AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in bacteria and photosynthetic organisms using either the acetylated, noncyclic (NC), or non-acetylated, cyclic (C) route of ornithine biosynthesis. Also included in this CD is a distinct group of uncharacterized (UC) bacterial and archeal NAGKs. Members of this CD belong to the Amino Acid Kinase Superfamily (AAK).
Feature 1:N-acetyl-L-glutamate binding site [chemical binding site]
Evidence:
Structure:1GS5; Escherichia coli NAGK complexed with the substrate NAG and with the inert nucleotide substrate analog AMPPNP, showing contacts with NAG.
Structure:2BUF; Pseudomonas aeruginosa NAGK complexed with NAG and ADP, showing contacts with NAG.
Jiyao W et al.(2023). "The conserved domain database in 2023.",