235 Rickettsia conorii
WP_010921536 141 PATLVDG-----QKVAVKVLRPGVERQVARDTAVLRLAARLAETLVPVSRRLRPTEFVEVVIRALELEMDLRFEAAGCAE 215 Caulobacter vib...
WP_004401600 138 KALLWSG-----KTVVVKVQRPGIEKIIAQDMRILEDIAKFVDNHTKYGKIYNFTKMVEDFKKRLEEELDFRIEGENAEK 212 Thermoanaerobac...
WP_011025524 140 RARTKEG-----KDVVVKVQRPEVDKKIHADVVILKNIARILNERIVDSP-VDFVEIVEELTDSLLNELDYTQEGNNADR 213 Caldanaerobacte...
WP_003481867 145 RAWLVDG-----TPVVLKIRRPDIGDTIDADLRLLARLAEIVETRAPDLKRYRPSEVVQQFTVSLRRELDFAAEGRNAER 219 Xanthomonas
WP_011715035 127 HAFTHDG-----DEVAVKVLRPDVAARVETDIAMLMTMASLVEELMPEWRRLKPRGVVKEFAQTIRNEMDFLVEASRAQK 201 Magnetococcus m...
Q8PQT0       217 LRRFWEGSDDLYVPEVIWSHTAERALTLERVYGIPSDDIAKLDAAGi-DRKALAAKGVRVFYTQVFRDNFFHADAHAGNI 295 Xanthomonas axo...
AAD21549     213 LAENMEAVPGFKVPVIDWNRTSQSMMVMQWIDGIKLSDHQKLQEAGy-DLKSLATRLVRSFLRQAIADGFFHADLHHGNL 291 Zymomonas mobil...
P27854       216 LRRNFEDSPMLYIPEVYPDYCSEGMMVMERIYGIPVSDVAALEKNGt-NMKLLAERGVQVFFTQVFRDSFFHADMHPGNI 294 Escherichia coli
Q9JVQ5       211 LGRNFHNSNMLIVPKVFYDYCTSDVLTIEWMDGTPVADIAKLKADGi-DLHKLADYGVEIFFTQVFRDGFFHADMHPGNI 289 Neisseria menin...
CDH87787     245 LGENTREDSGFRVPRVDWERTGRDVVTMEWIDGIKMSDIEGLKRAGh-DLNRLAETLIQSFLRHTLRDGFFHADMHQGNL 323 Sinorhizobium m...
WP_010962936 197 LKENTKNDRGFYVPEIDWNRTSKKVLTLEWIEATPIYEVEKLN-----NRKQIAINLIESFCNQVYRDCFFHADMHPGNL 271 Wolbachia endos...
WP_010977614 236 LTDNMRNDINVIIPKIYWDLTSENILTTEWLDGTSIYDTLLLKEMGl-EPAKISQDFAVMFFNQAYRDGFFHADLHAGNI 314 Rickettsia conorii
WP_010921536 216 LGEAMAKDPYMRAPAVCWEGVGKRVLTLSWAEGAPLSDPAALDLPGl-DRKALAENVTRGFLAQALDHGLFHADLHEGNL 294 Caulobacter vib...
WP_004401600 213 FKKNFLKDKKVKIPSIIWTHTTRRVLTMEYIGGIPLNDFNAIDEAGl-DRGAIARNLAKSVLNQILRDGFFHGDPHPGNI 291 Thermoanaerobac...
WP_011025524 214 FRENFKNQDYIYIPEVYWDYTTKRVLTMEYIDGISVKNKEILREKGy-DLKRIARNGAWSIFLQVYKYGLFHGDLHPGNI 292 Caldanaerobacte...
WP_003481867 220 IAANFAHDAQVVVPAVYWEWTSESLNVQEFIDGIPGRDLLAVDAAGl-DRRALARAGAGIVLKMVLQDGCFHADPHPGNI 298 Xanthomonas
WP_011715035 202 LGENFKDDVGMMIPQVYWPLTSSRVFTMAWIEGVSIDELPRERVAGrpDPRVVAERLLSSFFKQVFHDGYFHADQHPGNI 281 Magnetococcus m...
Q8PQT0       296 WVDSDperrlnPRFIALDFGIMGQLSQEDQYYLAENFMAIFHKDYRRMAELHVEAGWMPSNVRIDELEAAARSVCEPYFN 375 Xanthomonas axo...
AAD21549     292 FALKD------GSLAVVDFGIMGRIDKKARRWLAEILYGLITGNYSRIAEIHFEAGYVPSHHDIAEFTTALRTIGEPIRG 365 Zymomonas mobil...
P27854       295 FVSYEhp--enPKYIGIDCGIVGSLNKEDKRYLAENFIAFFNRDYRKVAELHVDSGWVPPDTNVEEFEFAIRTVCEPIFE 372 Escherichia coli
Q9JVQ5       290 LVAAD------NRYIALDFGIVGTLTDYDKRYLAINFLAFFNRDYRRVATAHIESGWVPADTRAEELEAAVRAVCEPVFN 363 Neisseria menin...
CDH87787     324 FVDEA------GHIVAVDMGIVGRLGRKERRFLAEILYGFIMRDYQRVADVHFEAGYVPSHHDAASFAQAIRAIGEPIHG 397 Sinorhizobium m...
WP_010962936 272 MVDSN------NNIIALDCGIMGRIDRETCYYVIEILKGFLNRDYDHVAKMHFRAGYVSS--QHRNFVTACRAIGEPIIG 343 Wolbachia endos...
WP_010977614 315 LVNKQ------GKIILLDFGIMGRLKEKDRLAVAESLFGFLRRDYKLVAKVHLRAGYIPSNTDLALFAQSCRAVTEPIVG 388 Rickettsia conorii
WP_010921536 295 FIAAP------AAITAVDYGIVGRLGPGERRYLAEILYGFLNRDYARVAKIHFDAGYVPAHQDMDAFAQALRAVGEPVFG 368 Caulobacter vib...
WP_004401600 292 MVLED------GTIAFLDFGMVGSLSPERKRQFSKMLLGIVYKNSRMIIESIIDLNAVTLNVNMKKLEKDINNLRDRYVE 365 Thermoanaerobac...
WP_011025524 293 LITKE------GKISYIDFGIVGYLDKSSREVLIELFKAFAENDTEEVIEILSDIGAIRADTNLRNLKADLGRIINYFYT 366 Caldanaerobacte...
WP_003481867 299 FYLRD------GRIAVIDFGMVGRVSEQRRFQVAQLLHGMVSYDAEAVIDVLLEWAGTSLEIDEARLQQDIGAFVDEYRG 372 Xanthomonas
WP_011715035 282 LVRED------GVVALIDFGIVSHVSEQTRQFLAEMVQGFITRDYKKVAQVHLDAGYIPHDTDMDAFEEACRQIGEPVFG 355 Magnetococcus m...
Q8PQT0       376 RPLSEISLAQVLIKLFRVAQRYELTLQPQLILLQKTLLNIEGVGRQLDPRLDIWAVARPVLERILRERYSPRRVL 450 Xanthomonas axonopod...
AAD21549     366 LSVRDISISHMLDGLFSITREFEMQTQPHLLLLQKTMVVVEGVATSLYPDINLWDTAEPFVREWLRSELGPEAKI 440 Zymomonas mobilis su...
P27854       373 KPLAEISFGHVLLNLFNTARRFNMEVQPQLVLLQKTLLYVEGVGRQLYPQLDLWKTAKPFLESWIKDQVGIPALV 447 Escherichia coli
Q9JVQ5       364 KPISQISFGLVLMRLFEVSRRFNVEIQPQLVLLQKTLLNIEGLGRQLDPDLDLWKTAKPFLVKWMNGQVGPKALW 438 Neisseria meningitid...
CDH87787     398 QPAETISMAKLLTLLFEVTELFDMQTRPELVMLQKTMVVVEGVARTLNPRFNMWKASEPVVGKWIRDNLGPKRIV 472 Sinorhizobium melilo...
WP_010962936 344 QPIQKISFASLLAQLLKITGDFDMKVQTQLLLLQKTMILLEGTCRKIYSEINMWKVVEAWISSQHENKIGYREKI 418 Wolbachia endosymbio...
WP_010977614 389 TPIKNISIGKLLAHLFKITEDFGMEVQPELLLLQKTLIMVEGIGRQLDGNVNMWQLAEPWIKKWAVKNLSPEAKL 463 Rickettsia conorii
WP_010921536 369 RNAREVSMGRLLAQLFEITALFDMALRPELVLLQKTMVTVEGVARRIDPTHDLWAAADPVVRRWIGRELSPAAKA 443 Caulobacter vibrioides
WP_004401600 366 IPLEKLKVGEVLNGIFDLVFSYNIVIPNEFNMLAKSLITLEGIVEKLDPKISVLEVAKPIAKQLIPKMFSTQHMK 440 Thermoanaerobacteraceae
WP_011025524 367 TPLKNINVNDSMRRIMGVVYKYKLMLPPGFTLLLKALATVEGVGRDLDPDFSISDVARDFVKEMYLKKIDVKEVI 441 Caldanaerobacter sub...
WP_003481867 373 VPLKELRIGAMLGDVTSILRDHGLTLPSDLALMIKAFLTLEGMGRQLDPDFDMATEARPYLERVVLQRYAPRAIV 447 Xanthomonas
WP_011715035 356 QPLKDISVARLLAKLFKTTEQYNMEVQPQLLLLQKTLFTLEGVGRELHPDLNAWEIAEPLVMAWMKARIGPKGQL 430 Magnetococcus marinus
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