Conserved Protein Domain Family
7tmA_LWS_opsin

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cd15081: 7tmA_LWS_opsin 
long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors
Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.
Statistics
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PSSM-Id: 320209
Aligned: 6 rows
Threshold Bit Score: 579.17
Created: 10-Nov-2008
Updated: 17-Oct-2022
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
P22329     39 GPNYHIAPRWVYNLTSVWMIFVVAASVFTNGLVLVATWKFKKlrhpLNWILVNLAVADLGETVIASTISVINQISGYFIL 118 chicken
P04000     42 GPNYHIAPRWVYHLTSVWMIFVVTASVFTNGLVLAATMKFKKlrhpLNWILVNLAVADLAETVIASTISIVNQVSGYFVL 121 human
Q8AYN0     38 GPNYHIAPRWVYNVATVWMFFVVVASTFTNGLVLVATAKFKKlrhpLNWILVNLAIADLGETLFASTISVINQVFGYFIL 117 zebrafish
O12948     41 GPNYHIAPRWVYNLTSIWMIFVVFASVFTNGLVIVATLKFKKlrhpLNWILVNMAIADLGETVIASTISVFNQIFGYFIL 120 African clawed frog
AAR14680   40 GPNYHIAPRWMYNLTSFWMIIVVILSLFTNGLVLVATLKFKKlrhpLNWILVNLAIADIGETIFASTVSVVNQIFGYFIL 119 pouched lamprey
ABS89280   40 GPNYHIAPRWVYNLTSLWMIFVVFASCFTNGLVLMATYKFKKlrhpLNWILVNLAIADLGETLIASTISVTNQIFGYFIL 119 Australian lungfish
Feature 1            #   ##  ##                                                               
P22329    119 GhpmCVVEGYTVSACGITALWSLAIISWERWFVVCKPfGNIKFdGKLAVAGILFSWLWSCAWTAPPIFGWSRYWPHGLKT 198 chicken
P04000    122 GhpmCVLEGYTVSLCGITGLWSLAIISWERWLVVCKPfGNVRFdAKLAIVGIAFSWIWSAVWTAPPIFGWSRYWPHGLKT 201 human
Q8AYN0    118 GhpmCIFEGYTVSVCGIAGLWSLTVISWERWVVVCKPfGNVKFdGKWASAGIIFSWVWAAVWCAPPIFGWSRYWPHGLKT 197 zebrafish
O12948    121 GhpmCVLEGFTVSTCGITALWSLTVIAWERWFVVCKPfGNIKFdEKLAATGIIFSWVWSAGWCAPPMFGWSRFWPHGLKT 200 African clawed frog
AAR14680  120 GhplCVFEGFTVSVCGITALWSLAIISFERWMVVCKPfGNLKFdGKVAIVLIIFSWAWSAGWCAPPIFGWSRYWPHGLKT 199 pouched lamprey
ABS89280  120 GhpmCMLEGFTVATCGITGLWSLTIIAWERWVVVCKPfGNIKFdGKWAAGGIIFSWVWSAFWCAMPLFGWSRFWPHGLKT 199 Australian lungfish
Feature 1     ####                 ##   #                                                    #
P22329    199 SCGPDVfsgssdpGVQSYMVVLMVTCCFFPLAIIILCYLQVWLAIravaaQQKESESTQKAEKEVSRMVVVMIVAYCFCW 278 chicken
P04000    202 SCGPDVfsgssypGVQSYMIVLMVTCCIIPLAIIMLCYLQVWLAIravakQQKESESTQKAEKEVTRMVVVMIFAYCVCW 281 human
Q8AYN0    198 SCGPDVfggnedpGVQSYMLVLMITCCILPLAIIILCYIAVFLAIhavaqQQKDSESTQKAEKEVSRMVVVMILAFCLCW 277 zebrafish
O12948    201 SCGPDVfsgssdpGVQSYMLVLMITCCIIPLAIIILCYLHVWWTIrqvaqQQKESESTQKAEREVSRMVVVMIVAYIFCW 280 African clawed frog
AAR14680  200 SCGPDVfsgstdpGVQSYMVVLMITCCFIPLALIIICYLQVWLAIhtvaqQQKESETTQKAERDVSRMVVVMIFAYIFCW 279 pouched lamprey
ABS89280  200 SCGPDVfsgedkyGTRSFMIALMITCCIIPLGVIILCYIQVWWAIrtvakQQKESESTQKAEKEVSRMVVVMIFAYCFCW 279 Australian lungfish
Feature 1        #                      #   #                     
P22329    279 GPYTFFACFAaanpgyaFHPLAAALPAYFAKSATIYNPIIYVFMNrQFRNCI 330 chicken
P04000    282 GPYTFFACFAaanpgyaFHPLMAALPAYFAKSATIYNPVIYVFMNrQFRNCI 333 human
Q8AYN0    278 GPYTAFACFAaanpgyaFHPLAAAMPAYFAKSATIYNPIIYVFMNrQFRVCI 329 zebrafish
O12948    281 GPYTFFACFAafspgysFHPLAAALPAYFAKSATIYNPIIYVFMNrQFRNCI 332 African clawed frog
AAR14680  280 GPYTFFACFAaanpgyaFHPLAAALPAYFAKSATIYNPIIYVFMNrQFRNCI 331 pouched lamprey
ABS89280  280 GPYTFMACFGaaypgyaFHPLAAALPAYFAKSATIYNPIIYVFMNrQFRNCI 331 Australian lungfish

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