1MRZ,2X0K


Conserved Protein Domain Family
FAD_synthetase_N

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cd02064: FAD_synthetase_N 
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FAD synthetase, N-terminal domain of the bifunctional enzyme
FAD synthetase_N. N-terminal domain of the bifunctional riboflavin biosynthesis protein riboflavin kinase/FAD synthetase. These enzymes have both ATP:riboflavin 5'-phosphotransferase and ATP:FMN-adenylyltransferase activities. The N-terminal domain is believed to play a role in the adenylylation reaction of FAD synthetases. The C-terminal domain is thought to have kinase activity. FAD synthetase is present among all kingdoms of life. However, the bifunctional enzyme is not found in mammals, which use separate enzymes for FMN and FAD formation.
Statistics
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PSSM-Id: 185679
Aligned: 95 rows
Threshold Bit Score: 133.049
Created: 7-Jan-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active site
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:2X0K_A; Corynebacterium ammoniagenes FAD synthetase bound to diphosphoric acid, defined using 4.0 A contacts.
  • Structure:1MRZ; Thermotoga maritima flavin-binding protein with bound citric acid, contacts 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1          ####  #  #                                                                 
1MRZ_B      1 MVVSIGVFDGvHIGHQKVLRTMKEiaffrkdDSLIYTISYPPeyf--lpDFPGLLMTVESRVEMLSRY--ARTVVLDFFR 76  Thermotoga maritima
2X0K_A     17 SAVTIGVFDGvHRGHQKLINATVEkarevgaKAIMVTFDPHPvsvflprRAPLGITTLAERFALAESFgiDGVLVIDFTR 96  Corynebacterium am...
NP_660500  17 SAVSIGNFDGvHLGHQKLLSNLYKigkknniLTVLILFEPQPleflnnkNSPKRLTTIQNKIKYIQSWkiDIILCIKFNE 96  Buchnera aphidicol...
BAC24441   20 CVITIGNFDGvHLGHQKIISKLKNeslkrnlPMIVVIFEPQPkef-inkNSPSRITGLRDKIKYFKKMgiKQVLCINFNK 98  Wigglesworthia glo...
YP_044828  18 TAVTIGNFDGvHLGHQAMISQLKNiadanslKTLVMIFEPQPleyfkgyEAPPRISSLREKVEYLTELgvDYIAIAKFDH 97  Acinetobacter sp. ...
YP_123326  17 AVATIGNFDGvHLGHQHLIKALRAkademnlPLVILLFEPQPkeyfhreKAPARLSTLREKIDALNLCqvDYIYCIKFDA 96  Legionella pneumop...
YP_169913  16 KAIAIGSFDGvHLGHQAIIKKLLTiakennlVPYILFFEPLPkefflkdKAPFRIYDFRNKVINIHKLgiKHIICQKFNT 95  Francisella tulare...
NP_636529  18 SVVCIGAFDGlHLGHQALVRHAVEraralgvPAVAVSFEPLPreffandTPPPRLTLARAKIEGLYGFgaDSVGMIRFDG 97  Xanthomonas campes...
YP_265584  16 SIILIGNFDGvHLGHQKLFKLANTykkkfnlKIGVLTFEPMPkmffnknFKNFRISNINQKKIILDHLgvDFIITKKFDK 95  Candidatus Pelagib...
AAY89951   15 KVVTIGNFDGiHKGHQSLIKKTQEishaenlESIIFTFNMLPeev-feqSNFQRIYNNELKFDYIKAHeiNTILSINFND 93  uncultured bacteri...
Feature 1                                 #                                #        ###       
1MRZ_B     77 IKdl-tPEGFVERYLsg---vSAVVVGRDFRFGKNASGNAs-------fLRKKGVEVYEIEDvvv-qgKRVSSSLIRNLV 144 Thermotoga maritima
2X0K_A     97 ELsgtsPEKYVEFLLedtlhaSHVVVGANFTFGENAAGTAdsl----rqICQSRLTVDVIDLldd-egVRISSTTVREFL 171 Corynebacterium am...
NP_660500  97 SFsslsAEKFIKNILitklniKFIIIGDDFRFGSKRNGNIsll---keiGYQYNFKVIEISSllyknkIKISSTNIRKCL 173 Buchnera aphidicol...
BAC24441   99 NFlmlnAKDFIKNFLikslnmKCIIIGKDFRFGYKAYGDVkll---knsGKKLGFNVLEVKTlei-dsEKISSTAIRNAL 174 Wigglesworthia glo...
YP_044828  98 YFrglsAQEFADLLKfkl-naKQLVLGDDFHFGKNRQGNSe-------fLRDYGFKITNLDTief-kgERVSSTRIRQVL 168 Acinetobacter sp. ...
YP_123326  97 RLaqtsALYFAQFYLfealkiRYLLVGQDFRFGKSREGDVnllktlganYSCEVTVQSDFLIe----nEKISSTRIREAL 172 Legionella pneumop...
YP_169913  96 KFanitANEFIEEFLvkklntKHIIVGDDFKFGKNRGGDYall---nqySQTHDFNVDKVSTlnl-dnHRISSSDIRQAL 171 Francisella tulare...
NP_636529  98 RLsamsAQDFVRLALvgrlcaREVWIGPEFRFGHRRGGDIall---ralGEQHGFAAGEIAPvhl-rgERISATRIRELL 173 Xanthomonas campes...
YP_265584  96 KFsaikSDFFIKEILskkleaQYIFVSNNFRFGNKREGDVrql---iknEGRYHYKIVKPQPlil-nkKVISSTYIRSLL 171 Candidatus Pelagib...
AAY89951   94 IKdl-sASFFCEEILikklitKYLVIGKNFKFGKGREGNIdklkeyhnsGDFHLIIPELEQYd----nEHISSTRVRKLL 168 uncultured bacteri...
Feature 1                              
1MRZ_B    145 QEGRVEEIPAYLGRYFEIEGIVHKD 169 Thermotoga maritima
2X0K_A    172 SEGDVARANWALGRHFYVTGPVVRG 196 Corynebacterium ammoniagenes
NP_660500 174 LENKIELARKLLGRPFSISGRVIHG 198 Buchnera aphidicola str. Sg (Schizaphis graminum)
BAC24441  175 KNNKLEKAIKFLGHEYSISGRVVCG 199 Wigglesworthia glossinidia endosymbiont of Glossina brevipalpis
YP_044828 169 AEGDLALAAKLLGRPYSMIGRVQYG 193 Acinetobacter sp. ADP1
YP_123326 173 QQGNLRFAAKLLGRPYSMCGRVIKG 197 Legionella pneumophila str. Paris
YP_169913 172 TNHDLIEANKLLGESLKINSRVIHG 196 Francisella tularensis subsp. tularensis SCHU S4
NP_636529 174 VAGEFAHAGELLGRPYAIGGRVVRG 198 Xanthomonas campestris pv. campestris str. ATCC 33913
YP_265584 172 EKGQLKKTNKLLSRNWSIEGIVQKG 196 Candidatus Pelagibacter ubique HTCC1062
AAY89951  169 KDGKFSDVKNCLGREYMLRGTVTTG 193 uncultured bacterium BAC13K9BAC

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